-
1
-
-
0023701349
-
Morphine-6-glucuronide: Analgesic effects and receptor binding profile in rats
-
F.V. Abbott, and R.M. Palmour Morphine-6-glucuronide: analgesic effects and receptor binding profile in rats Life Sci. 43 1988 1685 1695
-
(1988)
Life Sci.
, vol.43
, pp. 1685-1695
-
-
Abbott, F.V.1
Palmour, R.M.2
-
3
-
-
0030425327
-
Poor permeability of morphine 3-glucuronide and morphine 6-glucuronide through the blood-brain barrier in the rat
-
U. Bickel, O.P. Schumacher, Y.S. Kang, and K. Voigt Poor permeability of morphine 3-glucuronide and morphine 6-glucuronide through the blood-brain barrier in the rat J. Pharmacol. Exp. Ther. 278 1996 107 113
-
(1996)
J. Pharmacol. Exp. Ther.
, vol.278
, pp. 107-113
-
-
Bickel, U.1
Schumacher, O.P.2
Kang, Y.S.3
Voigt, K.4
-
4
-
-
0141432124
-
Evidence for an active transport of morphine-6-beta-d-glucuronide but not P-glycoprotein-mediated at the blood-brain barrier
-
F. Bourasset, S. Cisternino, J. Temsamani, and J.M. Scherrmann Evidence for an active transport of morphine-6-beta-d-glucuronide but not P-glycoprotein-mediated at the blood-brain barrier J. Neurochem. 86 2003 1564 1567
-
(2003)
J. Neurochem.
, vol.86
, pp. 1564-1567
-
-
Bourasset, F.1
Cisternino, S.2
Temsamani, J.3
Scherrmann, J.M.4
-
5
-
-
0034293553
-
Pharmacokinetic-pharmacodynamic modelling of morphine transport across the blood-brain barrier as a cause of the antinociceptive effect delay in rats - A microdialysis study
-
M.R. Bouw, M. Gårdmark, and M. Hammarlund-Udenaes Pharmacokinetic-pharmacodynamic modelling of morphine transport across the blood-brain barrier as a cause of the antinociceptive effect delay in rats - a microdialysis study Pharm. Res. 17 2000 1220 1227
-
(2000)
Pharm. Res.
, vol.17
, pp. 1220-1227
-
-
Bouw, M.R.1
Gårdmark, M.2
Hammarlund-Udenaes, M.3
-
6
-
-
0031786058
-
Methodological aspects of the use of a calibrator in in vivo microdialysis - Further development of the retrodialysis method
-
M.R. Bouw, and M. Hammarlund-Udenaes Methodological aspects of the use of a calibrator in in vivo microdialysis - further development of the retrodialysis method Pharm. Res. 15 1998 1673 1679
-
(1998)
Pharm. Res.
, vol.15
, pp. 1673-1679
-
-
Bouw, M.R.1
Hammarlund-Udenaes, M.2
-
7
-
-
0035679267
-
Blood-brain barrier transport and brain distribution of morphine-6-glucuronide in relation to the antinociceptive effect in rats - Pharmacokinetic/pharmacodynamic modelling
-
M.R. Bouw, R. Xie, K. Tunblad, and M. Hammarlund-Udenaes Blood-brain barrier transport and brain distribution of morphine-6-glucuronide in relation to the antinociceptive effect in rats - pharmacokinetic/pharmacodynamic modelling Br. J. Pharmacol. 134 2001 1796 1804
-
(2001)
Br. J. Pharmacol.
, vol.134
, pp. 1796-1804
-
-
Bouw, M.R.1
Xie, R.2
Tunblad, K.3
Hammarlund-Udenaes, M.4
-
8
-
-
0025051997
-
Steady-state theory for quantitative microdialysis of solutes and water in vivo and in vitro
-
P.M. Bungay, P.F. Morrison, and R.L. Dedrick Steady-state theory for quantitative microdialysis of solutes and water in vivo and in vitro Life Sci. 46 1990 105 119
-
(1990)
Life Sci.
, vol.46
, pp. 105-119
-
-
Bungay, P.M.1
Morrison, P.F.2
Dedrick, R.L.3
-
9
-
-
0032793959
-
OATP and P-glycoprotein transporters mediate the cellular uptake and excretion of fexofenadine
-
M. Cvetkovic, B. Leake, M.F. Fromm, G.R. Wilkinson, and R.B. Kim OATP and P-glycoprotein transporters mediate the cellular uptake and excretion of fexofenadine Drug Metab. Dispos. 27 1999 866 871
-
(1999)
Drug Metab. Dispos.
