-
1
-
-
0013118587
-
Platelet signal transduction
-
Colman R W, Hirsh J, Marder V J, Clows A W, George J N, eds. Baltimore, MD: Lippincott Williams & Wilkins
-
Abrams C S, Brass L F. Platelet signal transduction. In: Colman R W, Hirsh J, Marder V J, Clows A W, George J N, eds. Hemostasis and Thrombosis: Basic Principles and Clinical Practice. Baltimore, MD: Lippincott Williams & Wilkins, 2001: 541-59.
-
(2001)
Hemostasis and Thrombosis: Basic Principles and Clinical Practice
, pp. 541-559
-
-
Abrams, C.S.1
Brass, L.F.2
-
2
-
-
0013166880
-
Signal transduction during the initiation, extension and perpetuation of platelet plug formation
-
Michelson A D, ed. New York: Academic Press
-
Woulfe D, Yang J, Prevost N, O'Brien P J, Brass L F. Signal transduction during the initiation, extension and perpetuation of platelet plug formation. In: Michelson A D, ed. Platelets. New York: Academic Press, 2002: 197-214.
-
(2002)
Platelets
, pp. 197-214
-
-
Woulfe, D.1
Yang, J.2
Prevost, N.3
O'Brien, P.J.4
Brass, L.F.5
-
3
-
-
0026061235
-
Human platelet aggregation and shape change are coupled to separate thromboxane A2-prostaglandin H2 receptors
-
Dorn G W 2nd, De Jesus A. Human platelet aggregation and shape change are coupled to separate thromboxane A2-prostaglandin H2 receptors. Am J Physiol 1991; 260: H327-34.
-
(1991)
Am J Physiol
, vol.260
-
-
Dorn II, G.W.1
De Jesus, A.2
-
5
-
-
0029664751
-
Two thromboxane A2 receptor isoforms in human platelets. Opposite coupling to adenylyl cyclase with different sensitivity to Arg60 to Leu mutation
-
Hirata T, Ushikubi F, Kakizuka A, Okuma M, Narumiya S. Two thromboxane A2 receptor isoforms in human platelets. Opposite coupling to adenylyl cyclase with different sensitivity to Arg60 to Leu mutation. J Clin Invest 1996; 97: 949-56.
-
(1996)
J Clin Invest
, vol.97
, pp. 949-956
-
-
Hirata, T.1
Ushikubi, F.2
Kakizuka, A.3
Okuma, M.4
Narumiya, S.5
-
6
-
-
0033613968
-
Phosphorylation of the thromboxane receptor alpha, the predominant isoform expressed in human platelets
-
Habib A, FitzGerald G A, Maclouf J. Phosphorylation of the thromboxane receptor alpha, the predominant isoform expressed in human platelets. J Biol Chem 1999; 274: 2645-51.
-
(1999)
J Biol Chem
, vol.274
, pp. 2645-2651
-
-
Habib, A.1
Fitzgerald, G.A.2
Maclouf, J.3
-
7
-
-
0025880172
-
The G-protein coupled to the thromboxane-A2 receptor in human platelets is a member of the novel Gq family
-
Shenker A, Goldsmith P, Unson C G, Spiegel A M. The G-protein coupled to the thromboxane-A2 receptor in human platelets is a member of the novel Gq family. Journal of Biological Chemistry 1991; 266: 9309-13.
-
(1991)
Journal of Biological Chemistry
, vol.266
, pp. 9309-9313
-
-
Shenker, A.1
Goldsmith, P.2
Unson, C.G.3
Spiegel, A.M.4
-
8
-
-
0028179510
-
G-proteins of the G(12) family are activated via thromboxane a(2) and thrombin receptors in human platelets
-
Offermanns S, Laugwitz K L, Spicher K, Schultz G. G-proteins of the G(12) family are activated via thromboxane a(2) and thrombin receptors in human platelets. Proc Natl Acad Sci USA 1994; 91: 504-8.
-
(1994)
Proc Natl Acad Sci USA
, vol.91
, pp. 504-508
-
-
Offermanns, S.1
Laugwitz, K.L.2
Spicher, K.3
Schultz, G.4
-
9
-
-
0030756508
-
Defective platelet activation in G alpha(q)-deficient mice
-
Offermanns S, Toombs C F, Hu Y H, Simon M I. Defective platelet activation in G alpha(q)-deficient mice. Nature 1997; 389: 183-6.
-
(1997)
Nature
, vol.389
, pp. 183-186
-
-
Offermanns, S.1
Toombs, C.F.2
Hu, Y.H.3
Simon, M.I.4
-
10
-
-
0033593667
-
Activation of G12/G13 results in shape change and Rho/Rhokinase-mediated myosin light chain phosphorylation in mouse platelets
-
Klages B, Brandt U, Simon M I, Schultz G, Offermanns S. Activation of G12/G13 results in shape change and Rho/Rhokinase-mediated myosin light chain phosphorylation in mouse platelets. J Cell Biol 1999; 144: 745-54.
-
(1999)
J Cell Biol
, vol.144
, pp. 745-754
-
-
Klages, B.1
Brandt, U.2
Simon, M.I.3
Schultz, G.4
Offermanns, S.5
-
11
-
-
0033199252
-
Dichotomous regulation of myosin phosphorylation and shape change by Rho-kinase and calcium in intact human platelets
-
Bauer M, Retzer M, Wilde J I, Maschberger P, Essler M, Aepfelbacher M, et al. Dichotomous regulation of myosin phosphorylation and shape change by Rho-kinase and calcium in intact human platelets. Blood 1999; 94: 1665-72.
-
(1999)
Blood
, vol.94
, pp. 1665-1672
-
-
Bauer, M.1
Retzer, M.2
Wilde, J.I.3
Maschberger, P.4
Essler, M.5
Aepfelbacher, M.6
-
12
-
-
0032828089
-
Molecular mechanism of thromboxane A(2)-induced platelet aggregation. Essential role for p2t(ac) and alpha(2a) receptors
-
Paul B Z, Jin J, Kunapuli S P. Molecular mechanism of thromboxane A(2)-induced platelet aggregation. Essential role for p2t(ac) and alpha(2a) receptors. J Biol Chem 1999; 274: 29108-14.
