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Volumn 17, Issue 2, 2002, Pages 161-163

Novel Mutations of the CYP2A6 Gene in a Thai Population with Lowered Capacity of Coumarin 7-Hydroxylation

Author keywords

7 hydroxycoumarin; coumarin; genetic polymorphism; P450 2A6; poor metabolizer; silent mutation

Indexed keywords


EID: 1542264940     PISSN: 13474367     EISSN: 18800920     Source Type: Journal    
DOI: 10.2133/dmpk.17.161     Document Type: Article
Times cited : (4)

References (8)
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    • Miles, J. S., McLaren, A. W., Forrester, L. M., Glancey, M. J., Lang, M. A. and Wolf, C. R.: Identification of the human liver cytochrome P-450 responsible for coumarin 7-hydroxylase activity. Biochem. J., 267: 365-371 (1990).
    • (1990) Biochem. J. , vol.267 , pp. 365-371
    • Miles, J.S.1    McLaren, A.W.2    Forrester, L.M.3    Glancey, M.J.4    Lang, M.A.5    Wolf, C.R.6
  • 3
    • 0025841777 scopus 로고
    • Purification and characterization of human liver microsomal cytochrome P-450 2A6
    • Yun, C. H., Shimada, T. and Guengerich, F. P.: Purification and characterization of human liver microsomal cytochrome P-450 2A6. Mol. Pharmacol., 40: 679-685 (1991).
    • (1991) Mol. Pharmacol. , vol.40 , pp. 679-685
    • Yun, C.H.1    Shimada, T.2    Guengerich, F.P.3
  • 5
    • 0033664818 scopus 로고    scopus 로고
    • Roles of cytochromes P450 1A2, 2A6, and 2C8 in 5-fluorouracil formation from tegafur, an anticancer prodrug, in human liver microsomes
    • Komatsu, T., Yamazaki, H., Shimada, N., Nakajima, M. and Yokoi, T.: Roles of cytochromes P450 1A2, 2A6, and 2C8 in 5-fluorouracil formation from tegafur, an anticancer prodrug, in human liver microsomes. Drug Metab. Dispos., 28: 1457-1463 (2000).
    • (2000) Drug Metab. Dispos. , vol.28 , pp. 1457-1463
    • Komatsu, T.1    Yamazaki, H.2    Shimada, N.3    Nakajima, M.4    Yokoi, T.5
  • 8
    • 0036260293 scopus 로고    scopus 로고
    • Variation in coumarin 7-hydroxylase activity associated with genetic polymorphism of cytochrome P450 2A6 and the body status of iron stores in adult Thai males and females
    • Ujjin, P., Satarug, S., Vanavanitkun, Y., Daigo, S., Ariyoshi, N., Yamazaki, H., Reilly P. E. B., Moore, R. M. and Kamataki, T.: Variation in coumarin 7-hydroxylase activity associated with genetic polymorphism of cytochrome P450 2A6 and the body status of iron stores in adult Thai males and females. Pharmacogenetics, 12: 241-249 (2002).
    • (2002) Pharmacogenetics , vol.12 , pp. 241-249
    • Ujjin, P.1    Satarug, S.2    Vanavanitkun, Y.3    Daigo, S.4    Ariyoshi, N.5    Yamazaki, H.6    Reilly, P.E.B.7    Moore, R.M.8    Kamataki, T.9


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.