Integration of signalling pathways regulated by small GTPases and calcium

Biochimica et Biophysica Acta - Molecular Cell Research

Volumn 1742, Issue 1-3, 2004, Pages 51-58

  Aspenström, Pontus ^a  

^a LUDWIG INSTITUTE FOR CANCER RESEARCH   (Sweden)

Author keywords

Actin; Calcium; GTPase; Ras; Rho

Indexed keywords

ACTIN; CALCIUM; CALCIUM CHANNEL; CALMODULIN; GUANOSINE TRIPHOSPHATASE; PROTEIN DERIVATIVE;

CALCIUM BINDING; CALCIUM TRANSPORT; CELL ADHESION; CELL INTERACTION; CELL MIGRATION; CELL PROLIFERATION; CONFERENCE PAPER; CROSS LINKING; ENZYME ACTIVITY; EXOCYTOSIS; HUMAN; MOLECULAR BIOLOGY; MOLECULAR INTERACTION; MOLECULAR MECHANICS; NONHUMAN; ONCOGENE RAS; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN FAMILY; SIGNAL TRANSDUCTION;

ANIMALS; CALCIUM; GTP PHOSPHOHYDROLASES; HOMEOSTASIS; HUMANS; SIGNAL TRANSDUCTION;

EID: 10044275155     PISSN: 01674889     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbamcr.2004.09.029     Document Type: Conference Paper

References (75)

