Cellular functions of DNA polymerase ζ and REV1 protein

Advances in Protein Chemistry

Volumn 69, Issue , 2004, Pages 167-203

  Lawrence, Christopher W ^a  

^a UNIVERSITY OF ROCHESTER SCHOOL OF MEDICINE AND DENTISTRY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA POLYMERASE; DOUBLE STRANDED DNA; REV PROTEIN;

CELL FUNCTION; DNA DAMAGE; DNA REPAIR; DNA SEQUENCE; DNA STRAND BREAKAGE; ENZYME ACTIVITY; ENZYMOLOGY; GENE DELETION; GENE MUTATION; GENETIC ANALYSIS; HUMAN; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN INTERACTION; REVIEW; SEQUENCE ANALYSIS; SOMATIC HYPERMUTATION;

EID: 10044266718     PISSN: 00653233     EISSN: None     Source Type: Book Series    
DOI: 10.1016/S0065-3233(04)69006-1     Document Type: Article

References (133)

1. Aboussekhra A., Chanet R., Zgaga Z., Cassier-Chauvat C., Heude M., Fabre F. RADH, a gene of Saccharomyces cerevisiae encoding a putative DNA helicase involved in DNA repair. Characteristics of radH mutants and sequence of the gene. Nucleic Acids Res. 18:1989;7211-7219
2. Aboussekhra A., Chanet R., Adjiri A., Fabre F. Semidominant suppressors of Srs2 helicase mutations of Saccharomyces cerevisiae map in the RAD51 gene, whose sequence predicts a protein with similarities to procaryotic RecA proteins. Mol. Cell. Biol. 12:1992;3224-3234
3. Avkin S., Adar S., Livneh Z. Quantitative measurement of translesion replication in human cells: Evidence for bypass of an abasic site by a replicative DNA polymerase. Proc. Natl. Acad. Sci. USA. 99:2002;3764-3769
4. Bailly V., Lamb J., Sung P., Prakash S., Prakash L. Specific complex formation between yeast RAD6 and RAD18 proteins: A potential mechanism for targeting RAD6 ubiquitin-conjugating activity to DNA damage sites. Genes Dev. 8:1994;811-820
5. Baynton K., Bresson-Roy A., Fuchs R.P.P. Analysis of damage tolerance pathways in Saccharomyces cerevisiae: A requirement for Rev3 DNA Polymerase in translesion synthesis. Mol. Cell. Biol. 18:1998;960-966
6. Baynton K., Bresson-Roy A., Fuchs R.P.P. Distinct roles for Rev1p and Rev7p during translesion synthesis in Saccharomyces cerevisiae. Mol. Micro. 34:1999;124-133
7. Bemark M., Khamlichi A.A., Davies S.L., Neuberger M.S. Disruption of mouse polymerase ζ (Rev3) leads to embryonic lethality and impairs blastocyst development in vitro. Curr. Biol. 10:2000;1213-1216
8. Berdal K.G., Johansen R.F., Seeberg E. Release of normal bases from intact DNA by a native DNA repair enzyme. EMBO J. 17:1998;363-367
9. - mutant of the chicken DT40 cell line. Cell. 89:1997;185-193
10. Bresson A., Fuchs R.P.P. Lesion bypass in yeast cells: Pol η participates in a multi-DNA polymerase process. EMBO J. 21:2002;3881-3887
11. Braithwaite D.K., Ito J. Compilation, alignment, and phylogenetic relationships of DNA polymerases. Nucleic Acids Res. 21:1993;787-802
12. Cabral-Neto J.B., Caseira-Cabral R.E., Margot A., Le Page F., Sarasin A., Gentil A. Coding properties of a unique apurinicapyrimidinic site replicated in mammalian cells. J. Mol. Biol. 240:1994;416-420
13. Cassier C., Chanet R., Henriques J.A.P., Moustacchi E. The effect of three PSO genes on induced mutagenesis: A novel class of mutationally defective yeast. Genetics. 96:1980;841-857
