메뉴 건너뛰기




Volumn 55, Issue 3, 2003, Pages 279-289

Personalised prescribing for asthma - Is pharmacogenetics the answer?

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; ANTIASTHMATIC AGENT; ARACHIDONATE 5 LIPOXYGENASE; BECLOMETASONE; BETA 2 ADRENERGIC RECEPTOR; BETA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; CHOLINERGIC RECEPTOR BLOCKING AGENT; CYTOCHROME P450; DEXAMETHASONE; FENOTEROL; GLUCOCORTICOID; GLUCOCORTICOID RECEPTOR; IPRATROPIUM BROMIDE; LEUKOTRIENE C4 SYNTHASE; LEUKOTRIENE RECEPTOR; LEUKOTRIENE RECEPTOR BLOCKING AGENT; METHACHOLINE; MONTELUKAST; MUSCARINIC RECEPTOR; PHOSPHODIESTERASE; PHOSPHODIESTERASE IV INHIBITOR; PRANLUKAST; PREDNISOLONE; SALBUTAMOL; SALMETEROL; STEROID; THEOPHYLLINE DERIVATIVE; UNINDEXED DRUG; ZAFIRLUKAST; ZILEUTON;

EID: 0347925015     PISSN: 00223573     EISSN: None     Source Type: Journal    
DOI: 10.1211/0022357021080     Document Type: Review
Times cited : (17)

References (78)
  • 1
    • 0028881859 scopus 로고
    • Abnormal glucocorticoid receptor-activator protein 1 interaction in steroid-resistant asthma
    • Adcock, I. M., Lane, S. J., Brown, C. R., Lee, T. H., Barnes, P. J. (1995) Abnormal glucocorticoid receptor-activator protein 1 interaction in steroid-resistant asthma. J. Exp. Med. 182: 1951-1958
    • (1995) J. Exp. Med. , vol.182 , pp. 1951-1958
    • Adcock, I.M.1    Lane, S.J.2    Brown, C.R.3    Lee, T.H.4    Barnes, P.J.5
  • 3
    • 0002776555 scopus 로고    scopus 로고
    • The British Guidelines on Asthma Management
    • Anon. (1997) The British Guidelines on Asthma Management. Thorax 52: S1
    • (1997) Thorax , vol.52
  • 5
    • 0021329915 scopus 로고
    • 4 synthetase of rat basophil leukaemia cells: A novel particulate glutathione S-transferase
    • 4 synthetase of rat basophil leukaemia cells: A novel particulate glutathione S-transferase. Arch. Biochem. Biophys. 230: 455-465
    • (1984) Arch. Biochem. Biophys. , vol.230 , pp. 455-465
    • Bach, M.K.1    Brashler, J.R.2    Morton, D.R.3
  • 6
    • 0032825907 scopus 로고    scopus 로고
    • Population distribution and effects on drug metabolism of a genetic variant in the 5′ promoter region of CYP3A4
    • Ball, S. E., Scatina, J., Kao, J. (1999) Population distribution and effects on drug metabolism of a genetic variant in the 5′ promoter region of CYP3A4. Clin. Pharmacol. Ther. 66: 288-294
    • (1999) Clin. Pharmacol. Ther. , vol.66 , pp. 288-294
    • Ball, S.E.1    Scatina, J.2    Kao, J.3
  • 7
    • 0034129679 scopus 로고    scopus 로고
    • Steroid hormone receptors: An update
    • Beato, M., Klug, J. (2000) Steroid hormone receptors: An update. Hum. Reprod. Update 6: 225-236
    • (2000) Hum. Reprod. Update , vol.6 , pp. 225-236
    • Beato, M.1    Klug, J.2
  • 8
    • 0029618368 scopus 로고
    • Steroid hormone receptors: Many actors in search of a plot
    • Beato, M., Herrlich, P., Schutz, G. (1995) Steroid hormone receptors: Many actors in search of a plot. Cell 83: 851-857
    • (1995) Cell , vol.83 , pp. 851-857
    • Beato, M.1    Herrlich, P.2    Schutz, G.3
  • 9
    • 0030665303 scopus 로고    scopus 로고
    • Characterisation of five different proteins produced by alternatively spliced mRNAs from the human cAMP-specific phosphodiesterase PDE4D gene
    • Bolger, G. B., Erdogan, S., Jones, R. E. (1997) Characterisation of five different proteins produced by alternatively spliced mRNAs from the human cAMP-specific phosphodiesterase PDE4D gene. Biochem. J. 328: 539-548
