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Volumn 11, Issue 2, 2000, Pages 69-82

PI 3-kinase signalling in platelets: The significance of synergistic, autocrine stimulation

Author keywords

[No Author keywords available]

Indexed keywords

FIBRINOGEN; INTEGRIN; ISOENZYME; PHOSPHATIDYLINOSITOL; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 PHOSPHATE; PHOSPHATIDYLINOSITOL 3,4 BISPHOSPHATE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE; PHOSPHATIDYLINOSITOL 4 PHOSPHATE; PHOSPHATIDYLINOSITOL 4,5 BISPHOSPHATE; PROTEIN TYROSINE KINASE; THROMBOCYTE ENZYME; UNCLASSIFIED DRUG;

EID: 0034102421     PISSN: 09537104     EISSN: None     Source Type: Journal    
DOI: 10.1080/09537100075670     Document Type: Review
Times cited : (21)

References (166)
  • 1
    • 0021741336 scopus 로고
    • Inositol lipids, phosphatidate and diacylglycerol share stearoylarachidonoylglycerol as a common backbone in thrombin-stimulated human platelets
    • 1. Mauco G, Dangelmaier C A, Smith J B. Inositol lipids, phosphatidate and diacylglycerol share stearoylarachidonoylglycerol as a common backbone in thrombin-stimulated human platelets. Biochem J 1984; 224: 933-40.
    • (1984) Biochem J , vol.224 , pp. 933-940
    • Mauco, G.1    Dangelmaier, C.A.2    Smith, J.B.3
  • 2
    • 0027312364 scopus 로고
    • Mass and fatty acid composition of the 3-phosphorylated phosphatidylinositol bisphosphate isomer in stimulated human platelets
    • 2. Gaudette D C, Aukema H M, Jolly C A, Chapkin R S, Holub B J. Mass and fatty acid composition of the 3-phosphorylated phosphatidylinositol bisphosphate isomer in stimulated human platelets. J Biol Chem 1993; 268: 13773-6.
    • (1993) J Biol Chem , vol.268 , pp. 13773-13776
    • Gaudette, D.C.1    Aukema, H.M.2    Jolly, C.A.3    Chapkin, R.S.4    Holub, B.J.5
  • 3
    • 0023513693 scopus 로고
    • Receptor activation and inositol lipid hydrolysis in neural tissues
    • 3. Fisher S K, Agranoff B W. Receptor activation and inositol lipid hydrolysis in neural tissues. J Neurochem. 1987; 48: 999-1017.
    • (1987) J Neurochem. , vol.48 , pp. 999-1017
    • Fisher, S.K.1    Agranoff, B.W.2
  • 5
    • 0023810588 scopus 로고
    • An inositol tetrakisphosphate-containing phospholipid in activated neutrophils
    • 5. Traynor K A, Harris A L, Thompson B L, Taylor P, Sklar L A. An inositol tetrakisphosphate-containing phospholipid in activated neutrophils. Nature 1988; 334: 353-6.
    • (1988) Nature , vol.334 , pp. 353-356
    • Traynor, K.A.1    Harris, A.L.2    Thompson, B.L.3    Taylor, P.4    Sklar, L.A.5
  • 6
    • 0023897684 scopus 로고
    • Type 1 phosphatidylinositol kinase makes a novel inositol phospholipid, phosphatidylinositol-3-phosphate
    • 6. Whitman M, Downes C P, Keeler M, Keller T, Cantley L. Type 1 phosphatidylinositol kinase makes a novel inositol phospholipid, phosphatidylinositol-3-phosphate. Nature 1988; 332: 644-6.
    • (1988) Nature , vol.332 , pp. 644-646
    • Whitman, M.1    Downes, C.P.2    Keeler, M.3    Keller, T.4    Cantley, L.5
  • 7
    • 0024601010 scopus 로고
    • PDGF-dependent tyrosine phosphorylation stimulates production of novel polyphosphoinositides in intact cells
    • 7. Auger K R, Serunian L A, Soltoff S P, Libby P, Cantley L C. PDGF-dependent tyrosine phosphorylation stimulates production of novel polyphosphoinositides in intact cells. Cell 1989; 57: 167-75.
    • (1989) Cell , vol.57 , pp. 167-175
    • Auger, K.R.1    Serunian, L.A.2    Soltoff, S.P.3    Libby, P.4    Cantley, L.C.5
  • 8
    • 0030721527 scopus 로고    scopus 로고
    • A new pathway for synthesis of phosphatidylinositol-4,5-bisphosphate
    • 8. Rameh L E, Tolias K F, Duckworth B C, Cantley L C. A new pathway for synthesis of phosphatidylinositol-4,5-bisphosphate [see comments]. Nature 1997; 390: 192-6.
    • (1997) Nature , vol.390 , pp. 192-196
    • Rameh, L.E.1    Tolias, K.F.2    Duckworth, B.C.3    Cantley, L.C.4
  • 9
    • 0030669546 scopus 로고    scopus 로고
    • Osmotic stress activates phosphatidylinositol-3,5-bisphosphate synthesis
    • 9. Dove S K, Cooke F T, Douglas M R, Sayers L G, Parker P J, Michell R H. Osmotic stress activates phosphatidylinositol-3,5-bisphosphate synthesis [see comments]. Nature 1997; 390: 187-92.
    • (1997) Nature , vol.390 , pp. 187-192
    • Dove, S.K.1    Cooke, F.T.2    Douglas, M.R.3    Sayers, L.G.4    Parker, P.J.5    Michell, R.H.6
  • 10
    • 0030944761 scopus 로고    scopus 로고
    • Phosphatidylinositol 3,5-bisphosphate defines a novel PI 3-kinase pathway in resting mouse fibroblasts
    • 10. Whiteford C C, Brearley C A, Ulug E T. Phosphatidylinositol 3,5-bisphosphate defines a novel PI 3-kinase pathway in resting mouse fibroblasts. BiochemJ 1997; 323: 597-601.
    • (1997) BiochemJ , vol.323 , pp. 597-601
    • Whiteford, C.C.1    Brearley, C.A.2    Ulug, E.T.3
  • 11
    • 0029855991 scopus 로고    scopus 로고
    • Phosphoinositide 3-kinase activation and platelet function
    • published erratum appears in Blood 1997 (Apr 15); 89(8): 3075
    • 11. Rittenhouse S E. Phosphoinositide 3-kinase activation and platelet function [published erratum appears in Blood 1997 (Apr 15); 89(8): 3075]. Blood 1996; 88: 4401-14.
    • (1996) Blood , vol.88 , pp. 4401-4414
    • Rittenhouse, S.E.1
  • 12
    • 0024559479 scopus 로고
    • Physiological functions of platelets
    • 12. Holmsen H. Physiological functions of platelets. Ann Med 1989; 21: 23-30.
    • (1989) Ann Med , vol.21 , pp. 23-30
    • Holmsen, H.1
  • 13
    • 0023373014 scopus 로고
    • Turnover of the phosphomonoester groups of polyphosphoinositol lipids in unstimulated human platelets
    • 13. Verhoeven A J, Tysnes O B, Aarbakke G M, Cook C A, Holmsen H. Turnover of the phosphomonoester groups of polyphosphoinositol lipids in unstimulated human platelets. Eur J Biochem 1987; 166: 3-9.
    • (1987) Eur J Biochem , vol.166 , pp. 3-9
    • Verhoeven, A.J.1    Tysnes, O.B.2    Aarbakke, G.M.3    Cook, C.A.4    Holmsen, H.5
  • 14
    • 0013636116 scopus 로고
    • Polyphosphoinositide metabolism in resting and stimulated platelets
    • Meyers K M, Ed. Boca Raton, FL: Academic Press
    • 14. Holmsen H, Tysnes O B, Verhoeven A J. Polyphosphoinositide metabolism in resting and stimulated platelets. In: Meyers K M, Ed. The Platelet Amine Storage Granule. Boca Raton, FL: Academic Press, 1992; 97-148.
    • (1992) The Platelet Amine Storage Granule , pp. 97-148
    • Holmsen, H.1    Tysnes, O.B.2    Verhoeven, A.J.3
  • 15
    • 0030796803 scopus 로고    scopus 로고
    • Structural and mechanistic features of phospholipases C: Effectors of inositol phospholipid-mediated signal transduction
    • 15. James S R, Downes C P. Structural and mechanistic features of phospholipases C: effectors of inositol phospholipid-mediated signal transduction. Cell Signal 1997; 9: 329-36.
    • (1997) Cell Signal , vol.9 , pp. 329-336
    • James, S.R.1    Downes, C.P.2
  • 16
    • 0032209522 scopus 로고    scopus 로고
    • Signaling through protein kinase C
    • 16. Toker A. Signaling through protein kinase C. Front Biosci 1998; 3: 1134-47.
    • (1998) Front Biosci , vol.3 , pp. 1134-1147
    • Toker, A.1
  • 17
    • 0031903015 scopus 로고    scopus 로고
    • Downstream signalling events regulated by phosphatidylinositol 3-kinase activity
    • 17. Duronio V, Scheid M P, Ettinger S. Downstream signalling events regulated by phosphatidylinositol 3-kinase activity. Cell Signal. 1998; 10: 233-9.
    • (1998) Cell Signal , vol.10 , pp. 233-239
    • Duronio, V.1    Scheid, M.P.2    Ettinger, S.3
  • 18
    • 0029593535 scopus 로고
    • Purification and characterization of the human type 1 Ins(1,4,5)P3 receptor from platelets and comparison with receptor subtypes in other normal and transformed blood cells
    • 18. O'Rourke F, Matthews E, Feinstein M B. Purification and characterization of the human type 1 Ins(1,4,5)P3 receptor from platelets and comparison with receptor subtypes in other normal and transformed blood cells. Biochem J 1995; 312: 499-503.
    • (1995) Biochem J , vol.312 , pp. 499-503
    • O'Rourke, F.1    Matthews, E.2    Feinstein, M.B.3
  • 19
    • 0030790548 scopus 로고    scopus 로고
    • Using structure to define the function of phosphoinositide 3-kinase family members
    • 19. Domin J, Waterfield M D. Using structure to define the function of phosphoinositide 3-kinase family members. FEBS Lett 1997; 410: 91-5.
    • (1997) FEBS Lett , vol.410 , pp. 91-95
    • Domin, J.1    Waterfield, M.D.2
  • 20
    • 0032497832 scopus 로고    scopus 로고
    • Structure and function of phosphoinositide 3-kinases
    • 20. Wymann M P, Pirola L. Structure and function of phosphoinositide 3-kinases. Biochim Biophys Acta 1998; 1436: 127-50.
