PTEN regulates Akt kinase activity in hippocampal neurons and increases their sensitivity to glutamate and apoptosis

NeuroMolecular Medicine

Volumn 2, Issue 3, 2002, Pages 261-269

  Gary, Devin S ^a,b   Mattson, Mark P ^a,b  

^a NATIONAL INSTITUTE ON AGING   (United States)

^b UNIVERSITY OF KENTUCKY   (United States)

Author keywords

Alzheimer's disease; Epilepsy; Kainic acid; Seizures

Indexed keywords

DNA; GLUTAMATE RECEPTOR; GLUTAMIC ACID; KAINIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN KINASE B; AKT1 PROTEIN, RAT; DIAGNOSTIC AGENT; GREEN FLUORESCENT PROTEIN; HYBRID PROTEIN; NEUROTOXIN; ONCOPROTEIN; PHOSPHATASE; PHOTOPROTEIN; PROTEIN SERINE THREONINE KINASE; TUMOR SUPPRESSOR PROTEIN;

ALZHEIMER DISEASE; ANIMAL CELL; APOPTOSIS; ARTICLE; CELL DEATH; DEGENERATIVE DISEASE; ENZYME ASSAY; EPILEPSY; HIPPOCAMPUS; IMMUNOCYTOCHEMISTRY; MOUSE; NERVE CELL CULTURE; NERVE CELL PLASTICITY; NEUROLOGIC DISEASE; NONHUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; RAT; SEIZURE; ANIMAL; CELL CULTURE; DRUG EFFECT; ENZYMOLOGY; FETUS; GENETICS; IMMUNOHISTOCHEMISTRY; MALE; METABOLISM; MOUSE MUTANT; NERVE CELL;

ANIMALIA; HIPPOCAMPUS HIPPOCAMPUS;

ANIMALS; APOPTOSIS; CELLS, CULTURED; FETUS; GLUTAMIC ACID; GREEN FLUORESCENT PROTEINS; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; LUMINESCENT PROTEINS; MALE; MICE; MICE, KNOCKOUT; NEURODEGENERATIVE DISEASES; NEURONS; NEUROTOXINS; PHOSPHORIC MONOESTER HYDROLASES; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; PTEN PHOSPHOHYDROLASE; RATS; RECOMBINANT FUSION PROTEINS; TUMOR SUPPRESSOR PROTEINS;

EID: 0041825308     PISSN: 15351084     EISSN: None     Source Type: Journal    
DOI: 10.1385/NMM:2:3:261     Document Type: Article

References (39)