14. Cassier-Chauvat C., Moustacchi E. Allelism between psol-1 and rev3-1 mutants and between pso2-1 and snm1 mutants in Saccharomyces cerevisiae. Curr. Genet. 13:1988;37-40
15. Chae S.-K., Kafer E. uvs-1 mutants defective in UV mutagenesis define a fourth epistatic group of uvs genes in Aspergillus. Curr. Genet. 24:1993;67-74
16. Cheung K.-J., Li G. The tumor suppressor INGI: Structure and function. Exp. Cell Res. 268:2001;1-6
17. INGI mediates repair of UV-damaged DNA. Cancer Res. 61:2001;4974-4977
18. Clark D.R., Zacharias W., Panaitescu L., McGregor W.G. Ribozyme-mediated REV1 inhibition reduces the frequency of UV-induced mutations in the human HPRT gene. Nucleic Acids Res. 31:2003;4981-4988
19. Datta A., Jinks-Robertson S. Association of increased spontaneous mutation rates with high levels of transcription in yeast. Science. 268:1995;1616-1619
20. Diaz M., Storb U. A novel cytidine deaminase AIDs in the delivery of error-prone polymerases to immunoglobulin genes. DNA Repair. 2:2003;623-627
21. Diaz M., Verkoczy L.K., Flajnik M.F., Klinman N.R. Decreased frequency of somatic hypermutation and impaired affinity maturation but intact germinal center formation in mice expressing antisense RNA to DNA polymerase ζ J. Immunology. 167:2001;327-335
22. Di Noia J., Neuberger M. Altering the pathway of immunoglobulin hypermutation by inhibiting uracil-DNA glycosylase. Nature. 419:2002;1-3
23. Eeken J.C.J., Romeijn R.J., de Jong A.W.M., Pastink A., Lohman P.H.M. Isolation and genetic characterization of the Drosophila homologue of (SCE)REV3, encoding the catalytic subunit of DNA polymerase ζ Mutat. Res. 485:2001;237-253
24. Esposito G., Godin I., Klein U., Yaspo M.-L., Cumano A., Rajewsky K. Disruption of the Rev3l-encoded catalytic subunit of polymerase ζ in mice results in early embryonic lethality. Curr. Biol. 10:2000;1221-1224
25. ING1 cooperates with p53 in cell growth control. Nature. 391:1998;295-298
26. Gibbs P.E.M., Lawrence C.W. Novel mutagenic properties of abasic sites in Saccharomyces cerevisiae. J. Mol. Biol. 251:1995;229-236
27. Gibbs P.E.M., McGregor W.G., Maher V.M., Nisson P., Lawrence C.W. A human homolog of the Saccharomyces cerevisiae REV3 gene, which encodes the catalytic subunit of DNA polymerase ζ Proc. Natl. Acad. Sci. USA. 95:1998;6876-6880
28. Gibbs P.E.M., Wang X.-D., Li Z., McManus T.P., McGregor W.G., Lawrence C.W., Maher V.M. The function of the human homolog of Saccharomyces cerevisiae REV1 is required for mutagenesis induced by UV light. Proc. Natl. Acad. Sci. USA. 97:2000;4186-4191
29. Gibbs P.E.M., MacDonald J., Woodgate R., Lawrence C.W. The relative roles in vivo of Saccharomyces cerevisiae Pol η, Pol ζ, Rev1 protein, and Pol 32 in the bypass and mutation induction of an abasic site, T-T (6-4) photoadduct, and T-T cis-syn cyclobutane dimer. Genetics. 2004;. (in press)
30. Glassner B.J., Rasmussen L.J., Najarian M.T., Posnick L.M., Samson L.D. Generation of a strong mutator phenotype in yeast by imbalanced base excision repair. Proc. Nat. Acad. Sci. USA. 95:1998;9997-10002