    • (1998) Biochim Biophys Acta , vol.1436 , pp. 127-150
    • Wymann, M.P.1    Pirola, L.2
  • 22
    • 0025731596 scopus 로고
    • Pathway of phosphatidylinositol(3,4,5)-trisphosphate synthesis in activated neutrophils
    • 22. Stephens L R, Hughes K T, Irvine R F. Pathway of phosphatidylinositol(3,4,5)-trisphosphate synthesis in activated neutrophils. Nature 1991; 351: 33-9.
    • (1991) Nature , vol.351 , pp. 33-39
    • Stephens, L.R.1    Hughes, K.T.2    Irvine, R.F.3
  • 25
    • 0027361002 scopus 로고
    • Cloning of a novel, ubiquitously expressed human phosphatidylinositol 3-kinase and identification of its binding site on p85
    • 25. Hu P, Mondino A, Skolnik E Y, Schlessinger J. Cloning of a novel, ubiquitously expressed human phosphatidylinositol 3-kinase and identification of its binding site on p85. Mol.Cell Biol. 1993; 13: 7677-88.
    • (1993) Mol.cell Biol. , vol.13 , pp. 7677-7688
    • Hu, P.1    Mondino, A.2    Skolnik, E.Y.3    Schlessinger, J.4
  • 27
    • 0025755422 scopus 로고
    • Characterization of two 85 kd proteins that associate with receptor tyrosine kinases, middle-T/pp60c-src complexes, and PI3-kinase
    • 27. Otsu M, Hiles I, Gout I, Fry M J, Ruiz L F, Panayotou G, Thompson A, Dhand R, Hsuan J, Totty N, et al. Characterization of two 85 kd proteins that associate with receptor tyrosine kinases, middle-T/pp60c-src complexes, and PI3-kinase. Cell 1991; 65: 91-104.
    • (1991) Cell , vol.65 , pp. 91-104
    • Otsu, M.1    Hiles, I.2    Gout, I.3    Fry, M.J.4    Ruiz, L.F.5    Panayotou, G.6    Thompson, A.7    Dhand, R.8    Hsuan, J.9    Totty, N.10
  • 28
    • 0029964243 scopus 로고    scopus 로고
    • Phosphoinositide 3-kinase gamma and p85/phosphoinositide 3-kinase in platelets. Relative activation by thrombin receptor or beta-phorbol myristate acetate and roles in promoting the ligand-binding function of alphaIIbbeta3 integrin
    • 28. Zhang J, Shattil S J, Cunningham M C, Rittenhouse S E. Phosphoinositide 3-kinase gamma and p85/phosphoinositide 3-kinase in platelets. Relative activation by thrombin receptor or beta-phorbol myristate acetate and roles in promoting the ligand-binding function of alphaIIbbeta3 integrin. J Biol Chem 1996; 271: 6265-72.
    • (1996) J Biol Chem , vol.271 , pp. 6265-6272
    • Zhang, J.1    Shattil, S.J.2    Cunningham, M.C.3    Rittenhouse, S.E.4
  • 29
    • 0026774568 scopus 로고
    • Activated phosphoinositide 3-kinase associates with membrane skeleton in thrombin-exposed platelets
    • 29. Zhang J, Fry M J, Waterfield M D, Jaken S, Liao L, Fox J E, Rittenhouse S E. Activated phosphoinositide 3-kinase associates with membrane skeleton in thrombin-exposed platelets. J Biol Chem 1992; 267: 4686-92.
    • (1992) J Biol Chem , vol.267 , pp. 4686-4692
    • Zhang, J.1    Fry, M.J.2    Waterfield, M.D.3    Jaken, S.4    Liao, L.5    Fox, J.E.6    Rittenhouse, S.E.7
  • 30
    • 0028951061 scopus 로고
    • Sequestration of a G-protein beta gamma subunit or ADP-ribosylation of Rho can inhibit thrombin-induced activation of platelet phosphoinositide 3-kinases
    • 30. Zhang J, Benovic J L, Sugai M, Wetzker R, Gout I, Rittenhouse S E. Sequestration of a G-protein beta gamma subunit or ADP-ribosylation of Rho can inhibit thrombin-induced activation of platelet phosphoinositide 3-kinases. J Biol Chem 1995; 270: 6589-94.
    • (1995) J Biol Chem , vol.270 , pp. 6589-6594
    • Zhang, J.1    Benovic, J.L.2    Sugai, M.3    Wetzker, R.4    Gout, I.5    Rittenhouse, S.E.6
  • 32
    • 0028951464 scopus 로고
    • Integrin-dependent translocation of phosphoinositide 3-kinase to the cytoskeleton of thrombin-activated platelets involves specific interactions of p85 alpha with actin filaments and focal adhesion kinase
    • 32. Guinebault C, Payrastre B, Racaud S C, Mazarguil H, Breton M, Mauco G, Plantavid M, Chap H. Integrin-dependent translocation of phosphoinositide 3-kinase to the cytoskeleton of thrombin-activated platelets involves specific interactions of p85 alpha with actin filaments and focal adhesion kinase. J Cell Biol 1995; 129: 831-42.
    • (1995) J Cell Biol , vol.129 , pp. 831-842
    • Guinebault, C.1    Payrastre, B.2    Racaud, S.C.3    Mazarguil, H.4    Breton, M.5    Mauco, G.6    Plantavid, M.7    Chap, H.8
  • 33
    • 0031054182 scopus 로고    scopus 로고
    • Reversible translocation of phosphoinositide 3-kinase to the cytoskeleton of ADP-aggregated human platelets occurs independently of Rho A and without synthesis of phosphatidylinositol (3,4)-bisphosphate
    • 33. Gachet C, Payrastre B, Guinebault C, Trumel C, Ohlmann P, Mauco G, Cazenave J P, Plantavid M, Chap H. Reversible translocation of phosphoinositide 3-kinase to the cytoskeleton of ADP-aggregated human platelets occurs independently of Rho A and without synthesis of phosphatidylinositol (3,4)-bisphosphate. J Biol Chem 1997; 272: 4850-4.
    • (1997) J Biol Chem , vol.272 , pp. 4850-4854
    • Gachet, C.1    Payrastre, B.2    Guinebault, C.3    Trumel, C.4    Ohlmann, P.5    Mauco, G.6    Cazenave, J.P.7    Plantavid, M.8    Chap, H.9
  • 34
    • 0027374497 scopus 로고
    • Activation of platelet phosphatidylinositide 3-kinase requires the small GTP-binding protein Rho
    • 34. Zhang J, King W G, Dillon S, Hall A, Feig L, Rittenhouse S E. Activation of platelet phosphatidylinositide 3-kinase requires the small GTP-binding protein Rho. J Biol Chem 1993; 268: 22251-4.
    • (1993) J Biol Chem , vol.268 , pp. 22251-22254
    • Zhang, J.1    King, W.G.2    Dillon, S.3    Hall, A.4    Feig, L.5    Rittenhouse, S.E.6
  • 35
    • 0028918456 scopus 로고
    • Regulation of phosphatidylinositide 3-kinase, a potential signaling enzyme in platelets
    • published erratum appears in Semin Hematol 1995; 32(3): 241
    • 35. Rittenhouse S E. Regulation of phosphatidylinositide 3-kinase, a potential signaling enzyme in platelets [published erratum appears in Semin Hematol 1995; 32(3): 241]. Semin Hematol 1995; 32: 120-5.
    • (1995) Semin Hematol , vol.32 , pp. 120-125
    • Rittenhouse, S.E.1
  • 36
    • 0032101012 scopus 로고    scopus 로고
    • RhoA and the function of platelet integrin alphaIIbbeta3
    • 36. Leng L, Kashiwagi H, Ren X D, Shattil S J. RhoA and the function of platelet integrin alphaIIbbeta3. Blood 1998; 91: 4206-15.
    • (1998) Blood , vol.91 , pp. 4206-4215
    • Leng, L.1    Kashiwagi, H.2    Ren, X.D.3    Shattil, S.J.4
  • 37
    • 0026700090 scopus 로고
    • A rho gene product in human blood platelets. II. Effects of the ADP-ribosylation by botulinum C3 ADP-ribosyltransferase on platelet aggregation
    • 37. Morii N, Teru T, Tominaga T, Kumagai N, Kozaki S, Ushikubi F, Narumiya S. A rho gene product in human blood platelets. II. Effects of the ADP-ribosylation by botulinum C3 ADP-ribosyltransferase on platelet aggregation. J Biol Chem 1992; 267: 20921-6.
    • (1992) J Biol Chem , vol.267 , pp. 20921-20926
    • Morii, N.1    Teru, T.2    Tominaga, T.3    Kumagai, N.4    Kozaki, S.5    Ushikubi, F.6    Narumiya, S.7
  • 38
    • 0028334738 scopus 로고
    • A novel phosphoinositide 3 kinase activity in myeloid-derived cells is activated by G protein beta gamma subunits
    • 38. Stephens L, Smrcka A Cooke F T, Jackson T R, Sternweis P C, Hawkins P T. A novel phosphoinositide 3 kinase activity in myeloid-derived cells is activated by G protein beta gamma subunits. Cell 1994; 77: 83-93.
    • (1994) Cell , vol.77 , pp. 83-93
    • Stephens, L.1    Smrcka, A.2    Cooke, F.T.3    Jackson, T.R.4    Sternweis, P.C.5    Hawkins, P.T.6
  • 41
    • 0028178715 scopus 로고
    • A G-protein beta gamma-subunit-responsive phosphoinositide 3-kinase activity in human platelet cytosol
    • 41. Thomason P A, James S R, Casey P J, Downes C P. A G-protein beta gamma-subunit-responsive phosphoinositide 3-kinase activity in human platelet cytosol. J Biol Chem 1994; 269: 16525-8.
    • (1994) J Biol Chem , vol.269 , pp. 16525-16528
    • Thomason, P.A.1    James, S.R.2    Casey, P.J.3    Downes, C.P.4
  • 42
    • 0030611707 scopus 로고    scopus 로고
    • Purification and characterization of G beta gamma-responsive phosphoinositide 3-kinases from pig platelet cytosol
    • 42. Tang X, Downes C P. Purification and characterization of G beta gamma-responsive phosphoinositide 3-kinases from pig platelet cytosol. J Biol Chem 1997; 272: 14193-9.
    • (1997) J Biol Chem , vol.272 , pp. 14193-14199
    • Tang, X.1    Downes, C.P.2
  • 43
    • 0033026482 scopus 로고    scopus 로고
    • Synergistic activation of a family of phosphoinositide 3-kinase via G-protein coupled and tyrosine kinase-related receptors
    • 43. Katada T, Kurosu H, Okada T, Suzuki T, Tsujimoto N, Takasuga S, Kontani K, Hazeki O, Ui M. Synergistic activation of a family of phosphoinositide 3-kinase via G-protein coupled and tyrosine kinase-related receptors. Chem Phys Lipids 1999; 98: 79-86.
