Identification of N,N-disubstituted phenylalanines as a novel class of inhibitors of hepatitis C NS5B polymerase

Journal of Medicinal Chemistry

Volumn 46, Issue 8, 2003, Pages 1283-1285

  Chan, Laval ^a   Reddy, T Jagadeeswar ^a   Proulx, Mélanie ^a   Das, Sanjoy K ^a   Pereira, Oswy ^a   Wang, Wuyi ^a   Siddiqui, Arshad ^a   Yannopoulos, Constantin G ^a   Poisson, Carl ^a   Turcotte, Nathalie ^a   Drouin, Alexandre ^a   Alaoui Ismaili, M Hicham ^a   Bethell, Richard ^a   Hamel, Martine ^a   L'Heureux, Lucille ^a   Bilimoria, Darius ^a   Nguyen Ba, Nghe ^a  

^a Shire Canada   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ENZYME INHIBITOR; JTI; NS5B POLYMERASE INHIBITOR; PHENYLALANINE DERIVATIVE; RNA DIRECTED RNA POLYMERASE; UNCLASSIFIED DRUG;

ARTICLE; CRYSTAL STRUCTURE; DRUG ACTIVITY; DRUG IDENTIFICATION; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; HEPATITIS C; IC 50; STRUCTURE ACTIVITY RELATION; VIRUS REPLICATION;

ANTIVIRAL AGENTS; ENZYME INHIBITORS; HEPACIVIRUS; PHENYLALANINE; RNA REPLICASE; STRUCTURE-ACTIVITY RELATIONSHIP; VIRAL NONSTRUCTURAL PROTEINS;

EID: 0037431376     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm0340400     Document Type: Article

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23. Optimization of the benzamide portion of these inhibitors will be reported in a forthcoming publication.
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