, vol.27
, pp. 866-871
-
-
Cvetkovic, M.1
Leake, B.2
Fromm, M.F.3
Wilkinson, G.R.4
Kim, R.B.5
-
10
-
-
0031757312
-
BBB transport and P-glycoprotein functionality using MDR1A (-/-) and wild-type mice: Total brain versus microdialysis concentration profiles of rhodamine-123
-
E.C. de Lange, G. de Bock, A.H. Schinkel, A.G. de Boer, and D.D. Breimer BBB transport and P-glycoprotein functionality using MDR1A (-/-) and wild-type mice Total brain versus microdialysis concentration profiles of rhodamine-123 Pharm. Res. 15 1998 1657 1665
-
(1998)
Pharm. Res.
, vol.15
, pp. 1657-1665
-
-
De Lange, E.C.1
De Bock, G.2
Schinkel, A.H.3
De Boer, A.G.4
Breimer, D.D.5
-
11
-
-
0030918044
-
Effect of the P-glycoprotein inhibitor, SDZ PSC 833, on the blood and brain pharmacokinetics of colchicine
-
S. Desrayaud, P. Guntz, J.M. Scherrmann, and M. Lemaire Effect of the P-glycoprotein inhibitor, SDZ PSC 833, on the blood and brain pharmacokinetics of colchicine Life Sci. 61 1997 153 163
-
(1997)
Life Sci.
, vol.61
, pp. 153-163
-
-
Desrayaud, S.1
Guntz, P.2
Scherrmann, J.M.3
Lemaire, M.4
-
12
-
-
0026724017
-
Further evidence that morphine-6 beta-glucuronide is a more potent opioid agonist than morphine
-
B. Frances, R. Gout, B. Monsarrat, J. Cros, and J.M. Zajac Further evidence that morphine-6 beta-glucuronide is a more potent opioid agonist than morphine J. Pharmacol. Exp. Ther. 262 1992 25 31
-
(1992)
J. Pharmacol. Exp. Ther.
, vol.262
, pp. 25-31
-
-
Frances, B.1
Gout, R.2
Monsarrat, B.3
Cros, J.4
Zajac, J.M.5
-
13
-
-
0345310067
-
Delayed antinociceptive effect following morphine-6-glucuronide administration in the rat - Pharmacokinetic/pharmacodynamic modelling
-
M. Gårdmark, and M. Hammarlund-Udenaes Delayed antinociceptive effect following morphine-6-glucuronide administration in the rat - pharmacokinetic/pharmacodynamic modelling Pain 74 1998 287 296
-
(1998)
Pain
, vol.74
, pp. 287-296
-
-
Gårdmark, M.1
Hammarlund-Udenaes, M.2
-
14
-
-
0030898087
-
Drug equilibration across the blood-brain barrier - Pharmacokinetic considerations based on the microdialysis method
-
M. Hammarlund-Udenaes, L.K. Paalzow, and E.C. de Lange Drug equilibration across the blood-brain barrier - pharmacokinetic considerations based on the microdialysis method Pharm. Res. 14 1997 128 134
-
(1997)
Pharm. Res.
, vol.14
, pp. 128-134
-
-
Hammarlund-Udenaes, M.1
Paalzow, L.K.2
De Lange, E.C.3
-
15
-
-
0029786352
-
Evidence for P-glycoprotein-modulated penetration of morphine-6- glucuronide into brain capillary endothelium
-
J. Huwyler, J. Drewe, C. Klusemann, and G. Fricker Evidence for P-glycoprotein-modulated penetration of morphine-6-glucuronide into brain capillary endothelium Br. J. Pharmacol. 118 1996 1879 1885
-
(1996)
Br. J. Pharmacol.
, vol.118
, pp. 1879-1885
-
-
Huwyler, J.1
Drewe, J.2
Klusemann, C.3
Fricker, G.4
-
16
-
-
0023786649
-
An improved method for the simultaneous determination of morphine and its principal glucuronide metabolites
-
S.P. Joel, R.J. Osborne, and M.L. Slevin An improved method for the simultaneous determination of morphine and its principal glucuronide metabolites J. Chromatogr. 430 1988 394 399
-
(1988)
J. Chromatogr.
, vol.430
, pp. 394-399
-
-
Joel, S.P.1
Osborne, R.J.2
Slevin, M.L.3
-
17
-
-
0002322365
-
Xpose - An S-PLUS based population pharmacokinetic/pharmacodynamic model building aid for NONMEM
-
E.N. Jonsson, and M.O. Karlsson Xpose - an S-PLUS based population pharmacokinetic/pharmacodynamic model building aid for NONMEM Comput. Methods Progr. Biomed. 58 1999 51 64
-
(1999)
Comput. Methods Progr. Biomed.
