Recombinant expression and enzymatic subsite characterization of plasmepsin 4 from the four Plasmodium species infecting man

Molecular and Biochemical Parasitology

Volumn 135, Issue 1, 2004, Pages 101-109

  Li, Tang ^a,b   Yowell, Charles A ^a   Beyer, Bret B ^a,c   Hung, Su Hwi ^a,d   Westling, Jennifer ^a,e   Lam, Minh T ^a   Dunn, Ben M ^a   Dame, John B ^a  

^a UNIVERSITY OF FLORIDA   (United States)

^b FOUNDATION FOR APPLIED MOLECULAR EVOLUTION   (United States)

^c ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

^d TEMPLE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e UNIVERSITY OF SOUTH FLORIDA   (United States)

Author keywords

Aspartic proteinase; Enzyme active site; Inhibitor; Malaria; Plasmepsin 4

Indexed keywords

CATHEPSIN D; CATHEPSIN E; PEPTIDASE; PEPTIDE FRAGMENT; PLASMEPSIN IV; PROTEIN INHIBITOR; PROTOZOAL PROTEIN; RECOMBINANT ENZYME; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ARTICLE; COMPUTER MODEL; CONTROLLED STUDY; ENZYME ACTIVE SITE; ENZYME KINETICS; ENZYME SPECIFICITY; ENZYME STRUCTURE; ENZYME SUBSTRATE; HUMAN; HYDROPHILICITY; HYDROPHOBICITY; MALARIA; MOLECULAR INTERACTION; NONHUMAN; ORTHOLOGY; PLASMODIUM FALCIPARUM; PLASMODIUM MALARIAE; PLASMODIUM OVALE; PLASMODIUM VIVAX; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FAMILY;

ANIMALS; ASPARTIC ENDOPEPTIDASES; BINDING SITES; CATHEPSIN D; CATHEPSIN E; CHROMOGENIC COMPOUNDS; COMPUTER SIMULATION; ENZYME ACTIVATION; ENZYME INHIBITORS; HYDROGEN-ION CONCENTRATION; KINETICS; MODELS, MOLECULAR; PLASMODIUM FALCIPARUM; PLASMODIUM MALARIAE; PLASMODIUM OVALE; PLASMODIUM VIVAX; PROTEIN FOLDING; PROTOZOAN PROTEINS; RECOMBINANT PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY;

PLASMODIUM FALCIPARUM; PLASMODIUM MALARIAE; PLASMODIUM OVALE; PLASMODIUM VIVAX;

EID: 1842662675     PISSN: 01666851     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molbiopara.2004.01.010     Document Type: Article

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