Dynamics of NMDAR-mediated neurotoxicity during chronic ethanol exposure and withdrawal

Neuropharmacology

Volumn 39, Issue 2, 2000, Pages 218-226

  Thomas, Mark P ^a   Morrisett, Richard A ^a  

^a UNIVERSITY OF TEXAS AT AUSTIN   (United States)

Author keywords

Alcohol; Excitotoxicity; Glutamate; Organotypic; Propidium iodide

Indexed keywords

ALCOHOL; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; PROPIDIUM IODIDE;

ALCOHOL WITHDRAWAL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ELECTROPHYSIOLOGY; FEMALE; HIPPOCAMPUS; LONG TERM EXPOSURE; MALE; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR INTRINSIC ACTIVITY; SEIZURE;

ALCOHOLISM; ANIMALS; BIOLOGICAL TRANSPORT; DRUG INTERACTIONS; ETHANOL; FEMALE; INTERCALATING AGENTS; MALE; N-METHYLASPARTATE; NEUROTOXICITY SYNDROMES; PROPIDIUM; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, N-METHYL-D-ASPARTATE; SUBSTANCE WITHDRAWAL SYNDROME;

EID: 0033986985     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0028-3908(99)00107-0     Document Type: Article

References (34)

1. Ahern K.B., Lustig H.S., Greenberg D.A. Enhancement of NMDA toxicity and calcium responses by chronic exposure of cultured cortical neurons to ethanol. Neuroscience Letters. 165:1994;211-214.
2. Bahr B.A. Long-term hippocampal slices: a model system for investigating synaptic mechanisms and pathologic processes. Journal of Neuroscience Research. 42:1995;294-305.
3. Bruce A.J., Sakhi S., Schreiber S.S., Baudry M. Development of kainic acid and N-methyl-D-aspartic acid toxicity in organotypic hippocampal cultures. Experimental Neurology. 132:1995;209-219.
4. Chandler L.J., Newsom H., Sumners C., Crews F. Chronic ethanol exposure potentiates NMDA excitotoxicity in cerebral cortical neurons. Journal of Neurochemistry. 60:1993;1578-1581.
5. Chandler L.J., Sumners C., Crews F.T. Ethanol inhibits NMDA receptor-mediated excitotoxicity in rat primary neuronal cultures. Alcoholism, Clinical and Experimental Research. 17:1993;54-60.
6. Charness M.E. Brain lesions in alcoholics. Alcoholism, Clinical and Experimental Research. 17:1993;2-11.
7. Choi D.W. Glutamate neurotoxicity and diseases of the nervous system. Neuron. 1:1988;623-634.
8. Choi D.W. Excitotoxic cell death. Journal of Neurobiology. 23:1992;1261-1276.
9. Davidson M., Shanley B., Wilce P. Increased NMDA-induced excitability during ethanol withdrawal: a behavioural and histological study. Brain Research. 674:1995;91-96.
10. Grant K.A., Valverius P., Hudspith M., Tabakoff B. Ethanol withdrawal seizures and the NMDA receptor complex. European Journal of Pharmacology. 176:1990;289-296.
11. Hoffman P.L. Glutamate receptors in alcohol withdrawal-induced neurotoxicity. Metabolic Brain Disease. 10:1995;73-79.
12. Hoffman P.L., Rabe C.S., Moses F., Tabakoff B. N-methyl-D-aspartate receptors and ethanol: inhibition of calcium flux and cyclic GMP production. Journal of Neurochemistry. 52:1989;1937-1940.
13. Iorio K.R., Reinlib L., Tabakoff B., Hoffman P.L. Chronic exposure of cerebellar granule cells to ethanol results in increased N-methyl-D-aspartate receptor function. Molecular Pharmacology. 41:1992;1142-1148.
14. Iorio K.R., Tabakoff B., Hoffman P.L. Glutamate-induced neurotoxicity is increased in cerebellar granule cells exposed chronically to ethanol. European Journal of Pharmacology. 248:1993;209-212.
15. Kelly D.F., Lee S.M., Pinanong P.A., Hovda D.A. Paradoxical effects of acute ethanolism in experimental brain injury. Journal of Neurosurgery. 86:1997;876-882.
