Microarray analysis of p53 target gene expression patterns in the spleen and thymus in response to ionizing radiation

Cancer Biology and Therapy

Volumn 2, Issue 4, 2003, Pages 431-443

  Burns, Timothy F ^a   El Deiry, Wafik S ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Apoptosis; Ionizing radiation; Microarray; p53; Spleen; Thymus; Tissue specificity

Indexed keywords

ANTINEOPLASTIC AGENT; PROTEIN; PROTEIN P53;

ANIMAL; APOPTOSIS; ARTICLE; BINDING SITE; CELL CULTURE; DNA MICROARRAY; DRUG EFFECT; FEMALE; GAMMA RADIATION; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENETICS; HUMAN; METABOLISM; MOUSE; MOUSE MUTANT; NEOPLASM; NORTHERN BLOTTING; PATHOLOGY; PHYSIOLOGY; PROMOTER REGION; RADIATION EXPOSURE; SPLEEN; THYMUS; WHOLE BODY RADIATION;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; BINDING SITES; BLOTTING, NORTHERN; FEMALE; GAMMA RAYS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; HUMANS; MICE; MICE, KNOCKOUT; NEOPLASMS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PROMOTER REGIONS (GENETICS); PROTEINS; SPLEEN; THYMUS GLAND; TUMOR CELLS, CULTURED; TUMOR SUPPRESSOR PROTEIN P53; WHOLE-BODY IRRADIATION;

EID: 0842300074     PISSN: 15384047     EISSN: 15558576     Source Type: Journal    
DOI: 10.4161/cbt.2.4.478     Document Type: Article

References (59)

