Design and synthesis of novel benzofurans as a new class of antifungal agents targeting fungal N-myristoyltransferase. Part 1

Bioorganic and Medicinal Chemistry Letters

Volumn 11, Issue 14, 2001, Pages 1833-1837

  Masubuchi, Miyako ^a   Kawasaki, Ken ichi ^a   Ebiike, Hirosato ^a   Ikeda, Yoshihiko ^a   Tsujii, Shinji ^a   Sogabe, Satoshi ^a   Fujii, Toshihiko ^a   Sakata, Kiyoaki ^a   Shiratori, Yasuhiko ^a   Aoki, Yuko ^a   Ohtsuka, Tatsuo ^a   Shimma, Nobuo ^a  

^a NIPPON ROCHE RESEARCH CENTER   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ALPRENOLOL; ANTIFUNGAL AGENT; BENZOFURAN DERIVATIVE; CARBON; ENZYME INHIBITOR; FLUCONAZOLE; FUNGAL ENZYME; PROTEIN N MYRISTOYLTRANSFERASE; PYRIDIN 3 YLMETHYLAMINO DERIVATIVE; RO 094609; SC 58272; UNCLASSIFIED DRUG;

ANIMAL MODEL; ANTIFUNGAL ACTIVITY; ARTICLE; BETA ADRENERGIC RECEPTOR BLOCKING; CANDIDA ALBICANS; CANDIDIASIS; CHEMICAL MODIFICATION; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG DESIGN; DRUG IDENTIFICATION; DRUG MECHANISM; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; IN VITRO STUDY; MOUSE; NONHUMAN; STRUCTURE ACTIVITY RELATION;

ACYLTRANSFERASES; ANTIFUNGAL AGENTS; BENZOFURANS; CANDIDA ALBICANS; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; HUMANS; INHIBITORY CONCENTRATION 50; RECEPTORS, ADRENERGIC, BETA; SPECIES SPECIFICITY; STRUCTURE-ACTIVITY RELATIONSHIP;

CANDIDA ALBICANS;

EID: 0035939423     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(01)00319-5     Document Type: Article

References (22)