Leukotriene C4 synthase promoter polymorphism and risk of aspirin-induced asthma

Lancet

Volumn 350, Issue 9091, 1997, Pages 1599-1600

  Sanak, M ^a   Simon, H U ^a   Szczeklik, A ^a  

^a JAGIELLONIAN UNIVERSITY MEDICAL COLLEGE   (Poland)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; LEUKOTRIENE C4; SYNTHETASE; GLUTATHIONE TRANSFERASE; LEUKOTRIENE C4 SYNTHASE; LEUKOTRIENE-C4 SYNTHASE; NONSTEROID ANTIINFLAMMATORY AGENT;

ARTICLE; ASTHMA; DRUG TOLERANCE; GENETIC POLYMORPHISM; HUMAN; PHARMACOGENETICS; PRIORITY JOURNAL; PROMOTER REGION; ADULT; CHEMICALLY INDUCED DISORDER; COMPARATIVE STUDY; GENETICS; LETTER; MALE; MIDDLE AGED;

ADULT; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ASPIRIN; ASTHMA; GLUTATHIONE TRANSFERASE; HUMANS; MALE; MIDDLE AGED; POLYMORPHISM, GENETIC;

EID: 0031590522     PISSN: 01406736     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0140-6736(05)64015-9     Document Type: Article

References (5)

1. Szczeklik A. Mechanism of aspirin-induced asthma. Allergy 1997; 52: 613-19.
2. Szczeklik A, Sladek K, Dworski R, et al. Bronchial aspirin challenge causes specific eicosanoid response in aspirin-sensitive asthmatics. Am J Respir Crit Care Med 1996; 154: 1608-14.
3. Sampson AP, Cowburn AS, Sladek K, et al. Profound overexpression of leukotriene C4 synthase in bronchial biopsies from aspirin intolerant asthmatic patients. Int Arch Allergy Immunol 1997; 113: 355-57.
4. Penrose JF, Spector J, Baldasano M, et al. Molecular cloning of the gene for human leukotriene C4 synthase: organisation, nucleotide sequence, and chromosomal localisation to 5q35. J Biol Chem 1996; 271: 11356-61
5. Quand K, French K, Karas H, Wingender E, Werner T. MatInd and MatInspector: new fast and versatile tools for detection of consensus matches in nucleotide sequence data. Nucleic Acids Res 1995; 23: 4878-84.