1. G.W. Ruther, and C.J. Der The Ras branch of small GTPases: Ras family members don't fall far from the tree Curr. Opin. Cell Biol. 12 2000 157 165
2. J.M. Shields, K. Pruitt, A. McFall, A. Shaub, and C.J. Der Understanding Ras: 'it ain't over 'til it's over' Trends Cell Biol. 10 2000 147 154
3. A. Ehrhardt, G.R.A. Ehrhardt, X. Guo, and J.W. Schrader Ras and relatives-job sharing and networking keep an old family together Exp. Hematol. 30 2002 1089 1106
4. M. Barbacid ras genes Annu. Rev. Biochem. 56 1987 779 827
5. S.D. Balk Calcium as a regulator of the proliferation of normal, but not transformed, chicken fibroblasts in a plasma-containing medium Proc. Natl. Acad. Sci. U. S. A. 68 1971 271 275
6. M.J. Berridge, M.D. Bootman, and H.L. Roderick Calcium signalling: dynamics, homeostasis and remodelling Nat. Rev., Mol. Cell Biol. 4 2003 517 529
7. B. Weissman, and S.A. Aaronson Members of the src and ras oncogene families supplant the epidermal growth factor requirement of BALB/MK-2 keratinocytes and induce distinct alterations in their terminal differentiation program Mol. Cell. Biol. 5 1985 3386 3396
8. L.B. Rosen, D.D. Ginty, M.J. Weber, and M.E. Greenberg Membrane depolarization and calcium influx stimulate MEK and MAP kinase via activation of Ras Neuron 12 1994 1207 1221
9. 2+ FEBS Lett. 546 2003 6 10
10. 2+ channel expression at the cell surface by the small G-protein kir/Gem Nature 411 2001 701 706
11. 2+, calmodulin, Cdc42 and the cytoskeleton FEBS Lett. 542 2003 7 11
12. A.J. Ridley Rho family proteins: coordinating cell responses Trends Cell Biol. 11 2001 471 477
13. H. Avraham, S.-Y. Park, K. Schinkmann, and S. Avraham RAFT/Pyk2-mediated cellular signalling Cell. Signal. 12 2000 123 133
14. P.J. Cullen, and P.J. Lockyer Integration of calcium and Ras signalling Nat. Rev., Mol. Cell Biol. 3 2002 339 348
15. C.L. Farnsworth, N.W. Freshney, L.B. Rosen, A. Gosh, M.E. Greenberg, and L.A. Feig Calcium activation of Ras mediated by neuronal exchange factor Ras-GRF Nature 376 1995 524 527
16. Mm/Ras-GRF1 regulates both Ras and Rac signaling pathways FEBS Lett. 460 1999 357 362
17. N.P. Fam, W.-T. Fan, Z. Wang, L.-J. Zhang, H. Chen, and M.F. Moran Cloning and characterization of Ras-GRF2, a novel guanine nucleotide exchange factor for Ras Mol. Cell. Biol. 17 1997 1396 1406
18. C. Song, C.D. Hu, M. Masago, K. Kariya, Y. Yamawaki-Kataoka, M. Shibatohge, D. Wu, T. Sato, and T. Kataoka Regulation of a novel human phospholipase C, PLCε, through membrane targeting by Ras J. Biol. Chem. 276 2001 2752 2757
19. 12 and stimulates the Ras/mitogen-activated protein kinase pathway J. Biol. Chem. 276 2001 2758 2765
20. G.G. Kelley, S.E. Reks, J.M. Ondrako, and A.V. Smrcka Phospholipase Cε: a novel Ras effector EMBO J. 20 2001 743 754
21. J.A. Koehler, and M.F. Moran Regulation of extracellular signal-regulated kinase activity by p120 RasGAP does not involve its pleckstrin homology or calcium-dependent lipid binding domains but does require these domains to regulate cell proliferation Cell Growth Differ. 12 2001 551 561
22. 2+-dependent inactivation of the Ras-MAPK pathway Curr. Biol. 11 2001 981 986
23. 2+ oscillations EMBO J. 23 2004 1749 1760
24. T.G. Bivona, I. Pérez de Castro, I.M. Ahearn, T.M. Grana, V.K. Chiu, P.L. Lockyer, P.J. Cullen, A. Pellicer, A.D. Cox, and M.R. Philips Phospholipase Cγ activates Ras on the Golgi apparatus by means of RasGRP1 Nature 424 2003 694 698
25. P. Villalonga, C. López-Alcalá, M. Bosch, A. Chiloeches, N. Rocamora, J. Gil, R. Marais, C.J. Marshall, O. Bachs, and N. Agell Calmodulin binds to K-Ras, but not H-Ras or N-Ras, and modulates its downstream signaling Mol. Cell. Biol. 21 2001 7345 7354
26. P. Villalonga, C. López-Alcalá, A. Chiloeches, J. Gil, R. Marais, O. Bachs, and N. Agell Calmodulin prevents activation of Ras by PKC in 3T3 fibroblasts J. Biol. Chem. 277 2002 37929 37935
27. R.R. Clough, R.S. Sidhu, and R.P. Bhullar Calmodulin binds RalA and RalB and is required for the thrombin-induced activation of Ral in human platelets J. Biol. Chem. 277 2002 28972 28980
28. M. Hoshino, and S. Nakamura Small GTPase Rin induces neurite outgrowth through Rac/Cdc42 and calmodulin in PC12 cells J. Cell Biol. 163 2003 1067 1076
29. R. Fischer, Y. Wei, J. Anagli, and M.W. Berchtold Calmodulin binds to and inhibits GTP binding of the Ras-like GTPase Kir/Gem J. Biol. Chem. 271 1996 25067 25070
30. J.S. Moyers, P.J. Bilan, J. Zhu, and C.R. Kahn Rad and Rad-related GTPases interact with calmodulin and calmodulin-dependent protein kinase II J. Biol. Chem. 272 1997 11832 11839
31. J.S. Trimmer Unexpected cross talk: small GTPases regulation of calcium channel trafficking Sci. Signal Transduct. Knowl. Environ. 114 2002 1 3
32. B.S. Finlin, S.M. Crump, J. Satin, and D.A. Andres Regulation of voltage-gated calcium channel activity by Rem and Rad GTPases Proc. Natl. Acad. Sci. U. S. A. 100 2003 14469 14474
33. 2+ pump 4b and the proapoptotic tumor supressor Ras-associated factor 1 (RASSF1) J. Biol. Chem. 279 2004 31318 31328
34. 2+ leak across the endoplasmatic reticular membrane J. Biol. Chem. 278 2003 13672 13679
35. M.J. Wheelock, and K.R. Johnson Cadherins as modulators of cellular phenotype Annu. Rev. Cell Dev. Biol. 19 2003 207 235
36. V.M.M. Braga Cell-cell adhesion and signalling Curr. Opin. Cell Biol. 14 2002 546 556
37. M.J. Hart, M.G. Callow, B. Souza, and P. Polakis IQGAP1, a calmodulin-binding protein with a rasGAP-related domain, is a potential effector for cdc42Hs EMBO J. 17 1996 2997 3005
38. S. Kuroda, M. Fukata, K. Kobayashi, M. Nakafuku, N. Nomura, A. Iwamatsu, and K. Kaibuchi Identification of IQGAP as a putative target for the small GTPases, Cdc42 and Rac1 J. Biol. Chem. 271 1996 23363 23367
39. J.M. Swart-Mataraza, Z. Li, and D.B. Sacks IQGAP1 is a component of Cdc42 signaling to the cytoskeleton J. Biol. Chem. 277 2002 24753 24763
40. J.L. Joyal, R.S. Annan, Y.D. Ho, M.E. Huddleston, S.A. Carr, M.J. Hart, and D.B. Sacks Calmodulin modulates the interaction between IQGAP1 and Cdc42. Identification of IQGAP1 by nanoelectrospray tandem mass spectrometry J. Biol. Chem. 272 1997 15419 15425
41. S. Kuroda, M. Fukata, M. Nakagawa, K. Fujii, T. Nakamura, T. Ookubo, I. Izawa, T. Nagase, N. Nomura, H. Tani, I. Shoji, Y. Matsuura, S. Yonehara, and K. Kaibuchi Role of IQGAP1, a target of the small GTPases Cdc42 and Rac1, in regulation of E-cadherin-mediated cell-cell adhesion Science 281 1998 832 835
42. M. Fukata, T. Watanabe, J. Noritake, M. Nakagawa, M. Yamaga, S. Kuroda, Y. Matsuura, A. Iwamatsu, F. Perez, and K. Kaibuchi Rac1 and Cdc42 capture microtubules through IQGAP1 and CLIP-170 Cell 109 2002 873 885
43. M. Fukata, S. Koruda, K. Fuji, T. Nakmura, I. Shoji, Y. Matsuura, K. Okawa, A. Iwamatsu, A. Kikuchi, and K. Kaibuchi Regulation of cross-linking of actin filaments by IQGAP1, a target for Cdc42 J. Biol. Chem. 272 1997 29579 29583
44. A.M. Bashour, A.T. Fullerton, M.J. Hart, and G.S. Bloom IQGAP1, a Rac- and Cdc42-binding protein, directly binds and cross-links microfilaments J. Cell Biol. 137 1997 1555 1566
45. M. Fukata, S. Kuroda, M. Nakagawa, A. Kawajiri, N. Itoh, I. Shoji, Y. Matsuura, S. Yonehara, H. Fujisawa, A. Kikuchi, and K. Kaibuchi Cdc42 and Rac1 regulate the interaction of IQGAP1 with beta-catenin J. Biol. Chem. 274 1999 26044 26050
46. 2+/calmodulin and Cdc42 signaling J. Biol. Chem. 274 1999 464 470
47. Q. Li, and E.L. Stuenkel Calcium negatively modulates calmodulin interaction with IQGAP1 Biochem. Biophys. Res. Commun. 317 2004 787 795
48. S.C. Mateer, A.E. McDaniel, V. Nicolas, G.M. Habermacher, M.J. Lin, D.A. Cromer, M.E. King, and G.S. Bloom The mechanism for regulation of the F-actin binding activity of IQGAP1 by calcium/calmodulin J. Biol. Chem. 277 2002 12324 12333
49. T.M. Gomez, and N.C. Spitzer Regulation of growth cone behaviour by calcium: new dynamics to earlier perspectives J. Neurobiol. 44 2000 174 183
50. E. Giniger How do Rho family GTPases direct axon growth and guidance? A proposal relating signaling pathways to growth cone mechanics Differentiation 70 2002 385 396
51. A. Huttenlocher, S.P. Paleck, Q. Li, W. Zhang, R.L. Mellgren, D.A. Lauffenberger, M.H. Ginsberg, and A.F. Horwitz Regulation of cell migration by the calcium-dependent protease calpain J. Biol. Chem. 272 1997 32719 32722
52. E. Robles, A. Huttenlocher, and T.M. Gomez Filopodial calcium transients regulate growth cone motility and guidance through local activation of calpain Neuron 38 2003 597 609
53. A.M. Lokuta, P.A. Nuzzi, and A. Huttenlocher Calpain regulates neutrophil chemotaxis Proc. Natl. Acad. Sci. U. S. A. 100 2003 4006 4011
54. R. Henschler, A. Piiper, R. Bistrian, and D. Möbest SDF-1α-induced intracellular calcium transient involves Rho GTPase signalling and is required for migration of hematopoietic progenitor cells Biochem. Biophys. Res. Commun. 311 2003 1067 1071
55. 2+ sesitization of smooth muscle cells J. Biol. Chem. 272 1997 10704 10709
56. M. Uehata, T. Ishizaki, H. Satoh, T. Ono, T. Kawahara, T. Morishita, H. Tamakawa, K. Yamagami, J. Inui, M. Maekawa, and S. Narumiya Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension Nature 389 1997 990 994
57. 2+ sensitization of smooth muscle myosin II Am. J. Physiol., Cell Physiol. 281 2001 C257 C269
58. 2+ to GTP in the regulation of exocytosis Biochimie 82 2000 385 393
59. S. Gasman, S. Chasserot-Golaz, M.-F. Bader, and N. Vitale Regulation of exocytosis in adrenal chromaffin cells: focus on ARF and Rho GTPases Cell. Signal. 15 2003 893 899
60. P. Mariot, A.J. O'Sullivan, A.M. Brown, and P.E.R. Tatham Rho guanine nucleotide dissociation inhibitor protein (Rho-GDI) inhibits exocytosis in mast cells EMBO J. 15 1996 6476 6482
61. A.J. O'Sullivan, A.M. Brown, H.N. Freeman, and B.D. Gomperts Purification and identification of FOAD-II, a cytosolic protein that regulates secretion in streptolysin-O permeabilised masts cells, as a Rac/RhoGDI complex Mol. Biol. Cell 7 1996 397 408
62. A.M. Brown, A.J. O'Sullivan, and B.D. Gomperts Induction of exocytosis from permeabilised masts cells by the guanosine triphosphatases Rac and Cdc42 Mol. Biol. Cell 9 1998 1053 1063
63. N. Djouder, U. Prebens, K. Aktories, and A. Cavalié Inhibition of calcium release-activated calcium current by Rac/Cdc42-inactivating Clostridial cytotoxins in RBL cells J. Biol. Chem. 275 2000 18732 18738
64. E. Hong-Geller, and R.A. Cerione Cdc42 and Rac stimulate exocytosis of secretory granules by activating the IP3/calcium pathway in RBL-2H3 mast cells J. Cell Biol. 148 2000 481 493
65. 2+ mobilisation and degranulation in mutant RBL mast cells Proc. Natl. Acad. Sci. U. S. A. 98 2001 1154 1159
66. 2+-dependent exocytosis from PC12 cells Genes Cells 1 1996 943 951
67. 2+-dependent neurotransmitter exocytosis J. Biol. Chem. 275 2000 7764 7770
68. S. Gasman, S. Chasserot-Golaz, M.R. Popoff, D. Aunis, and M.-F. Bader Involvement of Rho GTPases in calcium-regulated exocytosis from adrenal chromaffin cells J. Cell. Sci. 112 1999 4763 4771
69. 2+-dependent exocytosis by Rac1-GTPase in bovine chromaffin cells J. Physiol. 550 2003 431 445
70. N. Vitale, S. Chasserot-Golaz, Y. Bailly, N. Morinaga, M.A. Frohman, and M.-F. Bader Calcium-regulated exocytosis of dense-core vesicles requires the activation of ADP-ribosylation factor (ARF)6 by ARF nucleotide binding site opener at the plasma membrane J. Cell Biol. 2002 159 2002 79 89
71. L. Wang, G. Li, and S. Sugita RalA-exocyst interaction mediates GTP-dependent exocytosis J. Biol. Chem. 279 2004 19875 19881
72. T. Okabe, T. Nakamura, Y.N. Nishimura, K. Kohu, S. Ohwada, Y. Morishita, and T. Akiyama RICS, a novel GTPase-activating protein for Cdc42 and Rac1, is involved in the β-catenin-N-cadherin and N-methyl-d-aspartate receptor signaling J. Biol. Chem. 278 2003 9920 9927
73. A. Harada, B. Furuta, K.-i. Takeuchi, M. Itakura, M. Takahashi, and M. Umeda Nadrin, a novel neuron-specific GTPase-activating protein involved in regulated exocytosis J. Biol. Chem. 275 2000 36885 36891
74. Å. Fransson, A. Ruusala, and P. Aspenström Atypical Rho GTPases have roles in mitochondrial homeostasis and apoptosis J. Biol. Chem. 278 2003 6495 6502
75. A.M. Wolff, J.G. Litske Petersen, T. Nilsson-Tillgren, and N. Din The open reading frame YAL048c affects the secretion of proteinase A in S. cerevisiae Yeast 15 1999 427 434