31. Guillet M., Boiteux S. Origin of endogenous DNA abasic sites in Saccharomyces cerevisiae. Mol. Cell. Biol. 23:2003;8366-8394
32. Guo D., Wu X., Rajpal D.K., Taylor J.-S., Wang Z. Translesion synthesis by yeast DNA polymerase ζ from templates containing lesions of ultraviolet radiation and acetylaminofluorene. Nucleic Acids Res. 29:2001;2875-2883
33. Guo C., Fischhaber P.L., Luk-Paszyc M.J., Masuda Y., Zhou J., Kamiya K., Kisker C., Friedberg E.C. Mouse Rev1 protein interacts with multiple DNA polymerases involved in translesion DNA synthesis. EMBO J. 22:2003;6621-6630
34. Han K.-Y., Chae S.-K., Han D.-M. The uvsI gene of Aspergillus nidulans required for UV-mutagenesis encodes a homolog to REV3, a subunit of the DNA polymerase ζ of yeast involved in translesion DNA synthesis. FEMS Microbiol. Lett. 164:1998;13-19
35. 6-methylguanine by yeast and human DNA polymerase η Mol. Cell. Biol. 20:2000;8001-8007
36. Haracska L., Washington M.T., Prakash S., Prakash L. Inefficient bypass of an abasic site by DNA polymerase η J. Biol. Chem. 276:2001a;6861-6866
37. Haracska L., Kondratick C.M., Unk I., Prakash S., Prakash L. Interaction with PCNA is essential for yeast DNA polymerase η function. Mol. Cell. 8:2001b;407-415
38. Haracska L., Unk I., Johnson R.E., Johansson E., Burgers P.M.J., Prakash S., Prakash L. Roles of yeast DNA polymerase δ and ζ and of Rev1 in the bypass of abasic sites. Genes Dev. 15:2001c;945-954
39. Haracska L., Johnson R.E., Unk I., Phillips B., Hurwitz J., Prakash L., Prakash S. Physical and functional interactions of human DNA polymerase η with PCNA. Mol. Cell. Biol. 21:2001d;7199-7206
40. Haracska L., Prakash S., Prakash L. Yeast Rev1 protein is a G template specific DNA polymerase. J. Biol. Chem. 277:2002;15546-15551
41. Haracska L., Prakash S., Prakash L. Yeast DNA polymerase ζ is an efficient extender of primer ends opposite from 7,8-dihydro-8-oxoguanine and O6-methyl guanine. Mol. Cell. Biol. 23:2003;1453-1459
42. Harfe B.D., Jinks-Robertson S. DNA polymerase ζ introduces multiple mutations when bypassing spontaneous DNA damage in Saccharomyces cerevisiae. Mol. Cell. 6:2000;1491-1499
43. Heidenreich E., Holzmann V., Eisler H. Polymerase ζ dependency of increased adaptive mutation frequencies in nucleotide excision repair-deficient yeast strains. DNA Repair. 3:2004;395-402
44. Henriques J.A.P., Moustacchi E. Isolation and characterization of pso mutants sensitive to photo-addition of psoralen derivatives in Saccharomyces cerevisiae. Genetics. 95:1980;273-288
45. Hoege C., Pfander B., Moldovan G.-L., Pyrowolakis G., Jentsch S. RAD6-dependent DNA repair is linked to modification of PCNA by ubiquitin and SUMO. Nature. 419:2002;135-141
46. Holbeck S.L., Strathern J.N. A role for REV3 in mutagenesis during double-strand break repair in Saccharomyces cerevisiae. Genetics. 147:1997;1017-1024
47. Huang M.-E., de Caligon A., Nicolas A., Galibert F. Pol32, a subunit of the Saccharomyces cerevisiae DNA polymerase δ, defines a link between DNA replication and the mutagenic bypass repair pathway. Curr. Genet. 38:2000;178-187
48. Ito J., Braithwaite D.K. Compilation and alignment of DNA polymerase sequences. Nucleic Acids Res. 19:1991;4045-4057
