Increased contribution of NR2A subunit to synaptic NMDA receptors in developing rat cortical neurons

Journal of Physiology

Volumn 507, Issue 1, 1998, Pages 13-24

  Stocca, Gabriella ^a   Vicini, Stefano ^a  

^a GEORGETOWN UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA AMINO 3 HYDROXY 5 METHYL 4 ISOXAZOLEPROPIONIC ACID; CLOZAPINE; DOPAMINE RECEPTOR BLOCKING AGENT; GLUTAMIC ACID; HALOPERIDOL; MESSENGER RNA; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; RECEPTOR SUBUNIT; SPIPERONE; SYNAPSE RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 1; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 2A; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 2B;

ANIMAL TISSUE; ARTICLE; BRAIN CELL; BRAIN CORTEX; BRAIN DEVELOPMENT; CONTROLLED STUDY; MEMBRANE CURRENT; NEWBORN; NONHUMAN; PATCH CLAMP; PRIORITY JOURNAL; RAT; RECEPTOR BLOCKING; VISUAL CORTEX; AMPLITUDE MODULATION; BRAIN SLICE; CORTEX LAYER V; EXCITATORY POSTSYNAPTIC POTENTIAL; NERVE CELL DIFFERENTIATION; OUTSIDE OUT PATCH CLAMP; PERINATAL PERIOD; PYRAMIDAL NERVE CELL;

ANIMALS; ANIMALS, NEWBORN; CEREBRAL CORTEX; ELECTRIC CONDUCTIVITY; EXCITATORY AMINO ACID ANTAGONISTS; HALOPERIDOL; N-METHYLASPARTATE; NEURONS; PIPERIDINES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, N-METHYL-D-ASPARTATE; RECEPTORS, NEUROTRANSMITTER; SYNAPSES;

EID: 0032520117     PISSN: 00223751     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1469-7793.1998.013bu.x     Document Type: Article

References (37)

