Parallel synthesis of pteridine derivatives as potent inhibitors for hepatitis C virus NS5B RNA-dependent RNA polymerase

Bioorganic and Medicinal Chemistry Letters

Volumn 15, Issue 3, 2005, Pages 675-678

  Ding, Yili ^a   Girardet, Jean Luc ^a   Smith, Kenneth L ^a   Larson, Gary ^a   Prigaro, Brett ^a   Lai, Vicky C H ^a   Zhong, Weidong ^a   Wu, Jim Z ^a  

^a Valeant Pharmaceuticals International   (United States)

Author keywords

HCV; Inhibitor; NS5B; Pteridine

Indexed keywords

ANTIVIRUS AGENT; BENZIMINAZOLE 5 CARBOXYLATE; CARBON; CARBOXYLIC ACID DERIVATIVE; ENZYME INHIBITOR; FUNCTIONAL GROUP; HYDROXYL GROUP; NITROGEN; PTERIDINE DERIVATIVE; RNA DIRECTED RNA POLYMERASE; UNCLASSIFIED DRUG;

ARTICLE; CELL MEMBRANE PERMEABILITY; DRUG ACTIVITY; DRUG DETERMINATION; DRUG IDENTIFICATION; DRUG INHIBITION; DRUG SYNTHESIS; ENZYMATIC ASSAY; GENE LIBRARY; GENETIC SCREENING; HEPATITIS C VIRUS; HYDROPHOBICITY; IC 50; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION;

ANTIVIRAL AGENTS; HEPACIVIRUS; HUMANS; INHIBITORY CONCENTRATION 50; PTERIDINES; REPLICON; RNA REPLICASE; STRUCTURE-ACTIVITY RELATIONSHIP; VIRAL NONSTRUCTURAL PROTEINS;

HEPATITIS C VIRUS;

EID: 12444313914     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2004.11.028     Document Type: Article

References (24)

1. M.I. Memon, and M.A. Memon J. Viral Hepatitis 9 2002 84
2. D. Moradpour, A. Cerny, M.H. Heim, and H.E. Blum Swiss Med. Wkly. 131 2001 291
3. A.M. DiBisceglie, and J.H. Hoofnagle Hepatology 36 2002 S121
4. G. Chandler Hepatology 36 2002 S135
5. M. Cornberg, H. Wedemeyer, and M.P. Manns Curr. Gastroenterol. Rep. 4 2002 23
6. M. Cornberg, D. Huppe, J. Wiegand, G. Felten, H. Wedemeyer, and M.P. Manns Gastroenterology 41 2003 517
7. B.W. Dymock Emergine Drug. 6 2001 13
8. G.M. Lauer, and B.D. Walker New. Engl. J. Med. 345 2001 41
9. S.R. LaPlante, A. Jakalian, N. Aubry, Y. Bousquet, J. Ferland, J. Gillard, S. Lefebvre, M. Poirier, Y.S. Tsantrizos, G. Kukolj, and P.L. Beaulieu Angew. Chem., Int. Ed. 43 2004 4306
10. C.G. Yannopoulos, P. Xu, F. Ni, L. Chan, O.Z. Pereira, T.J. Reddy, S.K. Dsa, C. Poisson, N. Nguyen-Ba, N. Turcotte, M. Proulx, L. Halab, W. Wang, J. Bedard, N. Morin, M. Hamel, O. Nicolas, D. Bilimoria, L. L'Heureux, R. Bethell, and G. Dionne Bioorg. Med. Chem. Lett. 14 2004 5333
11. I. Stansfiled, S. Avolio, S. Colarusso, N. Gennari, F. Narjes, B. Pacini, S. Ponzi, and S. Harper Bioorg. Med. Chem. Lett. 14 2004 5085
12. V. Summa, A. Petrocchi, V.G. Matassa, M. Taliani, R. Laufer, X. Ralph, R. DeFrancesco, S. Altamura, and P. Pace J. Med. Chem. 47 2004 5336
13. A. Gopalsamy, K. Lim, J.W. Ellingboe, G. Krishnamurthy, M. Orlowski, B. Feld, Z.M. Van, and A.Y.M. Howe Bioorg. Med. Chem. Lett. 14 2004 4221
14. P. Pace, E. Nizi, B. Pacini, S. Pesci, V. Matassa, R. DeFrancesco, S. Altamura, and V. Summa Bioorg. Med. Chem. Lett. 14 2004 3257
15. L. Chan, S.K. Das, T.J. Reddy, C. Poissson, M. Proulx, O. Pereira, M. Courchesne, C. Roy, W. Wang, A. Siddiqui, C.G. Yannopoulos, N. Nguyen-Ba, D. Labrecque, R. Bethell, H.M. Richard, P. Courtemanche-Asselin, L. L'Heureux, M. David, O. Nicolas, S. Brunette, D. Bilimoria, and J. Bedard Bioorg. Med. Chem. Lett. 14 2004 797
16. L. Chan, S.K. Das, T.J. Reddy, C. Poissson, M. Proulx, O. Pereira, M. Courchesne, C. Roy, W. Wang, A. Siddiqui, C.G. Yannopoulos, N. Nguyen-Ba, D. Labrecque, R. Bethell, H.M. Richard, P. Courtemanche-Asselin, L. L'Heureux, M. David, O. Nicolas, S. Brunette, D. Bilimoria, and J. Bedard Bioorg. Med. Chem. Lett. 14 2004 793
17. V. Summa, A. Petrocchi, P. Pace, V.G. Matassa, R. DeFrancesco, S. Altamura, L. Tomer, U. Koch, and P. Neuner J. Med. Chem. 47 2004 14
18. T.J. Reddy, L. Chan, N. Turcotte, M. Proulx, O.Z. Pereira, S.K. Das, A. Siddiqui, W. Wang, C. Poisson, C.G. Yannopoulos, D. Bilimoria, L. L'Heureux, H.M.A. Alaoui, and N. Nguyen-Ba Bioorg. Med. Chem. Lett. 13 2003 3341
19. J.Z. Wu, and Z. Hong Curr. Drug Target: Infect. Disorder. 3 2003 207
20. M. Wang, K.K.S. Ng, M.M. Cherney, L. Chan, C.G. Yannopoulos, J. Bedard, N. Morin, N. Nguyen-Ba, M.H. Alaoui-Ismaili, R.C. Bethell, and M.N.G. James J. Biol. Chem. 278 2003 9489
21. L. Chan, T.J. Reddy, M. Proulx, S.K. Das, O. Pereira, W. Wang, A. Siddiqui, C.G. Yannopoulos, C. Poisson, N. Turcotte, A. Drouin, M.H. Alaoui-Ismaili, R. Bethell, M. Hamel, L. L'Heureux, D. Bilimoria, and N. Nguyen-Ba J. Med. Chem. 46 2003 1283
22. J. Shim, G. Larson, V. Lai, S. Naim, and J.Z. Wu Antivir. Res. 58 2003 243
23. P.L. Beaulieu, M. Boes, Y. Bousquet, P. DeRoy, G. Fazal, J. Gauthier, J. Gillard, S. Goulet, G. McKercher, M. Poupart, S. Valois, and G. Kukolj Bioorg. Med. Chem. Lett. 14 2004 967
24. P.L. Beaulieu, M. Bos, Y. Bousquet, G. Fazal, J. Gauthier, J. Gillard, S. Goulet, S. Laplante, M. Poupart, S. Lefebvre, G. Mckercher, C. Pellerin, V. Austel, and G. Kukoij Bioorg. Med. Chem. Lett. 14 2004 119