-
1
-
-
0002859805
-
Systemic sclerosis (scleroderma)
-
Wyngaarden, J.B., Smith, L.H., and Bennett, J.C. (eds). WB Saunders, Philadelphia
-
LeRoy, E.G. (1992) Systemic sclerosis (scleroderma). In: Wyngaarden, J.B., Smith, L.H., and Bennett, J.C. (eds) Cecil Text Book of Medicine. 19th ed. WB Saunders, Philadelphia, pp. 1530-1535
-
(1992)
Cecil Text Book of Medicine. 19th Ed.
, pp. 1530-1535
-
-
LeRoy, E.G.1
-
2
-
-
0025838739
-
Immunological aspects of scleroderma
-
Korn, J.H. (1991) Immunological aspects of scleroderma. Curr. Opin. Rheumatol. 3, 947-952
-
(1991)
Curr. Opin. Rheumatol.
, vol.3
, pp. 947-952
-
-
Korn, J.H.1
-
3
-
-
0026528950
-
A brief overview of the pathogenesis of scleroderma (systemic sclerosis)
-
LeRoy, E.G. (1992) A brief overview of the pathogenesis of scleroderma (systemic sclerosis). Ann. Rheum. Dis. 51, 286-288
-
(1992)
Ann. Rheum. Dis.
, vol.51
, pp. 286-288
-
-
LeRoy, E.G.1
-
4
-
-
0036838772
-
Pathogenesis of fibrosis: Role of TGF-β and CTGF
-
Ihn, H. (2002) Pathogenesis of fibrosis: role of TGF-β and CTGF. Curr. Opin. Rheumatol. 14, 681-685
-
(2002)
Curr. Opin. Rheumatol.
, vol.14
, pp. 681-685
-
-
Ihn, H.1
-
5
-
-
0036448477
-
The role of TGF-β signaling in the pathogenesis of fibrosis in scleroderma
-
Ihn, H. (2002) The role of TGF-β signaling in the pathogenesis of fibrosis in scleroderma. Arch, Immunol. Ther. Exp. 50, 325-331
-
(2002)
Arch, Immunol. Ther. Exp.
, vol.50
, pp. 325-331
-
-
Ihn, H.1
-
7
-
-
0029765057
-
Heterogeneity of collagen synthesis in normal and systemic sclerosis skin fibroblasts: Increased proportion of high collagen-producing cells in systemic sclerosis fibroblasts
-
Jelaska, A., Arakawa, M., Broketa, G., and Korn, J.H. (1996) Heterogeneity of collagen synthesis in normal and systemic sclerosis skin fibroblasts: increased proportion of high collagen-producing cells in systemic sclerosis fibroblasts. Arthritis. Rheum. 39, 1338-1346
-
(1996)
Arthritis. Rheum.
, vol.39
, pp. 1338-1346
-
-
Jelaska, A.1
Arakawa, M.2
Broketa, G.3
Korn, J.H.4
-
8
-
-
0016302998
-
Increased collagen synthesis by scleroderma skin fibroblasts in vivo
-
LeRoy, E.G. (1974) Increased collagen synthesis by scleroderma skin fibroblasts in vivo. J. Clin. Invest. 54, 880-889
-
(1974)
J. Clin. Invest.
, vol.54
, pp. 880-889
-
-
LeRoy, E.G.1
-
9
-
-
0025641313
-
Increased expression of type VI collagen genes in systemic sclerosis
-
Peltonen, J., Kahari, L., Uitto, J., and Jimenez, S.A. (1990) Increased expression of type VI collagen genes in systemic sclerosis. Arthritis Rheum. 33, 1829-1835
-
(1990)
Arthritis Rheum.
, vol.33
, pp. 1829-1835
-
-
Peltonen, J.1
Kahari, L.2
Uitto, J.3
Jimenez, S.A.4
-
10
-
-
0026102075
-
Fibronectin release by systemic sclerosis and normal dermal fibroblasts in response to TGF-β
-
Xu, W., LeRoy, E.G., and Smith, E.A. (1991) Fibronectin release by systemic sclerosis and normal dermal fibroblasts in response to TGF-β. J. Rheumatol. 18, 241-246
-
(1991)
J. Rheumatol.
, vol.18
, pp. 241-246
-
-
Xu, W.1
LeRoy, E.G.2
Smith, E.A.3
-
11
-
-
0028351248
-
Elevated expression of type VII collagen in the skin of patients with systemic sclerosis. Regulation by transforming growth factor-β
-
Ludnica, L., Varga, J., Christiano, A.M., Iozzo, R.V., Jimenez, S.A., and Uitto, J. (1994) Elevated expression of type VII collagen in the skin of patients with systemic sclerosis. Regulation by transforming growth factor-β. J. Clin. Invest. 93, 1709-1715
-
(1994)
J. Clin. Invest.
, vol.93
, pp. 1709-1715
-
-
Ludnica, L.1
Varga, J.2
Christiano, A.M.3
Iozzo, R.V.4
Jimenez, S.A.5
Uitto, J.6
-
12
-
-
0023183348
-
Transforming growth factor β: Selective increase in glycosaminoglycan synthesis by cultures of fibroblasts from patients with progressive systemic sclerosis
-
Falanga, V., Tiegs, S.L., Alstadt, S.P., Roberts, A.B., and Sporn, M.B. (1987) Transforming growth factor β: selective increase in glycosaminoglycan synthesis by cultures of fibroblasts from patients with progressive systemic sclerosis. J. Invest. Dermatol. 89, 100-104
-
(1987)
J. Invest. Dermatol.
, vol.89
, pp. 100-104
-
-
Falanga, V.1
Tiegs, S.L.2
Alstadt, S.P.3
Roberts, A.B.4
Sporn, M.B.5
-
13
-
-
0033791928
-
Increased phosphorylation of transcription factor Sp1 in scleroderma fibroblasts: Association with increased expression of type 1 collagen gene
-
Ihn, H. and Tamaki, K. (2000) Increased phosphorylation of transcription factor Sp1 in scleroderma fibroblasts: association with increased expression of type 1 collagen gene. Arthritis Rheum. 43, 2240-2247
-
(2000)
Arthritis Rheum.
, vol.43
, pp. 2240-2247
-
-
Ihn, H.1
Tamaki, K.2
-
14
-
-
0035089825
-
Blockade of endogenous transforming growth factor β signaling prevents up-regulated collagen synthesis in scleroderma fibroblasts: Association with increased expression of transforming growth factor β receptors
-
Ihn, H., Yamane, K., Kubo, M., and Tamaki, K: (2001) Blockade of endogenous transforming growth factor β signaling prevents up-regulated collagen synthesis in scleroderma fibroblasts: association with increased expression of transforming growth factor β receptors. Arthritis Rheum. 44, 474-480
-
(2001)
Arthritis Rheum.
, vol.44
, pp. 474-480
-
-
Ihn, H.1
Yamane, K.2
Kubo, M.3
Tamaki, K.4
-
15
-
-
2942529076
-
Epidermal growth factor induces fibronectin expression in human dermal fibroblasts via protein kinase C δ signaling pathway
-
Mimura, Y., Ihn, H., Jinnin, M., Asano, Y., Yamane, K., and Tamaki, K. (2004) Epidermal growth factor induces fibronectin expression in human dermal fibroblasts via protein kinase C δ signaling pathway. J. Invest. Dermatol. 122, 1390-1398
-
(2004)
J. Invest. Dermatol.
, vol.122
, pp. 1390-1398
-
-
Mimura, Y.1
Ihn, H.2
Jinnin, M.3
Asano, Y.4
Yamane, K.5
Tamaki, K.6
-
16
-
-
0028854277
-
Myofibroblasts from scleroderma skin synthesize elevated levels of collagen and tissue inhibitor of metalloprotainase (TIMP-1) with two forms of TIMP-1
-
Kirk, T.Z., Mark, M.E., Chua, C.C., Chau, B.H., and Mayers, M.D. (1995) Myofibroblasts from scleroderma skin synthesize elevated levels of collagen and tissue inhibitor of metalloprotainase (TIMP-1) with two forms of TIMP-1. J. Biol. Chem. 270, 3423-3428
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 3423-3428
-
-
Kirk, T.Z.1
Mark, M.E.2
Chua, C.C.3
Chau, B.H.4
Mayers, M.D.5
-
17
-
-
0031469085
-
Circulating intercellular adhesion molecule-1 in the sera of patients with systemic sclerosis: Enhancement by inflammatory cytokines
-
Ihn, H., Sato, S., Fujimoto, M., Kikuchi, K., Kadono, T., Tamaki, T., Tamaki, K., and Takehara, K. (1997) Circulating intercellular adhesion molecule-1 in the sera of patients with systemic sclerosis: Enhancement by inflammatory cytokines. Br. J. Rheumatol. 36, 1270-1275
-
(1997)
Br. J. Rheumatol.
