Characterization of a genotype previously designated as CYP2A6 D-type: CYP2A6*4B, another entire gene deletion allele of the CYP2A6 gene in Japanese

Pharmacogenetics

Volumn 12, Issue 6, 2002, Pages 501-504

  Ariyoshi, Noritaka ^a   Sekine, Hiromi ^a   Saito, Katsuhiko ^a   Kamataki, Tetsuya ^a  

^a CHIBA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Cytochrome P450; Family study; Genetic polymorphism; Genotyping

Indexed keywords

3,5 DIMETHYL 2 (3 PYRIDYL) 4 THIAZOLIDINONE; CYTOCHROME P450 2A6; CYTOCHROME P450 2A6 4B; CYTOCHROME P450 2A6 D; CYTOCHROME P450 ISOENZYME; FADROZOLE; TEGAFUR; UNCLASSIFIED DRUG; COUMARIN 7 HYDROXYLASE; COUMARIN 7-HYDROXYLASE; MIXED FUNCTION OXIDASE; PRIMER DNA; UNSPECIFIC MONOOXYGENASE;

ARTICLE; CONTROLLED STUDY; DRUG METABOLISM; ENZYME ACTIVITY; EXON; FAMILY; FEMALE; GENE DELETION; GENE IDENTIFICATION; GENOTYPE; HETEROZYGOTE; HOMOZYGOSITY; HUMAN; INTRON; MALE; PRIORITY JOURNAL; ALLELE; CHEMISTRY; GENETIC POLYMORPHISM; GENETIC VARIABILITY; GENETICS; JAPAN; PEDIGREE; POLYMERASE CHAIN REACTION; RESTRICTION FRAGMENT LENGTH POLYMORPHISM;

ALLELES; ARYL HYDROCARBON HYDROXYLASES; DNA PRIMERS; FEMALE; GENE DELETION; GENOTYPE; HETEROZYGOTE; HUMAN; JAPAN; MALE; MIXED FUNCTION OXYGENASES; PEDIGREE; POLYMERASE CHAIN REACTION; POLYMORPHISM (GENETICS); POLYMORPHISM, RESTRICTION FRAGMENT LENGTH; SUPPORT, NON-U.S. GOV'T; VARIATION (GENETICS); HUMANS; POLYMORPHISM, GENETIC;

EID: 0036667958     PISSN: 0960314X     EISSN: None     Source Type: Journal    
DOI: 10.1097/00008571-200208000-00012     Document Type: Article

References (10)

1. In vitro metabolism of fadrozole (CGS 16949A) in human microsomes and human cell lines expressing a single P450 isozyme
2. Bioactivation of tegafur to 5-fluorouracil is catalyzed by cytochrome P-4502A6 in human liver microsomes in vitro
3. (+)-Cis-3,5-dimethyl-2-(3-pyridyl) thiazolidin-4-one hydrochloride (SM-12502) as a novel substrate for cytochrome P450 2A6 in human liver microsomes
4. A new deleted allele in the human cytochrome P450 2A6 (CYP2A6) gene found in individuals showing poor metabolic capacity to coumarin and (+)-cis-3,5-dimethyl-2-(3-pyridyl)thiazolidin-4-one hydrochloride (SM-12502)
5. Genetic polymorphism of drug metabolising enzymes: New mutations in CYP2D6 and CYP2A6 gene in Japanese
6. Homologous unequal cross-over within the human CYP2A gene cluster as a mechanism for the deletion of entire CYP2A6 gene associated with the poor metabolizer phenotype
7. CYP2A6: A human coumarin 7-hydroxylase
8. Structural characterization of a new variant of the CYP2A6 gene (CYP2A6*1B) apparently diagnosed as heterozygotes of CYP2A6*1A and CYP2A6*4C
9. Identification and characterisation of novel polymorphisms in the CYP2A locus: Implications for nicotine metabolism
10. CYP2A6 gene deletion reduces susceptibility to lung cancer