Cholestasis increases tumor necrosis factor-related apoptotis-inducing ligand (TRAIL)-R2/DR5 expression and sensitizes the liver to trail-mediated cytotoxicity

Journal of Pharmacology and Experimental Therapeutics

Volumn 303, Issue 2, 2002, Pages 461-467

  Higuchi, Hajime ^a   Bronk, Steven F ^a   Taniai, Makiko ^a   Canbay, Ali ^a   Gores, Gregory J ^a  

^a MAYO CLINIC COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE AMINOTRANSFERASE; ANTINEOPLASTIC AGENT; BILE ACID; CASPASE 3; MESSENGER RNA; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BILE DUCT LIGATION; CHOLESTASIS; CONTROLLED STUDY; CYTOTOXICITY; ENZYME ACTIVITY; GENE EXPRESSION; HISTOPATHOLOGY; IMMUNOBLOTTING; IMMUNOPRECIPITATION; LIVER CELL; LIVER TOXICITY; MALE; MOUSE; NICK END LABELING; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SENSITIZATION; SIGNAL TRANSDUCTION;

ALANINE TRANSAMINASE; ANIMALS; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; BLOTTING, WESTERN; CASPASE 3; CASPASES; CHOLESTASIS; COMMON BILE DUCT; HEPATOCYTES; IN SITU NICK-END LABELING; LIVER; MALE; MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED C57BL; PRECIPITIN TESTS; RECEPTORS, TNF-RELATED APOPTOSIS-INDUCING LIGAND; RECEPTORS, TUMOR NECROSIS FACTOR; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SIGNAL TRANSDUCTION; TNF-RELATED APOPTOSIS-INDUCING LIGAND; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0036827808     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: 10.1124/jpet.102.040030     Document Type: Article

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