, vol.36
, pp. 1270-1275
-
-
Ihn, H.1
Sato, S.2
Fujimoto, M.3
Kikuchi, K.4
Kadono, T.5
Tamaki, T.6
Tamaki, K.7
Takehara, K.8
-
18
-
-
0028843375
-
Oncostatin M stimulates collagen and glycosaminoglycan production by cultured normal dermal fibroblasts: Insensitivity of sclerodermal and keloidal fibroblasts
-
Duncan, M.A., Hasan, A., and Berman, B. (1995) Oncostatin M stimulates collagen and glycosaminoglycan production by cultured normal dermal fibroblasts: insensitivity of sclerodermal and keloidal fibroblasts. J. Invest. Dermatol. 104, 128-133
-
(1995)
J. Invest. Dermatol.
, vol.104
, pp. 128-133
-
-
Duncan, M.A.1
Hasan, A.2
Berman, B.3
-
19
-
-
0342561551
-
Regulation of interleukin-4 on collagen gene expression by systemic sclerosis fibroblasts in culture
-
Lee, K.S., Ro, Y.J., Ryoo, Y.W., Kwon, H.J., and Song, J.Y. (1996) Regulation of interleukin-4 on collagen gene expression by systemic sclerosis fibroblasts in culture. J. Dermatol. Sci. 12, 110-117
-
(1996)
J. Dermatol. Sci.
, vol.12
, pp. 110-117
-
-
Lee, K.S.1
Ro, Y.J.2
Ryoo, Y.W.3
Kwon, H.J.4
Song, J.Y.5
-
20
-
-
0025222517
-
The transforming growth factor-β family
-
Massague, J. (1990) The transforming growth factor-β family. Annu. Rev. Cell Biol. 6, 597-641
-
(1990)
Annu. Rev. Cell Biol.
, vol.6
, pp. 597-641
-
-
Massague, J.1
-
21
-
-
0024323330
-
A strategy for determining the pathogenesis of systemic sclerosis: Is transforming growth factor β the answer?
-
LeRoy, E.G., Smith, E.A., Kahaleh, M.B., Trojanowska, M., and Silver, R.M. (1989) A strategy for determining the pathogenesis of systemic sclerosis: is transforming growth factor β the answer? Arthritis Rheum. 32, 817-825
-
(1989)
Arthritis Rheum.
, vol.32
, pp. 817-825
-
-
LeRoy, E.G.1
Smith, E.A.2
Kahaleh, M.B.3
Trojanowska, M.4
Silver, R.M.5
-
22
-
-
0022359409
-
Cutaneous tissue repair: Basic biological considerations
-
Clark, R. A. (1985) Cutaneous tissue repair: Basic biological considerations. J. Am. Acad. Dermatol. 13, 701-725
-
(1985)
J. Am. Acad. Dermatol.
, vol.13
, pp. 701-725
-
-
Clark, R.A.1
-
23
-
-
0026778310
-
Transforming growth factor-β: The dark side of tissue repair
-
Border, W.A. and Ruoslahti, E. (1992) Transforming growth factor-β: the dark side of tissue repair. J. Clin. Invest. 90, 1-7
-
(1992)
J. Clin. Invest.
, vol.90
, pp. 1-7
-
-
Border, W.A.1
Ruoslahti, E.2
-
24
-
-
0016537594
-
Mitogenic effect of fibroblast growth factor on early passage cultures of human murine fibroblasts
-
Gospodarovvicz, D. and Moran, J.S. (1975) Mitogenic effect of fibroblast growth factor on early passage cultures of human murine fibroblasts. J. Cell Biol. 66, 451-457
-
(1975)
J. Cell Biol.
, vol.66
, pp. 451-457
-
-
Gospodarovvicz, D.1
Moran, J.S.2
-
25
-
-
0000686740
-
Human epidermal growth factor: Isolation and chemical and biological properties
-
Cohen, S. and Carpenter, G. (1975) Human epidermal growth factor: isolation and chemical and biological properties. Proc. Natl. Acad. Sci. USA 72, 1317-1321
-
(1975)
Proc. Natl. Acad. Sci. USA
, vol.72
, pp. 1317-1321
-
-
Cohen, S.1
Carpenter, G.2
-
26
-
-
0017280107
-
Platelet factors stimulate fibroblasts and smooth muscle cells quiescent in plasma serum to proliferate
-
Rutherford, R.B. and Ross, R. (1976) Platelet factors stimulate fibroblasts and smooth muscle cells quiescent in plasma serum to proliferate. J. Cell Biol. 69, 196-203
-
(1976)
J. Cell Biol.
, vol.69
, pp. 196-203
-
-
Rutherford, R.B.1
Ross, R.2
-
27
-
-
0022485610
-
Cathectin and tumor necrosis factor as two sides of the same biological coin
-
Beutler, B. and Cerami. A. (1986) Cathectin and tumor necrosis factor as two sides of the same biological coin. Nature 320, 584-588
-
(1986)
Nature
, vol.320
, pp. 584-588
-
-
Beutler, B.1
Cerami, A.2
-
28
-
-
0026446005
-
Human fibroblasts synthesize elevated levels of extracellular matrix protein in response to interleukin 4
-
Postlethwaite, A.E., Holness, M.A., Katai, H., and Raghow, R. (1992) Human fibroblasts synthesize elevated levels of extracellular matrix protein in response to interleukin 4. J. Clin. Invest. 90, 1479-1485
-
(1992)
J. Clin. Invest.
, vol.90
, pp. 1479-1485
-
-
Postlethwaite, A.E.1
Holness, M.A.2
Katai, H.3
Raghow, R.4
-
29
-
-
0024322543
-
Differential regulation of collagen, glycosaminoglycan, fibronectin and collagenase activity production in cultured human adult dermal fibroblasts by interleukin 1-α and β and tumor necrosis factor-α and β
-
Duncun, M.R. and Berman, B. (1989) Differential regulation of collagen, glycosaminoglycan, fibronectin and collagenase activity production in cultured human adult dermal fibroblasts by interleukin 1-α and β and tumor necrosis factor-α and β. J. Invest. Dermatol. 92, 699-706
-
(1989)
J. Invest. Dermatol.
, vol.92
, pp. 699-706
-
-
Duncun, M.R.1
Berman, B.2
-
30
-
-
0025989368
-
Stimulation of collagen and glycosaminoglycan production in cultured human adult dermal fibroblasts by recombinant human interleukin 6
-
Duncun, M.R. and Berman, B. (1991) Stimulation of collagen and glycosaminoglycan production in cultured human adult dermal fibroblasts by recombinant human interleukin 6. J. Invest. Dermatol. 97, 686-692
-
(1991)
J. Invest. Dermatol.
, vol.97
, pp. 686-692
-
-
Duncun, M.R.1
Berman, B.2
-
31
-
-
0034664022
-
Oncostatin M stimulates the growth of dermal fibroblasts via a mitogen-activated protein kinase-dependent pathway
-
Ihn, H. and Tamaki, K. (2000) Oncostatin M stimulates the growth of dermal fibroblasts via a mitogen-activated protein kinase-dependent pathway. J. Immunol. 165, 2149-2155
-
(2000)
J. Immunol.
, vol.165
, pp. 2149-2155
-
-
Ihn, H.1
Tamaki, K.2
-
32
-
-
0030427867
-
Signal transduction by members of the transforming growth factor-β super-family
-
Attisano, L. and Wrana, J.L. (1996) Signal transduction by members of the transforming growth factor-β super-family. Cytokine Growth Factor Rev. 7, 327-339
-
(1996)
Cytokine Growth Factor Rev.
, vol.7
, pp. 327-339
-
-
Attisano, L.1
Wrana, J.L.2
-
33
-
-
0031685620
-
TGF-β signal transduction
-
Massague, J, (1998) TGF-β signal transduction. Ann. Rev. Biochem. 67, 753-791
-
(1998)
Ann. Rev. Biochem.
