Substitutions of Asn-726 in the active site of yeast DNA topoisomerase I define novel mechanisms of stabilizing the covalent enzyme-DNA intermediate

Journal of Biological Chemistry

Volumn 275, Issue 20, 2000, Pages 15246-15253

  Fertala, Jolanta ^a   Vance, John R ^a,b   Pourquier, Philippe ^c   Pommier, Yves ^c   Bjornsti, Mary Ann ^a,b  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

^b ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

^c NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ASPARAGINE; CAMPTOTHECIN; DNA TOPOISOMERASE; GALACTOSE; GLUCOSE; TYROSINE;

AMINO ACID SUBSTITUTION; ANTINEOPLASTIC ACTIVITY; ARTICLE; DNA BINDING; DRUG MECHANISM; ENZYME ACTIVE SITE; ENZYME BINDING; ENZYME MECHANISM; ENZYME STABILITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN DNA INTERACTION; YEAST;

AMINO ACID SUBSTITUTION; ASPARAGINE; BASE SEQUENCE; BINDING SITES; CAMPTOTHECIN; DNA TOPOISOMERASES, TYPE I; ENZYME STABILITY; MUTAGENESIS, SITE-DIRECTED; NUCLEIC ACID CONFORMATION; PLASMIDS; SACCHAROMYCES CEREVISIAE; SUBSTRATE SPECIFICITY;

EUKARYOTA;

EID: 0034685879     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.275.20.15246     Document Type: Article

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