Evidence for P-glycoprotein-modulated penetration of morphine-6-glucuronide into brain capillary endothelium

British Journal of Pharmacology

Volumn 118, Issue 8, 1996, Pages 1879-1885

  Huwyler, Jörg ^a   Drewe, Jürgen ^a   Klusemann, Caterina ^a   Fricker, Gert ^b  

^a UNIVERSITY HOSPITAL BASEL   (Switzerland)

^b Inst Pharmazeut Technol B   (Germany)

Author keywords

Blood brain barrier; Brain; Endothelial cells; Morphine; Morphine 6 gluc uronide; Morphine glucuronides; Transport

Indexed keywords

ALKALINE PHOSPHATASE; BLOOD CLOTTING FACTOR 8; DIPEPTIDYL CARBOXYPEPTIDASE; GLYCOPROTEIN P; MORPHINE 6 GLUCURONIDE; SUCROSE; VERAPAMIL; VIMENTIN; VINCRISTINE;

ANALGESIA; ANIMAL CELL; ARTICLE; BLOOD BRAIN BARRIER; BRAIN CAPILLARY; CAPILLARY ENDOTHELIUM; CELL CULTURE; CONTROLLED STUDY; DRUG PENETRATION; DRUG TRANSPORT; ENZYME ACTIVITY; GENE EXPRESSION; IMMUNOHISTOCHEMISTRY; MOUSE; MULTIDRUG RESISTANCE; NONHUMAN; PRIORITY JOURNAL; SWINE;

EID: 0029786352     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1476-5381.1996.tb15619.x     Document Type: Article

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