1. Vousden KH, Lu X. Live or let die: the cell's response to p53. Nat Rev Cancer 2002; 2:594-604. (Pubitemid 37328926)
2. Haupt Y, Rowan S, Shaulian E, Vousden KH, Oren M. Induction of apoptosis in HeLa cells by trans-activation-deficient p53. Genes Dev 1995; 9:2170-83.
3. Haupt Y, Barak Y, Oren M. Cell type-specific inhibition of p53-mediated apoptosis by mdm2. EMBO J 1996; 15:1596-606. (Pubitemid 26112381)
4. Caelles C, Helmberg A, Karin M. p53-dependent apoptosis in the absence of transcriptional activation of p53-target genes. Nature 1994; 370:220-3. (Pubitemid 24236778)
5. Murphy M, Ahn J, Walker KK, et al. Transcriptional repression by wild-type p53 utilizes histone deacetylases, mediated by interaction with mSin3a. Genes Dev 1999; 13:2490-501. (Pubitemid 29489641)
6. Yap DBS, Hsieh JK, Lu X. Mdm2 inhibits the apoptotic function of p53 mainly by targeting it for degradation. J Biol Chem 2000; 275:37296-302. (Pubitemid 32002154)
7. Kastan MB, Onyekwere O, Sidransky D, Vogelstein B, Craig RW. Participation of p53 protein in the cellular response to DNA damage. Cancer Res 1991; 51:6304-11.
8. Chen Q, Fischer A, Reagan JD, Yan LJ, Ames BN. Oxidative DNA-Damage and Senescence of Human-Diploid Fibroblast Cells. Proc Natl Acad Sci USA 1995; 92:4337-41.
9. Vonzglinicki T, Saretzki G, Docke W, Lotze C. Mild Hyperoxia Shortens Telomeres and Inhibits Proliferation of Fibroblasts - a Model for Senescence. Exp Cell Res 1995; 220:186-193.
10. Clarke AR, Purdie CA, Harrison DJ, et al. Thymocyte apoptosis induced by p53-dependent and independent pathways. Nature 1993; 362:849-52. (Pubitemid 23132162)
11. Lowe SW, Schmitt EM, Smith SW, Osborne BA, Jacks T. p53 is required for radiation-induced apoptosis in mouse thymocytes. Nature 1993; 362:847-9. (Pubitemid 23132161)
12. El-Deiry WS, Tokino T, Velculescu VE, et al. WAF1, a potential mediator of p53 tumor suppression. Cell 1993; 75:817-25. (Pubitemid 23346378)
13. Deng C, Zhang P, Harper JW, Elledge SJ, Leder P. Mice lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control. Cell 1995; 82:675-84.
14. Hengartner MO. The biochemistry of apoptosis. Nature 2000; 407:770-6.
15. Miyashita T, Reed JC. Tumor suppressor p53 is a direct transcriptional activator of the human bax gene. Cell 1995; 80:293-9.
16. Wang X. The expanding role of mitochondria in apoptosis. Genes Dev 2001; 15:2922-33. (Pubitemid 33078942)
17. Knudson CM, Tung KS, Tourtellotte WG, Brown GA, Korsmeyer SJ. Bax-deficient mice with lymphoid hyperplasia and male germ cell death. Science 1995; 270:96-9.
18. Pritchard DM, Potten CS, Korsmeyer SJ, Roberts S, Hickman JA. Damage-induced apoptosis in intestinal epithelia from bcl-2-null and bax-null mice: investigations of the mechanistic determinants of epithelial apoptosis in vivo. Oncogene 1999; 18:7287-93. (Pubitemid 30032108)
19. Chong MJ, Murray MR, Gosink EC, et al. Atm and Bax cooperate in ionizing radiation- induced apoptosis in the central nervous system. Proc Natl Acad Sci USA 2000; 97:889-94. (Pubitemid 30070405)
20. McCurrach ME, Connor TM, Knudson CM, Korsmeyer SJ, Lowe SW. bax-deficiency promotes drug resistance and oncogenic transformation by attenuating p53-dependent apoptosis. Proc Natl Acad Sci USA 1997; 94:2345-9. (Pubitemid 27136877)
21. Oda E, Ohki R, Murasawa H, et al. Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis. Science 2000; 288:1053-8. (Pubitemid 30324238)
22. Yu J, Zhang L, Hwang PM, Kinzler KW, Vogelstein B. PUMA induces the rapid apoptosis of colorectal cancer cells. Mol Cell 2001; 7:673-82. (Pubitemid 32706358)
23. Nakano K, Vousden KH. PUMA, a novel proapoptotic gene, is induced by p53. Mol Cell 2001; 7:683-94. (Pubitemid 32706359)
24. Sax JK, Fei P, Murphy ME, Bernhard E, Korsmeyer SJ, El-Deiry WS. BID regulation by p53 contributes to chemosensitivity. Nat Cell Biol 2002; 4:842-9. (Pubitemid 35331358)
25. Lehar SM, Nacht M, Jacks T, Vater CA, Chittenden T, Guild BC. Identification and cloning of EI24, a gene induced by p53 in etoposide-treated cells. Oncogene 1996; 12:1181-7. (Pubitemid 26127248)
26. Polyak K, Xia Y, Zweier JL, Kinzler KW, Vogelstein B. A model for p53-induced apoptosis. Nature 1997; 389:300-5. (Pubitemid 27406646)
27. Gu Z, Flemington C, Chittenden T, Zambetti GP. ei24, a p53 response gene involved in growth suppression and apoptosis. Mol Cell Biol 2000; 20:233-41. (Pubitemid 30002565)
28. Owen-Schaub LB, Zhang W, Cusack JC, et al. Wild-type human p53 and a temperature- sensitive mutant induce Fas/APO-1 expression. Mol Cell Biol 1995; 15:3032-40.
29. Bennett M, Macdonald K, Chan SW, Luzio JP, Simari R, Weissberg P. Cell surface trafficking of Fas: a rapid mechanism of p53-mediated apoptosis. Science 1998; 282:290-3. (Pubitemid 28487200)
30. Fuchs EJ, McKenna KA, Bedi A. p53-dependent DNA damage-induced apoptosis requires Fas/APO-1-independent activation of CPP32beta. Cancer Res 1997; 57:2550-4. (Pubitemid 27283754)
31. Embree-Ku M, Venturini D, Boekelheide K. Fas is involved in the p53-dependent apoptotic response to ionizing radiation in mouse testis. Biol Reprod 2002; 66:1456-61. (Pubitemid 34462290)
