A transesterification reaction is implicated in the covalent binding of benzo[b]acronycine anticancer agents with DNA and glutathion

Bioorganic and Medicinal Chemistry

Volumn 12, Issue 1, 2004, Pages 23-29

  David Cordonnier, Marie Hélène ^a   Laine, William ^a   Kouach, Mostafa ^b   Briand, Gilbert ^b   Vezin, Hervé ^b   Gaslonde, Thomas ^c   Michel, Sylvie ^c   Doan Thi Mai, Huong ^c   Tillequin, Francois ^c   Koch, Michel ^c   Léonce, Stéphane ^d   Pierré, Alain ^d   Bailly, Christian ^a  

^a INSERM   (France)

^b UNIV LILLE   (France)

^c UNIVERSITÉ PARIS DESCARTES   (France)

^d INSTITUT DE RECHERCHES SERVIER   (France)

Author keywords

Acronycine; Anticancer drugs; DNA alkylation; Glutathion conjugation

Indexed keywords

ACETIC ACID; ACRONINE; ANTINEOPLASTIC AGENT; DNA; GLUTATHIONE; GUANINE; S 239061; S 286871; S 289071; UNCLASSIFIED DRUG;

ANALYTIC METHOD; ANTINEOPLASTIC ACTIVITY; ARTICLE; COVALENT BOND; CYTOTOXICITY; DNA ALKYLATION; DRUG MECHANISM; DRUG SCREENING; DRUG SELECTIVITY; DRUG TARGETING; HYDROLYSIS; IN VIVO STUDY; MASS SPECTROMETRY; MOLECULAR MODEL; NUCLEAR MAGNETIC RESONANCE; REACTION ANALYSIS; SOLID TUMOR; TRANSESTERIFICATION; VALIDATION PROCESS;

EID: 0347301864     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2003.10.056     Document Type: Article

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