Protein kinase A-mediated phosphorylation of the Gα13 switch I region alters the Gαβγ13-G protein-coupled receptor complex and inhibits Rho activation

Journal of Biological Chemistry

Volumn 278, Issue 1, 2003, Pages 124-130

  Manganello, Jeanne M ^a,b   Huang, Jin Sheng ^a   Kozasa, Tohru ^a   Voyno Yasenetskaya, Tatyana A ^a   Le Breton, Guy C ^a,c  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^b MILLENNIUM PHARMACEUTICALS INC   (United States)

^c UNIVERSITY OF ILLINOIS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CATALYSIS; ENZYME INHIBITION; IMMUNOLOGY; LIQUID CHROMATOGRAPHY; MUTAGENESIS; PROTEINS;

PHOSPHORYLATION;

BIOCHEMICAL ENGINEERING;

8 BROMO CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC AMP DEPENDENT PROTEIN KINASE INHIBITOR; G PROTEIN COUPLED RECEPTOR; RHO FACTOR; THROMBOXANE A2 RECEPTOR;

AFFINITY CHROMATOGRAPHY; AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; CATALYSIS; CHO CELL; CONTROLLED STUDY; DRUG EFFECT; ENZYME CONFORMATION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; IMMUNOPRECIPITATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; WILD TYPE;

ANIMALS; BLOOD PLATELETS; CATTLE; CELL LINE; CONSENSUS SEQUENCE; CYCLIC AMP; CYCLIC AMP-DEPENDENT PROTEIN KINASES; DNA-BINDING PROTEINS; GTP-BINDING PROTEIN ALPHA SUBUNITS, G12-G13; HETEROTRIMERIC GTP-BINDING PROTEINS; HUMANS; MACROMOLECULAR SUBSTANCES; MUTAGENESIS, SITE-DIRECTED; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN SUBUNITS; RECEPTORS, THROMBOXANE; RHO GTP-BINDING PROTEINS; SECOND MESSENGER SYSTEMS;

ANIMALIA; CRICETINAE; CRICETULUS GRISEUS;

EID: 0037414792     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M209219200     Document Type: Article

References (33)

1. Lefkowitz, R. J. (1998) J. Biol. Chem. 273, 18677-18680
2. Sagi-Eisenberg, R. (1989) Trends Biochem. Sci. 14, 355-357
3. Fields, T. A., and Casey, P. J. (1995) J. Biol. Chem. 270, 23119-23125
4. Kozasa, T., and Gilman, A. G. (1996) J. Biol. Chem. 271, 12562-12567
5. Aragay, A. M., and Quick, M. W. (1999) J. Biol. Chem. 274, 4807-4815
6. Murthy, K. S., and Makhlouf, G. M. (2000) J. Biol. Chem. 275, 30211-30219
7. Offermanns, S., Hu, Y. H., and Simon, M. I. (1996) J. Biol. Chem. 271, 26044-26048
8. Manganello, J. M., Djellas, Y., Borg, C., Antonakis, K., and Le Breton, G. C. (1999) J. Biol. Chem. 274, 28003-28010
9. Pal, E. F., Krengel, U., Petsko, G. A., Goody, R. S., Kabsch, W., and Wittinghofer, A. (1990) EMBO J. 9, 2351-2359
10. Milburn, M. V., Tong, L., deVos, A. M., Brunger, A., Yamaizumi, Z., Nishimura, S., and Kim, S. H. (1990) Science 247, 939-945
11. Tong, L. A., de Vos, A. M., Milburn, M. V., and Kim, S. H. (1991) J. Mol. Biol. 217, 503-516
12. Sondek, J., Lambright, D. G., Noel, J. P., Hamm, H. E., and Sigler, P. B. (1994) Nature 372, 276-279
13. Lambright, D. G., Noel, J. P., Hamm, H. E., and Sigler, P. B. (1994) Nature 369, 621-628
14. Coleman, D. E., and Sprang, S. R. (1998) Biochemistry 37, 14376-14385
15. Borg, C., Lam, S. C., Dieter, J. P., Lim, C. T., Komiotis, D., Venton, D. L., and Le Breton, G. C. (1993) Biochem. Pharmacol. 45, 2071-2078
16. Kozasa, T., Jiang, X., Hart, M. J., Sternweis, P. M., Singer, W. D., Gilman, A. G., Bollag, G., and Sternweis, P. C. (1998) Science 280, 2109-2111
17. Kozasa, T., and Gilman, A. G. (1995) J. Biol. Chem. 270, 1734-1741
18. Laemmli, U. K. (1970) Nature 227, 680-685
19. Morrissey, J. H. (1981) Anal. Biochem. 117, 307-310
20. Ren, X. D., Kiosses, W. B., and Schwartz, M. A. (1999) EMBO J. 18, 578-585
21. Knezevic, I., Borg, C., and Le Breton, G. C. (1993) J. Biol. Chem. 268, 26011-26017
22. Djellas, Y., Manganello, J. M., Antonakis, K., and Le Breton, G. C. (1999) J. Biol. Chem. 274, 14325-14330
23. Lounsbury, K. M., Schlegel, B., Poncz, M., Brass, L. F., and Manning, D. R. (1993) J. Biol. Chem. 268, 3494-3498
24. Buhl, A. M., Johnson, N. L., Dhanasekaran, N., and Johnson, G. L. (1995) J. Biol. Chem. 270, 24631-24634
25. Klages, B., Brandt, U., Simon, M. I., Schultz, G., and Offermanns, S. (1999) J. Cell Biol. 144, 745-754
26. Yuan, J., Slice, L. W., and Rozengurt, E. (2001) J. Biol. Chem. 276, 38619-38627
27. Gratacap, M. P., Payrastre, B., Nieswandt, B., and Offermanns, S. (2001) J. Biol. Chem. 276, 47906-47913
28. Glick, J. L., Meigs, T. E., Miron, A., and Casey, P. J. (1998) J. Biol. Chem. 273, 26008-26013
29. Imaizumi, T., Watanabe, Y., and Yoshida, H. (1991) Eur. J. Pharmacol. 207, 189-194
30. Pyne, N. J., Freissmuth, M., and Pyne, S. (1992) Biochem. Biophys. Res. Commun. 186, 1081-1086
31. Gilman, A. G. (1987) Annu. Rev. Biochem. 56, 615-649
32. Chen, Y., Yoo, B., Lee, J. B., Weng, G., and Iyengar, R. (2001) J. Biol. Chem. 276, 45751-45754
33. Li, Z., Xi, X., and Du, X. (2001) J. Biol. Chem. 276, 42226-42232