    • (1997) Biochem. J. , vol.328 , pp. 539-548
    • Bolger, G.B.1    Erdogan, S.2    Jones, R.E.3
  • 10
    • 0025810578 scopus 로고
    • A novel arachidonic acid-selective cytosolic phospholipase A2 contains a Ca2+-dependent translocation domain with homology to PKC and GAP
    • Clark, J. D., Lin, L. L., Kriz, R. W. (1991) A novel arachidonic acid-selective cytosolic phospholipase A2 contains a Ca2+-dependent translocation domain with homology to PKC and GAP. Cell 65: 1043-1051
    • (1991) Cell , vol.65 , pp. 1043-1051
    • Clark, J.D.1    Lin, L.L.2    Kriz, R.W.3
  • 11
    • 0032519008 scopus 로고    scopus 로고
    • 4 synthase in bronchial biopsies from patients with aspirin-tolerant asthma
    • 4 synthase in bronchial biopsies from patients with aspirin-tolerant asthma. J. Clin. Invest. 101: 1-13
    • (1998) J. Clin. Invest. , vol.101 , pp. 1-13
    • Cowburn, A.S.1    Sladek, K.2    Soja, J.3
  • 12
    • 0032437084 scopus 로고    scopus 로고
    • Recent advances in understanding the molecular basis of polymorphisms in genes encoding cytochrome P450 enzymes
    • Daly, A. K., Fairbrother, K. S., Smart, J. (1998) Recent advances in understanding the molecular basis of polymorphisms in genes encoding cytochrome P450 enzymes. Toxicol. Lett. 102-103: 143-147
    • (1998) Toxicol. Lett. , vol.102-103 , pp. 143-147
    • Daly, A.K.1    Fairbrother, K.S.2    Smart, J.3
  • 14
    • 0031596478 scopus 로고    scopus 로고
    • Beta2-adrenoceptor polymorphisms are in linkage disequilibrium, but are not associated with asthma in an adult population
    • Dewar, J. C., Wheatley, A. P., Venn, A., Morrison, J. F., Britton, J., Hall, J. P. (1998) Beta2-adrenoceptor polymorphisms are in linkage disequilibrium, but are not associated with asthma in an adult population. Clin. Exp. Allergy 28: 442-448
    • (1998) Clin. Exp. Allergy , vol.28 , pp. 442-448
    • Dewar, J.C.1    Wheatley, A.P.2    Venn, A.3    Morrison, J.F.4    Britton, J.5    Hall, J.P.6
  • 15
    • 0025022489 scopus 로고
    • Requirement of a 5-lipoxygenase-activating protein for leukotriene synthesis
    • Dixon, R. A., Diehl, R. E., Opas, E. (1990) Requirement of a 5-lipoxygenase-activating protein for leukotriene synthesis. Nature 343: 282-284
    • (1990) Nature , vol.343 , pp. 282-284
    • Dixon, R.A.1    Diehl, R.E.2    Opas, E.3
  • 16
    • 0002976110 scopus 로고
    • Leukotrienes in asthma and rhinitis
    • In: Busse, W., Holgate, S. T. (eds); Blackford Scientific Publications, Oxford
    • Drazen, J. M. (1995) Leukotrienes in asthma and rhinitis. In: Busse, W., Holgate, S. T. (eds) Asthma and Rhinitis. Blackford Scientific Publications, Oxford, pp 838-850
    • (1995) Asthma and Rhinitis , pp. 838-850
    • Drazen, J.M.1
  • 18
    • 0033059209 scopus 로고    scopus 로고
    • Pharmacogenetic association between ALOX-5 promoter genotype and the response to anti-asthma treatment
    • Drazen, J. M., Yandava, C. N., Dube, L. (1999) Pharmacogenetic association between ALOX-5 promoter genotype and the response to anti-asthma treatment. Nat. Genet. 22: 185-190
    • (1999) Nat. Genet. , vol.22 , pp. 185-190
    • Drazen, J.M.1    Yandava, C.N.2    Dube, L.3
  • 19
    • 0034443957 scopus 로고    scopus 로고
    • Heterogeneity of therapeutic responses in asthma
    • Drazen, J. M., Silverman, E. K., Lee, T. H. (2000) Heterogeneity of therapeutic responses in asthma. Br. Med. Bull. 56: 1054-1070