    • (1999) Chem Phys Lipids , vol.98 , pp. 79-86
    • Katada, T.1    Kurosu, H.2    Okada, T.3    Suzuki, T.4    Tsujimoto, N.5    Takasuga, S.6    Kontani, K.7    Hazeki, O.8    Ui, M.9
  • 44
    • 0030035099 scopus 로고    scopus 로고
    • Synergistic activation of PtdIns 3-kinase by tyrosine-phosphorylated peptide and beta gamma-subunits of GTP-binding proteins
    • 44. Okada T, Hazeki O, Ui M, Katada T. Synergistic activation of PtdIns 3-kinase by tyrosine-phosphorylated peptide and beta gamma-subunits of GTP-binding proteins. Biochem J 1996; 317: 475-80.
    • (1996) Biochem J , vol.317 , pp. 475-480
    • Okada, T.1    Hazeki, O.2    Ui, M.3    Katada, T.4
  • 45
    • 0030869757 scopus 로고    scopus 로고
    • Heterodimeric phosphoinositide 3-kinase consisting of p85 and p110beta is synergistically activated by the beta gamma subunits of G proteins and phosphotyrosyl peptide
    • 45. Kurosu H, Maehama T, Okada T, Yamamoto T, Hoshino S, Fukui Y, Ui M, Hazeki O, Katada T. Heterodimeric phosphoinositide 3-kinase consisting of p85 and p110beta is synergistically activated by the beta gamma subunits of G proteins and phosphotyrosyl peptide. J Biol Chem 1997; 272: 24252-6.
    • (1997) J Biol Chem , vol.272 , pp. 24252-24256
    • Kurosu, H.1    Maehama, T.2    Okada, T.3    Yamamoto, T.4    Hoshino, S.5    Fukui, Y.6    Ui, M.7    Hazeki, O.8    Katada, T.9
  • 46
    • 0030884527 scopus 로고    scopus 로고
    • Cloning of a human phosphoinositide 3-kinase with a C2 domain that displays reduced sensitivity to the inhibitor wortmannin
    • 46. Domin J, Pages F, Volinia S, Rittenhouse S E, Zvelebil M J, Stein R C, Waterfield M D. Cloning of a human phosphoinositide 3-kinase with a C2 domain that displays reduced sensitivity to the inhibitor wortmannin. Biochem J 1997; 326: 139-47.
    • (1997) Biochem J , vol.326 , pp. 139-147
    • Domin, J.1    Pages, F.2    Volinia, S.3    Rittenhouse, S.E.4    Zvelebil, M.J.5    Stein, R.C.6    Waterfield, M.D.7
  • 47
    • 0032486378 scopus 로고    scopus 로고
    • A type II phosphoinositide 3-kinase is stimulated via activated integrin in platelets. A source of phosphatidylinositol 3-phosphate
    • 47. Zhang J, Banfic H, Straforini F, Tosi L, Volinia S, Rittenhouse S E. A type II phosphoinositide 3-kinase is stimulated via activated integrin in platelets. A source of phosphatidylinositol 3-phosphate. J Biol Chem 1998; 273: 14081-4.
    • (1998) J Biol Chem , vol.273 , pp. 14081-14084
    • Zhang, J.1    Banfic, H.2    Straforini, F.3    Tosi, L.4    Volinia, S.5    Rittenhouse, S.E.6
  • 48
    • 0033515592 scopus 로고    scopus 로고
    • Phosphoinositide 3-kinases and their FYVE domain-containing effectors as regulators of vacuolar/lysosomal membrane trafficking pathways
    • 48. Wurmser A E, Gary J D, Emr S D. Phosphoinositide 3-kinases and their FYVE domain-containing effectors as regulators of vacuolar/lysosomal membrane trafficking pathways. J Biol Chem 1999; 274: 9129-32.
    • (1999) J Biol Chem , vol.274 , pp. 9129-9132
    • Wurmser, A.E.1    Gary, J.D.2    Emr, S.D.3
  • 49
    • 0033603214 scopus 로고    scopus 로고
    • Phosphoinositide binding domains: Embracing 3-phosphate
    • 49. Fruman D A, Rameh L E, Cantley L C. Phosphoinositide binding domains: embracing 3-phosphate. Cell 1999; 97: 817-20.
    • (1999) Cell , vol.97 , pp. 817-820
    • Fruman, D.A.1    Rameh, L.E.2    Cantley, L.C.3
  • 50
    • 0032211844 scopus 로고    scopus 로고
    • Direct targets of phosphoinositide 3-kinase products in membrane traffic and signal transduction
    • 50. Corvera S, Czech M P. Direct targets of phosphoinositide 3-kinase products in membrane traffic and signal transduction. Trends Cell Biol 1998; 8: 442-6.
    • (1998) Trends Cell Biol , vol.8 , pp. 442-446
    • Corvera, S.1    Czech, M.P.2
  • 51
    • 0025216568 scopus 로고
    • Human platelets form 3-phosphorylated phosphoinositides in response to alpha-thrombin, U46619, or GTP gamma S
    • 51. Kucera G L, Rittenhouse S E. Human platelets form 3-phosphorylated phosphoinositides in response to alpha-thrombin, U46619, or GTP gamma S. J Biol Chem. 1990; 265: 5345-8.
    • (1990) J Biol Chem. , vol.265 , pp. 5345-5348
    • Kucera, G.L.1    Rittenhouse, S.E.2
  • 52
    • 0025355637 scopus 로고
    • Thrombin stimulates the production of a novel polyphosphoinositide in human platelets
    • 52. Nolan R D, Lapetina E G. Thrombin stimulates the production of a novel polyphosphoinositide in human platelets. J Biol Chem 1990; 265: 2441-5.
    • (1990) J Biol Chem , vol.265 , pp. 2441-2445
    • Nolan, R.D.1    Lapetina, E.G.2
  • 53
    • 0025308833 scopus 로고
    • Protein kinase C-mediated formation of phosphatidylinositol 3,4-bisphosphate in human platelets
    • 53. Yamamoto K, Lapetina E G. Protein kinase C-mediated formation of phosphatidylinositol 3,4-bisphosphate in human platelets. Biochem Biophys Res Commun 1990; 168: 466-72.
    • (1990) Biochem Biophys Res Commun , vol.168 , pp. 466-472
    • Yamamoto, K.1    Lapetina, E.G.2
  • 54
    • 0025597978 scopus 로고
    • Pathway for the formation of D3 phosphate containing inositol phospholipids in intact human platelets
    • 54. Cunningham T W, Lips D L, Bansal V S, Caldwell K K, Mitchell C A, Majerus P W. Pathway for the formation of D3 phosphate containing inositol phospholipids in intact human platelets. J Biol Chem 1990; 265: 21676-83.
    • (1990) J Biol Chem , vol.265 , pp. 21676-21683
    • Cunningham, T.W.1    Lips, D.L.2    Bansal, V.S.3    Caldwell, K.K.4    Mitchell, C.A.5    Majerus, P.W.6
  • 55
    • 0025308860 scopus 로고
    • The novel inositol lipid phosphatidylinositol 3,4-bisphosphate is produced by human blood platelets upon thrombin stimulation
    • 55. Sultan C, Breton M, Mauco G, Grondin P, Plantavid M, Chap H. The novel inositol lipid phosphatidylinositol 3,4-bisphosphate is produced by human blood platelets upon thrombin stimulation. Biochem J 1990; 269: 831-4.
    • (1990) Biochem J , vol.269 , pp. 831-834
    • Sultan, C.1    Breton, M.2    Mauco, G.3    Grondin, P.4    Plantavid, M.5    Chap, H.6
  • 56
    • 0028788181 scopus 로고
    • Phosphorylation of the platelet p47 phosphoprotein is mediated by the lipid products of phosphoinositide 3-kinase
    • 56. Toker A, Bachelot C, Chen C S, Falck J R, Hartwig J H, Cantley L C, Kovacsovics T J. Phosphorylation of the platelet p47 phosphoprotein is mediated by the lipid products of phosphoinositide 3-kinase. J Biol Chem 1995; 270: 29525-31.
    • (1995) J Biol Chem , vol.270 , pp. 29525-29531
    • Toker, A.1    Bachelot, C.2    Chen, C.S.3    Falck, J.R.4    Hartwig, J.H.5    Cantley, L.C.6    Kovacsovics, T.J.7
  • 57
    • 0026340995 scopus 로고
    • Phosphoinositide 3-kinase: A new effector in signal transduction?
    • 57. Downes C P, Carter A N. Phosphoinositide 3-kinase: a new effector in signal transduction? Cell Signal 1991; 3: 501-13.
    • (1991) Cell Signal , vol.3 , pp. 501-513
    • Downes, C.P.1    Carter, A.N.2
  • 58
    • 0025824273 scopus 로고
    • Pathway for the formation of D-3 phosphate containing inositol phospholipids in PDGF stimulated NIH 3T3 fibroblasts
    • 58. Cunningham T W, Majerus P W. Pathway for the formation of D-3 phosphate containing inositol phospholipids in PDGF stimulated NIH 3T3 fibroblasts. Biochem Biophys Res Commun 1991; 175: 568-76.
    • (1991) Biochem Biophys Res Commun , vol.175 , pp. 568-576
    • Cunningham, T.W.1    Majerus, P.W.2
  • 60
    • 0027991781 scopus 로고
    • Phosphatidylinositol 3,4,5-trisphosphate is formed from phosphatidylinositol 4,5-bisphosphate in thrombin-stimulated platelets
    • 60. Carter A N, Huang R, Sorisky A, Downes C P, Rittenhouse S E. Phosphatidylinositol 3,4,5-trisphosphate is formed from phosphatidylinositol 4,5-bisphosphate in thrombin-stimulated platelets. Biochem J 1994; 301: 415-20.
    • (1994) Biochem J , vol.301 , pp. 415-420
    • Carter, A.N.1    Huang, R.2    Sorisky, A.3    Downes, C.P.4    Rittenhouse, S.E.5
  • 61
    • 0014421439 scopus 로고
    • Thrombin-induced platelet release reaction and platelet lysosomes
    • 61. Holmsen H, Day H J. Thrombin-induced platelet release reaction and platelet lysosomes. Nature 1968; 219: 760-1.
    • (1968) Nature , vol.219 , pp. 760-761
    • Holmsen, H.1    Day, H.J.2
  • 62
    • 0015379378 scopus 로고
    • Secretory mechanisms. Behaviour of adenine nucleotides during the platelet release reaction induced by adenosine diphosphate and adrenaline
    • 62. Holmsen H, Day H J, Setkowsky C A. Secretory mechanisms. Behaviour of adenine nucleotides during the platelet release reaction induced by adenosine diphosphate and adrenaline. Biochem J 1972; 129: 67-82.
