CD4+CD25+ regulatory T cells: II. Origin, disease models and clinical aspects

APMIS

Volumn 112, Issue 10, 2004, Pages 642-50

  Nielsen, Janne ^a   Holm, Thomas Lindebo ^a   Claesson, Mogens H ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

Review; T cells; Treg cells

Indexed keywords

CHEMOKINE RECEPTOR CCR8; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; TRANSCRIPTION FACTOR FOXP3;

ALLERGY; AUTOIMMUNE DISEASE; CANCER; CELL FUNCTION; CELL INTERACTION; CELL LINE; CELL SELECTION; CLINICAL FEATURE; COLITIS; DISEASE MODEL; ENTERITIS; GASTRITIS; HOMEOSTASIS AND REGULATION; HUMAN; IMMUNOLOGICAL TOLERANCE; IMMUNOPATHOLOGY; LYMPHOCYTOPENIA; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN FUNCTION; REVIEW; T LYMPHOCYTE; THYMOCYTE; TRANSPLANTATION; VACCINATION;

EID: 11944260595     PISSN: 09034641     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1600-0463.2004.apm1121002.x     Document Type: Review

References (51)

1. Roncarolo M, Levings MK. The role of different subsets of T regulatory cells controlling autoimmunity. Curr Opin Immunol 2000;12:676-83.
2. Sakaguchi S, Sakaguchi N, Asano M, Itoh M, Toda M. Immunologic self tolerance maintained by activated T cells expressing IL-2 receptor α-chains. J Immunol 1995;155:1151-64.
3. + suppressor T cells: More questions than answers. Nat Rev Immunol 2002;2:389-400.
4. Annacker O, Powrie F. Homeostasis of intestinal immune regulation. Microbes Infect 2002;4:567-74.
5. McHugh RS, Shevash EM. The role of suppressor T cells in regulation of immune responses. J Allergy Clin Immunol 2002;110:693-702.
6. Karim M, Bushell AR, Wood KJ. Regulatory T cells in transplantation. Curr Opin Immunol 2002;14:584-91.
7. + T cells. Immunology 2002;107:5-9.
8. + regulatory T cells and tumour immunity. Immunol Lett 2003;85:141-3.
9. + regulatory T cells that express toll-like receptors. J Exp Med 2003;197:397-401.
10. Sakaguchi S. Regulatory T cells: mediating compromises between host and parasite. Nat Immunol 2003;4:10-1.
11. + regulatory T cells: I. Phenotype and physiology. APMIS, 2004;112:629-41.
12. + thymocytes and peripheral T cells have immune suppressive activity. Eur J Immunol 2001;31:1247-54.
13. + naturally anergic and suppressive T cells as a key function of the thymus in maintaining immunologic self-tolerance. J Immunol 1999;162:5317-26.
14. Papiernik M, de Moraes ML, Pontoux C, Vasseur F, Penit C. Regulatory CD4 T cells: expression of IL-2R-chain, resistance to clonal deletion and IL-2 dependency. Int Immunol 1998;10:371-8.
15. + human thymocytes. J Exp Med 2002;196:379-87.
16. + regulatory T cells induced by an agonist self-peptide. Nat Immunol 2001;2:301-6.
17. Starr TK, Jameson SC, Hogquist KA. Positive and negative selection of T cells. Annu Rev Immunol 2003;21:139-76.
18. + immunoregulatory T cells. J Exp Med 2001;194:427-38.
19. Nocentini G, Giunchi L, Ronchetti S, Krausz LT, Bartoli A, Moraca R, Migliorati, Riccardi C. A new member of the tumor necrosis factor/nerve growth factor receptor family inhibits T cell receptor-induced apoptosis. Proc Natl Acad Sci USA 1997;94:6216-21.
20. Sakaguchi S. Policing the regulators. Nat Immunol 2001;2:283-4.
21. + regulatory T cells constitutively expressing cytotoxic lymphocyte-associated antigen 4. J Exp Med 2000;192:303-9.
22. + immunoregulatory T cells that control autoimmune diabetes. Immunity 2000;12: 431-40.
23. + regulatory T cells. Eur J Immunol 2002;32:1621-30.
24. Hori S, Nomura T, Sakaguchi S. Control of regulatory T cell development by the transcription factor Foxp3. Science 2003;299:1057-61.
25. Freitas AA, Rocha B. Peripheral T cell survival. Curr Opin Immunol 1999;11:152-6.
26. + T cells with regulatory properties isolated from peripheral blood. J Exp Med 2001;193:1285-94.
27. + T cells suppress naive and memory T-cell proliferation and can be expanded in vitro without loss of suppressor function. J Exp Med 2001;193:1295-1302.