-
(1999)
J Biol Chem
, vol.274
, pp. 29108-29114
-
-
Paul, B.Z.1
Jin, J.2
Kunapuli, S.P.3
-
13
-
-
0033939105
-
The role of heterotrimeric G proteins in platelet activation
-
Offermanns S. The role of heterotrimeric G proteins in platelet activation. Biol Chem 2000; 381: 389-96.
-
(2000)
Biol Chem
, vol.381
, pp. 389-396
-
-
Offermanns, S.1
-
14
-
-
0035080479
-
Rho-kinase is involved in the sustained phosphorylation of myosin and the irreversible platelet aggregation induced by PARI activating peptide
-
Missy K, Plantavid M, Pacaud P, Viala C, Chap H, Payrastre B. Rho-kinase is involved in the sustained phosphorylation of myosin and the irreversible platelet aggregation induced by PARI activating peptide. Thromb Haemost 2001; 85: 514-20.
-
(2001)
Thromb Haemost
, vol.85
, pp. 514-520
-
-
Missy, K.1
Plantavid, M.2
Pacaud, P.3
Viala, C.4
Chap, H.5
Payrastre, B.6
-
15
-
-
0035930528
-
Differential regulation of Rho and Rac through heterotrimeric G-proteins and cyclic nucleotides
-
Gratacap M P, Payrastre B, Nieswandt B, Offermanns S. Differential regulation of Rho and Rac through heterotrimeric G-proteins and cyclic nucleotides. J Bio Chem 2001; 276: 47906-13.
-
(2001)
J Bio Chem
, vol.276
, pp. 47906-47913
-
-
Gratacap, M.P.1
Payrastre, B.2
Nieswandt, B.3
Offermanns, S.4
-
16
-
-
0037130959
-
Costimulation of G(i)- And G(12)/G(13)-mediated signaling pathways induces integrin alpha(IIb) beta(3) activation in platelets
-
Nieswandt B, Schulte V, Zywietz A, Gratacap M P, Offermanns S. Costimulation of G(i)-and G(12)/G(13)-mediated signaling pathways induces integrin alpha(IIb) beta(3) activation in platelets. J BM Chem 2002; 277: 39493-8.
-
(2002)
J BM Chem
, vol.277
, pp. 39493-39498
-
-
Nieswandt, B.1
Schulte, V.2
Zywietz, A.3
Gratacap, M.P.4
Offermanns, S.5
-
17
-
-
0032493295
-
Coactivation of two different G protein-coupled receptors is essential for ADP-induced platelet aggregation
-
Jin J, Kunapuli S P. Coactivation of two different G protein-coupled receptors is essential for ADP-induced platelet aggregation. Proc Natl Acad Sci USA 1998; 95: 8070-4.
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, pp. 8070-8074
-
-
Jin, J.1
Kunapuli, S.P.2
-
18
-
-
0032508411
-
Concomitant activation of Gi and Gq protein-coupled receptors does not require an increase in cytosolic calcium for platelet aggregation
-
Pulcinelli F M, Pesciotti M, Pignatelli P, Riondino S. Gazzaniga PP. Concomitant activation of Gi and Gq protein-coupled receptors does not require an increase in cytosolic calcium for platelet aggregation. FEBS Lett 1998; 435: 115-8.
-
(1998)
FEBS Lett
, vol.435
, pp. 115-118
-
-
Pulcinelli, F.M.1
Pesciotti, M.2
Pignatelli, P.3
Riondino, S.4
Gazzaniga, P.P.5
-
19
-
-
0034746160
-
Potentiation of thromboxane A(2)-induced platelet secretion by Gi signaling through the phosphoinositide-3 kinase pathway
-
Dangelmaier C, Jin J G, Smith J B, Kunapuli S P. Potentiation of thromboxane A(2)-induced platelet secretion by Gi signaling through the phosphoinositide-3 kinase pathway. Thromb Haemost 2001; 85: 341-8.
-
(2001)
Thromb Haemost
, vol.85
, pp. 341-348
-
-
Dangelmaier, C.1
Jin, J.G.2
Smith, J.B.3
Kunapuli, S.P.4
-
20
-
-
0042733338
-
Two waves of platelet secretion induced by thromboxane A2 receptor, and a critical role for phosphoinositide 3-kinases
-
Li Z, Zhang G, Le Breton G C, Gao X, Malik A B, Du X. Two waves of platelet secretion induced by thromboxane A2 receptor, and a critical role for phosphoinositide 3-kinases. J Biol Chem 2003; 278: 30725-31.
-
(2003)
J Biol Chem
, vol.278
, pp. 30725-30731
-
-
Li, Z.1
Zhang, G.2
Le Breton, G.C.3
Gao, X.4
Malik, A.B.5
Du, X.6
-
21
-
-
0033760391
-
The central role of the P-2T receptor in amplification of human platelet activation, aggregation, secretion and procoagulant activity
-
Storey R F, Sanderson H M, White A E, May J A, Cameron K E, Heptinstall S. The central role of the P-2T receptor in amplification of human platelet activation, aggregation, secretion and procoagulant activity. Br J Haematol 2000; 110: 925-34.
-
(2000)
Br J Haematol
, vol.110
, pp. 925-934
-
-
Storey, R.F.1
Sanderson, H.M.2
White, A.E.3
May, J.A.4
Cameron, K.E.5
Heptinstall, S.6
-
22
-
-
0035181313
-
Effects of P2Y(1) and P2Y(12) receptor antagonists on platelet aggregation induced by different agonists in human whole blood
-
Storey R F, Newby L J, Heptinstall S. Effects of P2Y(1) and P2Y(12) receptor antagonists on platelet aggregation induced by different agonists in human whole blood. Platelets 2001; 12: 443-7.
-
(2001)
Platelets
, vol.12
, pp. 443-447
-
-
Storey, R.F.1
Newby, L.J.2
Heptinstall, S.3
-
23
-
-
0034695474
-
Alpha(2A)-adrenergic receptor stimulation potentiates calcium release in platelets by modulating cAMP levels
-
Keularts I M, van Gorp R M, Feijge M A, Vuist W M, Heemskerk J W. Alpha(2A)-adrenergic receptor stimulation potentiates calcium release in platelets by modulating cAMP levels. J Biol Chem 2000; 275: 1763-72.
