Active site inhibitors of HCV NS5B polymerase. The development and pharmacophore of 2-thienyl-5,6-dihydroxypyrimidine-4-carboxylic acid

Bioorganic and Medicinal Chemistry Letters

Volumn 14, Issue 20, 2004, Pages 5085-5088

  Stansfield, Ian ^a   Avolio, Salvatore ^a   Colarusso, Stefania ^a   Gennari, Nadia ^a   Narjes, Frank ^a   Pacini, Barbara ^a   Ponzi, Simona ^a   Harper, Steven ^a  

^a IRBM   (Italy)

Author keywords

HCV; Hepatitis C virus; Polymerase

Indexed keywords

2 THIENYL 5,6 DIHYDROXYPYRIDINE 4 CARBOXYLIC ACID; CARBOXYLIC ACID DERIVATIVE; NS5B PROTEIN; RNA DIRECTED DNA POLYMERASE INHIBITOR; SULFONAMIDE; TRIFLUOROMETHYL ACYLSULFONAMIDE; UNCLASSIFIED DRUG; VIRUS PROTEIN;

ARTICLE; DRUG ACTIVITY; DRUG STRUCTURE; HEPATITIS C VIRUS; PHARMACOPHORE;

ANTIVIRAL AGENTS; BINDING SITES; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; HEPACIVIRUS; HYDROLYSIS; PURINES; PYRIDINES; PYRIMIDINES; RNA REPLICASE; STRUCTURE-ACTIVITY RELATIONSHIP; THIOPHENES; VIRAL NONSTRUCTURAL PROTEINS;

HEPATITIS C VIRUS;

EID: 4544361061     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2004.07.075     Document Type: Article

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