28. + immunoregulatory T cells suppress polyclonal T-cell activation in vitro by inhibiting interleukin-2 production. J Exp Med 1998;188:287-96.
29. + naturally anergic and suppressive T cells: induction of autoimmune disease by breaking their anergic/suppressive state. Int Immunol 1998;10:1969-80.
30. Malek TR, Porter BO, Codias EK, Scibelli P, Yu A. Normal lymphoid homeostasis and lack of lethal autoimmunity in mice containing mature T cells with severely impaired IL-2 receptors. J Immunol 2000;164:2905-14.
31. Sakaguchi S, Takahashi T, Nishizuka Y. Study on cellular events in postthymectomy autoimmune oophoritis in mice. I. Requirement of Lyt-1 effector cells for oocytes damage after adoptive transfer. J Exp Med 1982;156:1565-76.
32. Asano M, Toda M, Sakaguchi N, Sakaguchi S. Autoimmune disease as a consequence of developmental abnormality of a T cell subpopulation. J Exp Med 1996;184:387-96.
33. Nehls M, Kyewski B, Messerle M, Waldschutz R, Schuddekopf K, Smith AJ, Boehm T. Two genetically separable steps in the differentiation of thymic epithelium. Science 1996;272:886-9.
34. Mombaerts P, Iacomini J, Johnson RS, Herrup K, Tonegawa S, Papaioannou VE. RAG-1-deficient mice have no mature B and T lymphocytes. Cell 1992;68:869-77.
35. Shinkai Y, Rathbun G, Lam KP, Oltz EM, Stewart V, Mendelsohn M, Charron J, Datta M, Young F, Stall AM. RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement. Cell 1992;68:855-67.
36. + T-cells. J Autoimmun 2001;16:115-23.
37. Blunt T, Finnie NJ, Taccioli GE, Smith GC, Demengeot J, Gottlieb TM, Mizuta R, Varghese AJ, Alt FW, Jeggo PA. Defective DNA-dependent protein kinase activity is linked to V(D)J recombination and DNA repair defects associated with the murine seid mutation. Cell 1995;80:812-23.
38. + T cells in the regulation of inflammatory responses in the intestine. Res Immunol 1997;148:576-81.
39. + T cells. Microbes Infect 2001;3:919-27.
40. Kohm AP, Carpentier PA, Anger HA, Miller SD. CD4+CD25+ regulatory T cells suppress antigen-specific autoreactive immune responses and central nervous system inflammation during active experimental autoimmune encephalomyelitis. J Immunol 2002;169:4712-16.
41. Read S, Malmström V, Powrie F. Cytotoxic T lymphocyte-associated antigen 4 plays an essential role in the function of CD4+CD25+ regulatory cells that control intestinal inflammation. J Exp Med 2000;192:295-302.
42. + T helper cells. J Exp med 2002;196:255-60.
43. Caramalho I, Lopes-Carvalho T, Ostler D, Zelenay S, Haury M, Demengeot J. Regulatory T cells selectively express toll-like receptors and are activated by lipopolysaccharide. J Exp Med 2003;197:403-11.
44. + regulatory T cells through GITR breaks immunological self-tolerance. Nat Immunol 2002;3:135-42.
45. +high regulatory T cell function. J Immunol 2002;169:6210-7.
46. Stockinger B, Barthlott T, Kassiotis G. T-cell regulation: a special job or everyone's responsibility. Nat Immunol 2001;2:757-8.
47. Barthlott T, Kassiotis G, Stockinger B. T cell regulation as a side effect of homeostasis and competition. J Exp Med 2003;197:451-60.
48. + regulatory T cells is necessary, but not sufficient, for induction of organ-specific autoimmune disease. J Immunol 2002;168:5979-83.
49. + cells: a naturally occurring population of regulatory T cells. Blood 2001;98: 2736-44.
50. + T cells: a common basis between tumor immunity and autoimmunity. J Immunol 1999;163:5211-8.
51. Sutmuller RP, van Duivenvoorde LM, van Elsas A, Schumacher TN, Wildenberg ME, Allison JP, Toes RE, Offringa R, Melief CJ. Synergism of cytotoxic T lymphocyte-associated antigen 4 blockade and depletion of CD25(+) regulatory T cells in antitumor therapy reveals alternative pathways for suppression of autoreactive cytotoxic T lymphocyte responses. J Exp Med 200;19:823-32.