Acronycine derivatives as promising antitumor agents

Anti-Cancer Drugs

Volumn 13, Issue 5, 2002, Pages 445-449

  Guilbaud, Nicolas ^a   Léonce, Stéphane ^a   Tillequin, François ^a   Koch, Michel ^a   Hickman, John A ^a   Pierré, Alain ^a  

^a INSTITUT DE RECHERCHES SERVIER   (France)

Author keywords

Acronycine; Cell cycle; Cytotoxic drug; Human tumors; Orthotopic models; S23906 1

Indexed keywords

ACRONINE; ANTINEOPLASTIC AGENT; CYCLIN E; S 23906 1; UNCLASSIFIED DRUG; DRUG DERIVATIVE; S 23906-1;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; CELL CYCLE; CLONOGENIC ASSAY; COLON CANCER; DNA ALKYLATION; DNA SYNTHESIS INHIBITION; DRUG DESIGN; DRUG EFFICACY; DRUG MECHANISM; DRUG STRUCTURE; HUMAN; LUNG CANCER; OVARY CANCER; PRIORITY JOURNAL; REVIEW; SOLID TUMOR; ANIMAL; DISEASE MODEL; DRUG SCREENING; EXPERIMENTAL NEOPLASM; IN VITRO STUDY; MOUSE; MOUSE STRAIN; NUDE MOUSE; PATHOLOGY; SURVIVAL RATE;

ACRONINE; ANIMAL; ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; CELL CYCLE; DISEASE MODELS, ANIMAL; HUMAN; IN VITRO; MICE; MICE, INBRED STRAINS; MICE, NUDE; NEOPLASMS, EXPERIMENTAL; SURVIVAL RATE; XENOGRAFT MODEL ANTITUMOR ASSAYS; ANIMALS; HUMANS;

EID: 0035987055     PISSN: 09594973     EISSN: None     Source Type: Journal    
DOI: 10.1097/00001813-200206000-00002     Document Type: Review

References (31)

1. Acronycine type alkaloids: Chemistry and biology
2. Alkaloids of the Australian Rutaceae
3. Alkaloids of Acronichia baueri - Extraction of the alkaloids and structure-activity relationships
4. Alkaloids of Acronychia baueri - Isolation of the alkaloids and study of the antitumor and other biological properties of acronycine
5. Development of a parenteral formulation for the anti-tumor agent acronycine
6. Antitumor activity and murine pharmacokinetics of parenteral acronycine
7. Phase I-II evaluation of acronycine in patients with multiple myeloma
8. Effects of the antineoplastic alkaloid acronycine on nucleoside uptake and incorporation into nucleic acids by cultured L5178Y cells
9. Effects of acronycine, bleomycine and cytosine arabinoside on the cell cycle
10. Evaluation of the cytotoxic mechanisms mediated by the broad-spectrum antitumor alkaloid acronycine and selected semi-synthetic derivatives
11. Acridone alkaloids: Experimental antitumor activity of acronycine
12. Alkaloids in the genus Sarcomelicope Engl. (Rutaceae)
13. Acronycine epoxide: A new acridone alkaloid from several sarcomelicope species
14. Oxidation of acridone alkaloids: Synthesis of 5-methoxyacronycine
15. Wege zum Acronycin-Epoxid und Acronycin-Diol
16. Synthese von Acronycinepoxid
17. Synthesis and cytotoxic and antitumor activity of esters in the 1,2-dihydroxy-1,2-dihydroacronycine series
18. Nouveaux dérivés de l'acronycine d'activité antitumorale accrue et de spectre élargi
19. Synthesis and biological activity of esters in the trans-1,2-dihydroxy-1,2-dihydroacronycine series
20. Synthesis and cytotoxic and antitumor activity of benzo[b]pyrano[3,2-h]acridin-7-one analogues of Acronycine
21. Cytotoxicity and cell cycle effect of S 23906, a new acronycine derivative
22. Induction of cyclin E and inhibition of DNA synthesis by the novel acronycine derivative S 23906-1 precede the irreversible arrest of tumor cells in S phase leading to apoptosis
23. Marked antitumor activity of a new potent acronycine derivative in orthotopic models of human solid tumors
24. What is the optimal model for anti-tumor drug testing?
25. Orthotopic models are necessary to predict therapy of transplantable tumors in mice
26. Orthotopic metastatic mouse models for anticancer drug discovery and evaluation: A bridge to the clinic
27. Biological and pharmacological characterization of three models of human ovarian carcinoma established in nude mice: Use of the CA125 tumor marker to predict antitumor activity
28. Histology and sensitivity to anticancer drugs of two human non-small cell lung carcinomas implanted in the pleural cavity of nude mice
29. The novel acronycine derivative S 23906-1 is orally active in therapeutic models of metastatic disease
30. 2 in the minor groove by S 23906-1, a novel potent antitumor compound derived from the plant alkaloid acronycine