1. Luukko, K., Ylikorkala, A., Tiainen, M., and Makela, T. P. (1999) Expression of LKB1 and PTEN tumor suppressor genes during mouse embryonic development. Mech. Dev. 83, 187-190.
2. Di Cristofano, A. and Pandolfi, P. P. (2000) The multiple roles of PTEN in tumor suppression. Cell 100, 387-390.
3. Marsh, D. J., Dahia, P. L., Zheng, Z., et al. (1997) Germline mutations in PTEN are present in Bannayan-Zonana syndrome. Nat. Genet. 16, 333-334.
4. Marsh, D. J., Dahia, P. L., Carson, S., et al. (1998) Germline PTEN mutations in Cowden syndrome-like families. J. Med. Gene. 35, 881-885.
5. Liaw, D., Marsh, D. J., Li, J., et al. (1997) Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome. Nat. Genet. 16, 64-67.
6. Di Cristofano, A., Kotsi, P., Peng, Y. E, Cordon-Cardo, C., Elkon, K. B., and Pandolfi, P. P. (1999) Impaired Fas response and autoimmunity in Pten +/-mice. Science 285, 2122-2125.
7. Datta, S. R., Brunet, A., and Greenberg, M. E. (1999) Cellular survival: a play in three acts. Genes Dev. 13, 2905-2927.
8. Lu, Y., Lin, Y. Z., LaPushin, R., et al. (1999) The PTEN/MMAC/TEP tumor suppressor gene decreases cell growth and induces apoptosis and anoikis in breast cancer cells. Oncogene 18, 7034-7045.
9. Tamura, M., Gu, J., Takino, T., and Tamada, K. M. (1999) Tumor suppressor PTEN inhibition of cell invasion, migration, and growth: differential involvement of focal adhesion kinase and p130 Cas. Cancer Res. 59, 442-449.
10. Li, J., Simpson, L., Takahashi, M., et al. (1998) The PTEN/MMAC1 tumor suppressor induces cell death that is rescued by the Akt/protein kinase B oncogene. Cancer Res. 58, 5667-5672.
11. Lachyankar, M. B., Sultana, N., Schonhoff, C. M., et al. (2000) A role for nuclear PTEN in neuronal differentiation. J. Neurosci. 20, 1404-1413.
12. Groszer, M., Erickson, R., Scripture-Adams, D. D., et al. (2001) Negative regulation of neural stem/progenitor cell proliferation by the Pten tumor suppressor gene in vivo. Science 294, 2186-2189.
13. Backman, S. A., Stambolic, V., Suzuki, A., et al. (2001) Deletion of Pten in mouse brain causes seizures, ataxia and defects in soma size resembling Lhermitte-Duclos disease. Nat. Genet. 29, 396-403.
14. Crowder, R. J. and Freeman, R. S. (1998) Phosphatidylinositol 3-kinase and Akt protein kinase are necessary and sufficient for the survival of nerve growth factor-dependent sympathetic neurons. J. Neurosci. 18, 2933-2943.
15. Dudek, H., Datta, S. R., Franke, T. F., et al. (1997) Regulation of neuronal survival by the serinethreonine protein kinase Akt. Science 275, 661-665.
16. Eves, E. M., Xiong, W., Bellacosa, A., et al. (1998) Akt, a target of phosphatidylinositol 3-kinase, inhibits apoptosis in a differentiating neuronal cell line. Mol. Cell. Biol. 18, 2143-2152.
17. Mattson, M. P., et al. (2000) Apoptosis in neurodegenerative disorders. Nat. Rev. Mol. Cell. Biol. 1, 120-129.
18. Kyrylenko, S., Roschier, M., Korhonen, P., and Salminen, A. (1999) Regulation of PTEN expression in neuronal apoptosis. Mol. Brain Res. 73, 198-202.
19. Mattson, M. P., Kumar, K., Cheng, B., Wang, H., and Michaelis, E. (1993) Basic FGF regulates the expression of a functional 71 kDa NMDA receptor protein that mediates calcium influx and neurotoxicity in cultured hippocampal neurons. J. Neurosci. 13, 4575-4588.
20. Gary, D. S. and Mattson, M. P. (2001) Integrin signaling via the PI3-kinase-Akt pathway increases neuronal resistance to glutamate-induced apoptosis. J. Neurochem. 76, 1485-1496.
21. Maehama, T. and Dixon, J. E. (1998) The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate. J. Biol. Chem 273, 13,375-13,378.
22. Gary, D. S., Sooy, K., Chan, S. L., Christakos, S., and Mattson, M. P. (2000) Concentration and cell type-specific effects of calbindin D28k on vulnerability of hippocampal neurons to seizure-induced injury. Mol. Brain Res. 75, 89-95.
23. Gary, D. S., Milhavet, O., Camandola, S., and Mattson, M. P. (2002) Essential role for integrin linked kinase in Akt-mediated integrin survival signaling in hippocampal neurons. J. Neurosci. Submitted
24. Davies, M. A., Koul, D., Dhesi, H., et al. (1999) Regulation of Akt/PKB activity, cellular growth, and apoptosis in prostate carcinoma cells by MMAC/PTEN. Cancer Res. 59, 2551-2556.
25. Stambolic, V., Suzuki, A., de la Pompa, J. L., et al. (1998) Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN. Cell 95, 29-39.
26. Noshita, N., Lewen, A., Sugawara, T., and Chan, P. H. (2001) Evidence of phosphorylation of Akt and neuronal survival after transient focal cerebral ischemia in mice. J. Cereb. Blood Flow Metab. 21, 1442-1450.
27. Yano, S., Morioka, M., Fukunaga, K., et al. (2001) Activation of Akt/protein kinase B contributes to induction of ischemic tolerance in the CA1 subfield of gerbil hippocampus. J. Cereb. Blood Flow Metab. 2, 351-360.
28. Duan W., Guo, Z., and Mattson, M. P. (2001) Brain-derived neurotrophic factor mediates an excito-protective effect of dietary restriction in mice. J. Neurochem. 76, 619-626.
29. Cheng, B. and Mattson, M. P. (1994) NT-3 and BDNF protect CNS neurons against metabolic/excitotoxic insults. Brain Res. 640, 56-67.
30. Pugazhenthi, S., Nesterova, A., Sable, C., et al. (2000) Akt/protein kinase B upregulates Bcl2 expression through cAMP-response element-binding protein. J. Biol. Chem. 275, 10,761-10,766.
31. Kwon, C. H., Zhu, X., Zhang, J., et al. (2001) Pten regulates neuronal soma size: a mouse model of Lhermitte-Duclos disease. Nat. Genet. 29, 404-411.
32. Zwick, M., Teng, L., Mu, X., Springer, J. E., and Davis, B. M. (2001) Overexpression of GDNF induces and maintains hyperinnervation of muscle fibers and multiple end-plate formation. J. Neurochem. 73, 70-78.
33. Mattson, M. P. (1988) Neurotransmitters in the regulation of neuronal cytoarchitecture. Brain Res. 472, 179-212.
34. Mattson, M. P., Lee, R. E., Adams, M. E., Guthrie, P. B., and Kater, S. B. (1988) Interactions between entorhinal axons and target hippocampal neurons: a role for glutamate in the development of hippocampal circuitry. Neuron. 1, 865-876.
35. Zipfel, G. J., Babcock, D. J., Lee, J. M., and Choi, D. W. (2000) Neuronal apoptosis after CNS injury: the roles of glutamate and calcium. J. Neurotrauma 17, 857-69.
36. Meldrum, B. S. (1993) Excitotoxicity and selective neuronal loss in epilepsy. Brain Pathol. 3, 405-412.
37. Doble, A. (1999) The role of excitotoxicity in neurodegenerative disease: implications for therapy. Pharmacol. Ther. 81, 163-221.
38. Rothstein, J. D. (1995) Excitotoxicity and neurodegeneration in amyotrophic lateral sclerosis. Clin. Neurosci. 3, 348-59.
39. Torres, J. and Pulido, R. (2001) The tumor suppressor PTEN is phosphorylated by the protein kinase CK2 at its C terminus. Implications for PTEN stability to proteasome-mediated degradation. J. Biol. Chem. 276, 993-998.