-
(2000)
J Biol Chem
, vol.275
, pp. 1763-1772
-
-
Keularts, I.M.1
Van Gorp, R.M.2
Feijge, M.A.3
Vuist, W.M.4
Heemskerk, J.W.5
-
24
-
-
0029855991
-
Phosphoinositide 3-kinase activation and platelet function
-
Rittenhouse S E. Phosphoinositide 3-kinase activation and platelet function. Blood 1996; 88: 4401-14.
-
(1996)
Blood
, vol.88
, pp. 4401-4414
-
-
Rittenhouse, S.E.1
-
25
-
-
0034680864
-
Adrenaline potentiates PI 3-kinase in platelets stimulated with thrombin and SFRLLN: Role of secreted ADP
-
Selheim F, Froyset A K, Strand I, Vassbotn F S, Holmsen H. Adrenaline potentiates PI 3-kinase in platelets stimulated with thrombin and SFRLLN: role of secreted ADP. FEBS Lett 2000; 485: 62-6.
-
(2000)
FEBS Lett
, vol.485
, pp. 62-66
-
-
Selheim, F.1
Froyset, A.K.2
Strand, I.3
Vassbotn, F.S.4
Holmsen, H.5
-
26
-
-
0034102421
-
PI 3-kinase signalling in platelets: The significance of synergistic, autocrine stimulation
-
Selheim F, Holmsen H, Vassbotn F S. PI 3-kinase signalling in platelets: the significance of synergistic, autocrine stimulation. Platelets 2000; 11: 69-82.
-
(2000)
Platelets
, vol.11
, pp. 69-82
-
-
Selheim, F.1
Holmsen, H.2
Vassbotn, F.S.3
-
27
-
-
0002659788
-
ADP: An important cofactor of PI 3-kinase activation in human blood platelets
-
Payrastre B, Gratacap M-P, Trumel C, Missy K, Chap H, Gachet C, et al. ADP: an important cofactor of PI 3-kinase activation in human blood platelets. Haematologica 2000; 85: 32-6.
-
(2000)
Haematologica
, vol.85
, pp. 32-36
-
-
Payrastre, B.1
Gratacap, M.-P.2
Trumel, C.3
Missy, K.4
Chap, H.5
Gachet, C.6
-
28
-
-
0034668175
-
The integrin alpha IIb/beta 3 in human platelet signal transduction
-
Payrastre B, Missy K, Trumel C, Bodin S, Plantavid M, Chap H. The integrin alpha IIb/beta 3 in human platelet signal transduction. Biochem Pharmacol 2000; 60: 1069-74.
-
(2000)
Biochem Pharmacol
, vol.60
, pp. 1069-1074
-
-
Payrastre, B.1
Missy, K.2
Trumel, C.3
Bodin, S.4
Plantavid, M.5
Chap, H.6
-
29
-
-
0037364062
-
Concurrent responses elicited by isolated activation of platelet Gq-coupled receptors, in vitro: A novel approach for their separation and analysis
-
Maayani S, Patel N D, Craddock-Royal B, Schwarz T E, Tagliente T M. Concurrent responses elicited by isolated activation of platelet Gq-coupled receptors, in vitro: a novel approach for their separation and analysis. Platelets 2003; 14: 89-102.
-
(2003)
Platelets
, vol.14
, pp. 89-102
-
-
Maayani, S.1
Patel, N.D.2
Craddock-Royal, B.3
Schwarz, T.E.4
Tagliente, T.M.5
-
30
-
-
0035071178
-
The balance of concurrent aggregation and deaggregation processes in platelets is linked to differential occupancy of ADP receptor subtypes
-
Maayani S, Tagliente T M, Schwarz T, Martinelli G, Martinez R, Shore-Lesserson L. The balance of concurrent aggregation and deaggregation processes in platelets is linked to differential occupancy of ADP receptor subtypes. Platelets 2001; 12: 83-93.
-
(2001)
Platelets
, vol.12
, pp. 83-93
-
-
Maayani, S.1
Tagliente, T.M.2
Schwarz, T.3
Martinelli, G.4
Martinez, R.5
Shore-Lesserson, L.6
-
31
-
-
0034908382
-
Deaggregation is an integral component of the response of platelets to ADP in vitro: Kinetic studies of literature and original data
-
Maayani S, Tagliente T M, Schwarz T, Craddock-Royal B, Alcala C, Marrero G, et al. Deaggregation is an integral component of the response of platelets to ADP in vitro: kinetic studies of literature and original data. Platelets 2001; 12: 279-91.
-
(2001)
Platelets
, vol.12
, pp. 279-291
-
-
Maayani, S.1
Tagliente, T.M.2
Schwarz, T.3
Craddock-Royal, B.4
Alcala, C.5
Marrero, G.6
-
32
-
-
0034828616
-
Activation of the alpha(2A)-adrenoceptor mediates deceleration of the deaggregation component of the response to ADP or 5-HT in human platelets in vitro
-
Maayani S, Schwarz T, Craddock-Royal B, Tagliente T M. Activation of the alpha(2A)-adrenoceptor mediates deceleration of the deaggregation component of the response to ADP or 5-HT in human platelets in vitro. Platelets 2001; 12: 359-75.
-
(2001)
Platelets
, vol.12
, pp. 359-375
-
-
Maayani, S.1
Schwarz, T.2
Craddock-Royal, B.3
Tagliente, T.M.4
-
33
-
-
0034744933
-
Activation of Gi-coupled receptors releases a tonic state of inhibited platelet aggregation
-
Maayani S, Schwarz T, Martinez R, Tagliente T M. Activation of Gi-coupled receptors releases a tonic state of inhibited platelet aggregation. Platelets 2001; 12: 94-8.
-
(2001)
Platelets
, vol.12
, pp. 94-98
-
-
Maayani, S.1
Schwarz, T.2
Martinez, R.3
Tagliente, T.M.4
-
34
-
-
0028262408
-
Detection of platelet aggregates with a particle counting method using light scattering
-
Ozaki Y, Satoh K, Yatomi Y, Yamamoto T, Shirasawa Y, Kume S. Detection of platelet aggregates with a particle counting method using light scattering. Anal Biochem 1994; 218: 284-94.
