Discovery of thiophene-2-carboxylic acids as potent inhibitors of HCV NS5B polymerase and HCV subgenomic RNA replication. Part 1: Sulfonamides

Bioorganic and Medicinal Chemistry Letters

Volumn 14, Issue 3, 2004, Pages 793-796

  Chan, Laval ^a   Das, Sanjoy K ^a   Reddy, T Jagadeeswar ^a   Poisson, Carl ^a   Proulx, Mélanie ^a   Pereira, Oswy ^a   Courchesne, Marc ^a   Roy, Caroline ^a   Wang, Wuyi ^a   Siddiqui, Arshad ^a   Yannopoulos, Constantin G ^a   Nguyen Ba, Nghe ^a   Labrecque, Denis ^a   Bethell, Richard ^a   Hamel, Martine ^a   Courtemanche Asselin, Philippe ^a   L'Heureux, Lucille ^a   David, Maud ^a   Nicolas, Olivier ^a   Brunette, Stéphanie ^a   Bilimoria, Darius ^a   Bédard, Jean ^a   more..

^a Shire Canada   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIVIRUS AGENT; CARBOXYLIC ACID DERIVATIVE; ENZYME INHIBITOR; GENOMIC RNA; NS5B POLYMERASE; NS5B POLYMERASE INHIBITOR; RNA POLYMERASE; SULFONAMIDE; UNCLASSIFIED DRUG; VIRUS ENZYME; VIRUS RNA;

ANTIVIRAL ACTIVITY; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; DRUG DETERMINATION; DRUG INHIBITION; DRUG POTENCY; DRUG SELECTIVITY; HEPATITIS C VIRUS; HEPATOMA CELL; HUMAN; HUMAN CELL; IC 50; QUANTUM YIELD; REPLICON; RNA REPLICATION; STRUCTURE ACTIVITY RELATION; VIRUS INHIBITION;

HEPATITIS C VIRUS;

EID: 1642534328     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2003.10.067     Document Type: Article

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