49. Johnson R.E., Prakash S., Prakash L. Efficient bypass of a thymine-thymine dimer by yeast DNA polymerase, Polη Science. 283:1999;1001-1004
50. Johnson R.E., Washington M.T., Haracska L., Prakash S., Prakash L. Eukaryotic Polymerases ι and ζ act sequentially to bypass DNA lesions. Nature. 406:2000;1015-1019
51. Johnson R.E., Haracska L., Prakash S., Prakash L. Role of DNA polymerase η in the bypass of a (6-4) TT photoproduct. Mol. Cell. Biol. 21:2001;3558-3563
52. Johnson R.E., Yu S.-L., Prakash S., Prakash L. Yeast DNA polymerase zeta (ζ) is essential for error-free replication past thymine glycol. Genes Dev. 17:2003;77-87
53. Kajiwara K., Nagawawa H., Shimizu-Nishikawa K., Ookuri T., Kimura M., Sugaya E. Molecular characterization of seizure-related genes isolated by differential screening. Biochem. Biophys. Res. Comm. 219:1996;795-799
54. Krejci L., Van Komen S., Li Y., Villemain J., Reddy M.S., Klein H., Ellenberger T., Sung P. DNA helicase Srs2 disrupts the Rad51 presynaptic filament. Nature. 423:2003;305-309
55. Kozak M. Point mutations define a sequence flanking the AUG initiator codon that modulates translation by eukaryotic ribosomes. Cell. 44:1986;283-292
56. Kunz B.A., Hensen E.S., Roches H., Ramotor D., Nunoshiba T., Demple B. Specificity of the mutator caused by the deletion of the yeast structural gene [APN1] for the major apurinic endonuclease. Proc. Nat. Acad. Sci. USA. 91:1994;8165-8169
57. Larimer F.W., Perry J.R., Hardigree A.A. The REV1 gene of Saccharomyces cerevisiae: Isolation, sequence, and functional analysis. J. Bacteriol. 171:1989;230-237
58. Lawrence C.W. Cellular roles of DNA polymerase ζ and Rev1 protein. DNA Repair. 1:2002;425-435
59. Lawrence C.W., Christensen R.B. UV mutagenesis in radiation-sensitive strains of yeast. Genetics. 82:1976;207-232
60. Lawrence C.W., Christensen R.B. Ultraviolet-induced reversion of cyc1 alleles in radiation-sensitive strains of yeast. I. rev1 mutant strains. J. Mol. Biol. 122:1978;1-21
61. Lawrence C.W., Christensen R.B. Ultraviolet-induced reversion of cyc1 alleles in radiation-sensitive strains of yeast. III. rev3 mutant strains. Genetics. 92:1979;397-408
62. Lawrence C.W., Hinkle D.C. DNA Polymerase ζ and the control of DNA damage induced mutagenesis in eukaryotes. Lindahl T. "Cancer Surveys" Genetic Stability in Cancer. Vol. 28:1996;21-31 Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY
63. Lawrence C.W., O'Brien T., Bond J. UV-induced reversion of his4 frameshift mutations in rad6, rev1, and rev3 mutants of yeast. Mol. Gen. Genet. 195:1984;487-490
64. Lawrence C.W., Das G., Christensen R.B. REV7, a new gene concerned with UV mutagenesis in yeast. Mol. Gen. Genet. 200:1985a;80-85
65. Lawrence C.W., Nisson P.E., Christensen R.B. UV and chemical mutagenesis in rev7 mutants of yeast. Mol. Gen. Genet. 200:1985b;86-91
66. Lawrence C.W., Kraus B.R., Christensen R.B. New mutations affecting induced mutagenesis in yeast. Mutat. Res. 150:1985c;211-216