-
(1994)
Anal Biochem
, vol.218
, pp. 284-294
-
-
Ozaki, Y.1
Satoh, K.2
Yatomi, Y.3
Yamamoto, T.4
Shirasawa, Y.5
Kume, S.6
-
35
-
-
0029106020
-
A laser light scattering in situ system for counting aggregates in blood platelet
-
Yamamoto T, Egawa Y, Shirasawa Y, Ozaki Y, Sato K, Yatomi Y, et al. A laser light scattering in situ system for counting aggregates in blood platelet. Meas Sci Technol 1995; 6; 174-80.
-
(1995)
Meas Sci Technol
, vol.6
, pp. 174-180
-
-
Yamamoto, T.1
Egawa, Y.2
Shirasawa, Y.3
Ozaki, Y.4
Sato, K.5
Yatomi, Y.6
-
36
-
-
0034493564
-
Progress in the assessment of platelet function
-
Harrison P. Progress in the assessment of platelet function. Br J Haematol 2000; 111: 733-44.
-
(2000)
Br J Haematol
, vol.111
, pp. 733-744
-
-
Harrison, P.1
-
37
-
-
0031758639
-
Role of autocrine stimulation for the effects of cyclic AMP on protein and lipid phosphorylation in platelets activated by particles
-
Ryningen A, Holmsen H. Role of autocrine stimulation for the effects of cyclic AMP on protein and lipid phosphorylation in platelets activated by particles. FEBS Lett 1998; 436: 335-8.
-
(1998)
FEBS Lett
, vol.436
, pp. 335-338
-
-
Ryningen, A.1
Holmsen, H.2
-
38
-
-
0033557421
-
Role of autocrine stimulation on the effects of cyclic AMP on protein and lipid phosphorylation in collagen-activated and thrombin-activated platelets
-
Ryningen A, Jensen B O, Holmsen H. Role of autocrine stimulation on the effects of cyclic AMP on protein and lipid phosphorylation in collagen-activated and thrombin-activated platelets. Eur J Biochem 1999; 260: 87-96.
-
(1999)
Eur J Biochem
, vol.260
, pp. 87-96
-
-
Ryningen, A.1
Jensen, B.O.2
Holmsen, H.3
-
39
-
-
0031596463
-
P2Y1-receptors in human platelets which are pharmacologically distinct from P2Y(ADP)-receptors
-
Fagura M S, Dainty I A, McKay G D, Kirk I P, Humphries R G, Robertson M J, et al. P2Y1-receptors in human platelets which are pharmacologically distinct from P2Y(ADP)-receptors. Br J Pharmacol 1998; 124: 157-64.
-
(1998)
Br J Pharmacol
, vol.124
, pp. 157-164
-
-
Fagura, M.S.1
Dainty, I.A.2
McKay, G.D.3
Kirk, I.P.4
Humphries, R.G.5
Robertson, M.J.6
-
40
-
-
0002326729
-
Platelet secretion
-
Colman R W, Hirsh J, Marder V J, Clowes A W, George J N, eds. Baltimore, MD: Lippincott Williams and Wilkins
-
Fukami M H, Holmse H, Kowalska M A, Niewiarowski S. Platelet secretion. In: Colman R W, Hirsh J, Marder V J, Clowes A W, George J N, eds. Hemostasis and Thrombosis: Basic Principles and Clinical Practice. 4th edn. Baltimore, MD: Lippincott Williams and Wilkins, 2001: 561-73.
-
(2001)
Hemostasis and Thrombosis: Basic Principles and Clinical Practice. 4th Edn.
, pp. 561-573
-
-
Fukami, M.H.1
Holmse, H.2
Kowalska, M.A.3
Niewiarowski, S.4
-
42
-
-
0000911106
-
Biological aspects: The antagonism of drugs
-
Gaddum J H. Biological aspects: the antagonism of drugs. Trans. Faraday Soc. 1943; 39: 323-33.
-
(1943)
Trans. Faraday Soc.
, vol.39
, pp. 323-333
-
-
Gaddum, J.H.1
-
43
-
-
70449154105
-
Theories of drug antagonism
-
Gaddum J H. Theories of drug antagonism. Pharmacol Rev 1957; 9: 211-8.
-
(1957)
Pharmacol Rev
, vol.9
, pp. 211-218
-
-
Gaddum, J.H.1
-
45
-
-
0032190008
-
Platelet aggregation in acute coronary syndromes: Use of a new aggregometer with laser light scattering to assess platelet aggregability
-
Eto K, Takeshita S, Ochiai M, Ozaki Y, Sato T, Isshiki T. Platelet aggregation in acute coronary syndromes: use of a new aggregometer with laser light scattering to assess platelet aggregability. Cardiovasc Res 1998; 40: 223-9.
-
(1998)
Cardiovasc Res
, vol.40
, pp. 223-229
-
-
Eto, K.1
Takeshita, S.2
Ochiai, M.3
Ozaki, Y.4
Sato, T.5
Isshiki, T.6
-
46
-
-
0024464276
-
A compartmental model of platelet aggregation in vitro: The kinetics of single platelets
-
Hause L L, Retzinger G S, Megan P A. A compartmental model of platelet aggregation in vitro: the kinetics of single platelets. Thromb Res 1989; 56: 133-46.
-
(1989)
Thromb Res
, vol.56
, pp. 133-146
-
-
Hause, L.L.1
Retzinger, G.S.2
Megan, P.A.3
-
47
-
-
0030951825
-
Kinetic studies of desensitization and resensitization of the relaxation response to beta-2 adrenoceptor agonists in isolated guinea pig trachea
-
Wachsman D E, Kavaler J P, Sugar I P, Schachter E N, Gonsiorek W, Maayani S. Kinetic studies of desensitization and resensitization of the relaxation response to beta-2 adrenoceptor agonists in isolated guinea pig trachea. J Pharmacol Exp Ther 1997; 280: 332-45.