, vol.67
, pp. 753-791
-
-
Massague, J.1
-
34
-
-
0030974902
-
Latent transforming growth factor-β binding protein domains involved in activation and transglutaminase-dependent cross-linking of latent transforming growth factor-β
-
Nunes, I., Gleizes, P.E., Metz, C.N., and Rifkin, D.B. (1997) Latent transforming growth factor-β binding protein domains involved in activation and transglutaminase-dependent cross-linking of latent transforming growth factor-β. J. Cell Biol. 136, 1151-1163
-
(1997)
J. Cell Biol.
, vol.136
, pp. 1151-1163
-
-
Nunes, I.1
Gleizes, P.E.2
Metz, C.N.3
Rifkin, D.B.4
-
35
-
-
3042822469
-
Increased expression of TGF-β1 in the sclerotic skin in bleomycin-'susceptible' mouse strains
-
Oi, M., Yamamoto, M., and Nishioka, K. (2004) Increased expression of TGF-β1 in the sclerotic skin in bleomycin-'susceptible' mouse strains. J. Med. Dent. Sci. 51, 7-17
-
(2004)
J. Med. Dent. Sci.
, vol.51
, pp. 7-17
-
-
Oi, M.1
Yamamoto, M.2
Nishioka, K.3
-
36
-
-
0025330462
-
Secretion and binding of transforming growth factor β by scleroderma and normal dermal fibroblasts
-
Needleman, B.W., Choi, J., Burrows-Menzu, A., and Fontana, J. A. (1990) Secretion and binding of transforming growth factor β by scleroderma and normal dermal fibroblasts. Arthritis Rheum. 33, 650-653
-
(1990)
Arthritis Rheum.
, vol.33
, pp. 650-653
-
-
Needleman, B.W.1
Choi, J.2
Burrows-Menzu, A.3
Fontana, J.A.4
-
37
-
-
0028170226
-
Mechanism of activation of the TGF-β receptor
-
Wrana, J.L., Attisano, L., Weisser, R., Ventura, F., and Massague, J. (1994) Mechanism of activation of the TGF-β receptor. Nature 370, 341-347
-
(1994)
Nature
, vol.370
, pp. 341-347
-
-
Wrana, J.L.1
Attisano, L.2
Weisser, R.3
Ventura, F.4
Massague, J.5
-
38
-
-
0030028533
-
Identification of important regions in the cytoplasmic juxtamembrane domain of type I receptor that separate signaling pathways of transforming growth factor β
-
Saitoh, M., Nishitoh, H., Amagasa, T., Miyazono, K., Takagi, M., and Ichijo, H. (1996) Identification of important regions in the cytoplasmic juxtamembrane domain of type I receptor that separate signaling pathways of transforming growth factor β. J. Biol. Chem. 271, 2769-2775
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 2769-2775
-
-
Saitoh, M.1
Nishitoh, H.2
Amagasa, T.3
Miyazono, K.4
Takagi, M.5
Ichijo, H.6
-
39
-
-
0031886413
-
Increased expression of TGF-β receptors by scleroderma fibroblasts: Evidence for contribution of autocrine TGF-β signaling to scleroderma phenotype
-
Kawakami, T., Ihn, H., Xu, W., Smith, E., LeRoy, C., and Trojanowska, M. (1998) Increased expression of TGF-β receptors by scleroderma fibroblasts: evidence for contribution of autocrine TGF-β signaling to scleroderma phenotype. J. Invest. Dermatol. 110, 47-51
-
(1998)
J. Invest. Dermatol.
, vol.110
, pp. 47-51
-
-
Kawakami, T.1
Ihn, H.2
Xu, W.3
Smith, E.4
LeRoy, C.5
Trojanowska, M.6
-
40
-
-
0035079964
-
Up-regulated expression of transforming growth factor β receptors in dermal fibroblasts in skin sections from patients with localized scleroderma
-
Kubo, M., Ihn, H., Yamane, K., and Tamaki, K. (2001) Up-regulated expression of transforming growth factor β receptors in dermal fibroblasts in skin sections from patients with localized scleroderma. Arthritis Rheum. 44, 731-734
-
(2001)
Arthritis Rheum.
, vol.44
, pp. 731-734
-
-
Kubo, M.1
Ihn, H.2
Yamane, K.3
Tamaki, K.4
-
41
-
-
0033036099
-
Role of transforming growth factor β type II receptor in hepatic fibrosis: Studies of human chronic hepatitis C and experimental fibrosis in rats
-
Roulot, D., Sevcsik, A.M., Coste, T., Strosberg, A.D., and Marullo, S. (1999) Role of transforming growth factor β type II receptor in hepatic fibrosis: studies of human chronic hepatitis C and experimental fibrosis in rats. Hepatology 29, 1730-1738.
-
(1999)
Hepatology
, vol.29
, pp. 1730-1738
-
-
Roulot, D.1
Sevcsik, A.M.2
Coste, T.3
Strosberg, A.D.4
Marullo, S.5
-
42
-
-
0036894848
-
Upregulated expression of transforming growth factor-β receptors in dermal fibroblasts of skin sections from patients with systemic sclerosis
-
Kubo, M., ihn, H., Yamane, K., and Tamaki, K. (2002) Upregulated expression of transforming growth factor-β receptors in dermal fibroblasts of skin sections from patients with systemic sclerosis. J. Rheumatol. 29, 2558-2564
-
(2002)
J. Rheumatol.
, vol.29
, pp. 2558-2564
-
-
Kubo, M.1
Ihn, H.2
Yamane, K.3
Tamaki, K.4
-
43
-
-
0036745067
-
Increased transcriptional activities of transforming growth factor β receptors in scleroderma fibroblasts
-
Yamane, K., Ihn, H., Kubo, M., and Tamaki, K. (2002) Increased transcriptional activities of transforming growth factor β receptors in scleroderma fibroblasts. Arthritis Rheum. 46, 2421-2428
-
(2002)
Arthritis Rheum.
, vol.46
, pp. 2421-2428
-
-
Yamane, K.1
Ihn, H.2
Kubo, M.3
Tamaki, K.4
-
44
-
-
0038313053
-
Epidermal growth factor up-regulates expression of transforming growth factor β receptor type II in human dermal fibroblasts by phosphoinositide 3-kinase/ Akt signaling pathway: Resistance to epidermal growth factor stimulation in scleroderma fibroblasts
-
Yamane, K., Ihn, H., and Tamaki, K. (2003) Epidermal growth factor up-regulates expression of transforming growth factor β receptor type II in human dermal fibroblasts by phosphoinositide 3-kinase/ Akt signaling pathway: resistance to epidermal growth factor stimulation in scleroderma fibroblasts. Arthritis Rheum. 48, 1652-1666
-
(2003)
Arthritis Rheum.
, vol.48
, pp. 1652-1666
-
-
Yamane, K.1
Ihn, H.2
Tamaki, K.3
-
45
-
-
0141955064
-
Antagonistic effects of TNF-α on TGF-β signaling through down-regulation of TGF-β receptor type II in human dermal fibroblasts
-
Yamane, K., Ihn, H., Asano, Y., Jinnin, M., and Tamaki, K. (2003) Antagonistic effects of TNF-α on TGF-β signaling through down-regulation of TGF-β receptor type II in human dermal fibroblasts. J. Immunol. 171, 3855-3862
-
(2003)
J. Immunol.
, vol.171
, pp. 3855-3862
-
-
Yamane, K.1
Ihn, H.2
Asano, Y.3
Jinnin, M.4
Tamaki, K.5
-
46
-
-
0030600234
-
Structure and expression of the promoter for the R4/ALK5 human type 1 transforming growth factor-β receptor: Regulation by TGF-β
-
Bloom, B.B., Humphries, D.E., Kuang, P.P., Fine, A., and Goldstein, R.H. (1996) Structure and expression of the promoter for the R4/ALK5 human type 1 transforming growth factor-β receptor: regulation by TGF-β. Biochim. Biophys. Acta. 1312, 243-248
-
(1996)
Biochim. Biophys. Acta
, vol.1312
, pp. 243-248
-
-
Bloom, B.B.1
Humphries, D.E.2
Kuang, P.P.3
Fine, A.4
Goldstein, R.H.5
-
47
-
-
0035788742
-
Differential regulation of transforming growth factor-β receptors type I and type II by platelet-derived growth factor in human dermal fibroblasts
-
Czuwara-Ladykowska, J., Gore, E.A., Shegogue, D.A., Smith, E.A., and Trojanowska, M. (2001) Differential regulation of transforming growth factor-β receptors type I and type II by platelet-derived growth factor in human dermal fibroblasts. Br. J. Dermatol. 145, 569-575
-
(2001)
Br. J. Dermatol.
