The conserved mitotic kinase polo is regulated by phosphorylation and has preferred microtubule-associated substrates in Drosophila embryo extracts

EMBO Journal

Volumn 15, Issue 18, 1996, Pages 4873-4883

  Tavares, Álvaro A M ^a,b   Glover, David M ^a   Sunkel, Claudio E ^b  

^a UNIVERSITY OF DUNDEE   (United Kingdom)

^b UNIVERSITY OF PORTO   (Portugal)

Author keywords

Drosophila; Kinase; Mitosis; Polo; Tubulin

Indexed keywords

BETA TUBULIN; MICROTUBULE ASSOCIATED PROTEIN; PROTEIN KINASE;

ARTICLE; CELL FREE SYSTEM; DROSOPHILA; EMBRYO; ENZYME PHOSPHORYLATION; HEAT TREATMENT; MICROTUBULE; MITOSIS; NONHUMAN; PRIORITY JOURNAL;

EID: 0029838630     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1002/j.1460-2075.1996.tb00868.x     Document Type: Article

References (44)

1. Byers, B. and Goetsch, L. (1974) Duplication of spindle plaques and integration of the yeast cell cycle. Cold Spring Harbor Symp. Quant. Biol., 38, 123-131.
2. Cambiazo, V., Gonzalez, M. and Maccioni, R. (1995) DMAP-85: a τ-like protein from Drosophila melanogaster larvae. J. Neurochem., 64, 1288-1297.
3. Clark, P. (1995) Cak-handed kinase activation. Curr. Biol., 5, 40-42.
4. Clay, F., McEwen, S., Bertoncello, I., Wilks, A. and Dunn, A. (1993) Identification and cloning of a protein kinase-encoding mouse gene, Plk, related to the polo gene of Drosophila. Proc. Natl Acad. Sci. USA, 90, 4882-4886.
5. Donohue, P., Alberts, G., Guo, Y. and Winkles, J. (1995) Identification by targeted differential display of an immediate early gene encoding a putative serine/threonine kinase. J. Biol. Chem., 270, 10351-10357.
6. Draetta, G., Piwnica-Worms, H., Morrison, D., Druker, B., Roberts, T. and Beach, D. (1988) Human cdc2 protein kinase is a major cell-cycle regulated tyrosine kinase substrate. Nature, 336, 736-744.
7. Eipper, B.A. (1972) Rat brain microtubule protein: purification and determination of covalently bound phosphate and carbohydrate. Proc. Natl Acad. Sci. USA, 69, 2283-2287.
8. Eipper, B.A. (1974) Rat brain tubulin and protein kinase activity. J. Biol. Chem., 249, 1398-1406.
9. Fenton, B. and Glover, D. (1993) A conserved mitotic kinase active at late anaphase-telophase in syncytial Drosophila embryos. Nature, 363, 637-640.
10. Gard, D. and Kirschner, M. (1985) A polymer-dependent increase in phosphorylation of β-tubulin accompanies differentiation of mouse neuroblastoma cell line. J. Cell Biol., 100, 764-774.
11. Gard, D. and Kirschner, M. (1987) A MAP from Xenopus eggs that specifically promotes assembly at the plus end. J. Cell Biol., 105, 2203-2215.
12. Gautier, J., Solomon, M.J., Booher, R.N., Bazan, J.F., and Kirschner, M.W. (1991) cdc25 is a specific tyrosine phosphatase that directly activates p34cdc2. Cell, 67, 197-211.
13. Goldstein, L.S.B., Laymon, R.A. and McIntosh, J.R. (1986) Amicrotubule-associated protein in Drosophila melanogaster: identification, characterization and isolation of coding sequences. J. Cell Biol., 102, 2076-2087.
14. Golsteyn, R., Schultz, S., Bartek, J., Ziemiecki, A., Ried, T. and Nigg, E. (1994) Cell cycle analysis and chromosomal localisation of human Plk1, a putative homologue of the mitotic kinases Drosophila polo and Saccharomyces cerevisiae Cdc5. J. Cell Sci., 107, 1509-1517.
15. Golsteyn, R., Mundt, K., Fry, A. and Nigg, E. (1995) Cell cycle regulation of the activity and subcellular localisation of PLK1, a human protein kinase implicated in mitotic spindle function. J. Cell Biol., 129, 1617-1628.
16. Hamanaka, R., Maloid, S., Smith, M., O'Connell, C., Longo, D. and Ferris, D. (1994) Cloning and characterization of human and murine homologues of the Drosophila polo serine-threonine kinase. Cell Growth Differ., 5, 249-257.
17. Hanks, S. and Hunter, T. (1995) The eukaryotic protein kinase superfamily: kinase (catalytic) domain structure and classification. FASEB J., 9, 576-596.
18. Hartwell, L.H., Mortimer, R.K., Culotti, J., and Culotti, M. (1973) Genetic control of the cell division cycle in yeast: V. genetic analysis of cdc mutants. Genetics, 74, 267-286.