-
(1997)
J Pharmacol Exp Ther
, vol.280
, pp. 332-345
-
-
Wachsman, D.E.1
Kavaler, J.P.2
Sugar, I.P.3
Schachter, E.N.4
Gonsiorek, W.5
Maayani, S.6
-
48
-
-
0015861774
-
Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (150) of an enzymatic reaction
-
Cheng Y, Prusoff W H. Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (150) of an enzymatic reaction. Biochem Pharmacol 1973; 22: 3099-108.
-
(1973)
Biochem Pharmacol
, vol.22
, pp. 3099-3108
-
-
Cheng, Y.1
Prusoff, W.H.2
-
49
-
-
0029945067
-
Role of catecholamines in platelet function: Pathophysiological and clinical significance
-
Anfossi G, Trovati M. Role of catecholamines in platelet function: pathophysiological and clinical significance. Eur J Clin Invest 1996; 26: 353-70.
-
(1996)
Eur J Clin Invest
, vol.26
, pp. 353-370
-
-
Anfossi, G.1
Trovati, M.2
-
50
-
-
0027518582
-
Potentiation of aggregation and inhibition of adenylate-cyclase in human platelets by prostaglandin-E analogs
-
Matthews J S, Jones R L. Potentiation of aggregation and inhibition of adenylate-cyclase in human platelets by prostaglandin-E analogs. Br J Pharmacol 1993; 108: 363-9.
-
(1993)
Br J Pharmacol
, vol.108
, pp. 363-369
-
-
Matthews, J.S.1
Jones, R.L.2
-
51
-
-
0035098077
-
Activation of the murine EP3 receptor for PGE(2) inhibits cAMP production and promotes platelet aggregation
-
Fabre J-E, Nguyen M, Athirakul K, Coggins K, McNeish J D, Austin S, et al. Activation of the murine EP3 receptor for PGE(2) inhibits cAMP production and promotes platelet aggregation. J Clin Invest 2001; 107: 603-10.
-
(2001)
J Clin Invest
, vol.107
, pp. 603-610
-
-
Fabre, J.-E.1
Nguyen, M.2
Athirakul, K.3
Coggins, K.4
McNeish, J.D.5
Austin, S.6
-
52
-
-
0024211242
-
Epinephrine potentiates human platelet activation but is not an aggregating agent
-
Lanza F, Beretz A, Stierle A, Hanau D, Kubina M, Cazenave J P. Epinephrine potentiates human platelet activation but is not an aggregating agent. Am J Physiol 1988; 255: H1276-88.
-
(1988)
Am J Physiol
, vol.255
-
-
Lanza, F.1
Beretz, A.2
Stierle, A.3
Hanau, D.4
Kubina, M.5
Cazenave, J.P.6
-
53
-
-
0027312903
-
The platelet-stimulating effect of adrenaline through alpha 2-adrenergic receptors requires simultaneous activation by a true stimulatory platelet agonist. Evidence that adrenaline per se does not induce human platelet activation in vitro
-
Steen V M, Holmsen H, Aarbakke G. The platelet-stimulating effect of adrenaline through alpha 2-adrenergic receptors requires simultaneous activation by a true stimulatory platelet agonist. Evidence that adrenaline per se does not induce human platelet activation in vitro. Thromb Haemost 1993; 70: 506-13.
-
(1993)
Thromb Haemost
, vol.70
, pp. 506-513
-
-
Steen, V.M.1
Holmsen, H.2
Aarbakke, G.3
-
54
-
-
0018166505
-
Inhibition of adenylate cyclase by adenosine analogues in preparations of broken and intact human platelets. Evidence for the unidirectional control of platelet function by cyclic AMP
-
Haslam R J, Davidson M M, Desjardins J V. Inhibition of adenylate cyclase by adenosine analogues in preparations of broken and intact human platelets. Evidence for the unidirectional control of platelet function by cyclic AMP. Biochem J 1978; 176: 83-95.
-
(1978)
Biochem J
, vol.176
, pp. 83-95
-
-
Haslam, R.J.1
Davidson, M.M.2
Desjardins, J.V.3
-
55
-
-
0037327312
-
Molecular and biochemical evidence for the presence of type III adenylyl cyclase in human platelets
-
Katsel P L, Tagliente T M, Schwartz T E, Craddock-Royal B D, Patel N D, Maayani S. Molecular and biochemical evidence for the presence of type III adenylyl cyclase in human platelets. Platelets 2003; 14: 21-33.
-
(2003)
Platelets
, vol.14
, pp. 21-33
-
-
Katsel, P.L.1
Tagliente, T.M.2
Schwartz, T.E.3
Craddock-Royal, B.D.4
Patel, N.D.5
Maayani, S.6
-
56
-
-
0025967721
-
Lack of correlation between activation of cyclic AMP-dependent protein kinase and inhibition of contraction of rat vas deferens by cyclic AMP analogs
-
Hei Y J, MacDonell K L, McNeill J H, Diamond J. Lack of correlation between activation of cyclic AMP-dependent protein kinase and inhibition of contraction of rat vas deferens by cyclic AMP analogs. Mol Pharmacol 1991; 39: 233-8.
-
(1991)
Mol Pharmacol
, vol.39
, pp. 233-238
-
-
Hei, Y.J.1
MacDonell, K.L.2
McNeill, J.H.3
Diamond, J.4
-
57
-
-
13044263119
-
A key role of adenosine diphosphate in the irreversible platelet aggregation induced by the PAR1-activating peptide through the late activation of phosphoinositide 3-kinase
-
Trumel C, Payrastre B, Plantavid M, Hechler B, Viala C, Presek P, et al. A key role of adenosine diphosphate in the irreversible platelet aggregation induced by the PAR1-activating peptide through the late activation of phosphoinositide 3-kinase. Blood 1999; 94: 4156-65.
-
(1999)
Blood
, vol.94
, pp. 4156-4165
-
-
Trumel, C.1
Payrastre, B.2
Plantavid, M.3
Hechler, B.4
Viala, C.5
Presek, P.6
-
58
-
-
0033835125
-
ADP-induced platelet shape change: An investigation of the signalling pathways involved and their dependence on the method of platelet preparation
-
Wilde J I, Retzer M, Siess W, Watson S P. ADP-induced platelet shape change: an investigation of the signalling pathways involved and their dependence on the method of platelet preparation. Platelets 2000; 11: 286-95.
