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0038322074
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For optimization of N-benzyl portion of 1 see:
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85031075537
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(b) During preparation of manuscript a patent on X-ray co-crstallization of inhibitors of an allosteric site of NS5B polymerase has appeared: Love, R. A.; Yu, X.; Diehl, W.; Hickey, M. J.; Parge, H. E.; Gao, J.; Fuhrman, S.; E. P. Patent 1256628 CAN 137:194827. Curr. Med. Chem.: Anti-Infect. Agents 2002, 1, 163.
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85031078660
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1H NMR spectra of test compounds also indicated the presence of numerous rotamers.
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85031076916
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2-Ethyl-4-chlorobenzoic acid was prepared from methyl 2-bromo-4-chlorobenzoic acid via a three step sequence employing vinyl Stille coupling, hydrogenation, and hydrolysis.
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22
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FlashPlate™ scintillation proximity assays for characterization and screening of DNA polymerase, primase, and helicase activities
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50 value of a positive internal control was within standard deviation range.
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