    • (2000) Br. Med. Bull. , vol.56 , pp. 1054-1070
    • Drazen, J.M.1    Silverman, E.K.2    Lee, T.H.3
  • 24
    • 0027519404 scopus 로고
    • A polymorphism of the human beta2-adrenergic receptor within the fourth transmembrane domain alters ligand binding and functional properties of the receptor
    • Green, S. A., Cole, G., Jacinto, M., Innis, M., Liggett, S. B. (1993) A polymorphism of the human beta2-adrenergic receptor within the fourth transmembrane domain alters ligand binding and functional properties of the receptor. J. Biol. Chem. 268: 23116-23121
    • (1993) J. Biol. Chem. , vol.268 , pp. 23116-23121
    • Green, S.A.1    Cole, G.2    Jacinto, M.3    Innis, M.4    Liggett, S.B.5
  • 25
    • 0028068550 scopus 로고
    • 2 adrenergic receptor impart distinct agonist-promoted regulatory properties
    • 2 adrenergic receptor impart distinct agonist-promoted regulatory properties. Biochemistry 33: 9414-9419
    • (1994) Biochemistry , vol.33 , pp. 9414-9419
    • Green, S.A.1    Turki, J.2    Innis, M.3    Liggett, S.B.4
  • 26
    • 0029045292 scopus 로고
    • 2 adrenoceptor polymorphism with lower airway reactivity in asthmatic subjects
    • 2 adrenoceptor polymorphism with lower airway reactivity in asthmatic subjects. Lancet 345: 1213-1214
    • (1995) Lancet , vol.345 , pp. 1213-1214
    • Hall, I.P.1    Wheatley, A.2    Wilding, P.3    Liggett, S.B.4
  • 27
    • 0031597001 scopus 로고    scopus 로고
    • Polymorphism of the beta (2)-adrenoceptor and the response to long term beta (2) agonist therapy in asthma
    • Hancox, R. J., Sears, M. R., Taylor, D. R. (1998) Polymorphism of the beta (2)-adrenoceptor and the response to long term beta (2) agonist therapy in asthma. Eur. Respir. J. 11: 589-593
    • (1998) Eur. Respir. J. , vol.11 , pp. 589-593
    • Hancox, R.J.1    Sears, M.R.2    Taylor, D.R.3
  • 28
    • 0034730638 scopus 로고    scopus 로고
    • Characterisation of the human cysteinyl leukotriene 2 receptor
    • Heise, C. E., O'Dowd, B. F., Figeuroa, D. J. (2000) Characterisation of the human cysteinyl leukotriene 2 receptor. J. Biol. Chem. 275: 30531-30536
    • (2000) J. Biol. Chem. , vol.275 , pp. 30531-30536
    • Heise, C.E.1    O'Dowd, B.F.2    Figeuroa, D.J.3
  • 30
    • 15144360854 scopus 로고    scopus 로고
    • A polymorphism in the glucocorticoid receptor gene may be associated with an increased sensitivity to glucocorticoids in vivo
    • Huizenga, N. A., Koper, J. W., De Lange, P. (1998) A polymorphism in the glucocorticoid receptor gene may be associated with an increased sensitivity to glucocorticoids in vivo. J. Clin. Endocrinol. Metab. 83: 144-151
    • (1998) J. Clin. Endocrinol. Metab. , vol.83 , pp. 144-151
    • Huizenga, N.A.1    Koper, J.W.2    De Lange, P.3
  • 31
    • 0026026319 scopus 로고
    • Point mutation causing a single amino acid substitution in the hormone binding domain of the glucocorticoid receptor in familial glucocorticoid resistance
    • Hurley, D. M., Accili, D., Stratakis, C. A. (1991) Point mutation causing a single amino acid substitution in the hormone binding domain of the glucocorticoid receptor in familial glucocorticoid resistance. J. Clin. Invest. 87: 680-686
    • (1991) J. Clin. Invest. , vol.87 , pp. 680-686
    • Hurley, D.M.1    Accili, D.2    Stratakis, C.A.3
  • 32
    • 0034041373 scopus 로고    scopus 로고