67. Lawrence C.W., Gibbs P.E.M., Murante R.S., Wang X.-D., Li Z., McManus T.P., McGregor W.G., Nelson J.R., Hinkle D.C., Maher V.M. Roles of DNA polymerase ζ and Rev1 protein in eukaryotic mutagenesis and translesion replication. "Cold Spring Harbor Symposia on Quantitative Biology," Vol. 65:2000;61-69 Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY
68. Lemontt J.F. Mutants of yeast defective in mutation induced by ultraviolet light. Genetics. 68:1971;21-33
69. Lemontt J.F. Induction of forward mutations in mutationally defective yeast. Mol. Gen. Genet. 119:1972;27-42
70. Li Z., Zhang H., Mcmanus T.P., McCormick J.J., Lawrence C.W., Maher V.M. hREV3 is essential for error-prone translesion synthesis past UV or benzo[a]pyrene diol epoxide-induced DNA lesions in human fibroblasts. Mutat. Res. 510:2002;71-80
71. Lin W., Wu X., Wang Z. A full-length cDNA of hREV3 is predicted to encode DNA polymerase ζ for damage-induced mutagenesis in humans. Mutat. Res. 433:1998;89-98
72. Lin W., Xin H., Zhang Y., Wu X., Yuan F., Wang Z. The human REV1 gene codes for a DNA template-dependent dCMP transferase. Nucleic Acids Res. 27:1999;4468-4475
73. Lindahl T. Instability and decay of the primary structure of DNA. Nature. 362:1993;709-715
74. ING1 are associated with histone acetyltransferase activities. Mol. Cell. Biol. 20:2000;3807-3816
75. Masuda Y., Takahashi M., Fukuda S., Sumii M., Kamiya K. Mechanisms of dCMP transferase reactions catalyzed by mouse Rev1 protein. J. Biol. Chem. 277:2002;3040-3046
76. Masuda Y., Ohmae M., Masuda K., Kamiya K. Structure and enzymatic properties of a stable complex of the human REV1 and REV7 proteins. J. Biol. Chem. 278:2003;12356-12360
77. Mendelman L.V., Petruska J., Goodman M.F. Base mispair extension kinetics. J. Biol. Chem. 265:1990;2338-2346
78. McKee R.H., Lawrence C.W. Genetic analysis of gamma-ray mutagenesis in yeast I. Reversion in radiation-sensitive strains. Genetics. 93:1979a;361-373
79. McKee R.H., Lawrence C.W. Genetic analysis of gamma-ray mutagenesis in yeast II. Allele-specific control of mutagenesis. Genetics. 93:1979b;375-381
80. Moerschell R.P., Tsunasawa S., Sherman F. Transformation of yeast with synthetic oligonucleotides. Proc. Natl. Acad. Sci. USA. 85:1988;524-528
81. Mol C.D., Izumi T., Mitra S., Tainer J.A. DNA-bound structures and mutants reveal abasic DNA binding by APE1 DNA repair and coordination. Nature. 403:2000;451-456
82. Morelli C., Mungall A.J., Negrini M., Barbanti-Brodano G., Croce C.M. Alternate splicing, genomic structure, and fine chromosome localization of Rev3L, Cytogenet. Cell Genet. 83:1998;18-20
83. Morrison A., Christensen R.B., Alley J., Beck A.K., Bernstine E.G., Lemontt J.F., Lawrence C.W. REV3, a Saccharomyces cerevisiae gene whose function is required for induced mutagenesis, is predicted to encode a nonessential DNA polymerase. J. Bacteriol. 171:1989;5659-5667
84. Murakumo Y. The property of DNA polymerase ζ: REV7 is a putative protein involved in translesion DNA synthesis and cell cycle control. Mutat. Res. 510:2002;37-44
85. Murakumo Y., Roth T., Ishii H., Rasio D., Numata S.-I., Croce C.M., Fishel R. A human REV7 homolog that interacts with the polymerase ζ catalytic subunit hREV3 and the spindle assembly checkpoint protein hMAD2. J. Biol. Chem. 275:2000;4391-4397
