HCV NS5b RNA-dependent RNA polymerase inhibitors: From α,γ- diketoacids to 4,5-dihydroxypyrimidine- or 3-methyl-5- hydroxypyrimidinonecarboxylic acids. Design and synthesis

Journal of Medicinal Chemistry

Volumn 47, Issue 22, 2004, Pages 5336-5339

  Summa, Vincenzo ^a   Petrocchi, Alessia ^a   Matassa, Victor G ^a,b   Taliani, Marina ^a   Laufer, Ralph ^a   De Francesco, Raffaele ^a   Altamura, Sergio ^a   Pace, Paola ^a  

^a IRBM   (Italy)

^b Graffinity Pharmaceuticals AG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

3 METHYL 5 HYDROXYPYRIMIDINONECARBOXYLIC ACID; CARBOXYLIC ACID DERIVATIVE; ENZYME INHIBITOR; MAGNESIUM; MANGANESE; OXOACID; RNA DIRECTED RNA POLYMERASE; RNA DIRECTED RNA POLYMERASE INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; CHROMATOGRAPHY; DRUG DESIGN; DRUG MECHANISM; DRUG POTENCY; DRUG SYNTHESIS; HEPATITIS C VIRUS; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PROTON NUCLEAR MAGNETIC RESONANCE;

ANIMALS; BINDING SITES; DRUG DESIGN; HEPACIVIRUS; ISOMERISM; KETO ACIDS; MICROSOMES, LIVER; MODELS, MOLECULAR; PYRIMIDINES; RATS; RNA REPLICASE; STRUCTURE-ACTIVITY RELATIONSHIP; VIRAL NONSTRUCTURAL PROTEINS;

EID: 6044267996     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm0494669     Document Type: Article

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