    • Catalytic activity of three variants (Ile, Leu, and Thr) at amino acid residue 359 in human CYP2C9 gene and simultaneous detection using single strand conformational polymorphism analysis
    • Ieri, I., Tainaka, H., Morita, T. (2000) Catalytic activity of three variants (Ile, Leu, and Thr) at amino acid residue 359 in human CYP2C9 gene and simultaneous detection using single strand conformational polymorphism analysis. Ther. Drug Monit. 22: 237-244
    • (2000) Ther. Drug Monit. , vol.22 , pp. 237-244
    • Ieri, I.1    Tainaka, H.2    Morita, T.3
  • 33
    • 0031003816 scopus 로고    scopus 로고
    • Naturally-occurring mutations in the human 5-lipoxygenase gene promoter that modify transcription factor binding and reporter gene transcription
    • In, K. H., Asano, K., Beier, D., Grobholz, J. (1997) Naturally-occurring mutations in the human 5-lipoxygenase gene promoter that modify transcription factor binding and reporter gene transcription. J. Clin. Invest. 99: 1130-1137
    • (1997) J. Clin. Invest. , vol.99 , pp. 1130-1137
    • In, K.H.1    Asano, K.2    Beier, D.3    Grobholz, J.4
  • 34
    • 0032793249 scopus 로고    scopus 로고
    • Polymorphic human cytochrome P450 enzymes: An opportunity for individualised drug treatment
    • Ingelman-Sundberg, M., Oscarson, M., McLellan, R. A. (1999) Polymorphic human cytochrome P450 enzymes: An opportunity for individualised drug treatment. Trends Pharmacol. Sci. 20: 342-349
    • (1999) Trends Pharmacol. Sci. , vol.20 , pp. 342-349
    • Ingelman-Sundberg, M.1    Oscarson, M.2    McLellan, R.A.3
  • 36
    • 0037173056 scopus 로고    scopus 로고
    • A molecular mechanism of action of theophylline: Induction of histone deacetylase activity to decrease inflammatory gene expression
    • Ito, K., Lim, S., Caramori, G., Cosio, B., Chung, K. F., Adcock, I. M., Barnes P.J. (2002) A molecular mechanism of action of theophylline: Induction of histone deacetylase activity to decrease inflammatory gene expression. Proc. Natl. Acad. Sci. USA 99: 8921-8926
    • (2002) Proc. Natl. Acad. Sci. USA , vol.99 , pp. 8921-8926
    • Ito, K.1    Lim, S.2    Caramori, G.3    Cosio, B.4    Chung, K.F.5    Adcock, I.M.6    Barnes, P.J.7
  • 37
    • 0033594963 scopus 로고    scopus 로고
    • Identification of human prostaglandin E synthase: A microsomal, glutathione dependent, inducible enzyme, constituting a potential novel drug treatment
    • Jakobsson, P. J., Thoren, S., Morgenstern, R. (1999) Identification of human prostaglandin E synthase: A microsomal, glutathione dependent, inducible enzyme, constituting a potential novel drug treatment. Proc. Natl Acad. Sci. USA 96: 7220-7225
    • (1999) Proc. Natl Acad. Sci. USA , vol.96 , pp. 7220-7225
    • Jakobsson, P.J.1    Thoren, S.2    Morgenstern, R.3
  • 39
    • 0347611670 scopus 로고
    • Budesonide is metabolised by cytochrome P450 3A (CYP3A) enzymes in human liver
    • Johnsson, G., Astrom, A., Anderson, P. (1995) Budesonide is metabolised by cytochrome P450 3A (CYP3A) enzymes in human liver. Drug Metab. Dispos. 50: 205-211
    • (1995) Drug Metab. Dispos. , vol.50 , pp. 205-211
    • Johnsson, G.1    Astrom, A.2    Anderson, P.3
  • 40
    • 0031840217 scopus 로고    scopus 로고
    • Genetic polymorphism of cytochrome p450s, CYP2C19, and CYP2C9 in a Japanese population
    • Kimura, M., Ieiri, I., Mamiya, K., Urae, A., Higuchi, S. (1998) Genetic polymorphism of cytochrome p450s, CYP2C19, and CYP2C9 in a Japanese population. Ther. Drug Monit. 20: 243-247