    • (1972) Biochem J , vol.129 , pp. 67-82
    • Holmsen, H.1    Day, H.J.2    Setkowsky, C.A.3
  • 63
    • 0025606039 scopus 로고
    • A novel pathway for the formation of phosphatidylinositol 3,4-bisphosphate. Phosphorylation of phosphatidylinositol 3-monophosphate by phosphatidylinositol-3-monophosphate 4-kinase
    • 63. Yamamoto K, Graziani A, Carpenter C, Cantley L C, Lapetina E G. A novel pathway for the formation of phosphatidylinositol 3,4-bisphosphate. Phosphorylation of phosphatidylinositol 3-monophosphate by phosphatidylinositol-3-monophosphate 4-kinase. J Biol Chem 1990; 265: 22086-9.
    • (1990) J Biol Chem , vol.265 , pp. 22086-22089
    • Yamamoto, K.1    Graziani, A.2    Carpenter, C.3    Cantley, L.C.4    Lapetina, E.G.5
  • 64
    • 0031982628 scopus 로고    scopus 로고
    • A novel integrin-activated pathway forms PKB/Akt-stimulatory phosphatidylinositol 3,4-bisphosphate via phosphatidylinositol 3-phosphate in platelets
    • 64. Banfic H, Tang X, Batty I H, Downes C P, Chen C, Rittenhouse S E. A novel integrin-activated pathway forms PKB/Akt-stimulatory phosphatidylinositol 3,4-bisphosphate via phosphatidylinositol 3-phosphate in platelets. J Biol Chem 1998; 273: 13-6.
    • (1998) J Biol Chem , vol.273 , pp. 13-16
    • Banfic, H.1    Tang, X.2    Batty, I.H.3    Downes, C.P.4    Chen, C.5    Rittenhouse, S.E.6
  • 65
    • 0033055446 scopus 로고    scopus 로고
    • Pathways for phosphoinositide synthesis
    • 65. Tolias K F, Cantley L C. Pathways for phosphoinositide synthesis. Chem Phys Lipids 1999; 98: 69-77.
    • (1999) Chem Phys Lipids , vol.98 , pp. 69-77
    • Tolias, K.F.1    Cantley, L.C.2
  • 66
    • 0032053708 scopus 로고    scopus 로고
    • The synthesis and cellular roles of phosphatidylinositol 4,5-bisphosphate
    • 66. Toker A. The synthesis and cellular roles of phosphatidylinositol 4,5-bisphosphate. Curr Opin Cell Biol 1998; 10: 254-61.
    • (1998) Curr Opin Cell Biol , vol.10 , pp. 254-261
    • Toker, A.1
  • 68
    • 0032541172 scopus 로고    scopus 로고
    • Type I phosphatidylinositol-4-phosphate 5-kinases synthesize the novel lipids phosphatidylinositol 3,5-bisphosphate and phosphatidylinositol 5-phosphate
    • 68. Tolias K F, Rameh L E, Ishihara H, Shibasaki Y, Chen J, Prestwich G D, Cantley L C, Carpenter C L. Type I phosphatidylinositol-4-phosphate 5-kinases synthesize the novel lipids phosphatidylinositol 3,5-bisphosphate and phosphatidylinositol 5-phosphate. J Biol Chem 1998; 273: 18040-6.
    • (1998) J Biol Chem , vol.273 , pp. 18040-18046
    • Tolias, K.F.1    Rameh, L.E.2    Ishihara, H.3    Shibasaki, Y.4    Chen, J.5    Prestwich, G.D.6    Cantley, L.C.7    Carpenter, C.L.8
  • 69
    • 0032042095 scopus 로고    scopus 로고
    • Phosphatidylinositol signalling reactions
    • 69. Zhang X, Majerus P W. Phosphatidylinositol signalling reactions. Semin Cell Dev Biol 1998; 9: 153-60.
    • (1998) Semin Cell Dev Biol , vol.9 , pp. 153-160
    • Zhang, X.1    Majerus, P.W.2
  • 70
    • 0032495874 scopus 로고    scopus 로고
    • Biphasic activation of PKBalpha/Akt in platelets. Evidence for stimulation both by phosphatidylinositol 3,4-bisphosphate, produced via a novel pathway, and by phosphatidylinositol 3,4,5-trisphosphate
    • 70. Banfic H, Downes C P, Rittenhouse S E. Biphasic activation of PKBalpha/Akt in platelets. Evidence for stimulation both by phosphatidylinositol 3,4-bisphosphate, produced via a novel pathway, and by phosphatidylinositol 3,4,5-trisphosphate. J Biol Chem 1998; 273: 11630-7.
    • (1998) J Biol Chem , vol.273 , pp. 11630-11637
    • Banfic, H.1    Downes, C.P.2    Rittenhouse, S.E.3
  • 72
    • 0032497845 scopus 로고    scopus 로고
    • The diversity and possible functions of the inositol polyphosphate 5-phosphatases
    • 72. Emeux C, Govaerts C, Communi D, Pesesse X. The diversity and possible functions of the inositol polyphosphate 5-phosphatases. Biochim Biophys Acta 1998; 1436: 185-99.
    • (1998) Biochim Biophys Acta , vol.1436 , pp. 185-199
    • Emeux, C.1    Govaerts, C.2    Communi, D.3    Pesesse, X.4
  • 73
    • 0030783120 scopus 로고    scopus 로고
    • Tyrosine phosphorylation and relocation of SHIP are integrin-mediated in thrombin-stimulated human blood platelets
    • 73. Giuriato S, Payrastre B, Drayer A L, Plantavid M, Woscholski R, Parker P, Erneux C, Chap H. Tyrosine phosphorylation and relocation of SHIP are integrin-mediated in thrombin-stimulated human blood platelets. J Biol Chem 1997; 272: 26857-63.
    • (1997) J Biol Chem , vol.272 , pp. 26857-26863
    • Giuriato, S.1    Payrastre, B.2    Drayer, A.L.3    Plantavid, M.4    Woscholski, R.5    Parker, P.6    Erneux, C.7    Chap, H.8
  • 74
    • 0029152796 scopus 로고
    • Phosphatidylinositol 3,4,5-trisphosphate is a substrate for the 75kDa inositol polyphosphate 5-phosphatase and a novel 5-phosphatase which forms a complex with the p85/p110 form of phosphoinositide 3-kinase
    • 74. Jackson S P, Schoenwaelder S M, Matzaris M, Brown S, Mitchell C A. Phosphatidylinositol 3,4,5-trisphosphate is a substrate for the 75kDa inositol polyphosphate 5-phosphatase and a novel 5-phosphatase which forms a complex with the p85/p110 form of phosphoinositide 3-kinase. EMBO J 1995; 14: 4490-500.
    • (1995) EMBO J , vol.14 , pp. 4490-4500
    • Jackson, S.P.1    Schoenwaelder, S.M.2    Matzaris, M.3    Brown, S.4    Mitchell, C.A.5
  • 75
    • 0029959174 scopus 로고    scopus 로고
    • A novel phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase associates with the interleukin-3 receptor
    • 75. Liu L, Jefferson A B, Zhang X, Norris F A, Majerus P W, Krystal G. A novel phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase associates with the interleukin-3 receptor. J Biol Chem 1996; 271: 29729-33.
    • (1996) J Biol Chem , vol.271 , pp. 29729-29733
    • Liu, L.1    Jefferson, A.B.2    Zhang, X.3    Norris, F.A.4    Majerus, P.W.5    Krystal, G.6
  • 76
    • 0033616619 scopus 로고    scopus 로고
    • The inositol polyphosphate 4-phosphatase forms a complex with phosphatidylinositol 3-kinase in human platelet cytosol
    • 76. Munday A D, Norris F A, Caldwell K K. Brown S, Majerus P W, Mitchell CA. The inositol polyphosphate 4-phosphatase forms a complex with phosphatidylinositol 3-kinase in human platelet cytosol. Proc Natl Acad Sci USA 1999; 96: 3640-5.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 3640-3645
    • Munday, A.D.1    Norris, F.A.2    Caldwell, K.K.3    Brown, S.4    Majerus, P.W.5    Mitchell, C.A.6
  • 77
    • 0033551070 scopus 로고    scopus 로고
    • New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway
    • 77. Cantley L C, Neel B G. New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway. Proc Natl Acad Sci USA 1999; 96: 4240-5.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 4240-4245
    • Cantley, L.C.1    Neel, B.G.2
  • 78
    • 0032904432 scopus 로고    scopus 로고
    • PTEN: A tumour suppressor that functions as a phospholipid phosphatase
    • 78. Maehama T, Dixon J E. PTEN: a tumour suppressor that functions as a phospholipid phosphatase. Trends Cell Biol 1999; 9: 125-8.
    • (1999) Trends Cell Biol , vol.9 , pp. 125-128
    • Maehama, T.1    Dixon, J.E.2
  • 79
    • 0029831486 scopus 로고    scopus 로고
    • Platelet-derived growth factor-dependent activation of phosphatidylinositol 3-kinase is regulated by receptor binding of SH2-domain-containing proteins which influence Ras activity
    • 79. Klinghoffer RA, Duckworth B, Valius M, Cantley L, Kazlauskas A. Platelet-derived growth factor-dependent activation of phosphatidylinositol 3-kinase is regulated by receptor binding of SH2-domain-containing proteins which influence Ras activity. Mol Cell Biol 1996; 16: 5905-14.
    • (1996) Mol Cell Biol , vol.16 , pp. 5905-5914
    • Klinghoffer, R.A.1    Duckworth, B.2    Valius, M.3    Cantley, L.4    Kazlauskas, A.5
  • 80
    • 14444287277 scopus 로고    scopus 로고
    • Phosphoinositide 3-kinase regulates phospholipase Cgamma-mediated calcium signaling
    • 80. Rameh L E, Rhee S G, Spokes K, Kazlauskas A, Cantley L C, Cantley L G. Phosphoinositide 3-kinase regulates phospholipase Cgamma-mediated calcium signaling. J Biol Chem 1998; 273: 23750-7.
    • (1998) J Biol Chem , vol.273 , pp. 23750-23757
    • Rameh, L.E.1    Rhee, S.G.2    Spokes, K.3    Kazlauskas, A.4    Cantley, L.C.5    Cantley, L.G.6
  • 81
    • 0344653108 scopus 로고    scopus 로고
    • Activation of phospholipase C-gamma by phosphatidylinositol 3,4,5-trisphosphate
    • 81. Bae Y S, Cantley L G, Chen C S, Kim S R, Kwon K S, Rhee S G. Activation of phospholipase C-gamma by phosphatidylinositol 3,4,5-trisphosphate. J Biol Chem 1998; 273: 4465-9.