86. Murakumo Y., Ogura Y., Ishii H., Numata S.-I., Ichihara M., Croce C.M., Fishel R., Takahashi M. Interactions in the error-prone post replication repair proteins hRev1, hRev3, and hRev7. J. Biol. Chem. 276:2001;35644-35651
87. Muramatsu M., Kinoshita K., Fagarasan S., Yamada S., Shinkai Y., Honjo T. Class switch recombination and somatic hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme. Cell. 102:2000;553-563
88. Nelson J.R., Lawrence C.W., Hinkle D.C. Thymine-thymine dimer bypass by yeast DNA polymerase ζ Science. 272:1996a;1646-1649
89. Nelson J.R., Lawrence C.W., Hinkle D.C. Deoxycytidyl transferase activity of yeast REV1 protein. Nature. 382:1996b;729-731
90. Nelson J.R., Gibbs P.E.M., Nowicka A.M., Hinkle D.C., Lawrence C.W. Evidence for a second function for Saccharomyces cerevisiae Rev1p. Mol. Micro. 37:2000;549-554
91. Ohashi E., Murakumo Y., Kanjo N., Akagi J.-I., Masutani C., Hanaoka F., Ohmori H. Interaction of hREV1 with three human Y-family DNA polymerases. Genes Cells. 9:2004;523-531
92. Ohmori H., Friedberg E.C., Fuchs R.P.P., Goodman M.F., Hanaoka F., Hinkle D., Kunkel T.A., Lawrence C.W., Livneh Z., Nohmi T., Prakash L., Prakash S., Todo T., Walker G.C., Wang Z., Woodgate R. The Y-family of DNA polymerases. Mol. Cell. 8:2001;7-8
93. Otsuka C., Kobayashi K., Kawaguchi N., Kunitomi N., Moriyama K., Hata Y., Iwai S., Loakes D., Noskov V.N., Pavlov Y., Negishi K. Use of yeast transformation by oligonucleotides to study DNA lesion bypass in vivo. Mutat. Res. 502:2002a;53-60
94. Otsuka C., Sanadai S., Hata Y., Okuto H., Noskov V.N., Loakes D., Negishi K. Difference between deoxyribose- and tetrahydrofuran-type abasic sites in the in vivo mutagenic response in yeast. Nucleic Acids Res. 30:2002b;5129-5135
95. Otsuka C., Loakes D., Negishi K. The role of deoxycytidyl transferase activity of yeast Rev1 protein in the bypass of abasic sites. Nucleic Acids Res. 2:2002c;87-88
96. Otsuka C., Kunitomi N., Iwai S., Loakes D., Negishi K. Role of REV1 polymerase domain and DNA polymerase h in translesion DNA synthesis in yeast in vivo. 2004;. Submitted
97. Paulovich A.G., Armout C.D., Hartwell L.H. The Saccharomyces cerevisiae RAD9, RAD17, RAD24, and MEC3 genes are required for tolerating irreparable, ultraviolet-induced damage. Genetics. 150:1998;75-93
98. Prakash L. Effect of genes controlling radiation sensitivity on chemically induced mutations in Saccharomyces cerevisiae. Genetics. 83:1976;285-301
99. Prakash S., Prakash L. Translesion DNA synthesis in eukaryotes: A one- or two-polymerase affair. Genes Dev. 16:2002;1872-1883
100. Quah S.-K., von Borstel R.C., Hastings P.J. The origin of spontaneous mutation in Saccharomyces cerevisae. Genetics. 96:1980;819-839
101. Rada C., Williams G., Nilsen H., Barnes D., Lindahl T., Neuberger M. Immunoglobulin isotype switching is inhibited and somatic hypermutation perturbed in UNG-deficient mice. Curr. Biol. 12:2002;1748-1755
102. Rattray A.J., Shafer B.K., McGill C.B., Strathern J.N. The roles of REV3 and RAD57 in double-strand-break-repair-induced-mutagenesis of Saccharomyces cerevisiae. Genetics. 162:2002;1063-1077