    • (1998) Ther. Drug Monit. , vol.20 , pp. 243-247
    • Kimura, M.1    Ieiri, I.2    Mamiya, K.3    Urae, A.4    Higuchi, S.5
  • 41
    • 0030943735 scopus 로고    scopus 로고
    • Lack of association between five polymorphisms in the human glucocorticoid receptor gene and glucocorticoid resistance
    • Koper, J. W., Stolk, R. P., De Lange, P., Huizenga, N. (1997) Lack of association between five polymorphisms in the human glucocorticoid receptor gene and glucocorticoid resistance. Hum. Genet. 99: 663-668
    • (1997) Hum. Genet , vol.99 , pp. 663-668
    • Koper, J.W.1    Stolk, R.P.2    De Lange, P.3    Huizenga, N.4
  • 42
    • 0025854165 scopus 로고
    • Glucocorticoid receptor characteristics in monocytes of patients with corticosteroid resistant bronchial asthma
    • Lane, S. J., Lee T. H. (1991) Glucocorticoid receptor characteristics in monocytes of patients with corticosteroid resistant bronchial asthma. Am. Rev. Respir. Dis. 143: 1020-1024
    • (1991) Am. Rev. Respir. Dis. , vol.143 , pp. 1020-1024
    • Lane, S.J.1    Lee, T.H.2
  • 43
    • 0028472787 scopus 로고
    • Chemical mutational analysis of the human glucocorticoid receptor cDNA in glucocorticoid resistant bronchial asthma
    • Lane, S. J., Arm, J. P., Staynov, D. Z., Lee, T. H. (1994) Chemical mutational analysis of the human glucocorticoid receptor cDNA in glucocorticoid resistant bronchial asthma. Hum. Genet. 11: 42-48
    • (1994) Hum. Genet. , vol.11 , pp. 42-48
    • Lane, S.J.1    Arm, J.P.2    Staynov, D.Z.3    Lee, T.H.4
  • 44
    • 0030048947 scopus 로고    scopus 로고
    • Hypothalamic-pituitary-adrenal axis in corticosteroid resistant bronchial asthma
    • Lane, S. J., Atkinson, B. A., Swaminathan, R., Lee T. H. (1996) Hypothalamic-pituitary-adrenal axis in corticosteroid resistant bronchial asthma. Am. J. Crit. Care Med. 153: 557-560
    • (1996) Am. J. Crit. Care Med. , vol.153 , pp. 557-560
    • Lane, S.J.1    Atkinson, B.A.2    Swaminathan, R.3    Lee, T.H.4
  • 45
    • 0032535369 scopus 로고    scopus 로고
    • Corticosteroid-resistant bronchial asthma is associated with increased c-fos expression in monocytes and T lymphocytes
    • Lane, S. J., Adcock, I. M., Richards, D., Hawrylowicz, C., Barnes, P. J., Lee, T. H. (1998) Corticosteroid-resistant bronchial asthma is associated with increased c-fos expression in monocytes and T lymphocytes. J. Clin. Invest. 102: 2156-2164
    • (1998) J. Clin. Invest. , vol.102 , pp. 2156-2164
    • Lane, S.J.1    Adcock, I.M.2    Richards, D.3    Hawrylowicz, C.4    Barnes, P.J.5    Lee, T.H.6
  • 46
    • 0020646863 scopus 로고
    • 4 by a dipeptidase released from the specific granules of human polymorphonuclear leucocytes
    • 4 by a dipeptidase released from the specific granules of human polymorphonuclear leucocytes. Immunology 48: 27-35
    • (1983) Immunology , vol.48 , pp. 27-35
    • Lee, C.W.1    Lewis, R.A.2    Corey, E.J.3    Austen, K.F.4
  • 47
    • 0027245726 scopus 로고
    • Pharmacology and molecular biology of adrenergic receptors
    • In: Bouloux, P. M. (ed.); Saunders, London
    • Liggett, S. B., Raymond, J. (1993) Pharmacology and molecular biology of adrenergic receptors. Catecholamines, Balliere's Clinical Endocrinology and Metabolism. 7 Edition, In: Bouloux, P. M. (ed.) Catecholamines, Balliere's Clinical Endocrinology and Metabolism. 7 Edition, Saunders, London, pp 279-306