    • (1998) J Biol Chem , vol.273 , pp. 4465-4469
    • Bae, Y.S.1    Cantley, L.G.2    Chen, C.S.3    Kim, S.R.4    Kwon, K.S.5    Rhee, S.G.6
  • 82
    • 0030055540 scopus 로고    scopus 로고
    • Thrombin receptors modulate insulin-stimulated phosphatidylinositol 3,4,5-trisphosphate accumulation in 1321N1 astrocytoma cells
    • 82. Batty I H, Downes C P. Thrombin receptors modulate insulin-stimulated phosphatidylinositol 3,4,5-trisphosphate accumulation in 1321N1 astrocytoma cells. Biochem J 1996; 317: 347-51.
    • (1996) Biochem J , vol.317 , pp. 347-351
    • Batty, I.H.1    Downes, C.P.2
  • 83
    • 0030681386 scopus 로고    scopus 로고
    • Cross-talk between phospholipase C and phosphoinositide 3-kinase signalling pathways
    • 83. Batty I H, Hickinson D M, Downes C P. Cross-talk between phospholipase C and phosphoinositide 3-kinase signalling pathways. Biochem Soc Trans 1997; 25: 1132-7.
    • (1997) Biochem Soc Trans , vol.25 , pp. 1132-1137
    • Batty, I.H.1    Hickinson, D.M.2    Downes, C.P.3
  • 84
    • 0017696018 scopus 로고
    • Prostaglandin endoperoxide-thromboxane synthesis and dense granule secretion as positive feedback loops in the propagation of platelet responses during 'the basic platelet reaction'
    • 84. Holmsen H. Prostaglandin endoperoxide-thromboxane synthesis and dense granule secretion as positive feedback loops in the propagation of platelet responses during 'the basic platelet reaction'. Thromb Haemost 1977; 38: 1030-41.
    • (1977) Thromb Haemost , vol.38 , pp. 1030-1041
    • Holmsen, H.1
  • 85
    • 0033557421 scopus 로고    scopus 로고
    • Role of autocrine stimulation on the effects of cyclic AMP on protein and lipid phosphorylation in collagen-activated and thrombin-activated platelets
    • 85. Ryningen A, Jensen B O, Holmsen H. Role of autocrine stimulation on the effects of cyclic AMP on protein and lipid phosphorylation in collagen-activated and thrombin-activated platelets. Eur J Biochem 1999; 260: 87-96.
    • (1999) Eur J Biochem , vol.260 , pp. 87-96
    • Ryningen, A.1    Jensen, B.O.2    Holmsen, H.3
  • 86
    • 0002500276 scopus 로고
    • Colman R W, Hirsh J, Marder V, Salzman E W, Eds. Philadelphia, PA: Lippincott
    • 86. Holmsen H. In: Colman R W, Hirsh J, Marder V, Salzman E W, Eds. Hemostasis and Thrombosis, 3rd ed. Philadelphia, PA: Lippincott, 1993; 524-45.
    • (1993) Hemostasis and Thrombosis, 3rd Ed. , pp. 524-545
    • Holmsen, H.1
  • 88
    • 0032576955 scopus 로고    scopus 로고
    • Thrombin per se does not induce tyrosine protein phosphorylation in human platelets as judged by western blotting, while collagen does: The significance of synergistic, autocrine stimulation
    • 88. Ryningen A, Holmsen H. Thrombin per se does not induce tyrosine protein phosphorylation in human platelets as judged by western blotting, while collagen does: the significance of synergistic, autocrine stimulation. Biochem Biophys Res Commun 1998; 245: 757-63.
    • (1998) Biochem Biophys Res Commun , vol.245 , pp. 757-763
    • Ryningen, A.1    Holmsen, H.2
  • 89
    • 0033527401 scopus 로고    scopus 로고
    • Formation of PI 3-Kinase products in platelets by thrombin, but not collagen, is dependent on synergistic autocrine stimulation, particularly through secreted ADP
    • 89. Selheim F, Idsøe R, Fukami M, Holmsen H, Vassbotn F S. Formation of PI 3-Kinase products in platelets by thrombin, but not collagen, is dependent on synergistic autocrine stimulation, particularly through secreted ADP. Biochem Biohys Res Commun 1999; 263: 780-5.
    • (1999) Biochem Biohys Res Commun , vol.263 , pp. 780-785
    • Selheim, F.1    Idsøe, R.2    Fukami, M.3    Holmsen, H.4    Vassbotn, F.S.5
  • 90
    • 0026354977 scopus 로고
    • Involvement of platelet glycoprotein IIb-IIIa (alpha IIb-beta 3 integrin) in thrombin-induced synthesis of phosphatidylinositol 3′,4′-bisphosphate
    • 90. Sultan C, Plantavid M, Bachelot C, Grondin P, Breton M, Mauco G, Levy T S, Caen J P, Chap H. Involvement of platelet glycoprotein IIb-IIIa (alpha IIb-beta 3 integrin) in thrombin-induced synthesis of phosphatidylinositol 3′,4′-bisphosphate. J Biol Chem 1991; 266: 23554-7.
    • (1991) J Biol Chem , vol.266 , pp. 23554-23557
    • Sultan, C.1    Plantavid, M.2    Bachelot, C.3    Grondin, P.4    Breton, M.5    Mauco, G.6    Levy, T.S.7    Caen, J.P.8    Chap, H.9
  • 93
    • 0029050557 scopus 로고
    • Phosphoinositide 3-kinase inhibition spares actin assembly in activating platelets but reverses platelet aggregation
    • 93. Kovacsovics T J, Bachelot C, Toker A, Vlahos C J, Duckworth B, Cantley L C, Hartwig J H. Phosphoinositide 3-kinase inhibition spares actin assembly in activating platelets but reverses platelet aggregation. J Biol Chem 1995; 270: 11358-66.
    • (1995) J Biol Chem , vol.270 , pp. 11358-11366
    • Kovacsovics, T.J.1    Bachelot, C.2    Toker, A.3    Vlahos, C.J.4    Duckworth, B.5    Cantley, L.C.6    Hartwig, J.H.7
  • 94
    • 0029011573 scopus 로고
    • Lysophosphatidic acid activates phosphoinositide 3-kinase and phospholipase C in human platelets: Inhibitory effects of Wortmannin on phosphoinositide 3-kinase and aggregation
    • 94. Zhang J, Rittenhouse S E. Lysophosphatidic acid activates phosphoinositide 3-kinase and phospholipase C in human platelets: inhibitory effects of Wortmannin on phosphoinositide 3-kinase and aggregation. Biochem Biophys Res Commun 1995; 211: 484-90.
    • (1995) Biochem Biophys Res Commun , vol.211 , pp. 484-490
    • Zhang, J.1    Rittenhouse, S.E.2
  • 95
    • 0030575178 scopus 로고    scopus 로고
    • AlphaIIb beta 3-integrin mediated adhesion of human platelets to a fibrinogen matrix triggers phospholipase C activation and phosphatidylinositol 3′,4′-biphosphate accumulation
    • 95. Gironcel D, Racaud S C, Payrastre B, Haricot M, Borchert G, Kieffer N, Breton M, Chap H. AlphaIIb beta 3-integrin mediated adhesion of human platelets to a fibrinogen matrix triggers phospholipase C activation and phosphatidylinositol 3′,4′-biphosphate accumulation. FEBS Lett 1996; 389: 253-6.
    • (1996) FEBS Lett , vol.389 , pp. 253-256
    • Gironcel, D.1    Racaud, S.C.2    Payrastre, B.3    Haricot, M.4    Borchert, G.5    Kieffer, N.6    Breton, M.7    Chap, H.8
  • 96
    • 0030614527 scopus 로고    scopus 로고
    • 1 receptor is an ADP receptor antagonized by ATP and expressed in platelets and megakaryoblastic cells
    • 1 receptor is an ADP receptor antagonized by ATP and expressed in platelets and megakaryoblastic cells. FEBS Lett 1997; 403: 26-30.
    • (1997) FEBS Lett , vol.403 , pp. 26-30
    • Leon, C.1    Hechler, B.2    Vial, C.3    Leray, C.4    Cazenave, J.P.5    Gachet, C.6
  • 98
    • 0029894287 scopus 로고    scopus 로고
    • Tyrosine phosphorylation of the Fc receptor gamma-chain in collagen-stimulated platelets
    • 98. Gibbins J, Asselin J, Farndale R, Barnes M, Law C L, Watson S P. Tyrosine phosphorylation of the Fc receptor gamma-chain in collagen-stimulated platelets. J Biol chem 1996; 271: 18095-99.
    • (1996) J Biol Chem , vol.271 , pp. 18095-18099
    • Gibbins, J.1    Asselin, J.2    Farndale, R.3    Barnes, M.4    Law, C.L.5    Watson, S.P.6
  • 99
    • 0030764155 scopus 로고    scopus 로고
    • A novel association of Fc receptor gamma-chain with glycoprotein VI and their coexpression as a collagen receptor in human platelets
    • 99. Tsuji M, Ezumi Y, Arai M, Takayama H. A novel association of Fc receptor gamma-chain with glycoprotein VI and their coexpression as a collagen receptor in human platelets. J Biol Chem 1997; 272: 23528-31.
    • (1997) J Biol Chem , vol.272 , pp. 23528-23531
    • Tsuji, M.1    Ezumi, Y.2    Arai, M.3    Takayama, H.4
  • 100
    • 0024980981 scopus 로고
    • Antigen receptor tail clue
    • 100. Reth M. Antigen receptor tail clue [letter]. Nature 1989; 338: 383-4.
    • (1989) Nature , vol.338 , pp. 383-384
    • Reth, M.1
  • 101
    • 0030833504 scopus 로고    scopus 로고
    • Syk and Fyn are required by mouse megakaryocytes for the rise in intracellular calcium induced by a collagen-related peptide
    • 101. Melford S K, Turner M, Briddon S J, Tybulewicz V L, Watson S P. Syk and Fyn are required by mouse megakaryocytes for the rise in intracellular calcium induced by a collagen-related peptide. J Biol Chem 1997; 272: 27539-42.
    • (1997) J Biol Chem , vol.272 , pp. 27539-27542
    • Melford, S.K.1    Turner, M.2    Briddon, S.J.3    Tybulewicz, V.L.4    Watson, S.P.5
  • 102
    • 0031825550 scopus 로고    scopus 로고
    • Physical and functional association of the Src family kinases Fyn and Lyn with the collagen receptor glycoprotein VI-Fc receptor gamma chain complex on human platelets
    • 102. Ezumi Y, Shindoh K, Tsuji M, Takayama H. Physical and functional association of the Src family kinases Fyn and Lyn with the collagen receptor glycoprotein VI-Fc receptor gamma chain complex on human platelets. J Exp Med 1998; 188: 267-76.
    • (1998) J Exp Med , vol.188 , pp. 267-276
    • Ezumi, Y.1    Shindoh, K.2    Tsuji, M.3    Takayama, H.4
  • 103
    • 0030917981 scopus 로고    scopus 로고
    • The Fc receptor gamma-chain and the tyrosine kinase Syk are essential for activation of mouse platelets by collagen
    • 103. Poole A, Gibbins J M, Turner M, van V M, van-de W J, Saito T, Tybulewicz V L, Watson S P. The Fc receptor gamma-chain and the tyrosine kinase Syk are essential for activation of mouse platelets by collagen. EMBO J 1997; 16: 2333-41.