-
(2000)
Platelets
, vol.11
, pp. 286-295
-
-
Wilde, J.I.1
Retzer, M.2
Siess, W.3
Watson, S.P.4
-
59
-
-
0027339671
-
Thromboxane A2 stimulated signal transduction in vascular smooth muscle
-
Dorn G W 2nd, Becker M W. Thromboxane A2 stimulated signal transduction in vascular smooth muscle. J Pharmacol Exp Ther 1993; 265: 447-56.
-
(1993)
J Pharmacol Exp Ther
, vol.265
, pp. 447-456
-
-
Dorn II, G.W.1
Becker, M.W.2
-
60
-
-
0026072992
-
Cloning and expression of cDNa for a human thromboxane-A2 receptor
-
Hirata M, Hayashi Y, Ushikubi F, Yokota Y, Kageyama R, Nakanishi S, et al. Cloning and expression of cDNA for a human thromboxane-A2 receptor. Nature 1991; 349: 617-20.
-
(1991)
Nature
, vol.349
, pp. 617-620
-
-
Hirata, M.1
Hayashi, Y.2
Ushikubi, F.3
Yokota, Y.4
Kageyama, R.5
Nakanishi, S.6
-
61
-
-
0030877837
-
Signaling through G proteins in platelets: To the integrins and beyond
-
Brass L F, Manning D R, Cichowski K, Abrams C S. Signaling through G proteins in platelets: to the integrins and beyond. Thromb Haemost 1997; 78: 581-9.
-
(1997)
Thromb Haemost
, vol.78
, pp. 581-589
-
-
Brass, L.F.1
Manning, D.R.2
Cichowski, K.3
Abrams, C.S.4
-
62
-
-
0029050557
-
Phosphoinositide 3-kinase inhibition spares actin assembly in activating platelets but reverses platelet aggregation
-
Kovacsovics T J, Bachelot C. Toker A, Vlahos C J, Duckworth B, Cantley L C, et al. Phosphoinositide 3-kinase inhibition spares actin assembly in activating platelets but reverses platelet aggregation. J Biol Chem 1995; 270: 11358-66.
-
(1995)
J Biol Chem
, vol.270
, pp. 11358-11366
-
-
Kovacsovics, T.J.1
Bachelot, C.2
Toker, A.3
Vlahos, C.J.4
Duckworth, B.5
Cantley, L.C.6
-
63
-
-
0346672400
-
Agonist concentration dependent differential responsivity of a human platelet purinergic receptor; pharmacological and kinetic studies of aggregation, deaggregation and shape change responses mediated by the purinergic P2Y1 receptor in vitro
-
in press
-
Maayani S, Patel N D, Craddock-Royal B, Schwarz T E, Tagliente T M. Agonist concentration dependent differential responsivity of a human platelet purinergic receptor; pharmacological and kinetic studies of aggregation, deaggregation and shape change responses mediated by the purinergic P2Y1 receptor in vitro. Platelets 2003; (in press).
-
(2003)
Platelets
-
-
Maayani, S.1
Patel, N.D.2
Craddock-Royal, B.3
Schwarz, T.E.4
Tagliente, T.M.5
-
64
-
-
0029893426
-
cAMP is not an important messenger for ADP-induced platelet aggregation
-
Savi P, Pflieger A M, Herbert J M. cAMP is not an important messenger for ADP-induced platelet aggregation. Blood Coagul Fibrinolysis 1996; 7: 249-52.
-
(1996)
Blood Coagul Fibrinolysis
, vol.7
, pp. 249-252
-
-
Savi, P.1
Pflieger, A.M.2
Herbert, J.M.3
-
65
-
-
0032798247
-
cAMP is an important messenger for ADP-induced platelet aggregation
-
Weber A-A, Hohlfeld T, Schror K. cAMP is an important messenger for ADP-induced platelet aggregation. Platelet 1999; 10: 238-41.
-
(1999)
Platelet
, vol.10
, pp. 238-241
-
-
Weber, A.-A.1
Hohlfeld, T.2
Schror, K.3
-
66
-
-
79960971369
-
Bi-directional modulation of platelet function by adenylyl cycclase. IV. Agents that affect intracellular cAMP levels influence platelet function through acceleration or deceleration of deaggregation in vitro
-
Maayani S, Schwarz T E, Craddock-Royal B, Patel N D, Tagliente T M. Bi-directional modulation of platelet function by adenylyl cycclase. IV. Agents that affect intracellular cAMP levels influence platelet function through acceleration or deceleration of deaggregation in vitro. Blood 2001; 98: 47b.
-
(2001)
Blood
, vol.98
-
-
Maayani, S.1
Schwarz, T.E.2
Craddock-Royal, B.3
Patel, N.D.4
Tagliente, T.M.5
-
67
-
-
0034730185
-
Loss of signaling through the G protein, Gz, results in abnormal platelet activation and altered responses to psychoactive drugs
-
Yang J, Wu J, Kowalska M A, Dalvi A, Prevost N, O'Brien P J, et al. Loss of signaling through the G protein, Gz, results in abnormal platelet activation and altered responses to psychoactive drugs. Proc Natl Acad Sci USA 2000; 97: 9984-9.
-
(2000)
Proc Natl Acad Sci USA
, vol.97
, pp. 9984-9989
-
-
Yang, J.1
Wu, J.2
Kowalska, M.A.3
Dalvi, A.4
Prevost, N.5
O'Brien, P.J.6
-
68
-
-
0036042496
-
The hyperaggregability of platelets from normal pregnancy is mediated through thromboxane A2 and cyclic AMP pathways
-
Sheu J R, Hsiao G, Shen M Y, Lin W Y, Tzeng C R. The hyperaggregability of platelets from normal pregnancy is mediated through thromboxane A2 and cyclic AMP pathways. Clin Lab Haematol 2002; 24: 121-9.
