Locking the DNA topoisomerase I protein clamp inhibits DNA rotation and induces cell lethality

Proceedings of the National Academy of Sciences of the United States of America

Volumn 100, Issue SUPPL. 2, 2003, Pages 13767-13772

  Woo, Michael H ^a,c   Losasso, Carmen ^b   Guo, Hong ^a   Pattarello, Luca ^b   Benedetti, Piero ^b   Bjornsti, Mary Ann ^a  

^a ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

^b UNIVERSITY OF PADOVA   (Italy)

^c BRISTOL MYERS SQUIBB   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2,3 BIS(3,5 DIOXO 1 PIPERAZINYL)BUTANE; CYTOTOXIC AGENT; DNA TOPOISOMERASE; GLUTAMIC ACID; GLYCINE; LYSINE; PHOSPHOTYROSINE; PROTEIN TOP1; SERINE; SINGLE STRANDED DNA; TYROSINE; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; CELL DEATH; CONTROLLED STUDY; COVALENT BOND; CYTOTOXICITY; DISULFIDE BOND; DNA PROTEIN COMPLEX; ENZYME ACTIVITY; IN VITRO STUDY; MOLECULAR MODEL; NONHUMAN; OXIDATION REDUCTION POTENTIAL; PRIORITY JOURNAL; SACCHAROMYCES CEREVISIAE;

CAMPTOTHECIN; CATALYTIC DOMAIN; DISULFIDES; DNA TOPOISOMERASES, TYPE I; DNA, FUNGAL; MACROMOLECULAR SUBSTANCES; MODELS, MOLECULAR; MUTATION; NUCLEIC ACID CONFORMATION; PROTEIN CONFORMATION; ROTATION; SACCHAROMYCES CEREVISIAE;

ERETMOCHELYS IMBRICATA; EUKARYOTA; SACCHAROMYCES; SACCHAROMYCES CEREVISIAE;

EID: 0344702740     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.2235886100     Document Type: Article

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