    • (1997) EMBO J , vol.16 , pp. 2333-2341
    • Poole, A.1    Gibbins, J.M.2    Turner, M.3    Van, V.M.4    Van-De, W.J.5    Saito, T.6    Tybulewicz, V.L.7    Watson, S.P.8
  • 104
    • 0030953664 scopus 로고    scopus 로고
    • Platelet activation and signal transduction by convulxin, a C-type lectin from Crotalus durissus terrificus (tropical rattlesnake) venom via the p6/2hGPVI collagen receptor
    • 104. Polgar J, Clemetson J M, Kehrel B E, Wiedemann M, Magnenat E M, Wells T C, Clemetson KJ. Platelet activation and signal transduction by convulxin, a C-type lectin from Crotalus durissus terrificus (tropical rattlesnake) venom via the p6/2hGPVI collagen receptor. J Biol Chem 1997; 272: 13576-83.
    • (1997) J Biol Chem , vol.272 , pp. 13576-13583
    • Polgar, J.1    Clemetson, J.M.2    Kehrel, B.E.3    Wiedemann, M.4    Magnenat, E.M.5    Wells, T.C.6    Clemetson, K.J.7
  • 105
    • 0032545307 scopus 로고    scopus 로고
    • The p85 subunit of phosphatidylinositol 3-kinase associates with the Fc receptor gamma-chain and linker for activitor of T cells (LAT) in platelets stimulated by collagen and convulxin
    • 105. Gibbins J M, Briddon S, Shutes A, van V M, van-de W J, Saito T, Watson S P. The p85 subunit of phosphatidylinositol 3-kinase associates with the Fc receptor gamma-chain and linker for activitor of T cells (LAT) in platelets stimulated by collagen and convulxin. J Biol Chem 1998; 273: 34437-43.
    • (1998) J Biol Chem , vol.273 , pp. 34437-34443
    • Gibbins, J.M.1    Briddon, S.2    Shutes, A.3    Van, V.M.4    Van-De, W.J.5    Saito, T.6    Watson, S.P.7
  • 106
    • 0030790042 scopus 로고    scopus 로고
    • Glycoprotein VI is the collagen receptor in platelets which underlies tyrosine phosphorylation of the Fc receptor gamma-chain
    • 106. Gibbins J M, Okuma M, Farndale R, Barnes M, Watson S P. Glycoprotein VI is the collagen receptor in platelets which underlies tyrosine phosphorylation of the Fc receptor gamma-chain. FEBS Lett 1997; 413: 255-9.
    • (1997) FEBS Lett , vol.413 , pp. 255-259
    • Gibbins, J.M.1    Okuma, M.2    Farndale, R.3    Barnes, M.4    Watson, S.P.5
  • 107
    • 0032524687 scopus 로고    scopus 로고
    • Convulxin induces platelet activation by a tyrosine-kinase-dependent pathway and stimulates tyrosine phosphorylation of platelet proteins, including PLC gamma 2, independently of integrin alpha IIb beta 3
    • 107. Francischetti I M, Ghazaleh F A, Reis R A, Carlini C R, Guimaraes J A. Convulxin induces platelet activation by a tyrosine-kinase-dependent pathway and stimulates tyrosine phosphorylation of platelet proteins, including PLC gamma 2, independently of integrin alpha IIb beta 3. Arch Biochem Biophys 1998; 353: 239-50.
    • (1998) Arch Biochem Biophys , vol.353 , pp. 239-250
    • Francischetti, I.M.1    Ghazaleh, F.A.2    Reis, R.A.3    Carlini, C.R.4    Guimaraes, J.A.5
  • 108
    • 0033567185 scopus 로고    scopus 로고
    • A collagen-related peptide regulates phospholipase Cγ2 via phosphatidylinositol 3-kinase in human platelets
    • 108. Pasquet J M, Bobe R, Gross B, Gratacap M P, Tomlinson M G, Payrastre B, Watson S P. A collagen-related peptide regulates phospholipase Cγ2 via phosphatidylinositol 3-kinase in human platelets. Biochem J 1999; 342: 171-7.
    • (1999) Biochem J , vol.342 , pp. 171-177
    • Pasquet, J.M.1    Bobe, R.2    Gross, B.3    Gratacap, M.P.4    Tomlinson, M.G.5    Payrastre, B.6    Watson, S.P.7
  • 109
    • 0029883665 scopus 로고    scopus 로고
    • Phosphoinositide 3-kinase and p72syk noncovalently associate with the low affinity Fc gamma receptor on human platelets through an immunoreceptor tyrosine-based activation motif. Reconstitution with synthetic phosphopeptides
    • 109. Chacko G W, Brandt J T, Coggeshall K M, Anderson C L. Phosphoinositide 3-kinase and p72syk noncovalently associate with the low affinity Fc gamma receptor on human platelets through an immunoreceptor tyrosine-based activation motif. Reconstitution with synthetic phosphopeptides. J Biol Chem 1996; 271: 10775-81.
    • (1996) J Biol Chem , vol.271 , pp. 10775-10781
    • Chacko, G.W.1    Brandt, J.T.2    Coggeshall, K.M.3    Anderson, C.L.4
  • 110
    • 0032544546 scopus 로고    scopus 로고
    • Phosphatidylinositol 3,4,5-trisphosphate-dependent stimulation of phospholipase C-gamma2 is an early key event in FcgammaRIIA-mediated activation of human platelets
    • 110. Gratacap M P, Payrastre B, Viala C, Mauco G, Plantavid M, Chap H. Phosphatidylinositol 3,4,5-trisphosphate-dependent stimulation of phospholipase C-gamma2 is an early key event in FcgammaRIIA-mediated activation of human platelets. J Biol Chem 1998; 273: 24314-21.
    • (1998) J Biol Chem , vol.273 , pp. 24314-24321
    • Gratacap, M.P.1    Payrastre, B.2    Viala, C.3    Mauco, G.4    Plantavid, M.5    Chap, H.6
  • 111
    • 0033593215 scopus 로고    scopus 로고
    • Fc receptor-mediated platelet activation is dependent on phosphatidylinositol 3-kinase activation and involves p120 (Cbl)
    • 111. Saci A, Pain S, Rendu F, Bachelot L C. Fc receptor-mediated platelet activation is dependent on phosphatidylinositol 3-kinase activation and involves p120 (Cbl). J Biol Chem 1999; 274: 1898-904.
    • (1999) J Biol Chem , vol.274 , pp. 1898-1904
    • Saci, A.1    Pain, S.2    Rendu, F.3    Bachelot, L.C.4
  • 112
    • 0032570711 scopus 로고    scopus 로고
    • Physical proximity and functional interplay of the glycoprotein Ib-IX-V complex and the Fc receptor FcgammaRIIA on the platelet plasma membrane
    • 112. Sullam P M, Hyun W C, Szollosi J, Dong J, Foss W M, Lopez J A. Physical proximity and functional interplay of the glycoprotein Ib-IX-V complex and the Fc receptor FcgammaRIIA on the platelet plasma membrane. J Biol Chem 1998; 273: 5331-6.
    • (1998) J Biol Chem , vol.273 , pp. 5331-5336
    • Sullam, P.M.1    Hyun, W.C.2    Szollosi, J.3    Dong, J.4    Foss, W.M.5    Lopez, J.A.6
  • 113
    • 0033199050 scopus 로고    scopus 로고
    • Glycoprotein Ib-V-IX, a receptor for von Willebrand factor, couples physically and functionally to the Fc receptor g-chain, Fyn, and Lyn to activate human platelets
    • 113. Falati S, Edmead C E, Poole A W. Glycoprotein Ib-V-IX, a receptor for von Willebrand factor, couples physically and functionally to the Fc receptor g-chain, Fyn, and Lyn to activate human platelets. Blood 1999; 94: 1648-56.
    • (1999) Blood , vol.94 , pp. 1648-1656
    • Falati, S.1    Edmead, C.E.2    Poole, A.W.3
  • 114
    • 0027985446 scopus 로고
    • Adhesion receptor activation of phosphatidylinositol 3-kinase. von Willebrand factor stimulates the cytoskeletal association and activation of phosphatidylinositol 3-kinase and pp60c-src in human platelets
    • 114. Jackson S P, Schoenwaelder S M, Yuan Y, Rabinowitz I, Salem H H, Mitchell C A. Adhesion receptor activation of phosphatidylinositol 3-kinase. von Willebrand factor stimulates the cytoskeletal association and activation of phosphatidylinositol 3-kinase and pp60c-src in human platelets. J Biol Chem 1994; 269: 27093-9.
    • (1994) J Biol Chem , vol.269 , pp. 27093-27099
    • Jackson, S.P.1    Schoenwaelder, S.M.2    Yuan, Y.3    Rabinowitz, I.4    Salem, H.H.5    Mitchell, C.A.6
  • 115
    • 0025738895 scopus 로고
    • Protein kinase C regulates the stimulated accumulation of 3-phosphorylated phosphoinositides in platelets
    • 115. King W G, Kucera G L, Sorisky A, Zhang J, Rittenhouse S E. Protein kinase C regulates the stimulated accumulation of 3-phosphorylated phosphoinositides in platelets. Biochem J 1991; 278: 475-80.
    • (1991) Biochem J , vol.278 , pp. 475-480
    • King, W.G.1    Kucera, G.L.2    Sorisky, A.3    Zhang, J.4    Rittenhouse, S.E.5
  • 116
    • 0023915806 scopus 로고
    • The action of the protein kinase C inhibitor, staurosporine, on human platelets. Evidence against a regulatory role for protein kinase C in the formation of inositol trisphosphate by thrombin
    • 116. Watson S P, McNally J, Shipman L J, Godfrey P P. The action of the protein kinase C inhibitor, staurosporine, on human platelets. Evidence against a regulatory role for protein kinase C in the formation of inositol trisphosphate by thrombin. Biochem J 1988; 249: 345-50.
    • (1988) Biochem J , vol.249 , pp. 345-350
    • Watson, S.P.1    McNally, J.2    Shipman, L.J.3    Godfrey, P.P.4
  • 117
    • 0030474160 scopus 로고    scopus 로고
    • D3 phosphoinositides and outside-in integrin signaling by glycoprotein IIb-IIIa mediate platelet actin assembly and filopodial extension induced by phorbol 12-myristate 13-acetate
    • 117. Hartwig J H, Kung S, Kovacsovics T, Janmey P A, Cantley L C, Stossel T P, Toker A. D3 phosphoinositides and outside-in integrin signaling by glycoprotein IIb-IIIa mediate platelet actin assembly and filopodial extension induced by phorbol 12-myristate 13-acetate. J Biol Chem 1996; 271: 32986-93.