-
(2002)
Clin Lab Haematol
, vol.24
, pp. 121-129
-
-
Sheu, J.R.1
Hsiao, G.2
Shen, M.Y.3
Lin, W.Y.4
Tzeng, C.R.5
-
69
-
-
25344464990
-
Bi-directional modulation of platelet function by adenylyl cycclase. III. Non-receptor-mediated inhibition of platelet adenylyl cyclase activity increased stability of transient aggregates formed in vitro through activation of Gq-coupled receptors
-
Schwarz T E, Maayani S, Craddock-Royal B, Patel N D, Tagliente T M. Bi-directional modulation of platelet function by adenylyl cycclase. III. Non-receptor-mediated inhibition of platelet adenylyl cyclase activity increased stability of transient aggregates formed in vitro through activation of Gq-coupled receptors. Blood 2001; 98: 45b.
-
(2001)
Blood
, vol.98
-
-
Schwarz, T.E.1
Maayani, S.2
Craddock-Royal, B.3
Patel, N.D.4
Tagliente, T.M.5
-
70
-
-
0033562781
-
Agonist-induced regulation of myosin phosphatase activity in human platelets through activation of Rho-kinase
-
Suzuki Y, Yamamoto M, Wada H, Ito M, Nakano T, Sasaki Y. et al. Agonist-induced regulation of myosin phosphatase activity in human platelets through activation of Rho-kinase. Blood 1999; 93: 3408-17.
-
(1999)
Blood
, vol.93
, pp. 3408-3417
-
-
Suzuki, Y.1
Yamamoto, M.2
Wada, H.3
Ito, M.4
Nakano, T.5
Sasaki, Y.6
-
71
-
-
0032575667
-
cAMP-induced morphological changes are counteracted by the activated RhoA small GTPase and the Rho kinase ROKalpha
-
Dong J M, Leung T, Manser E, Lim L. cAMP-induced morphological changes are counteracted by the activated RhoA small GTPase and the Rho kinase ROKalpha. J Biol Chem 1998; 273: 22554-62.
-
(1998)
J Biol Chem
, vol.273
, pp. 22554-22562
-
-
Dong, J.M.1
Leung, T.2
Manser, E.3
Lim, L.4
-
72
-
-
0028178715
-
A G-protein beta gamma-subunit-responsive phosphoinositide 3-kinase activity in human platelet cytosol
-
Thomason P A, James S R, Casey P J, Downes C P. A G-protein beta gamma-subunit-responsive phosphoinositide 3-kinase activity in human platelet cytosol. J Biol Chem 1994; 269: 16525-8.
-
(1994)
J Biol Chem
, vol.269
, pp. 16525-16528
-
-
Thomason, P.A.1
James, S.R.2
Casey, P.J.3
Downes, C.P.4
-
73
-
-
0028951061
-
Sequestration of a G-protein beta gamma subunit or ADP-ribosylation of Rho can inhibit thrombin-induced activation of platelet phosphoinositide 3-kinases
-
Zhang J, Benovic J L, Sugai M, Wetzker R, Gout I, Rittenhouse S E. Sequestration of a G-protein beta gamma subunit or ADP-ribosylation of Rho can inhibit thrombin-induced activation of platelet phosphoinositide 3-kinases. J Biol Chem 1995; 270: 6589-94.
-
(1995)
J Biol Chem
, vol.270
, pp. 6589-6594
-
-
Zhang, J.1
Benovic, J.L.2
Sugai, M.3
Wetzker, R.4
Gout, I.5
Rittenhouse, S.E.6
-
74
-
-
0029964243
-
Phosphoinositide 3-kinase gamma and p85/phosphoinositide 3-kinase in platelets. Relative activation by thrombin receptor or beta-phorbol myristate acetate and roles in promoting the ligand-binding function of alphaIIbeta3 integrin
-
Zhang J, Shattil S J, Cunningham M C, Rittenhouse S E. Phosphoinositide 3-kinase gamma and p85/phosphoinositide 3-kinase in platelets. Relative activation by thrombin receptor or beta-phorbol myristate acetate and roles in promoting the ligand-binding function of alphaIIbeta3 integrin. J Biol Chem 1996; 271: 6265-72.
-
(1996)
J Biol Chem
, vol.271
, pp. 6265-6272
-
-
Zhang, J.1
Shattil, S.J.2
Cunningham, M.C.3
Rittenhouse, S.E.4
-
75
-
-
0030611707
-
Purification and characterization of Gbetagamma-responsive phosphoinositide 3-kinases from pig platelet cytosol
-
Tang X, Downes C P. Purification and characterization of Gbetagamma-responsive phosphoinositide 3-kinases from pig platelet cytosol. J Biol Chem 1997; 272: 14193-9.
-
(1997)
J Biol Chem
, vol.272
, pp. 14193-14199
-
-
Tang, X.1
Downes, C.P.2
-
76
-
-
0032486378
-
A type II phosphoinositide 3-kinase is stimulated via activated integrin in platelets. A source of phosphatidylinositol 3-phosphate
-
Zhang J, Banfic H, Straforini F, Tosi L, Volinia S, Rittenhouse S E. A type II phosphoinositide 3-kinase is stimulated via activated integrin in platelets. A source of phosphatidylinositol 3-phosphate. J Biol Chem 1998; 273: 14081-4.
-
(1998)
J Biol Chem
, vol.273
, pp. 14081-14084
-
-
Zhang, J.1
Banfic, H.2
Straforini, F.3
Tosi, L.4
Volinia, S.5
Rittenhouse, S.E.6
-
77
-
-
0035464192
-
Resistance to thromboembolism in PI3Kgamma-deficient mice
-
Hirsch E, Bosco O, Tropel P, Laffargue M, Calvez R, Altruda F, et al. Resistance to thromboembolism in PI3Kgamma-deficient mice. FASEB J 2001; 15: 2019-21.
-
(2001)
FASEB J
, vol.15
, pp. 2019-2021
-
-
Hirsch, E.1
Bosco, O.2
Tropel, P.3
Laffargue, M.4
Calvez, R.5
Altruda, F.6
-
78
-
-
0033527401
-
Formation of PI3-kinase products in platelets by thrombin, but not collagen, is dependent on synergistic autocrine stimulation, particularly through secreted ADP
-
Selheim F, Idsoe R, Fukami M H, Holmsen H, Vassbotn F S. Formation of PI3-kinase products in platelets by thrombin, but not collagen, is dependent on synergistic autocrine stimulation, particularly through secreted ADP. Biochem Biophys Res Commun 1999; 263: 780-5.
