Substitution of conserved residues within the active site alters the cleavage religation equilibrium of DNA topoisomerase I

Journal of Biological Chemistry

Volumn 279, Issue 52, 2004, Pages 54069-54078

  Colley, William C ^a   Van Der Merwe, Marie ^a   Vance, John R ^a,c   Burgin Jr , Alex B ^b   Bjornsti, Mary Ann ^a  

^a ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

^b DeCODE Chemistry & Biostructures   (United States)

^c Plantaceutica Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CATALYSIS; CELLS; DNA; MUTAGENESIS; REACTION KINETICS; YEAST;

CELLULAR TARGET OF CAMPTOTHECIN (CPT); CLEAVAGE; ISOGENIC STRAINS; TYROSINE;

ENZYMES;

CAMPTOTHECIN; DNA TOPOISOMERASE; PROTEIN RAD9; UBIQUITIN;

ARTICLE; CELL DEATH; COVALENT BOND; CYTOTOXICITY; DNA BINDING; DNA CLEAVAGE; DNA REPLICATION; DNA SUPERCOILING; ENZYME ACTIVE SITE; ENZYME DEGRADATION; ENZYME MECHANISM; GENE MUTATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DNA INTERACTION; PROTEIN EXPRESSION; PROTEIN TARGETING;

ASPARAGINE; BINDING SITES; CAMPTOTHECIN; CONSERVED SEQUENCE; DNA; DNA TOPOISOMERASES, TYPE I; DNA, SUPERHELICAL; ENZYME INHIBITORS; HISTIDINE; MUTAGENESIS; PHENYLALANINE; SACCHAROMYCES CEREVISIAE; STRUCTURE-ACTIVITY RELATIONSHIP; TYROSINE;

EUKARYOTA;

EID: 11144227628     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M409764200     Document Type: Article

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