The monoethyl ester of meconic acid is an active site inhibitor of HCV NS5B RNA-dependent RNA polymerase

Bioorganic and Medicinal Chemistry Letters

Volumn 14, Issue 12, 2004, Pages 3257-3261

  Pace, Paola ^a   Nizi, Emanuela ^a   Pacini, Barbara ^a   Pesci, Silvia ^a   Matassa, Victor ^a   De Francesco, Raffaele ^a   Altamura, Sergio ^a   Summa, Vincenzo ^a  

^a IRBM   (Italy)

Author keywords

HCV polymerase inhibitors; Meconic acid

Indexed keywords

ESTER DERIVATIVE; MECONIC ACID DERIVATIVE; RNA DIRECTED RNA POLYMERASE; UNCLASSIFIED DRUG;

ARTICLE; DECARBOXYLATION; DRUG INHIBITION; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; ENZYME ACTIVE SITE; ENZYME INHIBITION; ESTERIFICATION; HEPATITIS C VIRUS; STRUCTURE ACTIVITY RELATION;

ANTIVIRAL AGENTS; BINDING SITES; HEPACIVIRUS; PYRONES; RNA REPLICASE; RNA, VIRAL; VIRAL NONSTRUCTURAL PROTEINS;

HEPATITIS C VIRUS;

EID: 2442473821     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2004.03.087     Document Type: Article

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