, vol.145
, pp. 569-575
-
-
Czuwara-Ladykowska, J.1
Gore, E.A.2
Shegogue, D.A.3
Smith, E.A.4
Trojanowska, M.5
-
48
-
-
0036069793
-
Dys-regulation of transforming growth factor-β signaling in scleroderma: Overexpression of endoglin in cutaneous scleroderma fibroblasts
-
Leask, A., Abraham, D.J., Finlay, D.R., Holmes, A., Pennington, D., Shi-Wen, X., Chen, Y., Venstrom, K., Dou, X., Ponticos, M., Black, C., Bernabeu, C., Jackman, J.K., Findell, P.R., and Connolly, M.K. (2002) Dys-regulation of transforming growth factor-β signaling in scleroderma: overexpression of endoglin in cutaneous scleroderma fibroblasts. Arthritis Rheum. 46, 1857-1865
-
(2002)
Arthritis Rheum.
, vol.46
, pp. 1857-1865
-
-
Leask, A.1
Abraham, D.J.2
Finlay, D.R.3
Holmes, A.4
Pennington, D.5
Shi-Wen, X.6
Chen, Y.7
Venstrom, K.8
Dou, X.9
Ponticos, M.10
Black, C.11
Bernabeu, C.12
Jackman, J.K.13
Findell, P.R.14
Connolly, M.K.15
-
49
-
-
2342547687
-
An increased transforming growth factor β receptor type I: Type 11 ratio contributes to elevated collagen protein synthesis that is resistant to inhibition via a kinase-deficient transforming growth factor β receptor type II in scleroderma
-
Pannu, J., Gore-Hyer, E., Yamanaka, M., Smith, E.A., Rubinchik, S., Dong, J.Y., Jablonska, M, Blaszczyk, M., and Trojanowska, M. (2004) An increased transforming growth factor β receptor type I: type 11 ratio contributes to elevated collagen protein synthesis that is resistant to inhibition via a kinase-deficient transforming growth factor β receptor type II in scleroderma. Arthritis Rheum. 50, 1566-1577
-
(2004)
Arthritis Rheum.
, vol.50
, pp. 1566-1577
-
-
Pannu, J.1
Gore-Hyer, E.2
Yamanaka, M.3
Smith, E.A.4
Rubinchik, S.5
Dong, J.Y.6
Jablonska, M.7
Blaszczyk, M.8
Trojanowska, M.9
-
50
-
-
0033515099
-
Blockade of type β transforming growth factor signaling prevents liver fibrosis and dysfunction in the rat
-
Qi, Z., Atsuchi, N., Ooshima, A., Takeshita, A., and Ueno, H. (1999) Blockade of type β transforming growth factor signaling prevents liver fibrosis and dysfunction in the rat. Proc. Natl. Acad. Sci. USA 96, 2345-2349
-
(1999)
Proc. Natl. Acad. Sci. USA
, vol.96
, pp. 2345-2349
-
-
Qi, Z.1
Atsuchi, N.2
Ooshima, A.3
Takeshita, A.4
Ueno, H.5
-
51
-
-
4243245023
-
Overexpression of a kinase-deficient TGFβ receptor II via an adenoviral vector potently inhibits extracellular matrix production in scleroderma and normal dermal fibroblasts
-
Trojanowska, M., Smith, E., Dong, J.Y., and Gore, E. (1999) Overexpression of a kinase-deficient TGFβ receptor II via an adenoviral vector potently inhibits extracellular matrix production in scleroderma and normal dermal fibroblasts. Arthritis Rheum. 42, S203
-
(1999)
Arthritis Rheum.
, vol.42
-
-
Trojanowska, M.1
Smith, E.2
Dong, J.Y.3
Gore, E.4
-
52
-
-
0034654497
-
Controlling TGF-β signaling
-
Massague, J. and Chen, Y.G. (2000) Controlling TGF-β signaling. Genes Dev. 14, 627-644
-
(2000)
Genes Dev.
, vol.14
, pp. 627-644
-
-
Massague, J.1
Chen, Y.G.2
-
53
-
-
0030837455
-
A structure basis for mutational inactivation of the tumor suppressor Smad4
-
Shi, Y., Hata, A., Lo, R.S., Massague, J., and Pavletich, N.P. (1997) A structure basis for mutational inactivation of the tumor suppressor Smad4. Nature 388, 87-93
-
(1997)
Nature
, vol.388
, pp. 87-93
-
-
Shi, Y.1
Hata, A.2
Lo, R.S.3
Massague, J.4
Pavletich, N.P.5
-
54
-
-
0032014216
-
Human Smad3 and Smad4 are sequence-specific transcription activators
-
Zawel, L., Dai, J.L., Buckhaults, P., Zhou, S., Kinzler, K. W., Vogelstein, B., and Kern, S.E. (1998) Human Smad3 and Smad4 are sequence-specific transcription activators. Mol. Cell 1, 611-617
-
(1998)
Mol. Cell
, vol.1
, pp. 611-617
-
-
Zawel, L.1
Dai, J.L.2
Buckhaults, P.3
Zhou, S.4
Kinzler, K.W.5
Vogelstein, B.6
Kern, S.E.7
-
55
-
-
0030765945
-
Smad6 inhibits signaling by the TGF-β superfamily
-
Imamura, T., Takase, M., Nishihara, A., Oeda, E., Hanai, J., Kawabata, M., and Miyazono, K. (1997) Smad6 inhibits signaling by the TGF-β superfamily. Nature 389, 622-626
-
(1997)
Nature
, vol.389
, pp. 622-626
-
-
Imamura, T.1
Takase, M.2
Nishihara, A.3
Oeda, E.4
Hanai, J.5
Kawabata, M.6
Miyazono, K.7
-
56
-
-
0029861965
-
Transcriptional regulation of the human α2(I) collagen gene: Combined action of upstream stimulatory and inhibitory cis-acting element
-
Ihn, H., Ohnishi, K., Tamaki, T., LeRoy, E.G., and Trojanowska, M. (1996) Transcriptional regulation of the human α2(I) collagen gene: combined action of upstream stimulatory and inhibitory cis-acting element. J. Biol. Chem. 271, 26717-26723
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 26717-26723
-
-
Ihn, H.1
Ohnishi, K.2
Tamaki, T.3
LeRoy, E.G.4
Trojanowska, M.5
-
57
-
-
0030870170
-
Oncostatin M stimulates transcription of the human α2(I) collagen gene via the Sp1/Sp3-binding site
-
Ihn, H., LeRoy, E.G., and Trojanowska, M. (1997) Oncostatin M stimulates transcription of the human α2(I) collagen gene via the Sp1/Sp3-binding site. J. Biol. Chem. 272, 24666-24672
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 24666-24672
-
-
Ihn, H.1
LeRoy, E.G.2
Trojanowska, M.3
-
58
-
-
0030820182
-
Sp3 is a transcriptional activator of the human α2(I) collagen gene
-
Ihn, H. and Trojanowska, M. (1997) Sp3 is a transcriptional activator of the human α2(I) collagen gene. Nucleic Acids Res. 25, 3712-3717
-
(1997)
Nucleic Acids Res.
