Role of p38 MAPK in transforming growth factor β stimulation of collagen production by scleroderma and healthy dermal fibroblasts

Journal of Investigative Dermatology

Volumn 118, Issue 4, 2002, Pages 704-711

  Sato, Madoka ^a   Shegogue, Daniel ^a   Gore, Elizabeth A ^a   Smith, Edwin A ^a   McDermott, Paul J ^a   Trojanowska, Maria ^a  

^a MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

Author keywords

Extracellular matrix; Fibrosis; MAPK

Indexed keywords

ADENOVIRUS VECTOR; COLLAGEN TYPE 1; COMPLEMENTARY DNA; MESSENGER RNA; SYNAPTOPHYSIN; TRANSFORMING GROWTH FACTOR BETA;

ADULT; ARTICLE; CELL STIMULATION; CELL TYPE; CLINICAL ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; FEMALE; GENE CONTROL; HUMAN; HUMAN CELL; MALE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; SKIN FIBROBLAST; SYSTEMIC SCLEROSIS;

EID: 0036226458     PISSN: 0022202X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1523-1747.2002.01719.x     Document Type: Article

References (40)

1. Role of transforming growth factor beta in human disease
2. Efficient generation of recombinant adenovirus vectors by homologous recombination in Escherichia coli
3. UV irradiation activates JNK and increases alphaI (I) collagen gene expression in rat hepatic stellate cells
4. Interaction of smad3 with a proximal smad-binding element of the human alpha2(I) procollagen gene promoter required for transcriptional activation by TGF-beta
5. Stimulation of pro-alpha(1)(I) collagen by TGF-beta(1) in mesangial cells: Role of the p38 MAPK pathway
6. Fli-1 inhibits collagen type I production in dermal fibroblasts via an Sp1-dependent pathway
7. Signal transduction by the JNK group of MAP kinases
8. Mechanisms by which bradykinin promotes fibrosis in vascular smooth muscle cells: Role of TGF-beta and MAPK
9. Signal transduction and transcription factors in rheumatic disease
10. c-Jun-dependent inhibition of cutaneous procollagen transcription following ultraviolet irradiation is reversed by all-trans retinoic acid
11. Smad-dependent stimulation of type I collagen gene expression in human skin fibroblasts by TGF-beta involves functional cooperation with p300/CBP transcriptional coactivators
12. Involvement of the p38 mitogen-activated protein kinase pathway in transforming growth factor-beta-induced gene expression
13. TGF-beta1 activates MAP kinase in human mesangial cells: A possible role in collagen expression
14. Basic fibroblast growth factor inhibits basal and transforming growth factor-beta induced collagen alpha 2(I) gene expression in scleroderma and normal fibroblasts
15. Transcriptional regulation of the human alpha2(I) collagen gene. Combined action of upstream stimulatory and inhibitory cis-acting elements
16. Blockade of endogenous transforming growth factor beta signaling prevents up-regulated collagen synthesis in scleroderma fibroblasts: Association with increased expression of transforming growth factor beta receptors
17. Persistent effect of TGF-beta 1 on extracellular matrix gene expression in human dermal fibroblasts
18. Integrin alpha2beta1 mediates isoform-specific activation of p38 and upregulation of collagen gene transcription by a mechanism involving the alpha2 cytoplasmic tail
19. Role of apoptosis and transforming growth factor beta1 in fibroblast selection and activation in systemic sclerosis
20. Heterogeneity of collagen synthesis in normal and systemic sclerosis skin fibroblasts. Increased proportion of high collagen-producing cells in systemic sclerosis fibroblasts
21. Endogenous IL-1alpha from systemic sclerosis fibroblasts induces IL-6 and PDGF-A
22. Increased expression of TGF-beta receptors by scleroderma fibroblasts: Evidence for contribution of autocrine TGF-beta signaling to scleroderma phenotype
23. Nuclear factor-kappa B mediates TNF-alpha inhibitory effect on alpha 2(I) collagen (COL1A2) gene transcription in human dermal fibroblasts
24. Collagen and collagenase gene expression in three-dimensional collagen lattices are differentially regulated by alpha 1 beta 1 and alpha 2 beta 1 integrins
25. Role of the CCAAT-binding protein CBF/NF-Y in transcription
26. The transforming growth factor-beta family
27. Controlling TGF-beta signaling
28. The p38 signal transduction pathway: Activation and function
29. Transforming growth factor-beta induces collagenase-3 expression by human gingival fibroblasts via p38 mitogen-activated protein kinase
30. Induction of collagenase-3 (MMP-13) expression in human skin fibroblasts by three-dimensional collagen is mediated by p38 mitogen- activated protein kinase
31. Activation of extracellular signal-regulated kinase 1/2 inhibits type I collagen expression by human skin fibroblasts
32. ATF-2 is a common nuclear target of Smad and TAK1 pathways in transforming growth factor-beta signaling
33. Autocrine overexpression of CTGF maintains fibrosis: RDA analysis of fibrosis genes in systemic sclerosis
34. Characterization of a GC-rich region containing Sp1 binding site(s) as a constitutive responsive element of the alpha 2(I) collagen gene in human fibroblasts
35. Pathogenesis of fibrosis: Type 1 collagen and the skin
36. Connective tissue alterations in systemic sclerosis
37. Tumor necrosis factor-alpha inhibits transforming growth factor-beta/Smad signaling in human dermal fibroblasts via AP-1 activation
38. Selective upregulation of platelet-derived growth factor alpha receptors by transforming growth factor beta in scleroderma fibroblasts
39. Synergistic cooperation between Sp1 and Smad3/Smad4 mediates transforming growth factor beta 1 stimulation of alpha 2(I)-collagen (COL1A2) transcription