103. 6-dA lesions catalyzed by DNA bypass polymerases. J. Biol. Chem. 277:2002;30488-30494
104. Roche H.R., Gietz R.D., Kunz B.A. Specificity of the rev3Δ antimutator and REV3 dependency of the mutator resulting from a defect (rad1Δ) in nucleotide excision repair. Genetics. 137:1994;637-646
105. Roche H.R., Gietz R.D., Kunz B.A. Specificities of the Saccharomyces cerevisiae rad6, rad18, and rad52 mutators exhibit different degrees of dependence on the REV3 gene product, a putative nonessential DNA polymerase. Genetics. 140:1995;443-456
106. Rogozin I.B., Pavlov Y.I., Bebenek K., Matsuda T., Kunkel T.A. Somatic mutation hotspots correlate with DNA polymerase η error spectrum. Nat. Immunol. 2:2001;530-536
107. Ruhland A., Brendel M. Mutagenesis by cytostatic alkylating agents in yeast strains of differing repair capacities. Genetics. 92:1979;83-97
108. Sakai W., Ishii C., Inoue H. The upr-1 gene encodes a catalytic subunit of the DNA polymerase ζ which is involved in damage-induced mutagenesis in Neurospora crassa. Mol. Genet. Genomics. 267:2002;401-408
109. Sakai W., Wada Y., Naoi Y., Ishii C., Inoue H. Isolation and genetic characterization of the Neurospora crassa REV1 and REV7 homologs: Evidence for involvement in damage-induced mutagenesis. DNA Repair. 2:2003;337-346
110. Sakamoto A., Lan V.T.T., Hase Y., Shikazono N., Matsunaga T., Tanaka A. Disruption of the AtREV3 gene causes hypersensitivity to ultraviolet B light and γ-rays in Arabidopsis: Implications of the presence of a translesion synthesis mechanism in plants. Plant Cell. 15:2003;2042-2057
111. Sale J.E., Calandrini D.M., Takata M., Takeda S., Neuberger M. Ablation of XRCC23 transforms immunoglobulin V gene conversion into somatic hypermutation. Nature. 412:2001;921-926
112. Schiestl R.H., Prakash S., Prakash L. The SRS2 suppressor of Rad6 mutations of Saccharomyces cerevisiae acts by channeling DNA lesions into the RAD52 DNA repair pathway. Genetics. 124:1990;817-831
113. Simhadri S., Kramata P., Zajc B., Sayer J.M., Jerina D.M., Hinkle D.C., Wei C. S.-J. Benzo[a]pyrene diol epoxide-deoxyguanosine adducts are accurately bypassed by yeast DNA polymerase ζ in vitro. Mutat. Res. 508:2002;137-145
114. Simon J.A., Szankasi P., Nguyen D.K., Ludlow C., Dunstan H.M., Roberts C.J., Jensen E.L., Hartwell L.H., Friend S.H. Differential toxicities of anticancer agents among DNA repair and checkpoint mutants of Saccharomyces cerevisiae. Cancer Res. 60:2000;328-333
115. Simpson L.J., Sale J.E. Rev1 is essential foe DNA damage tolerance and non-teplated immunogobulin gene mutation in a vertebrate cell line. EMBO J. 22:2003;1654-1664
116. Singhal R.K., Hinkle D.C., Lawrence C.W. The REV3 gene of Saccharomyces cerevisiae is regulated more like a repair gene than one encoding a DNA polymerase. Mol. Gen. Genet. 236:1992;17-24
117. Sonoda E., Okada T., Zhao G.Y., Tateishi S., Araki K., Yamaizumi M., Yagi T., Verkaik N.S., van Gent D.C., Takata M., Takeda S. Multiple roles of Rev3, the catalytic subunit of pol ζ in maintaining genome stability in vertebrates. EMBO J. 22:2003;3189-3197