, vol.25
, pp. 3712-3717
-
-
Ihn, H.1
Trojanowska, M.2
-
59
-
-
0034068629
-
Competition analysis of the human αr2(I) collagen promoter using synthetic oligonucleotides
-
Ihn, H. and Tamaki, K. (2000) Competition analysis of the human αr2(I) collagen promoter using synthetic oligonucleotides. J. invest. Dermatol. 114, 1011-1016
-
(2000)
J. Invest. Dermatol.
, vol.114
, pp. 1011-1016
-
-
Ihn, H.1
Tamaki, K.2
-
60
-
-
0035723342
-
Sp1 phosphorylation induced by serum stimulates the human α2(I) collagen gene
-
Ihn, H., Ihn, Y., and Trojanowska, M, (2001) Sp1 phosphorylation induced by serum stimulates the human α2(I) collagen gene. J. Invest. Dermatol. 117, 301-308
-
(2001)
J. Invest. Dermatol.
, vol.117
, pp. 301-308
-
-
Ihn, H.1
Ihn, Y.2
Trojanowska, M.3
-
61
-
-
0028176086
-
Transforming growth factor-β stimulates α2(I) collagen gene expression through a cis-acting element that contains an Sp1-binding site
-
Inagaki, Y., Truter, S., and Ramirez, F. (1994) Transforming growth factor-β stimulates α2(I) collagen gene expression through a cis-acting element that contains an Sp1-binding site. J. Biol. Chem. 269, 14828-14834
-
(1994)
J. Biol. Chem.
, vol.269
, pp. 14828-14834
-
-
Inagaki, Y.1
Truter, S.2
Ramirez, F.3
-
63
-
-
0032921867
-
Stimulation of type I collagen transcription in human skin fibroblasts by TGF-β: Involvement of Smad3
-
Chen, S.J., Yuan, W., Mori, Y., Levenson, A., Trojanowska, M., and Varga, J. (1999) Stimulation of type I collagen transcription in human skin fibroblasts by TGF-β: Involvement of Smad3. J. Invest. Dermatol. 112, 49-57
-
(1999)
J. Invest. Dermatol.
, vol.112
, pp. 49-57
-
-
Chen, S.J.1
Yuan, W.2
Mori, Y.3
Levenson, A.4
Trojanowska, M.5
Varga, J.6
-
64
-
-
0034011221
-
Interaction of Smad3 with proximal Smad-binding element of the human α2(I) collagen gene promoter required for transcriptional activation by TGF-β
-
Chen, S.J., Yuan, W., Lo, S., Trojanowska, M., and Varga, J. (2000) Interaction of Smad3 with proximal Smad-binding element of the human α2(I) collagen gene promoter required for transcriptional activation by TGF-β. J. Cell. Physiol. 183, 381-392
-
(2000)
J. Cell. Physiol.
, vol.183
, pp. 381-392
-
-
Chen, S.J.1
Yuan, W.2
Lo, S.3
Trojanowska, M.4
Varga, J.5
-
65
-
-
0034255634
-
Modulation of endogenous Smad expression in normal skin fibroblasts by transforming growth factor-β
-
Mori, Y., Chen, S.J., and Varga, J. (2000) Modulation of endogenous Smad expression in normal skin fibroblasts by transforming growth factor-β, Exp. Cell Res. 258, 374-383
-
(2000)
Exp. Cell Res.
, vol.258
, pp. 374-383
-
-
Mori, Y.1
Chen, S.J.2
Varga, J.3
-
67
-
-
0035831503
-
1-induced α2(I) collagen expression in human glomerular mesangial cells
-
1-induced α2(I) collagen expression in human glomerular mesangial cells. J. Biol. Chem. 276, 6983-6992
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 6983-6992
-
-
Poncelet, A.C.1
Schnaper, H.W.2
-
68
-
-
0035844276
-
Interaction between GC box binding factors and Smad proteins modulates cell lineage-specific α2(I) collagen gene transcription
-
Inagaki, Y., Nemoto, T., Nakao, A., ten Dijke, P., Kobayashi, K., Takehara, K., and Greenwel, P. (2001) Interaction between GC box binding factors and Smad proteins modulates cell lineage-specific α2(I) collagen gene transcription. J. Biol. Chem. 276, 16573-16579
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 16573-16579
-
-
Inagaki, Y.1
Nemoto, T.2
Nakao, A.3
Ten Dijke, P.4
Kobayashi, K.5
Takehara, K.6
Greenwel, P.7
-
69
-
-
0034691764
-
Smad-dependent stimulation of type I collagen gene expression in human skin fibroblasts by TGF-β involves functional cooperation with p300/CBP transcriptional coactivators
-
Ghosh, A.K., Yuan, W., Mori, Y., and Varga, J. (2000) Smad-dependent stimulation of type I collagen gene expression in human skin fibroblasts by TGF-β involves functional cooperation with p300/CBP transcriptional coactivators. Oncogene 19, 3546-3555
-
(2000)
Oncogene
, vol.19
, pp. 3546-3555
-
-
Ghosh, A.K.1
Yuan, W.2
Mori, Y.3
Varga, J.4
-
70
-
-
0035815696
-
Antagonistic regulation of type I collagen gene expression by interferon-γ and transforming growth factor-β. Integration at the level of p300/CBP transcriptional coactivators
-
Ghosh, A.K., Yuan, W., Mori, Y., Chen, S.J., and Varga, J. (2001) Antagonistic regulation of type I collagen gene expression by interferon-γ and transforming growth factor-β. Integration at the level of p300/CBP transcriptional coactivators. J. Biol. Chem. 276, 11041-11048
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 11041-11048
-
-
Ghosh, A.K.1
Yuan, W.2
Mori, Y.3
Chen, S.J.4
Varga, J.5
-
71
-
-
0037036387
-
Ets1 is an effector of the TGF-β signaling pathway and an antagonist of the profibrotic effects of TGF-β
-
Czuwara-Ladykowska, J., Sementchenko, V.I., Watson, F.K., and Trojanowska, M. (2002) Ets1 is an effector of the TGF-β signaling pathway and an antagonist of the profibrotic effects of TGF-β. J. Biol. Chem. 277, 20399-20408
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 20399-20408
-
-
Czuwara-Ladykowska, J.1
Sementchenko, V.I.2
Watson, F.K.3
Trojanowska, M.4
-
72
-
-
1642403894
-
Tenascin-C upregulation by transforming growth factor-β in human dermal fibroblasts involves Smad3, Sp1, and Ets1
-
Jinnin, M., Ihn, H., Asano, Y., Yamane, K., Trojanowska, M., and Tamaki, K. (2004) Tenascin-C upregulation by transforming growth factor-β in human dermal fibroblasts involves Smad3, Sp1, and Ets1. Oncogene 23, 1656-1667
-
(2004)
Oncogene
, vol.23
, pp. 1656-1667
-
-
Jinnin, M.1
Ihn, H.2
Asano, Y.3
Yamane, K.4
Trojanowska, M.5
Tamaki, K.6
-
73
-
-
0033576676
-
Ets transcription factors cooperate with Sp1 to activate the human tenascin-C promoter
-
Shirasaki, F., Makhluf, H.A., LeRoy, E.C., Watson, D.K., and Trojanowska, M. (1999) Ets transcription factors cooperate with Sp1 to activate the human tenascin-C promoter. Oncogene 18, 7754-7764
-
(1999)
Oncogene
, vol.18
, pp. 7754-7764
-
-
Shirasaki, F.1
Makhluf, H.A.2
LeRoy, E.C.3
Watson, D.K.4
Trojanowska, M.5
-
74
-
-
0035877684
-
Fli-1 inhibits collagen type I production in human dermal fibroblasts via an Sp-dependent manner
-
Czuwara-Ladykowska, J., Shirasaki, F., Jackers, P., Watson, D.K., and Trojanowska, M. (2001) Fli-1 inhibits collagen type I production in human dermal fibroblasts via an Sp-dependent manner. J. Biol. Chem. 15, 20839-20848
-
(2001)
J. Biol. Chem.
, vol.15
, pp. 20839-20848
-
-
Czuwara-Ladykowska, J.1
Shirasaki, F.2
Jackers, P.3
Watson, D.K.4
Trojanowska, M.5
-
75
-
-
0034684614
-
Ets factors and regulation of the extracellular matrix
-
Trojanowska, M. (2000) Ets factors and regulation of the extracellular matrix. Oncogene 18, 6464-6471
-
(2000)
Oncogene
, vol.18
, pp. 6464-6471
-
-
Trojanowska, M.1
-
76
-
-
0035914339
-
Transforming growth factor-β repression of matrix metalloproteinase 1 in dermal fibroblasts involves Smad3
-
Yuan, W. and Varga, J. (2001) Transforming growth factor-β repression of matrix metalloproteinase 1 in dermal fibroblasts involves Smad3. J. Biol. Chem. 276, 38502-38510
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 38502-38510
-
-
Yuan, W.1
Varga, J.2
-
77
-
-
0036124599
-
Mice lacking Smad3 are protected against cutaneous injury induced by ionizing radiation
-
Flanders, K.C, Sullivan, C.D., Fujii, M., Sowers, A, Anzano, M.A., Arabshahi, A., Major, C., Deng, C., Russo, A., Mitchell, J.B., and Roberts, A.B. (2002) Mice lacking Smad3 are protected against cutaneous injury induced by ionizing radiation. Am. J. Pathol. 160, 1057-1068
-
(2002)
Am. J. Pathol.