    • (1993) Catecholamines, Balliere's Clinical Endocrinology and Metabolism. 7 Edition , pp. 279-306
    • Liggett, S.B.1    Raymond, J.2
  • 48
    • 0002779276 scopus 로고    scopus 로고
    • 2 adrenergic receptor: Focus on interactions of agonist with receptor
    • In: Pauwels, R., Lofdahl, C. G., O'Byrne, P. (eds); Marcel Dekker, New York
    • 2 Agonists in Asthma Treatment. Marcel Dekker, New York, pp 19-34
    • (1996) 2 Agonists in Asthma Treatment , pp. 19-34
    • Liggett, S.B.1    Green, S.A.2
  • 49
    • 0033059182 scopus 로고    scopus 로고
    • 2 adrenoceptor polymorphism and bronchoprotective sensitivity with regular short and long acting beta2 agonist therapy
    • 2 adrenoceptor polymorphism and bronchoprotective sensitivity with regular short and long acting beta2 agonist therapy. Clin. Sci. 96: 253-259
    • (1999) Clin. Sci. , vol.96 , pp. 253-259
    • Lipworth, B.1    Hall, I.P.2    Aziz, I.3    Tan, K.S.4    Wheatley, A.5
  • 51
    • 0033600291 scopus 로고    scopus 로고
    • Characterisation of the human cysteinyl leukotriene Cys LT1 receptor
    • Lynch, K. R., O'Neill, G. P., Liu, Q. (1999) Characterisation of the human cysteinyl leukotriene Cys LT1 receptor. Nature 399: 789-793
    • (1999) Nature , vol.399 , pp. 789-793
    • Lynch, K.R.1    O'Neill, G.P.2    Liu, Q.3
  • 52
    • 0027217319 scopus 로고
    • A mutation of the glucocorticoid receptor in primary cortisol resistance
    • Malchoff, D. M., Brufsky, A., Reardon G (1993) A mutation of the glucocorticoid receptor in primary cortisol resistance. J. Clin. Invest. 91: 1981-1925
    • (1993) J. Clin. Invest. , vol.91 , pp. 1981-1925
    • Malchoff, D.M.1    Brufsky, A.2    Reardon, G.3
  • 53
    • 0029960236 scopus 로고    scopus 로고
    • The aliphatic oxidation of salmeterol to alpha-hydroxysalmeterol in human liver microsome is catalysed by CYP3A
    • Manchee, G. R., Eddershaw, P. J., Ranshaw, L. E. (1996) The aliphatic oxidation of salmeterol to alpha-hydroxysalmeterol in human liver microsome is catalysed by CYP3A. Drug Metab. Dispos. 24: 555-559
    • (1996) Drug Metab. Dispos. , vol.24 , pp. 555-559
    • Manchee, G.R.1    Eddershaw, P.J.2    Ranshaw, L.E.3
  • 54
    • 0031466866 scopus 로고    scopus 로고
    • Genetic polymorphisms of the beta2 adrenoceptor and response to albuterol in children with and without a history of wheezing
    • Martinez, F. D., Graves, P. E., Baldini, M., Solomon, S., Erickson, R. (1997) Genetic polymorphisms of the beta2 adrenoceptor and response to albuterol in children with and without a history of wheezing. J. Clin. Invest. 100: 3184-3188
    • (1997) J. Clin. Invest. , vol.100 , pp. 3184-3188
    • Martinez, F.D.1    Graves, P.E.2    Baldini, M.3    Solomon, S.4    Erickson, R.5
  • 57
    • 0028336794 scopus 로고
    • Phenotyping of CYP1A2 in Japanese population by analysis of caffeine urinary metabolites: Absence of mutation prescribing in the phenotype in the CYP1A2 gene
    • Nakajima, M., Yokoi, T., Mizutani, M., Shin, S., Kadlubar, F.F., Kamataki, T. (1994) Phenotyping of CYP1A2 in Japanese population by analysis of caffeine urinary metabolites: Absence of mutation prescribing in the phenotype in the CYP1A2 gene. Cancer Epidemiol. Biomarkers Prev. 3: 413-421
    • (1994) Cancer Epidemiol. Biomarkers Prev. , vol.3 , pp. 413-421
    • Nakajima, M.1    Yokoi, T.2    Mizutani, M.3    Shin, S.4    Kadlubar, F.F.5    Kamataki, T.6
  • 58