, vol.58
, pp. 51-64
-
-
Jonsson, E.N.1
Karlsson, M.O.2
-
18
-
-
0035993509
-
Regional response of cerebral blood volume to graded hypoxic hypoxia in rat brain
-
C. Julien-Dolbec, I. Tropres, O. Montigon, H. Reutenauer, A. Ziegler, M. Decorps, and J.F. Payen Regional response of cerebral blood volume to graded hypoxic hypoxia in rat brain Br. J. Anaesth. 89 2002 287 293
-
(2002)
Br. J. Anaesth.
, vol.89
, pp. 287-293
-
-
Julien-Dolbec, C.1
Tropres, I.2
Montigon, O.3
Reutenauer, H.4
Ziegler, A.5
Decorps, M.6
Payen, J.F.7
-
19
-
-
0033060742
-
Effects of a potent and specific P-glycoprotein inhibitor on the blood-brain barrier distribution and antinociceptive effect of morphine in the rat
-
S.P. Letrent, G.M. Pollack, K.R. Brouwer, and K.L. Brouwer Effects of a potent and specific P-glycoprotein inhibitor on the blood-brain barrier distribution and antinociceptive effect of morphine in the rat Drug Metab. Dispos. 27 1999 827 834
-
(1999)
Drug Metab. Dispos.
, vol.27
, pp. 827-834
-
-
Letrent, S.P.1
Pollack, G.M.2
Brouwer, K.R.3
Brouwer, K.L.4
-
20
-
-
0036799701
-
Increased CNS uptake and enhanced antinociception of morphine-6- glucuronide in rats after inhibition of P-glycoprotein
-
J. Lötsch, R. Schmidt, G. Vetter, H. Schmidt, E. Niederberger, G. Geisslinger, and I. Tegeder Increased CNS uptake and enhanced antinociception of morphine-6-glucuronide in rats after inhibition of P-glycoprotein J. Neurochem. 83 2002 241 248
-
(2002)
J. Neurochem.
, vol.83
, pp. 241-248
-
-
Lötsch, J.1
Schmidt, R.2
Vetter, G.3
Schmidt, H.4
Niederberger, E.5
Geisslinger, G.6
Tegeder, I.7
-
21
-
-
0037199658
-
The influence of inhibition of probenecid sensitive transporters on the central nervous system (CNS) uptake and the antinociceptive activity of morphine-6-glucuronide in rats
-
J. Lötsch, R. Schmidt, G. Vetter, H. Schmidt, C. Skarke, E. Niederberger, G. Geisslinger, and I. Tegeder The influence of inhibition of probenecid sensitive transporters on the central nervous system (CNS) uptake and the antinociceptive activity of morphine-6-glucuronide in rats Neurosci. Lett. 329 2002 145 148
-
(2002)
Neurosci. Lett.
, vol.329
, pp. 145-148
-
-
Lötsch, J.1
Schmidt, R.2
Vetter, G.3
Schmidt, H.4
Skarke, C.5
Niederberger, E.6
Geisslinger, G.7
Tegeder, I.8
-
22
-
-
0037081556
-
A co-culture-based model of human blood-brain barrier: Application to active transport of indinavir and in vivo-in vitro correlation
-
I. Megard, A. Garrigues, S. Orlowski, S. Jorajuria, P. Clayette, E. Ezan, and A. Mabondzo A co-culture-based model of human blood-brain barrier: application to active transport of indinavir and in vivo-in vitro correlation. Brain Res. 15 2002 153 167
-
(2002)
Brain Res.
, vol.15
, pp. 153-167
-
-
Megard, I.1
Garrigues, A.2
Orlowski, S.3
Jorajuria, S.4
Clayette, P.5
Ezan, E.6
Mabondzo, A.7
-
23
-
-
0024369341
-
Pharmacological characterization of morphine-6 beta-glucuronide, a very potent morphine metabolite
-
D. Paul, K.M. Standifer, C.E. Inturrisi, and G.W. Pasternak Pharmacological characterization of morphine-6 beta-glucuronide, a very potent morphine metabolite J. Pharmacol. Exp. Ther. 251 1989 477 483
-
(1989)
