Rho guanine nucleotide dissociation inhibitor protein (RhoGDI) inhibits exocytosis in mast cells

EMBO Journal

Volumn 15, Issue 23, 1996, Pages 6476-6482

  Mariot, Pascal ^a   O'Sullivan, Antony J ^a   Brown, Anna M ^a   Tatham, Peter E R ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Exocytosis; GTP binding proteins; Patch clamp capacitance

Indexed keywords

GUANINE NUCLEOTIDE; GUANINE NUCLEOTIDE BINDING PROTEIN; GUANOSINE 5' O (3 THIOTRIPHOSPHATE);

ANIMAL CELL; ARTICLE; CATTLE; CELL MEMBRANE TRANSPORT; CONTROLLED STUDY; CYTOSOL; DISSOCIATION; EXOCYTOSIS; MAST CELL; MONITORING; NONHUMAN; PRIORITY JOURNAL; PROTEIN TRANSPORT;

ANIMALIA; BOS TAURUS; BOVINAE;

EID: 0029803812     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1002/j.1460-2075.1996.tb01038.x     Document Type: Article

References (25)

1. Ando, S. et al. (1992) Post-translational processing of rac p21s is important both for their interaction with the GDP/GTP exchange proteins and for their activation of NADPH oxidase. J. Biol. Chem., 267, 25709-25713.
2. Aridor, M., Rajmilevich, G., Beaven, M.A. and Sagi-Eisenberg, R. (1993) Activation of exocytosis by the heterotrimeric G protein Gi3. Science, 262, 1569-1572.
3. Bourmeyster, N. and Vignais, P.V. (1996) Phosphorylation of Rho GDI stabilises the Rho A-Rho GDI complex in neutrophil cytosol. Biochem. Biophys. Res. Commun., 218, 54-60.
4. Fernandez, J.M., Neher, E. and Gomperts, B.D. (1984) Capacitance measurements reveal stepwise fusion events in degranulating mast cells. Nature, 312, 453-455.
5. Fidler, N. and Fernandez, J.M. (1989) Phase tracking: an improved phase detection technique for cell membrane capacitance measurements. Biophys. J., 56, 1153-1162.
6. Fukumoto, Y., Kaibuchi, K., Hori, Y., Fujioka, H., Araki, S., Ueda, T., Kikuchi, A. and Takai, Y. (1990) Molecular cloning and characterization of a novel type of regulatory protein (GDI) for the rho proteins, ras p21-like small GTP-binding proteins. Oncogene, 5, 1321-1328.
7. Gomperts, B.D. and Tatham, P.E.R. (1992) Regulated exocytotic secretion from permeabilized cells. Methods Enzymol., 219, 178-189.
8. Hancock, J.F. and Hall, A. (1993) A novel role for RhoGDI as an inhibitor of GAP proteins. EMBO J., 12, 1915-1921.
9. Helander, H.F. and Bloom, G.D. (1974) Quantitative analysis of mast cell structure. J. Microsc., 100, 315-321.
10. 2+ and guanine nucleotides: an all-or-none event. J. Cell Biol., 123, 585-593.
11. 2+ and guanine nucleotides in exocytotic secretion from permeabilized mast cells. J. Cell Biol., 105, 191-197.
12. 2+ for GTP-γ-S stimulated exocytosis from permeabilized mast cells. Cell Signalling, 1, 157-163.
13. Joshi, C. and Fernandez, J.M. (1988) Capacitance measurements: an analysis of the phase detector technique used to study exocytosis and endocytosis. Biophys. J., 53, 885-892.
14. Laemmli, U.K. (1970) Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature, 227, 680-685.
15. 2+ is a modulator, in the exocytotic reaction of permeabilized rat mast cells. Biochem. J., 288, 181-187.
16. Lindau, M. (1991) Time-resolved capacitance measurements: monitoring exocytosis in single cells. Q. Rev. Biophys., 24, 75-101.
17. Lindau, M. and Neher, E. (1988) Patch-clamp techniques for time-resolved capacitance measurements in single cells. Eur. J. Physiol., 411, 137-146.
18. Monck, J.R., Alvarez de Toledo, G. and Fernandez, J.M. (1990) Tension in secretory granule membranes causes extensive membrane transfer through the exocytolic fusion pore. Proc. Natl Acad. Sci. USA, 87, 7804-7808.
19. Nusse, O., Lindau, M., Cromwell, O., Kay, A.B. and Gomperts, B.D. (1990) Intracellular application of GTP-5′-O-(3-thiotriphosphate) induces exocytotic granule fusion in guinea pig eosinophils. J. Exp. Med., 171, 775-786.
20. Oberhauser, A.F., Monck, J.R., Balch, W.E. and Fernandez, J.M. (1992) Exocytotic fusion is activated by Rab3a peptides. Nature, 360, 270-273.
21. O'Sullivan, A.J., Brown, A.M., Freeman, H.N.M. and Gomperts, B.D. (1996) Purification and identification of FOAD-II, a cytosolic protein that regulates secretion in streptolysin-O permeabilized mast cells, as a rac/rhoGDI complex. Mol. Biol. Cell, 7, 397-408.
22. Penner, R., Pusch, M. and Neher, E. (1987) Washout phenomena in dialyzed mast cells allow discrimination of different steps in stimulus-secretion coupling. Biosci. Rep., 7, 313-321.
23. Price, L.S., Norman, J.C., Ridley, A.J. and Koffer, A. (1995) Small GTPases, rac and rho, as regulators of secretion in mast cells. Curr. Biol., 5, 68-73.
24. Pusch, M. and Neher, E. (1988) Rates of diffusional exchange between small cells and a measuring patch pipette. Pflügers Arch., 411, 204-211.
25. Tatham, P.E.R. and Gomperts, B.D. (1990) Cell permeabilization. In Siddle, K. and Hutton, J.C. (eds.), Peptide Hormones: A Practical Approach. IRL Press, Oxford, pp. 257-269.