The hepatitis B virus encoded oncoprotein pX amplifies TGF-β family signaling through direct interaction with Smad4: Potential mechanism of hepatitis B virus-induced liver fibrosis

Genes and Development

Volumn 15, Issue 4, 2001, Pages 455-466

  Lee, Dug Keun ^a   Park, Seok Hee ^a   Yi, Youngsuk ^a   Choi, Shin Geon ^d   Lee, Cecile ^a   Parks, W Tony ^a   Cho, HyeSeong ^b   De Caestecker, Mark P ^a   Shaul, Yosef ^c   Roberts, Anita B ^a   Kim, Seong Jin ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b Ajou University School of Medicine   (South Korea)

^c WEIZMANN INSTITUTE OF SCIENCE   (Israel)

^d Kangwon National University   (South Korea)

Author keywords

Fibrosis; Hepatitis B virus pX; Signaling; Smad; TGF

Indexed keywords

COMPLEMENTARY DNA; ONCOPROTEIN; RNA; TRANSCRIPTION FACTOR; TRANSFORMING GROWTH FACTOR BETA;

ANIMAL CELL; ARTICLE; CHRONIC HEPATITIS; GENETIC TRANSCRIPTION; HEPATITIS B VIRUS; HUMAN; HUMAN CELL; LIVER CELL CARCINOMA; LIVER CIRRHOSIS; LIVER DISEASE; LIVER FIBROSIS; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; VIRUS HEPATITIS;

3T3 CELLS; ANIMALS; CELL NUCLEUS; DNA-BINDING PROTEINS; HEPATITIS B VIRUS; LIVER CIRRHOSIS; MICE; ONCOGENE PROTEINS, VIRAL; PROTEIN BINDING; SIGNAL TRANSDUCTION; SMAD4 PROTEIN; TRANS-ACTIVATION (GENETICS); TRANS-ACTIVATORS; TRANSFORMING GROWTH FACTOR BETA;

ANIMALIA; HEPATITIS B VIRUS;

EID: 0035112148     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: 10.1101/gad.856201     Document Type: Article

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