Undetectable expression of hMLH1 protein in sporadic colorectal cancer with replication error phenotype

Diseases of the Colon and Rectum

Volumn 40, Issue 10 SUPPL., 1997, Pages

  Koike, Junichi ^a,b   Yamada, Kanae ^b   Takano, Shoichi ^c   Kikuchi, Yoshinori ^b   Hemmi, Hiromichi ^b   Koi, Minoru ^d   Tsujita, Kazunori ^a   Yanagita, Kenzo ^a   Yoshio, Toshifumi ^a   Shimatake, Hiroyuki ^b  

^a TOHO UNIVERSITY   (Japan)

^b TOHO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c Department of Advanced Medicine and Development   (Japan)

^d NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

Author keywords

Antibody; Colorectal cancer; Hereditary nonpolyposis colorectal cancer; hMLH1; hMSH2; Immunoblot; Microsatellite instability; Replication error

Indexed keywords

ARTICLE; BASE MISPAIRING; CANCER SUSCEPTIBILITY; CARCINOGENESIS; COLORECTAL CANCER; DNA DETERMINATION; GENETIC SUSCEPTIBILITY; HUMAN; HUMAN TISSUE; COLORECTAL TUMOR; DNA REPAIR; GENETICS; IMMUNOBLOTTING; METABOLISM; MIDDLE AGED; PHENOTYPE;

CARRIER PROTEIN; DNA; DNA BINDING PROTEIN; MICROSATELLITE DNA; MLH1 PROTEIN, HUMAN; MSH2 PROTEIN, HUMAN; NUCLEAR PROTEIN; ONCOPROTEIN; PROTEIN MSH2; TUMOR PROTEIN;

CARRIER PROTEINS; COLORECTAL NEOPLASMS; COLORECTAL NEOPLASMS, HEREDITARY NONPOLYPOSIS; DNA REPAIR; DNA, NEOPLASM; DNA-BINDING PROTEINS; HUMANS; IMMUNOBLOTTING; MICROSATELLITE REPEATS; MIDDLE AGED; MUTS HOMOLOG 2 PROTEIN; NEOPLASM PROTEINS; NUCLEAR PROTEINS; PHENOTYPE; PROTO-ONCOGENE PROTEINS;

EID: 0031255604     PISSN: 00123706     EISSN: None     Source Type: Journal    
DOI: 10.1007/bf02062016     Document Type: Article

References (25)

1. Fishel R, Lescoe MK, Rao MR, et al. The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer. Cell 1993;75:1027-38.
2. Leach FS, Nicolaides NC, Papadopoulos N, et al. Mutations of a mutS homolog in hereditary nonpolyposis colorectal cancer. Cell 1993;75:1215-25.
3. Bronner CE, Baker SM, Morrison PT, et al. Mutation in the DNA mismatch repair gene homologue hMLH1 is associated with hereditary non-polyposis colon cancer. Nature 1994;368:258-61.
4. Papadopoulos N, Nicolaides NC, Wei Y.-F, et al. Mutation of mutL homolog in hereditary colon cancer. Science 1994;263:1625-9.
5. Nicolaides NC, Papadopoulos N, Liu B, et al. Mutations of two PMS homologues in hereditary nonpolyposis colon cancer. Nature 1994;371:75-80.
6. Shibata D, Peinado MA, Ionov Y, Malkhosyan S, Perucho M. Genomic instability in repeated sequences is an early somatic event in colorectal tumorigenesis that persists after transformation. Nat Genet 1994;6:273-81.
7. Ionov Y, Peinado MA, Malkhosyan S, Shibata D, Perucho M. Ubiquitous somatic mutations in simple repeated sequences reveal a new mechanism for colonic carcinogenesis. Nature 1993;363;558-61.
8. Han H-J, Maruyama M, Baba S, Park J-G, Nakamura Y. Genomic structure of human mismatch repair gene, hMLH1, and its mutation analysis in patients with hereditary non-polyposis colorectal cancer (HNPCC). Hum Mol Genet 1995;4:237-42.
9. Jacoby RF, Marshall DJ, Kailas S, Schlack S, Harms B, Love R. Genetic instability associated with adenoma to carcinoma progression in hereditary nonpolyposis colon cancer. Gastroenterology 1995;109:73-82.
10. Parsons R, Li G-M, Longley MJ, et al. Hypermutability and mismatch repair deficiency in RER+ tumor cells. Cell 1993;75:1227-36.
11. Aaltonen LA, Peltomäki P, Leach FS, et al. Clues to the pathogenesis of familial colorectal cancer. Science 1993;260:812-6.
12. Thibodeau SN, Bren G, Schaid D. Microsatellite instability in cancer of the proximal colon. Science 1993;260: 816-9.
13. Lothe RA, Peltomäki P, Meling GI, et al. Genomic instability in colorectal cancer: relationship to clinicopathological variables and family history. Cancer Res 1993; 53:5849-52.
14. Kim H, Jen J, Vogelstein B, Hamilton SR. Clinical and pathological characteristics of sporadic colorectal carcinomas with DNA replication errors in microsatellite sequences. Am J Pathol 1994;145:1-8.
15. Liu B, Parsons R, Papadopoulos N, et al. Analysis of mismatch repair genes in hereditary non-polyposis colorectal cancer patients. Nature Med 1996;2:169-74.
16. Umar A, Boyer JC, Thomas DC, et al. Defective mismatch repair in extracts of colorectal and endometrial cancer cell lines exhibiting microsatellite instability. J Biol Chem 1994;269:14367-70.
17. Koi M, Umar A, Chauhan DP, et al. Human chromosome 3 corrects mismatch repair deficiency and microsatellite instability and reduces N-methyl-N′-nitro-N-nitrosoguanidine tolerance in colon tumor cells with homozygous hMLH1 mutation. Cancer Res 1994;54: 4308-12.
18. Kikuchi Y, Takano S. Preparation of antibodies against hMSH2 and hMLH1 and its cellular localization in human colon cancer cell lines. J Med Soc Toho 1997;43: 432-45.
19. Vasen HF, Mecklin JP, Kahn PM, et al. The international collaborative group on hereditary non-polyposis colorectal cancer (ICG-HNPCC). Dis Colon Rectum 1991;34: 424-5.
20. Ausubel FM, Brent R, Kingston RE, et al. Current protocols in molecular biology. New York: John Wiley & Sons, 1987.
21. Williamson R, Bowcock A, Kidd K, et al. Report of the DNA committee and catalogues of cloned and mapped genes, markers formatted for PCR and DNA polymorphisms. Cytogenet Cell Genet 1991;58:1190-832.
22. Mertz LM, Rashtchian A. Nucleotide imbalance and polymerase chain reaction: effects on DNA amplification and synthesis of high specific activity radiolabeled DNA probes. Anal Biochem 1994;221:160-5.
23. Drewinko B, Romsdahl MM, Yang LY, Ahearn MJ, Trujillo JM. Establishment of a human carcinoembryonic antigen-producing colon adenocarcinoma cell line. Cancer Res 1976;36:467-75.
24. Brattain MG, Fine WD, Khaled FM, Thompson J, Brattain DE. Heterogeneity of malignant cells from a human colonic carcinoma. Cancer Res 1981;41:1751-6.
25. Watanabe Y, Umer A, Kunkel TA, Hemmi H, Barrett JC, Koi M. Correction of hMSH2-deficiency by chromosome 2 transfer. Proc Am Assoc Cancer Res 1997;38:148.