118. Stelter P., Ulrich H.D. Control of spontaneous and damage-induced mutagenesis by SUMO and ubiquitin conjugation. Nature. 425:2003;188-191
119. Takeshita M., Eisenberg W. Mechanism of mutation on DNA templates containing synthetic abasic sites: study with a double strand vector. Nucleic Acids Res. 22:1994;1897-1902
120. Thomas D.C., Roberts J.D., Sabatino R.D., Myers T.W., Tan C.-K., Downey K.M., So A.G., Bambara R.A., Kunkel T.A. Fidelity of mammalian DNA replication and replicative DNA polymerases. Biochem. 30:1991;11751-11759
121. Torpey L.E., Gibbs P.E.M., Nelson J.R., Lawrence C.W. Cloning and sequence of REV7, a gene whose function is required for DNA damage-induced mutagenesis in Saccharomyces cerevisiae. Yeast. 10:1994;1503-1509
122. Vanderwiele D., Borden A., O'Grady P.I., Woodgate R., Lawrence C.W. Efficient translesion replication in the absence of Escherichia coli Umu proteins and 3′-5′ exonuclease proofreading function. Proc. Natl. Acad. Sci. USA. 95:1998;15519-15534
123. Van Sloun P.P., Romeijn R.J., Eeken J.C. Molecular cloning, expression and chromosomal location of the mouse Rev31 gene, encoding the catalytic subunit of polymerase ζ Mutat. Res. 109:1999;109-116
124. Van Sloun P.P., Varlet I., Sonneveld E., Boei J.J., Romeijn R.J., Eeken J.C., De Wind N. Involvement of Mouse Rev3 in tolerance of endogenous and exogenous DNA damage. Mol. Cell. Biol. 22:2002;2159-2169
125. Vaisman A., Frank E.G., McDonald J.P., Tissier A., Woodgate R. Polι-dependent lesion bypass in vitro. Mutat. Res. 510:2002;9-22
126. Veaute X., Jeusset J., Soustelle C., Kowalczkowski S.C., Le Cam E., Fabre F. The Srs2 helicase prevents recombination by disrupting Rad51 nucleoprotein filaments. Nature. 423:2003;309-312
127. Wittschieben J., Shivji M.K., Lalani E., Jacobs M.A., Marini F., Gearhart P.J., Rosewell I., Stamp G., Wood R.D. Disruption of the developmentally regulated Rev3l gene causes embryonic lethality. Curr. Biol. 10:2000;1217-1220
128. Xiao W., Lechler T., Chow B.L., Fontanie T., Agustus M., Carter K.C., Wei Y.-F. Identification, chromosomal mapping and tissue-specific expression of hREV3 encoding a putative human DNA polymerase ζ Carcinogenesis. 19:1998;945-949
129. Yang I.-Y., Miller H., Wang Z., Frank E.G., Ohmori H., Hanaoka F., Moriya M. Mammalian translesion DNA synthesis across an acrolein-derived deoxyguanosine adduct. J. Biol. Chem. 278:2003;13989-13994
130. Yuan F., Zhang Y., Rajpal D.K., Wu X., Guo D., Wang M., Taylor J.-S., Wang Z. Specificity of DNA lesion bypass by the yeast DNA polymerase η J. Biol. Chem. 275:2000;8233-8239
131. Zan H., Komori A., Li Z., Cerutti A., Schaffer A., Fajnok M.F., Diaz M., Casali P. The translesion DNA polymerase ζ plays a major role in Ig and bcl-6 somatic hypermutation. Immunity. 14:2001;643-653
132. Zeng X., Winter D.B., Kasmer C., Kraemer K.H., Lehmann A.R., Gearhart P.J. DNA polymerase η is an A·T mutator in somatic hypermutation of immunoglobulin variable genes. Nature Immunology. 2:2001;537-541
133. Zhang Y., Wu X., Rechkoblit O., Geacintov N.E., Taylor J.-S., Wang Z. Response of human Rev1 to different DNA damage: Preferential dCMP insertion opposite the lesion. Nucleic Acids Res. 30:2002;1630-1638