, vol.160
, pp. 1057-1068
-
-
Flanders, K.C.1
Sullivan, C.D.2
Fujii, M.3
Sowers, A.4
Anzano, M.A.5
Arabshahi, A.6
Major, C.7
Deng, C.8
Russo, A.9
Mitchell, J.B.10
Roberts, A.B.11
-
78
-
-
0036086293
-
Smad3 deficiency attenuates bleomycin-induced pulmonary fibrosis in mice
-
Zhao, J., Shi, W., Wang, Y.L., Chen, H., Bringas, P., Jr., Datto, M.B., Frederick, J.P., Wang, X.F., and Warburton, D. (2002) Smad3 deficiency attenuates bleomycin-induced pulmonary fibrosis in mice. Am. J. Physiol. Lung Cell. Mol. Physiol. 282, 585-593
-
(2002)
Am. J. Physiol. Lung Cell. Mol. Physiol.
, vol.282
, pp. 585-593
-
-
Zhao, J.1
Shi, W.2
Wang, Y.L.3
Chen, H.4
Bringas Jr., P.5
Datto, M.B.6
Frederick, J.P.7
Wang, X.F.8
Warburton, D.9
-
79
-
-
0035112148
-
The hepatitis B virus encoded oncoprotein pX amplifies TGF-β family signaling through direct interaction with Smad4: Potential mechanism of hepatitis B virus-induced liver fibrosis
-
Lee, D.K., Park, S.H., Yi, Y., Choi, S.G., Lee, C., Parks, W.T., Cho, H., de Caestecker, M.P., Shual, Y., Roberts, A.B., and Kim, S.J. (2001) The hepatitis B virus encoded oncoprotein pX amplifies TGF-β family signaling through direct interaction with Smad4: potential mechanism of hepatitis B virus-induced liver fibrosis. Genes Dev. 15, 455-466
-
(2001)
Genes Dev.
, vol.15
, pp. 455-466
-
-
Lee, D.K.1
Park, S.H.2
Yi, Y.3
Choi, S.G.4
Lee, C.5
Parks, W.T.6
Cho, H.7
De Caestecker, M.P.8
Shual, Y.9
Roberts, A.B.10
Kim, S.J.11
-
80
-
-
0034956559
-
The role of Smad3 in mediating mouse hepatic stellate cell activation
-
Schnabl, B., Kweon, Y.O, Frederick, J.P., Wang, X.F., Rippe, R.A., and Brenner, D.A. (2001) The role of Smad3 in mediating mouse hepatic stellate cell activation. Hepatology 34, 89-100
-
(2001)
Hepatology
, vol.34
, pp. 89-100
-
-
Schnabl, B.1
Kweon, Y.O.2
Frederick, J.P.3
Wang, X.F.4
Rippe, R.A.5
Brenner, D.A.6
-
81
-
-
0035120166
-
Constitutive phosphorylation and nuclear localization of Smad3 are correlated with increased collagen gene transcription in activated hepatic satellate cells
-
Inagaki, Y., Mamura, M., Kanamaru, Y., Greenwel, P., Nemoto, T., Takehara, K., ten Dijke, P., and Nakao, A. (2001) Constitutive phosphorylation and nuclear localization of Smad3 are correlated with increased collagen gene transcription in activated hepatic satellate cells. J. Cell. Physiol. 187, 117-123
-
(2001)
J. Cell. Physiol.
, vol.187
, pp. 117-123
-
-
Inagaki, Y.1
Mamura, M.2
Kanamaru, Y.3
Greenwel, P.4
Nemoto, T.5
Takehara, K.6
Ten Dijke, P.7
Nakao, A.8
-
82
-
-
18244401140
-
Differential regulation of TGF-β signal in hepatic stellate cells between acute and chronic rat liver injury
-
Takahashi, Y., Matsuzaki, K., Date, M., Yoshida, K., Furukavva, F., Sugano, Y., Matsushita, M., Himeno, Y., Inagaki, Y., and Inoue, K. (2002) Differential regulation of TGF-β signal in hepatic stellate cells between acute and chronic rat liver injury. Hepatology 35, 49-61
-
(2002)
Hepatology
, vol.35
, pp. 49-61
-
-
Takahashi, Y.1
Matsuzaki, K.2
Date, M.3
Yoshida, K.4
Furukavva, F.5
Sugano, Y.6
Matsushita, M.7
Himeno, Y.8
Inagaki, Y.9
Inoue, K.10
-
83
-
-
0036181284
-
Gene transfer of Smad7 using electroporation of adenovirus prevents renal fibrosis in post-obstructed kidney
-
Terada, Y., Hanada, S., Nakao, A., Kuwahara, M., Sasaki, S., and Marumo, F. (2002) Gene transfer of Smad7 using electroporation of adenovirus prevents renal fibrosis in post-obstructed kidney. Kidney Int. 61, 94-98
-
(2002)
Kidney Int.
, vol.61
, pp. 94-98
-
-
Terada, Y.1
Hanada, S.2
Nakao, A.3
Kuwahara, M.4
Sasaki, S.5
Marumo, F.6
-
84
-
-
0035815683
-
CTGF and SMADs, maintenance of scleroderma phenotype is independent of SMAD signaling
-
Holmes, A., Abraham, D.J., Sa, S., Shiwen, X., Black, C. M., and Leask, A. (2001) CTGF and SMADs, maintenance of scleroderma phenotype is independent of SMAD signaling. J. Biol. Chem. 276, 10594-10601
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 10594-10601
-
-
Holmes, A.1
Abraham, D.J.2
Sa, S.3
Shiwen, X.4
Black, C.M.5
Leask, A.6
-
85
-
-
0038004796
-
Expression and regulation of intracellular SMAD signaling in scleroderma skin fibroblasts
-
Mori, Y., Chen, S.J., and Varga, J. (2003) Expression and regulation of intracellular SMAD signaling in scleroderma skin fibroblasts. Arthritis Rheum. 48, 1964-1978
-
(2003)
Arthritis Rheum.
, vol.48
, pp. 1964-1978
-
-
Mori, Y.1
Chen, S.J.2
Varga, J.3
-
86
-
-
2442640271
-
Phosphatidylinositol 3-kinase is involved in α2(I) collagen gene expression in normal and scleroderma fibroblasts
-
Asano, Y., Ihn, H., Yamane, K., Jinnin, M., Mimura, Y., and Tamaki, K. (2004) Phosphatidylinositol 3-kinase is involved in α2(I) collagen gene expression in normal and scleroderma fibroblasts. J. Immunol. 172, 7123-7135
-
(2004)
J. Immunol.
, vol.172
, pp. 7123-7135
-
-
Asano, Y.1
Ihn, H.2
Yamane, K.3
Jinnin, M.4
Mimura, Y.5
Tamaki, K.6
-
87
-
-
0037133596
-
Deficient Smad7 expression: A putative molecular defect in scleroderma
-
Dong, C., Zhu, S., Wang, T., Yoon, W., Alvarez, R.J., ten Dijke, P., White, B., Wigley, P.M., and Goldschmidt-Clemont, P.J. (2002) Deficient Smad7 expression: a putative molecular defect in scleroderma. Proc. Natl. Acad. Sci. USA 99, 3908-3913
-
(2002)
Proc. Natl. Acad. Sci. USA
, vol.99
, pp. 3908-3913
-
-
Dong, C.1
Zhu, S.2
Wang, T.3
Yoon, W.4
Alvarez, R.J.5
Ten Dijke, P.6
White, B.7
Wigley, P.M.8
Goldschmidt-Clemont, P.J.9
-
88
-
-
85047692249
-
Impaired Smad7-Smurf-mediated negative regulation of TGF-β signaling in scleroderma fibroblasts
-
Asano, Y., Ihn, H., Yamane, K., Kubo, M., and Tamaki, K. (2004) Impaired Smad7-Smurf-mediated negative regulation of TGF-β signaling in scleroderma fibroblasts. J. Clin. Invest. 113, 253-264
-
(2004)
J. Clin. Invest.
, vol.113
, pp. 253-264
-
-
Asano, Y.1
Ihn, H.2
Yamane, K.3
Kubo, M.4
Tamaki, K.5
-
89
-
-
0029011218
-
The MAPK signaling cascade
-
Seger, R. and Krebs, E.G. (1995) The MAPK signaling cascade. FASEB J. 9, 726-735
-
(1995)
FASEB J.