    • (1996) J Biol Chem , vol.271 , pp. 32986-32993
    • Hartwig, J.H.1    Kung, S.2    Kovacsovics, T.3    Janmey, P.A.4    Cantley, L.C.5    Stossel, T.P.6    Toker, A.7
  • 118
    • 0026014052 scopus 로고
    • Protein kinase C and cyclic AMP regulate reversible exposure of binding sites for fibrinogen on the glycoprotein IIB-IIIA complex of human platelets
    • 118. van-Willigen G, Akkerman J W. Protein kinase C and cyclic AMP regulate reversible exposure of binding sites for fibrinogen on the glycoprotein IIB-IIIA complex of human platelets. Biochem J 1991; 273: 115-20.
    • (1991) Biochem J , vol.273 , pp. 115-120
    • Van-Willigen, G.1    Akkerman, J.W.2
  • 119
    • 0026781093 scopus 로고
    • Regulation of glycoprotein IIb-IIIa receptor function studied with platelets permeabilized by the pore-forming complement proteins C5b-9
    • 119. Shattil S J, Cunningham M. Wiedmer T, Zhao J, Sims P J, Brass L F. Regulation of glycoprotein IIb-IIIa receptor function studied with platelets permeabilized by the pore-forming complement proteins C5b-9. J Biol Chem 1992; 267: 18424-31.
    • (1992) J Biol Chem , vol.267 , pp. 18424-18431
    • Shattil, S.J.1    Cunningham, M.2    Wiedmer, T.3    Zhao, J.4    Sims, P.J.5    Brass, L.F.6
  • 122
    • 0028343099 scopus 로고
    • Identification and cloning of a megakaryocyte growth and development factor that is a ligand for the cytokine receptor Mpl
    • 122. Bartley T D, Bogenberger J, Hunt P, Li Y S, Lu H S, Martin F, Chang M S, Samal B, Nichol J L, Swift S, et al. Identification and cloning of a megakaryocyte growth and development factor that is a ligand for the cytokine receptor Mpl. Cell 1994; 77: 1117-24.
    • (1994) Cell , vol.77 , pp. 1117-1124
    • Bartley, T.D.1    Bogenberger, J.2    Hunt, P.3    Li, Y.S.4    Lu, H.S.5    Martin, F.6    Chang, M.S.7    Samal, B.8    Nichol, J.L.9    Swift, S.10
  • 124
    • 0029080417 scopus 로고
    • Megakaryocyte growth and development factor (MGDF) moderately enhances in-vitro platelet aggregation
    • 124. Toombs C F, Young C H, Glaspy J A, Varnum B C. Megakaryocyte growth and development factor (MGDF) moderately enhances in-vitro platelet aggregation. Thromb Res 1995; 80: 23-33.
    • (1995) Thromb Res , vol.80 , pp. 23-33
    • Toombs, C.F.1    Young, C.H.2    Glaspy, J.A.3    Varnum, B.C.4
  • 125
    • 0028820319 scopus 로고
    • Regulation of platelet activation in vitro by the c-Mpl ligand, thrombopoietin
    • 125. Chen J, Herceg H L, Groopman J E, Grabarek J. Regulation of platelet activation in vitro by the c-Mpl ligand, thrombopoietin. Blood 1995; 86: 4054-62.
    • (1995) Blood , vol.86 , pp. 4054-4062
    • Chen, J.1    Herceg, H.L.2    Groopman, J.E.3    Grabarek, J.4
  • 126
    • 0028827190 scopus 로고
    • Thrombopoietin, c-Mpl ligand, induces tyrosine phosphorylation of Tyk2, JAK2, and STAT3, and enhances agonists-induced aggregation in platelets in vitro
    • 126. Ezumi Y, Takayama H, Okuma M. Thrombopoietin, c-Mpl ligand, induces tyrosine phosphorylation of Tyk2, JAK2, and STAT3, and enhances agonists-induced aggregation in platelets in vitro. FEBS Lett 1995; 374: 48-52.
    • (1995) FEBS Lett , vol.374 , pp. 48-52
    • Ezumi, Y.1    Takayama, H.2    Okuma, M.3
  • 128
    • 0029979883 scopus 로고    scopus 로고
    • Thrombopoietin potentiates activation of human platelets in association with JAK2 and TYK2 phosphorylation
    • 128. Rodriguez L B, Watson S P. Thrombopoietin potentiates activation of human platelets in association with JAK2 and TYK2 phosphorylation. Biochem J 1996; 316: 93-8.
    • (1996) Biochem J , vol.316 , pp. 93-98
    • Rodriguez, L.B.1    Watson, S.P.2
  • 129
    • 0032006890 scopus 로고    scopus 로고
    • The p85 and p110 subunits of phosphatidylinositol 3-kinase-alpha are substrates, in vitro, for a constitutively associated protein tyrosine kinase in platelets
    • 129. Geltz N R, Augustine J A. The p85 and p110 subunits of phosphatidylinositol 3-kinase-alpha are substrates, in vitro, for a constitutively associated protein tyrosine kinase in platelets. Blood 1998; 91: 930-9.
    • (1998) Blood , vol.91 , pp. 930-939
    • Geltz, N.R.1    Augustine, J.A.2
  • 130
    • 0027207172 scopus 로고
    • Identification of a functional receptor for granulocyte colony-stimulating factor on platelets
    • 130. Shimoda K, Okamura S, Harada N, Kondo S, Okamura T, Niho Y. Identification of a functional receptor for granulocyte colony-stimulating factor on platelets. J Clin Invest 1993; 91: 1310-3.
    • (1993) J Clin Invest , vol.91 , pp. 1310-1313
    • Shimoda, K.1    Okamura, S.2    Harada, N.3    Kondo, S.4    Okamura, T.5    Niho, Y.6
  • 132
    • 0028221289 scopus 로고
    • Negative feedback regulation of human platelets via autocrine activation of the platelet-derived growth factor alpha-receptor
    • 132. Vassbotn F S, Havnen O K, Heldin C H, Holmsen H. Negative feedback regulation of human platelets via autocrine activation of the platelet-derived growth factor alpha-receptor. J Biol Chem 1994; 269: 13874-9.
    • (1994) J Biol Chem , vol.269 , pp. 13874-13879
    • Vassbotn, F.S.1    Havnen, O.K.2    Heldin, C.H.3    Holmsen, H.4
  • 133
    • 0024542429 scopus 로고
    • Collagen-induced binding to human platelets of platelet-derived growth factor leading to inhibition of P43 and P20 phosphorylation
    • 133. Bryckaert M C, Rendu F, Tobelem G, Wasteson A. Collagen-induced binding to human platelets of platelet-derived growth factor leading to inhibition of P43 and P20 phosphorylation. J Biol Chem 1989; 264: 4336-41.
    • (1989) J Biol Chem , vol.264 , pp. 4336-4341
    • Bryckaert, M.C.1    Rendu, F.2    Tobelem, G.3    Wasteson, A.4
  • 134
    • 0022504044 scopus 로고
    • PDGF modifies phosphoinositide metabolism and inhibits aggregation and release in human platelets
    • 134. Bryckaert M C, Rendu F, Tobelem G, Caen J. PDGF modifies phosphoinositide metabolism and inhibits aggregation and release in human platelets. Biochem Biophys Res Commun 1986; 135: 52-7.
    • (1986) Biochem Biophys Res Commun , vol.135 , pp. 52-57
    • Bryckaert, M.C.1    Rendu, F.2    Tobelem, G.3    Caen, J.4
  • 135
    • 0032831455 scopus 로고    scopus 로고
    • Platelet-derived growth factor (PDGF) inhibits platelet activation in heparinired whole blood
    • 135. Selheim F, Holmsen H, Vassbotn F S. Platelet-derived growth factor (PDGF) inhibits platelet activation in heparinired whole blood. Thromb Res 1999; 95: 185-96.
    • (1999) Thromb Res , vol.95 , pp. 185-196
    • Selheim, F.1    Holmsen, H.2    Vassbotn, F.S.3
  • 136
    • 0032938716 scopus 로고    scopus 로고
    • Regulation of tyrosine kinase cascades by G-protein-coupled receptors
    • 136. Luttrell L M, Daaka Y, Lefkowitz R J. Regulation of tyrosine kinase cascades by G-protein-coupled receptors. Curr Opin Cell Biol 1999; 11: 177-83.
    • (1999) Curr Opin Cell Biol , vol.11 , pp. 177-183
    • Luttrell, L.M.1    Daaka, Y.2    Lefkowitz, R.J.3
  • 137
    • 0029670904 scopus 로고    scopus 로고
    • Stimulation of betal integrins on fibroblasts induces PDGF independent tyrosine phosphorylation of PDGF beta-receptors
    • 137. Sundberg C, Rubin K. Stimulation of betal integrins on fibroblasts induces PDGF independent tyrosine phosphorylation of PDGF beta-receptors. J Cell Biol 1996; 132: 741-52.
    • (1996) J Cell Biol , vol.132 , pp. 741-752
    • Sundberg, C.1    Rubin, K.2
  • 138
    • 0032547385 scopus 로고    scopus 로고
    • Signal transduction via platelet-derived growth factor receptors
    • 138. Heldin C H, Ostman A, Ronnstrand L. Signal transduction via platelet-derived growth factor receptors. Biochim Biophys Acta 1998; 1378: F79-113.
    • (1998) Biochim Biophys Acta , vol.1378
    • Heldin, C.H.1    Ostman, A.2    Ronnstrand, L.3
  • 139
    • 0028095620 scopus 로고
    • Structure, regulation and function of phosphoinositide 3-kinases
    • 139. Fry M J. Structure, regulation and function of phosphoinositide 3-kinases. Biochim Biophys Acta 1994; 1226: 237-68.
    • (1994) Biochim Biophys Acta , vol.1226 , pp. 237-268
    • Fry, M.J.1
  • 141
    • 0032143284 scopus 로고    scopus 로고
    • Phosphoinositide 3-kinase: The key switch mechanism in insulin signalling
    • 141. Shepherd P R, Withers D J, Siddle K. Phosphoinositide 3-kinase: the key switch mechanism in insulin signalling. Biochem J 1998; 333: 471-90.
    • (1998) Biochem J , vol.333 , pp. 471-490
    • Shepherd, P.R.1    Withers, D.J.2    Siddle, K.3
  • 142
    • 0032929762 scopus 로고    scopus 로고
    • Signalling through phosphoinositide 3-kinases: The lipids take centre stage
    • 142. Leevers S J, Vanhaesebroeck B, Waterfield M D. Signalling through phosphoinositide 3-kinases: the lipids take centre stage. Curr Opin Cell Biol 1999; 11: 219-25.