1. BEHE, P., STERN, P., WYLLIE, D. J., NASSAR, M., SCHOEPFER, R. & COLQUHOUN, D. (1995). Determination of NMDA NR1 subunit copy number in recombinant NMDA receptors. Proceedings of the Royal Society B 262, 205-213.
2. BOECKMAN, F. A. & AIZENMAN, E. (1996). Pharmacological properties of acquired excitotoxicity in Chinese hamster ovary cells transfected with N-methyl-D-aspartate receptor subunits. Journal of Pharmacology and Experimental Therapeutics 279, 515-523.
3. CARMIGNOTO, G. & VICINI, S. (1992). Activity-dependent decrease in NMDA receptor responses during development of the visual cortex. Science 258, 1007-1011.
4. CHENARD, B. L., BORDNER, J., BUTLER, T. W., CHAMBERS, L. K., COLLINS, M. A., DECOSTA, D. L., DUCAT, M. F., DUMONT, M. L., FOX, C. B., MENA, E. E., MENNITI, F. S., NIELSEN, J., PAGNOZZI, M. J., RICHTER, K. E. G., RONAU, R. T., SHALABY, I. A., STEMPLE, J. Z. & WHITE, W. F. (1995). (1S,2S)-1-(4-hydroxyphenyl)-2-(4-hydroxy-4-phenylpiperidino)-1-propanol: a potent new neuroprotectant which blocks N-methyl-D-aspartate responses. Journal of Medicinal Chemistry 38, 3138-3145.
5. 2+ channels in rat and mouse cultured hippocampal pyramidal neurones: comparison with N-methyl-D-aspartate receptor antagonist actions. British Journal of Pharmacology 113, 499-507.
6. CLARK, A. B., FARRANT, M. & CULL-CANDY, S. G. (1997). A direct comparison of the single-channel properties of synaptic and extrasynaptic NMDA receptors. Journal of Neuroscience 17, 107-116.
7. COLQUHOUN, D., JONAS, P. & SAKMANN, B. (1992). Action of brief pulses of glutamate on AMPA/kainate receptors in patches from different neurones of rat hippocampal slices. Journal of Physiology 458, 261-287.
8. CRAIR, M. C. & MALENKA, R. C. (1995). A critical period for long-term potentiation at thalamocortical synapses. Nature 375, 325-328.
9. 2+ channels in hippocampal neurones. European Journal of Pharmacology 267, 249-252.
10. FLINT, A. C., MAISCH, U. S., WEISHAUPT, J. H., KRIEGSTEIN, A. R. & MONYER, H. (1997). NR2A Subunit expression shortens NMDA receptor synaptic currents in developing neocortex. Journal of Neuroscience 17, 2469-2476.
11. FOX, K. (1995). The critical period for long-term potentiation in primary sensory cortex. Neuron 15, 485-488.
12. GOODMAN, L. S. & GILMAN, A. (1990). The Pharmacological Basis of Therapeutics, ed. GOODMAN, L. S., GILMAN, A., RALL, T. W., NIES, A. S. & TAYLOR, P., pp. 383-389. Pergamon Press, Inc., New York.
13. GOTZ, T., KRAUSHAAR, U., GEIGER, J., LUBKE, J., BERGER, T. & JONAS, P. (1997). Functional properties of AMPA and NMDA receptors expressed in identified types of basal ganglia neurons. Journal of Neuroscience 17, 204-215.
14. HAMILL, O. P., MARTY, A., NEHER, E., SAKMANN, B. & SIGWORTH, F. J. (1981). Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches. Pflügers Archiv 391, 85-100.
15. HESTRIN, S. (1992). Developmental regulation of NMDA receptor-mediated synaptic currents at a central synapse. Nature 357, 686-689.
16. HOLLMANN, M., BOULTER, J., MARON, C., BEASLEY, J., SULLIVAN, C., PECHT, G. & HEINEMANN, S. (1993). Zinc potentiates agonist induced currents at certain splice variants of the NMDA receptor. Neuron 10, 943-954.
17. ILYIN, V., WITTERMORE, E. R., GUASTELLA, J., WEBER, E. & WOODWARD, R. M. (1996). Subtypes-selective inhibition of N-methyl-D-aspartate receptors by haloperidol. Molecular Pharmacology 50, 1541-1550.
18. KIM, H. G., FOX, K. & CONNORS, B. W. (1995). Properties of excitatory synaptic events in neurons of primary somatosensory cortex of neonatal rats. Cerebral Cortex 5, 148-157.
19. KIRSON, E. H. & YAARI, Y. (1996). Synaptic NMDA receptors in developing mouse hippocampal neurones: functional properties and sensitivity to ifenprodil. Journal of Physiology 497, 437-455.
20. LAURIE, D. J. & SEEBURG, P. H. (1994). Ligand affinities at recombinant N-methyl-D-aspartate receptors depends on subunit composition. European Journal of Pharmacology 268, 335-345.
21. LESTER, R. A. J. & JAHR, C. E. (1992). NMDA channel behavior depends on agonist affinity. Journal of Neuroscience 12, 635-643.
22. LI, J. H., WANG, J. F., LUO, J. H., WANG, Y. H., WOLFE, B. B. & VICINI, S. (1996). Properties of NMDA responses in HEK293 cells expressing heteromers of NR1/NR2A/NR2B subunit. Society for Neuroscience Abstracts 22, 237.6.
23. 2+-dependent phosphatase. Nature 369, 235-239.
24. LUO, J. H., WANG, Y. H., YASUDA, R. P., DUNAH, A. W. & WOLFE, B. B. (1997). The majority of N-methyl-D-aspartate receptor complexes in adult cerebral cortex contain at least three different subunits (NR1/NR2A/NR2B). Molecular Pharmacology 51, 79-86.
25. MCBAIN, C. J. & MAYER, M. L. (1994). N-Methyl-D-aspartic acid receptor structure and function. Physiological Reviews 74, 723-760.
26. MONYER, H., BURNASHEV, H., LAURIE, D. J., SAKMANN, B. & SEEBURG, P. H. (1994). Developmental and regional expression in the rat brain and functional properties of the four NMDA receptors. Neuron 12, 529-540.
27. MORI, H. & MISHINA, M. (1995). Structure and function of the NMDA receptor channel. Neuropharmacology 34, 1219-1237.
28. PETERS, A. (1985). The visual cortex of the rat. In Cerebral Cortex, vol. 3, Visual Cortex, ed. PETERS, A. & JONES, E. G., pp. 19-80. Plenum Press, New York.
29. PLANT, T., SCHIRRA, C., GARASHUCK, O., ROSSIER, J. & KONNERTH A. (1997). Molecular determinants of NMDA receptor function in GABAergic neurones of rat forebrain. Journal of Physiology 499, 47-63.
30. PRIESTLY, T., LAUGHTON, P., MYERS, J., LE BOURDELLES, B., KERBY, J. & WHITING, P. J. (1995). Pharmacological properties of recombinant human N-methyl-D-aspartate receptors comprising NR1a/NR2A and NR1a/NR2B subunit assemblies expressed in permanently transfected mouse fibroblast cells. Molecular Pharmacology 48, 841-848.
31. SHEETZ, A. J. & CONSTANTINE-PATON, M. (1994). Modulation of NMDA receptor function: implication for vertebrate neural development. FASEB Journal 8, 745-752.
32. SPRUSTON, N., JONAS, P. & SAKMANN, B. (1995). Dendritic glutamate receptor channels in rat hippocampal CA3 and CA1 pyramidal neurons. Journal of Physiology 482, 325-352.
33. STORM-MATHISEN, J. & OTTERSEN, O. P. (1989). Anatomy of putative glutamatergic neurons. In Neurotransmitters and Cortical Function, ed. AVOLI, M., READER, T. A., DYKES, R. W. & GLOOR, P., pp. 39-70. Plenum Press, New York and London.
34. TAKAHASHI, T., FELDMEYER, D., SUZUKI, N., ONODERA, K., CULLCANDY, S. G., SAKIMURA, K. & MISHINA, M. (1996). Functional correlation of NMDA receptor epsilon subunits expression with the properties of single-channel and synaptic currents in the developing cerebellum. Journal of Neuroscience 16, 4376-4382.
35. WILLIAMS, K. (1993). Ifenprodil discriminates subtypes of the N-methyl-D-aspartate receptor: selectivity and mechanisms at recombinant heteromeric receptors. Molecular Pharmacology 44, 851-859.
36. ZUKIN, R. S. & BENNETT, M. V. L. (1995). Alternatively spliced isoforms of the NMDAR1 receptor subunit. Trends in Neurosciences 18, 306-313.
37. YU, X.-M., ASKALAN, R., KEIL II, G. J. & SALTER, M. W. (1997). NMDA channel regulation by channel-associated protein tyrosine kinase Src. Science 275, 674-678.