, vol.9
, pp. 726-735
-
-
Seger, R.1
Krebs, E.G.2
-
90
-
-
0037083458
-
1L-4 up-regulates the expression of tissue inhibitor of metalloproteinase-2 in dermal fibroblasts via the p38 mitogen-activated protein kinase-dependent pathway
-
Ihn, H., Yamane, K., Asano, Y., Kubo, M., and Tamaki, K. (2002) 1L-4 up-regulates the expression of tissue inhibitor of metalloproteinase-2 in dermal fibroblasts via the p38 mitogen-activated protein kinase-dependent pathway. J. Immunol. 168, 1895-1902
-
(2002)
J. Immunol.
, vol.168
, pp. 1895-1902
-
-
Ihn, H.1
Yamane, K.2
Asano, Y.3
Kubo, M.4
Tamaki, K.5
-
91
-
-
0036226458
-
Role of p38 MAPK in transforming growth factor β stimulation of collagen production by scleroderma and healthy dermal fibroblasts
-
Sato, M., Shegogue, D., Gore, E.A., Smith, E.A., McDermott, P.J., and Trojanowska, M. (2002) Role of p38 MAPK in transforming growth factor β stimulation of collagen production by scleroderma and healthy dermal fibroblasts. J. Invest. Dermatol. 118, 704-711
-
(2002)
J. Invest. Dermatol.
, vol.118
, pp. 704-711
-
-
Sato, M.1
Shegogue, D.2
Gore, E.A.3
Smith, E.A.4
McDermott, P.J.5
Trojanowska, M.6
-
92
-
-
0033104505
-
TGF-β induces fibronectin synthesis through a c-Jun N-termial kinase-dependent Smad4-independent pathway
-
Hocevar, B.A., Brown, T.L., and Howe, P.H. (1999) TGF-β induces fibronectin synthesis through a c-Jun N-termial kinase-dependent Smad4-independent pathway. EMBO J. 18, 1345-1356
-
(1999)
EMBO J.
, vol.18
, pp. 1345-1356
-
-
Hocevar, B.A.1
Brown, T.L.2
Howe, P.H.3
-
93
-
-
0034602286
-
Activation of extracellular signal-regulated kinase 1/2 inhibits type I collagen expression by human skin fibroblasts
-
Reunanen, N., Foschi, M., Han, J., and Hahari, V.M. (2000) Activation of extracellular signal-regulated kinase 1/2 inhibits type I collagen expression by human skin fibroblasts. J. Biol. Chem. 275, 34634-34639
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 34634-34639
-
-
Reunanen, N.1
Foschi, M.2
Han, J.3
Hahari, V.M.4
-
94
-
-
0037205048
-
The phosphoinositide 3-kinase pathway
-
Cantley, L.C. (2002) The phosphoinositide 3-kinase pathway. Science 296, 1655-1657
-
(2002)
Science
, vol.296
, pp. 1655-1657
-
-
Cantley, L.C.1
-
95
-
-
0034074486
-
Protein kinases as mediators of phosphoinositide 3-kinase signaling
-
Toker, A. (2000) Protein kinases as mediators of phosphoinositide 3-kinase signaling. Mol. Pharmacol. 57, 652-658
-
(2000)
Mol. Pharmacol.
, vol.57
, pp. 652-658
-
-
Toker, A.1
-
96
-
-
0034711307
-
Phosphatidylinositol 3-kinase function is required for transforming growth factor β-mediated epithelial to mesenchymal transition and cell migration
-
Bakin, A.V., Tomlinson, A.K., Bhowmick, N.A., Moses, H.L., and Arteaga, CL. (2000) Phosphatidylinositol 3-kinase function is required for transforming growth factor β-mediated epithelial to mesenchymal transition and cell migration. J. Biol. Chem. 275, 36803-36810
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 36803-36810
-
-
Bakin, A.V.1
Tomlinson, A.K.2
Bhowmick, N.A.3
Moses, H.L.4
Arteaga, C.L.5
-
98
-
-
0032428684
-
SARA, a FYVE domain protein that recruits Smad2 to the TGF-β receptor
-
Tezuka, T., Chiang, T.A., Davison, A.F., Attisano, L., and Wrana, J.L. (1998) SARA, a FYVE domain protein that recruits Smad2 to the TGF-β receptor. Cell 95, 779-791
-
(1998)
Cell
, vol.95
, pp. 779-791
-
-
Tezuka, T.1
Chiang, T.A.2
Davison, A.F.3
Attisano, L.4
Wrana, J.L.5
-
99
-
-
0036201871
-
The FYVE domain in Smad anchor for receptor activation (SARA) is sufficient for localization of SARA in early endosomes and regulates TGF-β/Smad signaling
-
Itoh, F., Divecha, N., Brocks, L., Oomen, L., Janssen, H., Calafat, J., Itoh, S., and ten Dijke, P. (2002) The FYVE domain in Smad anchor for receptor activation (SARA) is sufficient for localization of SARA in early endosomes and regulates TGF-β/Smad signaling. Genes Cells 7, 321-331
-
(2002)
Genes Cells
, vol.7
, pp. 321-331
-
-
Itoh, F.1
Divecha, N.2
Brocks, L.3
Oomen, L.4
Janssen, H.5
Calafat, J.6
Itoh, S.7
Ten Dijke, P.8
-
100
-
-
2542422760
-
Mammalian target of rapamycin positively regulates collagen type I production via a phosphatidylinositol 3-kinase-independent pathway
-
Shegogou, D. and Trojanowska, M. (2004) Mammalian target of rapamycin positively regulates collagen type I production via a phosphatidylinositol 3-kinase-independent pathway. J. Biol. Chem. 279, 23166-23175
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 23166-23175
-
-
Shegogou, D.1
Trojanowska, M.2
-
101
-
-
0026055366
-
Connective tissue growth factor: A cystein-rich mitogen secreted by human vascular endothelial cells is related to the SRC induced immediate early gene product CEF-10
-
Bradham, D.M., Igarashi, A., Potter, R.L., and Grotendorst, G.R. (1991) Connective tissue growth factor: a cystein-rich mitogen secreted by human vascular endothelial cells is related to the SRC induced immediate early gene product CEF-10. J. Cell Biol. 114, 1285-1294
-
(1991)
J. Cell Biol.
, vol.114
, pp. 1285-1294
-
-
Bradham, D.M.1
Igarashi, A.2
Potter, R.L.3
Grotendorst, G.R.4
-
102
-
-
0027229995
-
Regulation of connective tissue growth factor gene expression in human skin fibroblasts and during wound repair
-
Igarashi, A., Okochi, H., Bradham, D.M., and Grotendorst, G.R. (1993) Regulation of connective tissue growth factor gene expression in human skin fibroblasts and during wound repair. Mol. Biol. Cell 4, 637-645
-
(1993)
Mol. Biol. Cell
, vol.4
, pp. 637-645
-
-
Igarashi, A.1
Okochi, H.2
Bradham, D.M.3
Grotendorst, G.R.4
-
103
-
-
0031576414
-
Induction of subcutaneous tissue fibrosis in newborn mice by transforming growth factor β: Simultaneous application with basic fibroblast growth factor causes persistant fibrosis
-
Shinozaki, M., Kawara, S., Hayashi, N., Kakinuma, T., Igarashi, A., and Takehara, K. (1997) Induction of subcutaneous tissue fibrosis in newborn mice by transforming growth factor β: simultaneous application with basic fibroblast growth factor causes persistant fibrosis. Biochem. Biophys. Res. Commun. 240, 292-297
-
(1997)
Biochem. Biophys. Res. Commun.
