High-level expression of the Smad ubiquitin ligase Smurf2 correlates with poor prognosis in patients with esophageal squamous cell carcinoma

Cancer Research

Volumn 62, Issue 24, 2002, Pages 7162-7165

  Fukuchi, Minoru ^a   Fukai, Yasuyuki ^a   Masuda, Norihiro ^a   Miyazaki, Tatsuya ^a   Nakajima, Masanobu ^a   Sohda, Makoto ^a   Manda, Ryokuhei ^a   Tsukada, Katsuhiko ^a   Kato, Hiroyuki ^a   Kuwano, Hiroyuki ^a  

^a GUNMA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN SMURF2; SMAD PROTEIN; SMAD UBIQUITINATION REGULATORY FACTOR 2; TRANSFORMING GROWTH FACTOR BETA; UBIQUITIN; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; CANCER INVASION; CANCER STAGING; CANCER SURVIVAL; CONTROLLED STUDY; CORRELATION ANALYSIS; DIAGNOSTIC VALUE; ESOPHAGUS CARCINOMA; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROGNOSIS; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; SQUAMOUS CELL CARCINOMA; TUMOR GROWTH; WESTERN BLOTTING;

ACTIVIN RECEPTORS, TYPE I; ADULT; AGED; CARCINOMA, SQUAMOUS CELL; DNA-BINDING PROTEINS; ESOPHAGEAL NEOPLASMS; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; LIGASES; MALE; MIDDLE AGED; NEOPLASM STAGING; PHOSPHORYLATION; PROGNOSIS; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA; SMAD2 PROTEIN; SMAD7 PROTEIN; TRANS-ACTIVATORS; TUMOR CELLS, CULTURED; UBIQUITIN-PROTEIN LIGASES;

EID: 0037115624     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (20)

1. Massagué, J. TGF-β signal transduction. Annu. Rev. Biochem., 67: 753-791, 1998.
2. Heldin, C. H., Miyazono, K., and ten Dijke, P. TGF-β signaling from cell membrane to nucleus through SMAD proteins. Nature (Lond.), 390: 465-471, 1997.
3. Miyazono, K. Positive and negative regulation of TGF-β signaling. J. Cell Sci., 113: 1101-1109, 2000.
4. White, R. L. Tumor suppressing pathways. Cell. 92: 591-592, 1998.
5. Markowitz, S. D., and Roberts, A. B. Tumor suppressor activity of the TGF-β pathway in human cancers. Cytokine Growth Factor Rev., 7: 93-102, 1996.
6. Riggns, G. J., Kinzler, K. W., Vogelstein, B., and Thiagalingam, S. Frequency of Smad gene mutations in human cancers. Cancer Res., 57: 2578-2580, 1997.
7. Prunier, C., Ferrand, N., Frottier, B., Pessah, M., and Atfi, A. Mechanism for mutational inactivation of the tumor suppressor Smad2. Mol. Cell. Biol., 21: 3302-3313, 2001.
8. 1nkB transcription in response to TGF-β. EMBO J., 19: 5178-5193, 2000.
9. Osawa. H., Shitara, Y., Shoji, H., Mogi, A., Kuwano, H., Hagiwara, K., and Takenoshita, S. Mutation analysis of transforming growth factor β type II receptor, Smad2, Smad3 and Smad4 in esophageal squamous cell carcinoma. Int. J. Oncol., 17: 723-728, 2000.
10. Hershko, A., and Ciechanover, A. The ubiquitin system. Annu. Rev. Biochem., 67: 425-479, 1998.
11. Laney, J. D., and Hochstrasser, M. Substrate targeting in the ubiquitin system. Cell, 97: 427-430, 1999.
12. Zhu, H., Kavsak, P., Abdollah, S., and Wrana, J. L. A SMAD ubiquitin ligase targets the BMP pathway and affects embryonic pattern formation. Nature (Lond.), 400: 687-693, 1999.
13. Lin, X., Liang, M., and Feng, X. H. Smurf2 is a ubiquitin E3 ligase mediating proteasome-dependent degradation of Smad2 in TGF-β signaling. J. Biol. Chem., 275: 36818-36822, 2000.
14. Zhang, Y., Chang, C., Gehling, D. J., Hemmati-Brivanlou, A., and Derynck, R. Regulation of Smad degradation and activity by Smurf2, an E3 ubiquitin ligase. Proc. Natl. Acad. Sci. USA, 98: 974-979, 2001.
15. Kavsak, P., Rasmussen, R. K., Causing, C. G., Bonni, S., Zhu, H., Thomsen, G. H., and Wrana, J. L. Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGF-β receptor for degradation. Mol. Cell, 6: 1365-1375, 2000.
16. Fukuchi. M., Masuda, N., Miyazaki, T., Nakajima, M., Osawa, H., Kato, H., and Kuwano, H. Decreased Smad4 expression in the transforming growth factor-β signaling pathway during progression of esophageal squamous cell carcinoma. Cancer (Phila.), 95: 737-743, 2002.
17. Nishihira, T., Hashimoto, Y., Katayama, M., Mori, S., and Kuroki, T. Molecular and cellular features of esophageal cancer cells. J. Cancer Res. Clin. Oncol., 119: 441-449, 1993.
18. Muro-Cacho, C. A., Rosario-Ortiz, K., Livingston, S., and Munoz-Antonia, T. Defective transforming growth factor-β signaling pathway in head and neck squamous cell carcinoma as evidenced by the lack of expression of activated Smad2. Clin. Cancer Res., 7: 1618-1626, 2001.
19. Kuwano, H., Saeki, H., Kawaguchi, H., Sonoda, K., Kitamura, K., Nakashima, H., Toh, Y., and Sugimachi, K. Proliferative activity of cancer cells in front and center areas of carcinoma in situ and invasive sites of esophageal squamous-cell carcinoma. Int. J. Cancer, 78: 149-152, 1998.
20. Lo, R. S., and Massagué, J. Ubiquitin-dependent degradation of TGF-β activated Smad2. Nat. Cell Biol., 1: 472-478, 1999.