16. Lovinger D.M. Excitotoxicity and alcohol-related brain damage. Alcoholism, Clinical and Experimental Research. 17:1993;19-27.
17. Lovinger D.M., White G., Weight F.F. Ethanol inhibits NMDA-activated ion current in hippocampal neurons. Science. 243:1989;1721-1724.
18. Lovinger D.M., White G., Weight F.F. NMDA receptor-mediated synaptic excitation selectively inhibited by ethanol in hippocampal slice from adult rat. Journal of Neuroscience. 10:1990;1372-1379.
19. Lustig H.S., Chan J., Greenberg D.A. Ethanol inhibits excitotoxicity in cerebral cortical cultures. Neuroscience Letters. 135:1992;259-261.
20. Monaghan D.T., Cotman C.W. Distribution of N-methyl-D-aspartate-sensitive L-[3H]glutamate-binding sites in rat brain. Journal of Neuroscience. 5:1985;2909-2919.
21. Morrisett R.A., Rezvani A.H., Overstreet D., Janowsky D.S., Wilson W.A., Swartzwelder H.S. MK-801 potently inhibits alcohol withdrawal seizures in rats. European Journal of Pharmacology. 176:1990;103-105.
22. Morrisett R.A., Swartzwelder H.S. Attenuation of hippocampal long-term potentiation by ethanol: a patch-clamp analysis of glutamatergic and GABAergic mechanisms. Journal of Neuroscience. 13:1993;2264-2272.
23. Muller D., Buchs P.A., Stoppini L. Time course of synaptic development in hippocampal organotypic cultures. Brain Research-Developmental Brain Research. 71:1993;93-100.
24. Pringle A.K., Iannotti F., Wilde G.J., Chad J.E., Seeley P.J., Sundstrom L.E. Neuroprotection by both NMDA and non-NMDA receptor antagonists in in vitro ischemia. Brain Research. 755:1997;36-46.
25. Sakaguchi T., Okada M., Kuno M., Kawasaki K. Dual mode of N-methyl-D-aspartate-induced neuronal death in hippocampal slice cultures in relation to N-methyl-D-aspartate receptor properties. Neuroscience. 76:1997;411-423.
26. Sanna E., Harris R.A. Recent developments in alcoholism: neuronal ion channels. Recent Developments in Alcoholism. 11:1993;169-186.
27. Stoppini L., Buchs P.A., Muller D. A simple method for organotypic cultures of nervous tissue. Journal of Neuroscience Methods. 37:1991;173-182.
28. Takadera T., Suzuki R., Mohri T. Protection by ethanol of cortical neurons from N-methyl-D-aspartate-induced neurotoxicity is associated with blocking calcium influx. Brain Research. 537:1990;109-114.
29. Thomas M.P., Davis M.I., Monaghan D.T., Morrisett R.A. Organotypic brain slice cultures for functional analysis of alcohol-related disorders: novel versus conventional preparations. Alcoholism, Clinical and Experimental Research. 22:1998;51-59.
30. Thomas M.P., Monaghan D.T., Morrisett R.A. Evidence for a causative role of NMDA receptors in an in vitro model of alcohol withdrawal hyperexcitability. Journal of Pharmacology and Experimental Therapeutics. 287:1998;87-97.
31. Thomas, M.P., Morrisett, R.A., 1997. Neuronal viability and NMDA-induced neurotoxicity following ethanol withdrawal in hippocampal explants. Research Society on Alcoholism, San Francisco, CA.
32. Vornov J.J., Tasker R.C., Coyle J.T. Direct observation of the agonist-specific regional vulnerability to glutamate, NMDA, and kainate neurotoxicity in organotypic hippocampal cultures. Experimental Neurology. 114:1991;11-22.
33. Vornov J.J., Tasker R.C., Park J. Neurotoxicity of acute glutamate transport blockade depends on coactivation of both NMDA and AMPA/Kainate receptors in organotypic hippocampal cultures. Experimental Neurology. 133:1995;7-17.
34. Whittington M.A., Lambert J.D., Little H.J. Increased NMDA receptor and calcium channel activity underlying ethanol withdrawal hyperexcitability. Alcohol and Alcoholism. 30:1995;105-114.