, vol.240
, pp. 292-297
-
-
Shinozaki, M.1
Kawara, S.2
Hayashi, N.3
Kakinuma, T.4
Igarashi, A.5
Takehara, K.6
-
104
-
-
0032794692
-
Role and interaction of connective tissue growth factor with transforming growth factor β in persistant fibrosis: A mouse fibrosis model
-
Mori, T., Kawara, S., Shinozaki, M., Hayashi, N., Kakinuma, T., Igarashi, A., Takigawa, M., Nakanishi, T., and Takehara, K. (1999) Role and interaction of connective tissue growth factor with transforming growth factor β in persistant fibrosis: a mouse fibrosis model. J. Cell. Physiol. 181, 153-159
-
(1999)
J. Cell. Physiol.
, vol.181
, pp. 153-159
-
-
Mori, T.1
Kawara, S.2
Shinozaki, M.3
Hayashi, N.4
Kakinuma, T.5
Igarashi, A.6
Takigawa, M.7
Nakanishi, T.8
Takehara, K.9
-
105
-
-
0029154782
-
Significant correlation between connective tissue growth factor gene expression and skin sclerosis in tissue sections from patients with systemic sclerosis
-
Igarashi, A., Nashiro, K., Kikuchi, K., Sato, S., Ihn, H., Grotendorst, G.R., and Takehara, K. (1995) Significant correlation between connective tissue growth factor gene expression and skin sclerosis in tissue sections from patients with systemic sclerosis. J. Invest. Dermatol. 105, 280-284
-
(1995)
J. Invest. Dermatol.
, vol.105
, pp. 280-284
-
-
Igarashi, A.1
Nashiro, K.2
Kikuchi, K.3
Sato, S.4
Ihn, H.5
Grotendorst, G.R.6
Takehara, K.7
-
106
-
-
0029996247
-
Connective tissue growth factor gene expression in tissue sections from localized scleroderma, keloid, and other fibrotic skin disorders
-
Igarashi, A., Nashiro, K., Kikuchi, K., Sato, S., Ihn, H., Fujimoto, M., Grotendorst, G.R., and Takehara, K. (1996) Connective tissue growth factor gene expression in tissue sections from localized scleroderma, keloid, and other fibrotic skin disorders. J. Invest. Dermatol. 106, 723-733
-
(1996)
J. Invest. Dermatol.
, vol.106
, pp. 723-733
-
-
Igarashi, A.1
Nashiro, K.2
Kikuchi, K.3
Sato, S.4
Ihn, H.5
Fujimoto, M.6
Grotendorst, G.R.7
Takehara, K.8
-
107
-
-
0029816069
-
Stimulation of fibroblast cell growth, matrix production, and granulation tissue formation by connective tissue growth factor
-
Frazer, K., Williams, S.K.D., Klapper, H., and Grotendorst, G.R. (1996) Stimulation of fibroblast cell growth, matrix production, and granulation tissue formation by connective tissue growth factor. J. Invest. Dermatol. 107, 404-411
-
(1996)
J. Invest. Dermatol.
, vol.107
, pp. 404-411
-
-
Frazer, K.1
Williams, S.K.D.2
Klapper, H.3
Grotendorst, G.R.4
-
108
-
-
0032862910
-
Expression of connective tissue growth factor in experimental rat and human liver fibrosis
-
Paradis, V., Dargere, D., Vidaud, M., De Gouville, A.C., Huet, S., Martinez, V., Gauthier, J.M., Sobesky, R., Ratziu, V., and Bedossa, P. (1999) Expression of connective tissue growth factor in experimental rat and human liver fibrosis. Hepatology 30, 968-976
-
(1999)
Hepatology
, vol.30
, pp. 968-976
-
-
Paradis, V.1
Dargere, D.2
Vidaud, M.3
De Gouville, A.C.4
Huet, S.5
Martinez, V.6
Gauthier, J.M.7
Sobesky, R.8
Ratziu, V.9
Bedossa, P.10
-
109
-
-
0033592753
-
A preliminary study of long-term treatment with interferon γ-1b and low-dose predonisolone in patients with idiopathic pulmonary fibrosis
-
Ziesche, R., Hofbauer, E., Wittmann, K., Petkov, V., and Block, L.H. (1999) A preliminary study of long-term treatment with interferon γ-1b and low-dose predonisolone in patients with idiopathic pulmonary fibrosis. N. Engl. J. Med. 341, 1264-1269
-
(1999)
N. Engl. J. Med.
, vol.341
, pp. 1264-1269
-
-
Ziesche, R.1
Hofbauer, E.2
Wittmann, K.3
Petkov, V.4
Block, L.H.5
-
110
-
-
0033915471
-
Connective tissue growth factor in human liver cirrhosis
-
Abou-Shady, M., Freiss, H., Zimmermann, A., di Mola, F.F., Guo, X.Z., Baer, H.U., and Buchler, M.W. (2000) Connective tissue growth factor in human liver cirrhosis. Liver 20, 296-304
-
(2000)
Liver
, vol.20
, pp. 296-304
-
-
Abou-Shady, M.1
Freiss, H.2
Zimmermann, A.3
Di Mola, F.F.4
Guo, X.Z.5
Baer, H.U.6
Buchler, M.W.7
-
111
-
-
0033745462
-
CTGF expression is induced by TGF-β in cardiac myocytes: A potential role in heart fibrosis
-
Chen, M.M., Lam, A., Abraham, J.A., Schreiner, G.F., and Joly, A.H. (2000) CTGF expression is induced by TGF-β in cardiac myocytes: a potential role in heart fibrosis. J. Mol. Cell. Cardiol. 32, 1805-1819
-
(2000)
J. Mol. Cell. Cardiol.
, vol.32
, pp. 1805-1819
-
-
Chen, M.M.1
Lam, A.2
Abraham, J.A.3
Schreiner, G.F.4
Joly, A.H.5
-
112
-
-
0034953832
-
Iloprost suppresses connective tissue growth factor production in fibroblasts and in the skin of scleroderma patients
-
Stratton, R., Shiwen, X., Martini, G., Holmes, A., Leask, A., Haberberger, T., Martin, G.R., Black, C.M., and Abraham, D. (2001) Iloprost suppresses connective tissue growth factor production in fibroblasts and in the skin of scleroderma patients. J. Clin. Invest. 108, 241-250
-
(2001)
J. Clin. Invest.
, vol.108
, pp. 241-250
-
-
Stratton, R.1
Shiwen, X.2
Martini, G.3
Holmes, A.4
Leask, A.5
Haberberger, T.6
Martin, G.R.7
Black, C.M.8
Abraham, D.9
-
113
-
-
0037384658
-
Hypothesis: Pathogenesis of systemic sclerosis
-
Takehara, K. (2003) Hypothesis: pathogenesis of systemic sclerosis. J. Rheumatol. 30, 755-759
-
(2003)
J. Rheumatol.
, vol.30
, pp. 755-759
-
-
Takehara, K.1
-
114
-
-
0037333862
-
Selective stimulation of collagen synthesis in the presence of costimulatory insulin signaling by connective tissue growth factor in scleroderma fibroblasts
-
Gore-Hyer, E., Pannu, J., Smith, E.A., Grotendorst, G., and Trojanowska, M. (2003) Selective stimulation of collagen synthesis in the presence of costimulatory insulin signaling by connective tissue growth factor in scleroderma fibroblasts. Arthritis Rheum. 48, 798-806
-
(2003)
Arthritis Rheum.
, vol.48
, pp. 798-806
-
-
Gore-Hyer, E.1
Pannu, J.2
Smith, E.A.3
Grotendorst, G.4
Trojanowska, M.5
-
115
-
-
0028135622
-
Decreased collagenase expression in cultured systemic sclerosis fibroblasts
-
Takeda, K., Hatamochi, A., Ueki, H., Nakata, M., and Oishi, Y. (1994) Decreased collagenase expression in cultured systemic sclerosis fibroblasts, J. Invest. Dermatol. 103, 359-363
-
(1994)
J. Invest. Dermatol.
, vol.103
, pp. 359-363
-
-
Takeda, K.1
Hatamochi, A.2
Ueki, H.3
Nakata, M.4
Oishi, Y.5
-
116
-
-
0025045079
-
Smooth muscle differentiation in scleroderma fibroblastic cells
-
Sappino, A.P., Masouye, I., Saurai, J.H., and Gabbiani, G. (1990) Smooth muscle differentiation in scleroderma fibroblastic cells. Am. J. Pathol. 137, 585-591
-
(1990)
Am. J. Pathol.
, vol.137
, pp. 585-591
-
-
Sappino, A.P.1
Masouye, I.2
Saurai, J.H.3
Gabbiani, G.4
|