    • (1999) Curr Opin Cell Biol , vol.11 , pp. 219-225
    • Leevers, S.J.1    Vanhaesebroeck, B.2    Waterfield, M.D.3
  • 143
    • 0032514903 scopus 로고    scopus 로고
    • Lipid products of phosphoinositide 3-kinase interact with Rac1 GTPase and stimulate GDP dissociation
    • 143. Missy K, Van P V, Raynal P, Viala C, Mauco G, Plantavid M, Chap H, Payrastre B. Lipid products of phosphoinositide 3-kinase interact with Rac1 GTPase and stimulate GDP dissociation. J Biol Chem 1998; 273: 30279-86.
    • (1998) J Biol Chem , vol.273 , pp. 30279-30286
    • Missy, K.1    Van, P.V.2    Raynal, P.3    Viala, C.4    Mauco, G.5    Plantavid, M.6    Chap, H.7    Payrastre, B.8
  • 144
    • 0033605718 scopus 로고    scopus 로고
    • The role of phosphoinositide 3-kinase lipid products in cell function
    • 144. Rameh L E, Cantley L C. The role of phosphoinositide 3-kinase lipid products in cell function. J Biol Chem 1999; 274: 8347-50.
    • (1999) J Biol Chem , vol.274 , pp. 8347-8350
    • Rameh, L.E.1    Cantley, L.C.2
  • 145
    • 0030992837 scopus 로고    scopus 로고
    • Signalling through the lipid products of phosphoinositide-3-OH kinase
    • 145. Toker A, Cantley L C. Signalling through the lipid products of phosphoinositide-3-OH kinase. Nature 1997; 387: 673-6.
    • (1997) Nature , vol.387 , pp. 673-676
    • Toker, A.1    Cantley, L.C.2
  • 146
    • 0031039024 scopus 로고    scopus 로고
    • Direct regulation of the Akt proto-oncogene product by phosphatidylinositol-3,4-bisphosphate
    • 146. Franke T F, Kaplan D R, Cantley L C, Toker A. Direct regulation of the Akt proto-oncogene product by phosphatidylinositol-3,4-bisphosphate [see comments]. Science 1997; 275: 665-8.
    • (1997) Science , vol.275 , pp. 665-668
    • Franke, T.F.1    Kaplan, D.R.2    Cantley, L.C.3    Toker, A.4
  • 148
    • 0031127305 scopus 로고    scopus 로고
    • Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha
    • 148. Alessi D R, James S R, Downes C P, Holmes A B, Gaffney P R, Reese C B, Cohen P. Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha. Curr Biol 1997; 7: 261-9.
    • (1997) Curr Biol , vol.7 , pp. 261-269
    • Alessi, D.R.1    James, S.R.2    Downes, C.P.3    Holmes, A.B.4    Gaffney, P.R.5    Reese, C.B.6    Cohen, P.7
  • 149
    • 0032523064 scopus 로고    scopus 로고
    • Integrin signaling: The platelet paradigm
    • 149. Shattil SJ, Kashiwagi H, Pampori N. Integrin signaling: the platelet paradigm. Blood 1998; 91: 2645-57.
    • (1998) Blood , vol.91 , pp. 2645-2657
    • Shattil, S.J.1    Kashiwagi, H.2    Pampori, N.3
  • 152
    • 0032497629 scopus 로고    scopus 로고
    • A role for Bruton's tyrosine kinase (Btk) in platelet activation by collagen
    • 152. Quek L S, Bolen J, Watson S P. A role for Bruton's tyrosine kinase (Btk) in platelet activation by collagen. Curr Biol 1998; 8: 1137-40.
    • (1998) Curr Biol , vol.8 , pp. 1137-1140
    • Quek, L.S.1    Bolen, J.2    Watson, S.P.3
  • 153
    • 0031471231 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase-gamma activates Bruton's tyrosine kinase in concert with Src family kinases
    • 153. Li Z, Wahl M I, Eguinoa A, Stephens L R, Hawkins P T, Witte O N. Phosphatidylinositol 3-kinase-gamma activates Bruton's tyrosine kinase in concert with Src family kinases. Proc Natl Acad Sci USA 1997; 94: 13820-5.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 13820-13825
    • Li, Z.1    Wahl, M.I.2    Eguinoa, A.3    Stephens, L.R.4    Hawkins, P.T.5    Witte, O.N.6
  • 156
    • 0032518666 scopus 로고    scopus 로고
    • Activation of phospholipase C gamma by PI 3-kinase-induced PH domain-mediated membrane targeting
    • 156. Falasca M, Logan S K, Lehto V P, Baccante G, Lemmon M A, Schlessinger J. Activation of phospholipase C gamma by PI 3-kinase-induced PH domain-mediated membrane targeting. EMBO J 1998; 17: 414-22.
    • (1998) EMBO J , vol.17 , pp. 414-422
    • Falasca, M.1    Logan, S.K.2    Lehto, V.P.3    Baccante, G.4    Lemmon, M.A.5    Schlessinger, J.6
  • 157
    • 0029084949 scopus 로고
    • Phosphatidylinositol (3,4,5)-trisphosphate stimulates phosphorylation of pleckstrin in human platelets
    • 157. Zhang J, Falck J R, Reddy K K, Abrams C S, Zhao W, Rittenhouse S E. Phosphatidylinositol (3,4,5)-trisphosphate stimulates phosphorylation of pleckstrin in human platelets. J Biol Chem. 1995; 270: 22807-10.
    • (1995) J Biol Chem. , vol.270 , pp. 22807-22810
    • Zhang, J.1    Falck, J.R.2    Reddy, K.K.3    Abrams, C.S.4    Zhao, W.5    Rittenhouse, S.E.6
  • 158
    • 0026757550 scopus 로고
    • Suppression by wortmannin of platelet responses to stimuli due to inhibition of pleckstrin phosphorylation
    • 158. Yatomi Y, Hazeki O, Kume S, Ui M. Suppression by wortmannin of platelet responses to stimuli due to inhibition of pleckstrin phosphorylation. Biochem J 1992; 285: 745-51.
    • (1992) Biochem J , vol.285 , pp. 745-751
    • Yatomi, Y.1    Hazeki, O.2    Kume, S.3    Ui, M.4
  • 159
    • 0024336014 scopus 로고
    • Molecular analysis of pleckstrin: The major protein kinase C substrate of platelets
    • 159. Tyers M, Haslam R J, Rachubinski R A, Harley C B. Molecular analysis of pleckstrin: the major protein kinase C substrate of platelets. J Cell Biochem 1989; 40: 133-45.
    • (1989) J Cell Biochem , vol.40 , pp. 133-145
    • Tyers, M.1    Haslam, R.J.2    Rachubinski, R.A.3    Harley, C.B.4
  • 160
    • 0029661976 scopus 로고    scopus 로고
    • Phosphopleckstrin inhibits Gβγ-activable platelet phosphatidylinositol-4,5-bisphosphate 3-kinase
    • 160. Abrams C S, Zhang J, Downes C P, Tang X, Zhao W, Rittenhouse S E. Phosphopleckstrin inhibits Gβγ-activable platelet phosphatidylinositol-4,5-bisphosphate 3-kinase. J Biol Chem. 1996; 271: 25192-7.
    • (1996) J Biol Chem. , vol.271 , pp. 25192-25197
    • Abrams, C.S.1    Zhang, J.2    Downes, C.P.3    Tang, X.4    Zhao, W.5    Rittenhouse, S.E.6
  • 161
    • 0030998128 scopus 로고    scopus 로고
    • Pleckstrin associates with plasma membranes and induces the formation of membrane projections: Requirements for phosphorylation and the NH2-terminal PH domain
    • 161. Ma A D, Brass L F, Abrams C S. Pleckstrin associates with plasma membranes and induces the formation of membrane projections: requirements for phosphorylation and the NH2-terminal PH domain. J Cell Biol 1997; 136: 1071-9.
    • (1997) J Cell Biol , vol.136 , pp. 1071-1079
    • Ma, A.D.1    Brass, L.F.2    Abrams, C.S.3
  • 162
    • 0029055503 scopus 로고
    • Pleckstrin inhibits phosphoinositide hydrolysis initiated by G-protein-coupled and growth factor receptors. A role for pleckstrin's PH domains
    • 162. Abrams C S, Wu H, Zhao W, Belmonte E, White D, Brass L F. Pleckstrin inhibits phosphoinositide hydrolysis initiated by G-protein-coupled and growth factor receptors. A role for pleckstrin's PH domains. J Biol Chem 1995; 270: 14485-92.
    • (1995) J Biol Chem , vol.270 , pp. 14485-14492
    • Abrams, C.S.1    Wu, H.2    Zhao, W.3    Belmonte, E.4    White, D.5    Brass, L.F.6
  • 163
    • 0028865255 scopus 로고
    • Protein kinase C regulates pleckstrin by phosphorylation of sites adjacent to the N-terminal pleckstrin homology domain
    • 163. Abrams C S, Zhao W, Belmonte E, Brass L F. Protein kinase C regulates pleckstrin by phosphorylation of sites adjacent to the N-terminal pleckstrin homology domain. J Biol Chem 1995; 270: 23317-21.
    • (1995) J Biol Chem , vol.270 , pp. 23317-23321
    • Abrams, C.S.1    Zhao, W.2    Belmonte, E.3    Brass, L.F.4
  • 164
    • 0031018359 scopus 로고    scopus 로고
    • Phosphorylation of platelet pleckstrin activates inositol polyphosphate 5-phosphatase I
    • 164. Auethavekiat V, Abrams C S, Majerus P W. Phosphorylation of platelet pleckstrin activates inositol polyphosphate 5-phosphatase I. J Biol Chem 1997; 272: 1786-90.
    • (1997) J Biol Chem , vol.272 , pp. 1786-1790
    • Auethavekiat, V.1    Abrams, C.S.2    Majerus, P.W.3
  • 165
    • 0032932813 scopus 로고    scopus 로고
    • Editorial overview: Intracellular networking
    • 165. Brugge J S, McCormick F. Editorial overview: Intracellular networking. Curr Opin Cell Biol 1999; 11: 173-6.
    • (1999) Curr Opin Cell Biol , vol.11 , pp. 173-176
    • Brugge, J.S.1    McCormick, F.2
  • 166
    • 0032500730 scopus 로고    scopus 로고
    • Bifurcation of lipid and protein kinase signals of PI3Kgamma to the protein kinases PKB and MAPK
    • 166. Bondeva T, Pirola L, Bulgarelli L G, Rubio I, Wetzker R, Wymann M P. Bifurcation of lipid and protein kinase signals of PI3Kgamma to the protein kinases PKB and MAPK. Science 1998; 282: 293-6.
    • (1998) Science , vol.282 , pp. 293-296
    • Bondeva, T.1    Pirola, L.2    Bulgarelli, L.G.3    Rubio, I.4    Wetzker, R.5    Wymann, M.P.6


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