New horizons in the regulation of bile acid and lipid homeostasis: Critical role of the nuclear receptor fxr as an intracellular bile acid sensor

Gut

Volumn 49, Issue 4, 2001, Pages 465-466

  Arrese, M ^a  

^a PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE   (Chile)

Author keywords

[No Author keywords available]

Indexed keywords

BILE ACID; BILE ACID RECEPTOR; BINDING PROTEIN; CARRIER PROTEIN; CELL NUCLEUS RECEPTOR; CHOLESTEROL; CHOLESTEROL 7ALPHA MONOOXYGENASE; LIPID; LIPOPROTEIN; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

ATHEROGENESIS; BILE ACID BLOOD LEVEL; CHOLESTASIS; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; FECES LEVEL; GENE EXPRESSION; HOMEOSTASIS; IN VIVO STUDY; INTRAHEPATIC BILE DUCT; LIVER LEVEL; MOUSE; NONHUMAN; NOTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY MECHANISM; SENSOR; TRIACYLGLYCEROL BLOOD LEVEL;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; APOPTOSIS REGULATORY PROTEINS; BILE ACIDS AND SALTS; CARRIER PROTEINS; DNA-BINDING PROTEINS; HOMEOSTASIS; LIPID METABOLISM; MEMBRANE PROTEINS; MICE; MICE, INBRED STRAINS; RECEPTORS, CYTOPLASMIC AND NUCLEAR; TRANSCRIPTION FACTORS;

EID: 0034829606     PISSN: 00175749     EISSN: None     Source Type: Journal    
DOI: 10.1136/gut.49.4.465     Document Type: Note

References (15)

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5. Hepatic transport of bile salts
6. Transcriptional control of hepatocanalicular transporter gene expression
7. Identification of a bile acid response element in the cholesterol 7 alpha-hydroxylase gene CYP7A
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9. Molecular basis for feedback regulation of bile acid synthesis by nuclear receptors
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12. Bile acids: Natural ligands for an orphan nuclear receptor
13. Don't know much bile-ology
14. An essential role for nuclear receptors SXR/PXR in detoxification of cholestatic bile acids
15. The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity