Calmodulin binds to K-Ras, but not to H- or N-Ras, and modulates its downstream signaling

Molecular and Cellular Biology

Volumn 21, Issue 21, 2001, Pages 7345-7354

  Villalonga, P ^a   Lopez Alcala C ^a   Bosch, M ^a   Chiloeches, A ^a   Rocamora, N ^a   Gil, J ^a   Marais, R ^a   Marshall, C J ^a   Bachs, O ^a   Agell, N ^a  

^a UNIVERSITY OF BARCELONA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

BOMBESIN; BOVINE SERUM ALBUMIN; CALMODULIN; CALMODULIN BINDING PROTEIN; EPIDERMAL GROWTH FACTOR; GUANOSINE TRIPHOSPHATE; K RAS PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; PLATELET DERIVED GROWTH FACTOR; PROTEIN H RAS; RAS PROTEIN; UNCLASSIFIED DRUG;

AFFINITY CHROMATOGRAPHY; ANIMAL CELL; ARTICLE; CELL LYSATE; CONTROLLED STUDY; FIBROBLAST; GENE ACTIVATION; GENE CONTROL; MOUSE; NONHUMAN; ONCOGENE H RAS; ONCOGENE K RAS; ONCOGENE N RAS; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN N RAS;

3T3 CELLS; ANIMALS; BOMBESIN; CALCIUM; CALMODULIN; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROPHORESIS, POLYACRYLAMIDE GEL; ENZYME ACTIVATION; EPIDERMAL GROWTH FACTOR; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENES, RAS; HUMANS; IMMUNOBLOTTING; MICE; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; PLATELET-DERIVED GROWTH FACTOR; PRECIPITIN TESTS; PROTEIN BINDING; PROTEIN ISOFORMS; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; PROTO-ONCOGENE PROTEINS P21(RAS); RAS PROTEINS; SIGNAL TRANSDUCTION;

ANIMALIA; BOVINAE;

EID: 0034790751     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.21.21.7345-7354.2001     Document Type: Article

References (61)

1. New nuclear functions for calmodulin
2. Mechanism of activation and function of protein kinase B
3. Calmodulin and calmodulin-binding proteins in the nucleus
4. Ras genes
5. Proteins regulating Ras and its relatives
6. Ras oncogenes in human cancer: A review
7. Calmodulin inhibitor W13 induces sustained activation of ERK2 and expression of p21(cip1)
8. Phosphorylation of rat liver heterogeneous nuclear ribonucleo-proteins A2 and C can be modulated by calmodulin
9. The dual specificity mitogen-activated protein kinase phosphatase-1 and -2 are induced by the p42/p44MAPK cascade
10. Calmodulin and the cell cycle: Involvement in the regulation of the cell-cycle progression
11. Protein kinase B (c-Akt): A multifunctional mediator of phosphatidylinositol 3-kinase activation
12. Regulation of mitogen-activated protein kinase phosphatase-I expression by extracellular signal-related kinase-dependent and Ca2+-dependent signal pathways in Rat-1 cells
13. Minimal Ras-binding domain of Raf1 can be used as an activation-specific probe for Ras
14. Regulation of p21ras by GTPase activating proteins and guanine nucleotide exchange proteins
15. Ras signalling and apoptosis
16. Calmodulin modulates mitogen-activated protein kinase activation in response to membrane depolarization in PC12 cells
17. Calcium influx activates extracellular-regulated kinase/mitogen-activated protein kinase pathway through a calmodulin-sensitive mechanism in PC12 cells
18. 2+ and calmodulin
19. Regulation of mitogen-activated protein kinases by a calcium/calmodulin-dependent protein kinase cascade
20. Cloning and characterization of Ras-GRF2, a novel guanine nucleotide exchange factor for Ras
21. Calcium activation of Ras mediated by neuronal exchange factor Ras-GRF
22. Spectrin and related molecules
23. Epidermal growth factor receptors: Critical mediators of multiple receptor pathways
24. Overexpression of the myristoylated alanine-rich C-kinase substrate in Rat1 cells increases sensitivity to calmodulin antagonists
25. Role of basal calcium in the EGF activation of MAP kinases
26. K-ras is an essential gene in the mouse with partial functional overlap with N-ras
27. Coordinate, biphasic activation of p44 mitogen-activated protein kinase and S6 kinase by growth factors in hamster fibroblasts. Evidence for thrombin-induced signals different from phosphoinositide turnover and adenylylcyclase inhibition
28. Signal transduction from multiple Ras effectors
29. Increasing complexity of Ras signal transduction: Involvement of Rho family proteins
30. Regulation of the calmodulin-stimulated protein phosphatase, calcineurin
31. Calmodulin
32. A scaffold protein in the c-Jun NH2-terminal kinase signaling pathways suppresses the extracellular signal-regulated kinase signaling pathways
33. Cleavage of structural protein during the assembly of the head of bacteriophage T4
34. Growth factor-induced p42/p44 MAPK nuclear translocation and retention requires both MAPK activation and neosynthesis of nuclear anchoring proteins
35. Signal transduction through MAP kinase cascades
36. Calmodulin regulates DNA polymerase alpha activity during proliferative activation of NRK cells
37. Regulation of the cell cycle by calcium and calmodulin
38. How do small GTPase signal transduction pathways regulate cell cycle entry?
39. Specificity of receptor tyrosine kinase signaling: Transient versus sustained extracellular signal-regulated kinase activation
40. Ras effectors
41. The human epidermal growth factor receptor contains a juxtamembrane calmodulin-binding site
42. Calcium/calmodulin-dependent protein kinase II alpha mediates activation of mitogen-activated protein kinase and cytosolic phospholipase A2 in norepinephrine-induced arachidonic acid release in rabbit aortic smooth muscle cells
43. Cell cycle arrest mediated by the MEK/mitogen-activated protein kinase pathway
44. Ras proteins: Recent advances and new functions
45. Growth factor activation of MAP kinase requires cell adhesion
46. Opposing effects of Ras on p53: Transcriptional activation of mdm2 and induction of p19ARF
47. Mitogen-activated protein kinase pathways
48. Phosphatidylinositol-3-OH kinase as a direct target of Ras
49. Dominant-negative caveolin inhibits H-Ras function by disrupting cholesterol-rich plasma membrane domains
50. Calmodulin inhibits the epidermal growth factor receptor tyrosine kinase
51. The multifunctional Ca2+/calmodulin-dependent protein kinases
52. High-intensity Raf signal causes cell cycle arrest mediated by p21Cip1
53. The hsp90-binding antibiotic geldanamycin decreases Raf levels and epidermal growth factor signaling without disrupting formation of signaling complexes or reducing the specific enzymatic activity of Raf kinase
54. MKP-1 (3CH134), an immediate early gene product, is a dual specificity phosphatase that dephosphorylates MAP kinase in vivo
55. Calmodulin is essential for cyclin-dependent kinase 4 (Cdk4) activity and nuclear accumulation of cyclin D1-Cdk4 during G(1)
56. Calmodulin binds to p21(Cip1) and is involved in the regulation of its nuclear localization
57. The murine N-ras gene is not essential for growth and development
58. Ras caught in another affair: The exchange factors for Ral
59. Raf-induced proliferation or cell cycle arrest is determined by the level of Raf activity with arrest mediated by p21Cip1
60. Ras isoforms vary in their ability to activate Raf-1 and phosphoinositide 3-kinase