19. Holtrich, U., Wolf, G., Brauninger, A., Karn, T., Bohme, B., Rubsamen-Waigmann, H. and Strebhardt, K. (1994) Induction and down-regulation of PLK, a human serine/threonine kinase expressed in proliferating cells and tumours. Proc. Natl Acad. Sci. USA, 91, 1736-1740.
20. Jimenez, J., Alphey, L., Nurse, P. and Glover, D.M. (1990) Complement of fission yeast cdc2ts and cdc25ts mutants identifies two cell cycle genes from Drosophila: a cdc2 homologue and string. EMBO J., 11, 3565-3571.
21. 1 cell cycle mutant gene dbf4 encodes a protein kinase and is identified as CDC5. Mol. Cell. Biol., 13, 4445-4457.
22. Lake, R. and Jelinek, W. (1993) Cell cycle- and terminal differentiation-associated regulation of the mouse mRNA encoding a conserved mitotic protein kinase. Mol. Cell Biol., 13, 7793-7801.
23. Lee, M.G. and Nurse, P. (1987) Complementation used to clone a human homologue of the fission yeast cell cycle control gene cdc2. Nature, 327, 31-35.
24. Lee, M.S., Ogg, S., Xu, M., Parker, L.L., Donoghue, D.J., Maller, J.L., and Piwnica-Worms, H. (1992) cdc25+ encodes a protein phosphatase that dephosphorylates p34cdc2. Mol. Biol. Cell, 3, 73-84.
25. Llamazares, S., Moreira, A., Tavares, A., Girdham, C., Spruce, B., Gonzalez, C., Karess, R., Glover, D. and Sunkel, C. (1991) polo encodes a protein kinase homologue required for mitosis in Drosophila. Genes Dev., 5, 2153-2165.
26. Mandelkow, E. and Mandelkow, E.M. (1995) Microtubules and microtubules-associated proteins. Curr. Opin. Cell Biol., 7, 72-81.
27. Marshall, C.J. (1994) Hot lips and phosphorylation of protein kinases. Nature, 367, 686.
28. Millar, J., McGowan, C., Lenaers, G., Jones, R. and Russell, P. (1991) p80cdc25 mitotic inducer is the tyrosine phosphatase that activates p34cdc2 kinase in fission yeast. EMBO J., 10, 4301-4309.
29. Morgan, D.O. (1995) Principles of CDK regulation. Nature, 374, 131-134.
30. Nigg, E.A. (1993) Targets of cyclin-dependent protein kinases. Curr. Opin. Cell Biol., 5, 187-193.
31. Nurse, P. (1990) Universal control mechanism regulating onset of M-phase. Nature, 344, 503-508.
32. 2 cells. Genes Dev., 9, 1059-1073.
33. Ookata, K. et al. (1995) Cyclin-B interaction with microtubule-associated protein-4 (MAP4) targets p34cdc2 kinase to microtubules and is a potential regulator of M-phase microtubule dynamics. J. Cell Biol., 128, 849-862.
34. Pfeffer, R.S., Drubin, D.G. and Kelly, R.B. (1983) Identification of three coated vesicle components as α- and β-tubulin linked to a phosphorylated 50000-dalton polypeptide. J. Biol. Chem., 97, 40-47.
35. Rappaport, L., Leterrier, J., Virion, A. and Nunez, J. (1976) Phosphorylation of microtubule-associated proteins. Eur. J. Biochem., 62, 539-549.
36. Sandoval, I.V. and Cuatrecasas, P. (1976) Protein kinase associated with tubulin: affinity chromatography and properties. Biochemistry, 15, 3424-3432.
37. Serrano, L., Diaz-Nido, J., Wandosell, F. and Avila, J. (1987) Tubulin phosphorylation by casein kinase II is similar to that found in vivo. J. Cell Biol., 105, 1731-1739.
38. Serrano, L., Hernadez, M.A., Diaz-Nido, J. and Avila, J. (1989) Association of casein kinase II with microtubules. Exp. Cell Res., 181, 263-272.
39. Simmons, D., Neel, B., Stevens, R., Evett, G. and Erikson, R. (1992) Identification of an early-growth-response gene encoding a novel putative protein kinase. Mol. Cell. Biol., 12, 4164-4169.
40. Sunkel, C. and Glover, D. (1988) polo, a mitotic mutant of Drosophila displaying abnormal spindle poles. J. Cell Sci., 89, 25-38.
41. Van der Geer, P., Luo, K., Sefton, B. and Hunter, T. (1993) In Hardie, D. (ed.), Protein Phosphorylation - A Practical Approach. IRL press, Oxford, UK, pp. 61-84.
42. Wandosell, F., Serrano, L., Hernandez, M. and Avila, J. (1986) Phosphorylation of tubulin by a calmodulin-dependent protein kinase. J. Biol. Chem., 261, 10332-10339.
43. Wood, J.S. and Hartwell, L.H. (1982) A dependent pathway of gene functions leading to chromosome segregation in Saccharomyces cerevisiae. J. Cell Biol., 94, 718-726.
44. Zhou, R., Oskarsson, M., Paules, R., Schulz, N., Cleveland, D. and Woude, G. (1991) Ability of the c-mos product to associate with and phosphorylate tubulin. Science, 251, 671-675.