    • 0035496056 scopus 로고    scopus 로고
    • Linkages and associations to intermediate phenotypes underlying asthma and allergic disease
    • Palmer, L. J. (2001) Linkages and associations to intermediate phenotypes underlying asthma and allergic disease. Curr. Opin. Allergy Clin. Immunol. 1: 393-398
    • (2001) Curr. Opin. Allergy Clin. Immunol. , vol.1 , pp. 393-398
    • Palmer, L.J.1
  • 59
    • 0024324831 scopus 로고
    • Leukotrienes and the airways
    • Piper, P. J. (1989) Leukotrienes and the airways. Eur. J. Anaesthesiol. 6: 241-255
    • (1989) Eur. J. Anaesthesiol. , vol.6 , pp. 241-255
    • Piper, P.J.1
  • 61
    • 0034845924 scopus 로고    scopus 로고
    • Characterisation of two novel mutations in the glucocorticoid receptor gene in patients with primary cortisol resistance
    • Ruiz, M., Lind, U., Gavfels, M., Eggerston, G. (2001) Characterisation of two novel mutations in the glucocorticoid receptor gene in patients with primary cortisol resistance. Clin. Endocrinol. 55: 363-371
    • (2001) Clin. Endocrinol. , vol.55 , pp. 363-371
    • Ruiz, M.1    Lind, U.2    Gavfels, M.3    Eggerston, G.4
  • 62
    • 0032908778 scopus 로고    scopus 로고
    • Functional significance of a C → A polymorphism in intron 1 of the cytochrome P450 CYP1A2 gene tested with caffeine
    • Sachse, C., Brockmoller, J., Bauer, S., Roots, I. (1999) Functional significance of a C → A polymorphism in intron 1 of the cytochrome P450 CYP1A2 gene tested with caffeine. Br. J. Clin. Pharmacol. 47: 445-449
    • (1999) Br. J. Clin. Pharmacol. , vol.47 , pp. 445-449
    • Sachse, C.1    Brockmoller, J.2    Bauer, S.3    Roots, I.4
  • 64
    • 0020597565 scopus 로고
    • Leukotrienes: Mediators of immediate hypersensitivity reactions and inflammation
    • Samuelsson, B. (1983) Leukotrienes: Mediators of immediate hypersensitivity reactions and inflammation. Science 220: 568-575
    • (1983) Science , vol.220 , pp. 568-575
    • Samuelsson, B.1
  • 65
    • 0031590522 scopus 로고    scopus 로고
    • 4 synthase promoter polymorphism and risk of aspirin induced asthma
    • 4 synthase promoter polymorphism and risk of aspirin induced asthma. Lancet 350: 1599-1600
    • (1997) Lancet , vol.350 , pp. 1599-1600
    • Sanak, M.1    Simon, H.-U.2    Szczeklik, A.3
  • 67
    • 0029165312 scopus 로고
    • PDE isoforms as targets for anti-asthma drugs
    • Schudt, C., Tenor, H., Hatzelman, A. (1995) PDE isoforms as targets for anti-asthma drugs. Eur. Respir. J. 8: 1179-1183
    • (1995) Eur. Respir. J. , vol.8 , pp. 1179-1183
    • Schudt, C.1    Tenor, H.2    Hatzelman, A.3
  • 68
    • 0032911765 scopus 로고    scopus 로고
    • Identification of novel polymorphisms within the promoter region of the human beta-2-adrenergic receptor gene
    • Scott, M. G., Swan, C., Wheatley, A. P., Hall, I. P. (1999) Identification of novel polymorphisms within the promoter region of the human beta-2-adrenergic receptor gene. Br. J. Pharmacol. 126: 841-844
    • (1999) Br. J. Pharmacol. , vol.126 , pp. 841-844
    • Scott, M.G.1    Swan, C.2    Wheatley, A.P.3    Hall, I.P.4
  • 69
    • 0031766873 scopus 로고    scopus 로고
    • Pharmacogenetics of the 5-lipoxygenase pathway in asthma
    • Silverman, E., In, K. H., Yandava, C., Drazen, J. M. (1998) Pharmacogenetics of the 5-lipoxygenase pathway in asthma. Clin. Exp. Allergy 28: 164-170
    • (1998) Clin. Exp. Allergy , vol.28 , pp. 164-170