32. Wu GS, Burns TF, McDonald ER, 3rd, et al. KILLER/DR5 is a DNA damage-inducible p53-regulated death receptor gene. Nat Genet 1997; 17:141-3.
33. Li H, Zhu H, Xu CJ, Yuan J. Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis. Cell 1998; 94:491-501. (Pubitemid 28391865)
34. Hakem R, Hakem A, Duncan GS, et al. Differential requirement for caspase 9 in apoptotic pathways in vivo. Cell 1998; 94:339-52. (Pubitemid 28376078)
35. Varfolomeev EE, Schuchmann M, Luria V, et al. Targeted disruption of the mouse Caspase 8 gene ablates cell death induction by the TNF receptors, Fas/Apo1, and DR3 and is lethal prenatally. Immunity 1998; 9:267-76. (Pubitemid 28400040)
36. Burns TF, Bernhard EJ, El-Deiry WS. Tissue specific expression of p53 target genes suggests a key role for KILLER/DR5 in p53-dependent apoptosis in vivo. Oncogene 2001; 20:4601-12. (Pubitemid 32762432)
37. Wang Y, Ramqvist T, Szekely L, Axelson H, Klein G, Wiman KG. Reconstitution of wild-type p53 expression triggers apoptosis in a p53-negative v-myc retrovirus-induced T-cell lymphoma line. Cell Growth Differ 1993; 4:467-73.
38. Takimoto R, MacLachlan TK, Dicker DT, Niitsu Y, Mori T, el-Deiry WS. BRCA1 transcriptionally regulates damaged DNA binding protein (DDB2) in the DNA repair response following UV-irradiation. Cancer Biol Ther 2002; 1:177-86.
39. Wu GS, El-Deiry WS. Apoptotic death of tumor cells correlates with chemosensitivity, independent of p53 or bcl-2. Clin Cancer Res 1996; 2:623-33. (Pubitemid 26135334)
40. Lockhart DJ, Dong H, Byrne MC, et al. Expression monitoring by hybridization to high-density oligonucleotide arrays. Nat Biotechnol 1996; 14:1675-80. (Pubitemid 26414810)
41. Wodicka L, Dong H, Mittmann M, Ho MH, Lockhart DJ. Genome-wide expression monitoring in Saccharomyces cerevisiae. Nat Biotechnol 1997; 15:1359-67. (Pubitemid 28022729)
42. Midgley CA, Owens B, Briscoe CV, Thomas DB, Lane DP, Hall PA. Coupling between gamma irradiation, p53 induction and the apoptotic response depends upon cell type in vivo. J Cell Sci 1995; 108 ( Pt 5):1843-8.
43. Vogelstein B, Lane D, Levine AJ. Surfing the p53 network. Nature 2000; 408:307-10.
44. Wu GS, Saftig P, Peters C, El-Deiry WS. Potential role for cathepsin D in p53-dependent tumor suppression and chemosensitivity. Oncogene 1998; 16:2177-83. (Pubitemid 28220647)
45. Luster AD. Chemokines - chemotactic cytokines that mediate inflammation. N Engl J Med 1998; 338:436-45. (Pubitemid 28135672)
46. Taub DD, Conlon K, Lloyd AR, Oppenheim JJ, Kelvin DJ. Preferential migration of activated CD4+ and CD8+ T cells in response to MIP-1 alpha and MIP-1 beta. Science 1993; 260:355-8. (Pubitemid 23160144)
47. Foti M, Granucci F, Aggujaro D, et al. Upon dendritic cell (DC) activation chemokines and chemokine receptor expression are rapidly regulated for recruitment and maintenance of DC at the inflammatory site. Int Immunol 1999; 11:979-86. (Pubitemid 29276610)
48. van Deventer HW, Serody JS, McKinnon KP, Clements C, Brickey WJ, Ting JP. Transfection of macrophage inflammatory protein 1 alpha into B16 F10 melanoma cells inhibits growth of pulmonary metastases but not subcutaneous tumors. J Immunol 2002; 169:1634-9. (Pubitemid 34809213)
49. Sutton MD, Walker GC. Managing DNA polymerases: coordinating DNA replication, DNA repair, and DNA recombination. Proc Natl Acad Sci USA 2001; 98:8342-9.
50. Velasco-Miguel S, Richardson JA, Gerlach VL, et al. Constitutive and regulated expression of the mouse Dinb (Polkappa) gene encoding DNA polymerase kappa. DNA Repair (Amst) 2003; 2:91-106. (Pubitemid 35435441)
51. O'Connor L, Strasser A, O' ;. kmReilly LA, et al. Bim: a novel member of the Bcl-2 family that promotes apoptosis. EMBO J 1998; 17:384-95.
52. Puthalakath H, Huang DC, O'Reilly LA, King SM, Strasser A. The proapoptotic activity of the Bcl-2 family member Bim is regulated by interaction with the dynein motor complex. Mol Cell 1999; 3:287-96. (Pubitemid 29290669)
53. Bouillet P, Purton JF, Godfrey DI, et al. BH3-only Bcl-2 family member Bim is required for apoptosis of autoreactive thymocytes. Nature 2002; 415:922-6. (Pubitemid 34174755)
54. Bouillet P, Metcalf D, Huang DC, et al. Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity. Science 1999; 286:1735-8. (Pubitemid 129515880)
55. Baldwin AS. Control of oncogenesis and cancer therapy resistance by the transcription factor NF-kappaB. J Clin Invest 2001; 107:241-6. (Pubitemid 32157954)
56. McKeithan TW, Takimoto GS, Ohno H, et al. BCL3 rearrangements and t(14;19) in chronic lymphocytic leukemia and other B-cell malignancies: a molecular and cytogenetic study. Genes Chromosomes Cancer 1997; 20:64-72. (Pubitemid 27377101)
57. Doerks T, Strauss M, Brendel M, Bork P. GRAM, a novel domain in glucosyltransferases, myotubularins and other putative membrane-associated proteins. Trends Biochem Sci 2000; 25:483-5.
58. Tao W, Pennica D, Xu L, Kalejta RF, Levine AJ. Wrch-1, a novel member of the Rho gene family that is regulated by Wnt-1. Genes Dev 2001; 15:1796-807. (Pubitemid 32905637)
59. Jimenez GS, Nister M, Stommel JM, et al. A transactivation-deficient mouse model provides insights into Trp53 regulation and function. Nat Genet 2000; 26:37-43.