J. Pharmacol. Exp. Ther.
, vol.251
, pp. 477-483
-
-
Paul, D.1
Standifer, K.M.2
Inturrisi, C.E.3
Pasternak, G.W.4
-
24
-
-
0035167174
-
In vivo evidence for P-glycoprotein-mediated transport of phenytoin at the blood-brain barrier of rats
-
H. Potschka, and W. Loscher In vivo evidence for P-glycoprotein-mediated transport of phenytoin at the blood-brain barrier of rats Epilepsia 42 2001 1231 1240
-
(2001)
Epilepsia
, vol.42
, pp. 1231-1240
-
-
Potschka, H.1
Loscher, W.2
-
25
-
-
0018903891
-
Bulk flow of brain interstitial fluid under normal and hyperosmolar conditions
-
G.A. Rosenberg, W.T. Kyner, and E. Estrada Bulk flow of brain interstitial fluid under normal and hyperosmolar conditions Am. J. Physiol. 238 1980 42 49
-
(1980)
Am. J. Physiol.
, vol.238
, pp. 42-49
-
-
Rosenberg, G.A.1
Kyner, W.T.2
Estrada, E.3
-
26
-
-
0028229150
-
Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs
-
A.H. Schinkel, J.J. Smit, O. van Tellingen, J.H. Beijnen, E. Wagenaar, L. van Deemter, and C.A. Mol Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs Cell 77 1994 491 502
-
(1994)
Cell
, vol.77
, pp. 491-502
-
-
Schinkel, A.H.1
Smit, J.J.2
Van Tellingen, O.3
Beijnen, J.H.4
Wagenaar, E.5
Van Deemter, L.6
Mol, C.A.7
-
28
-
-
0031830331
-
A preliminary study on the distribution of morphine and its glucuronides in the subcompartments of blood
-
G. Skopp, L. Potsch, B. Ganssmann, R. Aderjan, and R. Mattern A preliminary study on the distribution of morphine and its glucuronides in the subcompartments of blood J. Anal. Toxicol. 22 1998 261 264
-
(1998)
J. Anal. Toxicol.
, vol.22
, pp. 261-264
-
-
Skopp, G.1
Potsch, L.2
Ganssmann, B.3
Aderjan, R.4
Mattern, R.5
-
29
-
-
0034978374
-
Characterization of the efflux transport of 17beta-estradiol-d-17beta- glucuronide from the brain across the blood-brain barrier
-
D. Sugiyama, H. Kusuhara, Y. Shitara, T. Abe, P.J. Meier, T. Sekine, H. Endou, H. Suzuki, and Y. Sugiyama Characterization of the efflux transport of 17beta-estradiol-d-17beta-glucuronide from the brain across the blood-brain barrier J. Pharmacol. Exp. Ther. 298 2001 316 322
-
(2001)
J. Pharmacol. Exp. Ther.
, vol.298
, pp. 316-322
-
-
Sugiyama, D.1
Kusuhara, H.2
Shitara, Y.3
Abe, T.4
Meier, P.J.5
Sekine, T.6
Endou, H.7
Suzuki, H.8
Sugiyama, Y.9
-
31
-
-
0037392850
-
Morphine blood-brain barrier transport is influenced by probenecid co-administration
-
K. Tunblad, E.N. Jonsson, and M. Hammarlund-Udenaes Morphine blood-brain barrier transport is influenced by probenecid co-administration Pharm. Res. 20 2003 618 623
-
(2003)
Pharm. Res.
, vol.20
, pp. 618-623
-
-
Tunblad, K.1
Jonsson, E.N.2
Hammarlund-Udenaes, M.3
-
32
-
-
11144243288
-
An integrated model for the analysis of pharmacokinetic data from microdialysis experiments
-
K. Tunblad, M. Hammarlund-Udenaes, and E.N. Jonsson An integrated model for the analysis of pharmacokinetic data from microdialysis experiments Pharm. Res. 21 2004 1698 1707
-
(2004)
Pharm. Res.
, vol.21
, pp. 1698-1707
-
-
Tunblad, K.1
Hammarlund-Udenaes, M.2
Jonsson, E.N.3
-
33
-
-
0027769788
-
Distributional transport kinetics of zidovudine between plasma and brain extracellular fluid/cerebrospinal fluid in the rabbit: Investigation of the inhibitory effect of probenecid utilizing microdialysis
-
S.L. Wong, K. van Belle, and R.J. Sawchuk Distributional transport kinetics of zidovudine between plasma and brain extracellular fluid/cerebrospinal fluid in the rabbit: investigation of the inhibitory effect of probenecid utilizing microdialysis J. Pharmacol. Exp. Ther. 264 1993 899 909
-
(1993)
J. Pharmacol. Exp. Ther.
, vol.264
, pp. 899-909
-
-
Wong, S.L.1
Van Belle, K.2
Sawchuk, R.J.3
|