    • Silverman, E.1    In, K.H.2    Yandava, C.3    Drazen, J.M.4
  • 70
    • 0030811225 scopus 로고    scopus 로고
    • Glucocorticoid resistant asthma: Pathogenesis and clinical implications for management
    • Szefler, S. J., Leung, D.Y. (1997) Glucocorticoid resistant asthma: Pathogenesis and clinical implications for management Eur. Respir. J. 10: 1640-1647
    • (1997) Eur. Respir. J. , vol.10 , pp. 1640-1647
    • Szefler, S.J.1    Leung, D.Y.2
  • 71
    • 0030860288 scopus 로고    scopus 로고
    • Association between beta 2-adrenoceptor polymorphism and susceptibility to bronchodilator desensitisation in asthmatics
    • Tan, S., Hall, I. P., Dewar, J., Dow, E., Lipworth, B. (1997) Association between beta 2-adrenoceptor polymorphism and susceptibility to bronchodilator desensitisation in asthmatics. Lancet 350: 995-999
    • (1997) Lancet , vol.350 , pp. 995-999
    • Tan, S.1    Hall, I.P.2    Dewar, J.3    Dow, E.4    Lipworth, B.5
  • 73
    • 0032565364 scopus 로고    scopus 로고
    • Worldwide variation in the prevalence of symptoms of asthma, allergic rhino-conjunctivitis, atopic eczema: ISAAC
    • The International Study of Asthma and Allergies in Childhood (ISAAC) Steering Committee (1998) Worldwide variation in the prevalence of symptoms of asthma, allergic rhino-conjunctivitis, atopic eczema: ISAAC. Lancet 351: 1225-1232
    • (1998) Lancet , vol.351 , pp. 1225-1232
  • 74
    • 0028987632 scopus 로고
    • 2 adrenergic receptor in nocturnal and non-nocturnal asthma: Evidence that Gly 16 correlates with the nocturnal phenotype
    • 2 adrenergic receptor in nocturnal and non-nocturnal asthma: Evidence that Gly 16 correlates with the nocturnal phenotype. J. Clin. Invest. 95: 1635-1641
    • (1995) J. Clin. Invest. , vol.95 , pp. 1635-1641
    • Turki, J.1    Pak, J.2    Green, S.3    Martin, R.4    Liggett, S.B.5
  • 75
    • 17044446216 scopus 로고    scopus 로고
    • Novel single nucleotide polymorphisms (SNPs) at positions 497 (T/G)Q and 829 (T/C) in the human c-fos gene and haplotype association
    • Umino, Y., Hohjoh, H., Tokunaga, K. (2000) Novel single nucleotide polymorphisms (SNPs) at positions 497 (T/G)Q and 829 (T/C) in the human c-fos gene and haplotype association. Hum. Mutat. 16: 279
    • (2000) Hum. Mutat. , vol.16 , pp. 279
    • Umino, Y.1    Hohjoh, H.2    Tokunaga, K.3
  • 77
    • 0033861614 scopus 로고    scopus 로고
    • CYP3A activity in African American and European American men: Population differences and functional effect of the CYP3A4 1B4 1B5′-promoter region polymorphism
    • Wandel, C., Witte, J. S., Hall, J. M., Stein, C. M., Wood, A. J., Wilkinson, G. R. (2000) CYP3A activity in African American and European American men: Population differences and functional effect of the CYP3A4 1B4 1B5′-promoter region polymorphism. Clin. Pharmacol. Ther. 68: 82-91
    • (2000) Clin. Pharmacol. Ther. , vol.68 , pp. 82-91
    • Wandel, C.1    Witte, J.S.2    Hall, J.M.3    Stein, C.M.4    Wood, A.J.5    Wilkinson, G.R.6
  • 78
    • 0029018483 scopus 로고
    • Characterisation of the human cytochromes p450 involved in theophylline 8-hydroxylation
    • Zhang, Z. Y., Kaminsky, L. S. (1995) Characterisation of the human cytochromes p450 involved in theophylline 8-hydroxylation. Biochem. Pharmacol. 50: 205-211
    • (1995) Biochem. Pharmacol. , vol.50 , pp. 205-211
    • Zhang, Z.Y.1    Kaminsky, L.S.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.