IL-4 up-regulates the expression of tissue inhibitor of metalloproteinase-2 in dermal fibroblasts via the p38 mitogen-activated protein kinase-dependent pathway

Journal of Immunology

Volumn 168, Issue 4, 2002, Pages 1895-1902

  Ihn, Hironobu ^a   Yamane, Kenichi ^a   Asano, Yoshihide ^a   Kubo, Masahide ^a   Tamaki, Kunihiko ^a  

^a UNIVERSITY OF TOKYO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

COLLAGENASE; CYTOKINE; GELATINASE; INTERLEUKIN 4; MATRIX METALLOPROTEINASE; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; ONCOSTATIN M; TISSUE INHIBITOR OF METALLOPROTEINASE 2; TRANSFORMING GROWTH FACTOR BETA;

ARTICLE; CONNECTIVE TISSUE; CONTROLLED STUDY; EXTRACELLULAR MATRIX; FIBROBLAST; HUMAN; HUMAN CELL; IMMUNOBLOTTING; LUNG ALVEOLUS MACROPHAGE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION;

EID: 0037083458     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.168.4.1895     Document Type: Article

References (54)

1. Cutaneous tissue repair: Basic biological considerations
2. Transforming growth factor-β: The dark side of tissue repair
3. Mitogenic effect of fibroblast growth factor on early passage cultures of human and murine fibroblasts
4. Human epidermal growth factor: Isolation and chemical and biological properties
5. Platelet factors stimulate fibroblasts and smooth muscle cells quiescent in plasma serum to proliferate
6. Cathectin and tumor necrosis factor as two sides of the same biological coin
7. Human fibroblasts synthesize elevated levels of extracellular matrix protein in response to interleukin 4
8. Differential regulation of collagen, glycosaminoglycan, fibronectin and collagenase activity production in cultured human adult dermal fibroblasts by interleukin 1-α and β and tumor necrosis factor-α and β
9. Stimulation of collagen and glycosaminoglycan production in cultured human adult dermal fibroblasts by recombinant human interleukin 6
10. A strategy for determining the pathogenesis of systemic sclerosis
11. Immunohistologic demonstration of platelet-derived growth factor (PDGF) and sis-oncogene expression in scleroderma
12. Activation of collagen gene expression in keloids: Co-localization of type I and type VI collagen and transforming growth factor-β1 mRNA
13. Proteolytic remodeling of extracellular matrix
14. Sequence of human tissue inhibitor of metalloproteinases and its identity to erythroid-potentiating activity
15. Tissue inhibitor of metalloproteinase (TIMP-2), a new member of the metalloproteinase inhibitor family
16. Cloning of the cDNA encoding human tissue inhibitor of metalloproteinase-3 (TIMP-3) and mapping of the TIMP-3 gene to chromosome 22
17. Molecular cloning and characterization of human tissue inhibitor of metalloproteinase 4
18. Evidence for metalloproteinase and metalloproteinase inhibitor imbalance in human osteoarthritis cartilage
19. Independent regulation of collagenase, 72-kDa progelatinase, and metalloendoproteinase inhibitor expression in human dermal fibroblasts by transforming growth factor-β
20. Selective regulation of metalloproteinase inhibitor (TIMP-1) by oncostatin M in fibroblasts in culture
21. Tissue inhibitor of metalloproteinase-3 (TIMP-3) is an extracellular matrix-associated protein with a distinctive pattern of expression in mouse cells and tissues
22. 1 progression, mitogenic stimulation, differentiation, and senescence
23. Tissue inhibitor of metalloproteinases-2 (TIMP-2) mRNA expression in tumor cell lines and human tumor tissues
24. Identification of TIMP-2 in human alveolar macrophages: Regulation of biosynthesis is opposite to that of metalloproteinases and TIMP-1
25. Serum levels of tissue inhibitor of metalloproteinases 2 in patients with systemic sclerosis
26. Sp3 is a transcriptional activator of the human α2(I) collagen gene
27. Oncostatin M stimulates transcription of the human α2(I) collagen gene via the Sp1/Sp3-binding site
28. Transcriptional regulation of the human α2(I) collagen gene: Combined action of upstream stimulatory and inhibitory cis-acting elements
29. Competition analysis of the human α2(I) collagen promoter using synthetic oligonucleotides
30. Platelet-derived growth factor activates p38 mitogen-activated protein kinase through a Ras-dependent pathway that is important for actin reorganization and cell migration
31. Cardiac muscle cell hypertrophy and apoptosis induced by distinct members of the p38 mitogen-activated protein kinase family
32. Oncostatin M stimulates the growth of dermal fibroblasts via a mitogen-activated protein kinase-dependent pathway
33. Requirement for MAP kinase (ERK2) activity in interferon α- and interferon β-stimulated gene expression through STAT proteins
34. Mammalian mitogen-activated protein kinase pathways are regulated through formation of specific kinase-activator complexes
35. A synthetic inhibitor of the mitogen-activated protein kinase cascade
36. PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo
37. Platelet-derived growth factor-induced phosphatidylinositol 3-kinase activation mediates actin rearrangements in fibroblasts
38. A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002)
39. SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin-1
40. Activation of the HIV-1 long terminal repeat by cytokines and environmental stress requires an active CSBP/p38 MAP kinase
41. Identification of a T cell-derived B cell growth factor distinct from interleukin-2
42. IL-4 upregulates tenascin synthesis in scleroderma and healthy skin fibroblasts
43. Antagonistic effects of interferon-γ and interleukin-4 on fibroblast cultures
44. Role of T cells and cytokines in effecting fibrosis
45. Mast cells and their mediators in cutaneous wound healing: Active participants or innocent bystanders?
46. Involvement of the Jak-3 Janus kinase in signaling by interleukins 2 and 4 in lymphoid and myeloid cells
47. An interleukin-4-induced transcription factor: IL-4 stat
48. Interleukin-4 induces association of the c-fes proto-oncogene product with phosphatidylinositol-3 kinase
49. Analysis of signal transduction pathways regulating cytokine-mediated Fc receptor activation on human eosinophils
50. Induction of collagenase-3 (MMP-13) expression in human dermal fibroblasts by three-dimensional collagen is mediated by p38 mitogen-activated protein kinase
51. Parallel signal processing among mammalian MAPKs
52. A protein kinase involved in the regulation of inflammatory cytokine biosynthesis
53. Pro-inflammatory cytokines and environmental stress cause p38 mitogen-activated protein kinase activation by dual phosphorylation on tyrosine and threonine
54. Implication of interleukin-4 in wound healing