-
(1999)
Biochem Biophys Res Commun
, vol.263
, pp. 780-785
-
-
Selheim, F.1
Idsoe, R.2
Fukami, M.H.3
Holmsen, H.4
Vassbotn, F.S.5
-
79
-
-
0037178831
-
Potent activation of RhoA by Galpha q and Gq-coupled receptors
-
Chikumi H, Vazquez-Prado J. Servitja J M, Miyazaki H, Gutkind J S. Potent activation of RhoA by Galpha q and Gq-coupled receptors. J Biol Chem 2002; 277: 27130-4.
-
(2002)
J Biol Chem
, vol.277
, pp. 27130-27134
-
-
Chikumi, H.1
Vazquez-Prado, J.2
Servitja, J.M.3
Miyazaki, H.4
Gutkind, J.S.5
-
80
-
-
0034810277
-
Small GTPase Rho regulates thrombin-induced platelet aggregation
-
Nishioka H, Horiuchi H, Tabuchi A, Yoshioka A, Shirakawa R, Kita T. Small GTPase Rho regulates thrombin-induced platelet aggregation. Biochem Biophys Res Commun 2001; 280: 970-5.
-
(2001)
Biochem Biophys Res Commun
, vol.280
, pp. 970-975
-
-
Nishioka, H.1
Horiuchi, H.2
Tabuchi, A.3
Yoshioka, A.4
Shirakawa, R.5
Kita, T.6
-
81
-
-
0037032558
-
Coordinated signaling through both G12/13 and G(i) pathways is sufficient to activate GPIIb/IIIa in human platelets
-
Dorsam R T, Kim S, Jin J, Kunapuli S P. Coordinated signaling through both G12/13 and G(i) pathways is sufficient to activate GPIIb/IIIa in human platelets. J Biol Chem 2002; 277: 47588-95.
-
(2002)
J Biol Chem
, vol.277
, pp. 47588-47595
-
-
Dorsam, R.T.1
Kim, S.2
Jin, J.3
Kunapuli, S.P.4
-
82
-
-
0033600865
-
Cyclic AMP-dependent phosphorylation of thromboxane A(2) receptor-associated Galpha(13)
-
Manganello J M, Djellas Y, Borg C, Antonakis K, Le Breton G C. Cyclic AMP-dependent phosphorylation of thromboxane A(2) receptor-associated Galpha(13). J Biol Chem 1999; 274: 28003-10.
-
(1999)
J Biol Chem
, vol.274
, pp. 28003-28010
-
-
Manganello, J.M.1
Djellas, Y.2
Borg, C.3
Antonakis, K.4
Le Breton, G.C.5
-
83
-
-
0037414792
-
Protein kinase A-mediated phosphorylation of the Galpha 13 switch I region alters the Galpha beta gamma 13-G protein-coupled receptor complex and inhibits Rho activation
-
Manganello J M, Huang J S, Kozasa T, Voyno-Yasenetskaya T A, Le Breton G C. Protein kinase A-mediated phosphorylation of the Galpha 13 switch I region alters the Galpha beta gamma 13-G protein-coupled receptor complex and inhibits Rho activation. J Biol Chem 2003; 278: 124-30.
-
(2003)
J Biol Chem
, vol.278
, pp. 124-130
-
-
Manganello, J.M.1
Huang, J.S.2
Kozasa, T.3
Voyno-Yasenetskaya, T.A.4
Le Breton, G.C.5
-
84
-
-
0033635908
-
Epinephrine correction of impaired platelet thromboxane receptor signaling
-
Dunlop P C, Leis L A, Johnson G J. Epinephrine correction of impaired platelet thromboxane receptor signaling. Am J Physiol Cell Physiol 2000; 279: C1760-C71.
-
(2000)
Am J Physiol Cell Physiol
, vol.279
-
-
Dunlop, P.C.1
Leis, L.A.2
Johnson, G.J.3
-
85
-
-
0022363178
-
Pharmacological actions of SQ 29,548, a novel selective thromboxane antagonist
-
Ogletree M L, Harris D N, Greenberg R, Haslanger M F. Nakane M. Pharmacological actions of SQ 29,548, a novel selective thromboxane antagonist. J Pharmacol Exp Ther 1985; 234: 435-41.
-
(1985)
J Pharmacol Exp Ther
, vol.234
, pp. 435-441
-
-
Ogletree, M.L.1
Harris, D.N.2
Greenberg, R.3
Haslanger, M.F.4
Nakane, M.5
-
87
-
-
0025193358
-
The response to thromboxane A2 analogues in human platelets. Discrimination of two binding sites linked to distinct effector systems
-
Takahara K, Murray R, FitzGerald G A, Fitzgerald D J. The response to thromboxane A2 analogues in human platelets. Discrimination of two binding sites linked to distinct effector systems. J Biol Chem 1990; 265: 6836-44.
-
(1990)
J Biol Chem
, vol.265
, pp. 6836-6844
-
-
Takahara, K.1
Murray, R.2
Fitzgerald, G.A.3
Fitzgerald, D.J.4
-
88
-
-
0025836328
-
Thromboxane-A2 prostaglandin-H2 receptors - Characterization and antagonism
-
Morinelli T A, Halushka P V. Thromboxane-A2 prostaglandin-H2 receptors - characterization and antagonism. Trends Cardiovasc Med 1991; 1: 157-61.
-
(1991)
Trends Cardiovasc Med
, vol.1
, pp. 157-161
-
-
Morinelli, T.A.1
Halushka, P.V.2
-
91
-
-
0019431334
-
Lithium inhibits adenylate cyclase of human platelets
-
Imandt L, Tijhuis D, Wessels H, Haanen C. Lithium inhibits adenylate cyclase of human platelets. Thromb Haemost 1981; 45: 142-5. Platelets (September 2003) 14(6), 375-379
-
(1981)
Thromb Haemost
, vol.45
, pp. 142-145
-
-
Imandt, L.1
Tijhuis, D.2
Wessels, H.3
Haanen, C.4
|