Rho-kinase is involved in the sustained phosphorylation of myosin and the irreversible platelet aggregation induced by PAR1 activating peptide

Thrombosis and Haemostasis

Volumn 85, Issue 3, 2001, Pages 514-520

  Missy, K ^a   Plantavid, M ^a   Pacaud, P ^a   Viala, C ^a   Chap, H ^a   Payrastre, B ^a  

^a CHU PURPAN   (France)

Author keywords

Irreversible platelet aggregation; Myosin; Rho kinase; TRAP

Indexed keywords

4 (1 AMINOETHYL) N (4 PYRIDYL)CYCLOHEXANECARBOXAMIDE; ADENOSINE DIPHOSPHATE; ADRENALIN; MYOSIN; MYOSIN HEAVY CHAIN; MYOSIN LIGHT CHAIN; RHO KINASE; THROMBIN RECEPTOR ACTIVATING PEPTIDE;

ARTICLE; CELL ACTIVATION; CYTOSKELETON; DOSE RESPONSE; ENZYME ACTIVITY; ERYTHROCYTE AGGREGATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SEROTONIN RELEASE;

EID: 0035080479     PISSN: 03406245     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-0037-1615614     Document Type: Article

References (43)

1. Rho effectors and reorganization of actin cytoskeleton
2. Rho GTPases and signaling networks
3. RHO - Theme and variations
4. Rho GTPases and the actin cytoskeleton
5. The P160 RhoA-binding kinase ROK-alpha is a member of a kinase family and is involved in the reorganization of the cytoskeleton
6. Formation of actin stress fibers and focal adhesions enhanced by Rho-kinase
7. p160ROCK, a Rho-associated coiled-coil forming protein kinase, works downstream of Rho and induces focal adhesions
8. RhoA effector mutants reveal distinct effector pathways for cytoskeletal reorganization, SRF activation and transformation
9. Interplay between Rac and Rho in the control of substrate contact dynamics
10. Regulation of myosin phosphatase by Rho and Rho-associated kinase (Rho-kinase)
11. Phosphorylation and activation of myosin by Rho-associated kinase (Rho-kinase)
12. Cytoskeletal rearrangements and transcriptional activation of c-fos serum response element by Rho-kinase
13. Regulation of myosin phosphatase through phosphorylation of the myosin-binding subunit in platelet activation
14. Agonist-induced regulation of myosin phosphatase activity in human platelets through activation of Rho-kinase
15. Evidence for a role of myosin phosphorylation in the initiation of the platelet shape change response
16. Activation of G12/G13 results in shape change and Rho/Rho-kinase- mediated myosin light chain phosphorylation in mouse platelets
17. Dichotomous regulation of myosin phosphorylation and shape change by Rho-kinase and calcium in intact human platelets
18. Platelet shape change is mediated by both calcium-dependent and -independent signaling pathways
19. A rho gene product in human blood platelets. II. Effects of the ADP-ribosylation by botulinum C3 ADP-ribosyltransferase on platelet aggregation
20. RhoA and the function of platelet integrin αIIbβ3
21. Integrin signaling: The platelet paradigm
22. 3-mediated TXA2 synthesis
23. Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension
24. Platelet aggregation: A tool for clinical investigation and pharmacological study. Methodology
25. The selectivity of the thrombin-induced platelet release reaction: Subcellular localization of released and retained constituents
26. Integrin dependent translocation of phosphoinositide 3-kinase to the cytoskeleton of thrombin activated platelets involves specific interactions of p85alpha with actin filaments and focal adhesion kinase
27. Tyrosine phosphorylation and relocation of SHIP are integrin-mediated in thrombin-stimulated human blood platelets
28. Cleavage of structural proteins during the assembly of the head of bacteriophage T4
29. Purification and characterization of platelet myosin
30. Thrombin-receptor agonist peptides, in contrast to thrombin itself, are not full agonists for activation and signal transduction in human platelets in the absence of platelet-derived secondary mediators
31. A key role of adenosine diphosphate in the irreversible platelet aggregation induced by the PAR1-activating peptide through the late activation of phosphoinositide 3-kinase
32. Antagonists of the platelet P2T receptor: A novel approach to antithrombotic therapy
33. Dephosphorylation of platelet myosin by myosin light chain kinase
34. Signal transduction and regulation in smooth muscle
35. Integrin cytoplasmic tyrosine motif is required for outside-in alphaIIb-beta3 signalling and platelet function
36. Signaling from Rho to the actin cytoskeleton through protein kinases ROCK and LIM-kinase
37. Na-H exchange acts downstream of RhoA to regulate integrin-induced cell adhesion and spreading
38. p160ROCK mediates RhoA activation of Na-H exchange
39. Defective platelet activation in G-Alpha(Q)-deficient mice
40. 13 stimulate Rho-dependent stress fiber formation and focal adhesion assembly
41. The G-protein G13 but not G12 mediates signaling from lysophosphatidic acid receptor via epidermal growth factor receptor to Rho
42. Constitutively active Galpha12, Galpha13, and Galphaq induce Rho-dependent neurite retraction through different signaling pathways
43. Differential involvement of Galpha12 and Galpha13 in receptor-mediated stress fiber formation