Candida glabrata STE12 is required for wild-type levels of virulence and nitrogen starvation induced filamentation

Molecular Microbiology

Volumn 50, Issue 4, 2003, Pages 1309-1318

  Calcagno, Ana Maria ^a   Bignell, Elaine ^a   Warn, Peter ^b   Jones, Michael D ^a   Denning, David W ^b   Mühlschlegel, Fritz A ^c   Rogers, Thomas R ^a   Haynes, Ken ^a  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY OF MANCHESTER   (United Kingdom)

^c UNIVERSITY OF KENT   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

NITROGEN;

ARTICLE; CANDIDA GLABRATA; CONTROLLED STUDY; DNA BINDING; FUNGUS HYPHAE; MOLECULAR CLONING; MUTANT; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DOMAIN; SACCHAROMYCES CEREVISIAE; VIRULENCE; WILD TYPE;

ANIMALS; CANDIDA GLABRATA; CANDIDIASIS; FUNGAL PROTEINS; GENETIC COMPLEMENTATION TEST; LIVER; MICE; NITROGEN; PHYLOGENY; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; TRANSCRIPTION FACTORS; VIRULENCE FACTORS;

ANIMALIA; CANDIDA; CANDIDA GLABRATA; FUNGI; MURINAE; SACCHAROMYCES; SACCHAROMYCES CEREVISIAE;

EID: 0344394991     PISSN: 0950382X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2958.2003.03755.x     Document Type: Article

References (46)

1. Bardwell, L., Cook, J.G., Inouye, C.J., and Thorner, J. (1994) Signal propagation and regulation in the mating pheromone response pathway of the yeast Saccharomyces cerevisiae. Dev Biol 166: 363-379.
2. Beck-Sague, C., and Jarvis, W.R. (1993) Secular trends in the epidemiology of nosocomial fungal infections in the United States, 1980-90. National Nosocomial Infections Surveillance System. J Infect Dis 167: 1247-1251.
3. Borneman, A.R., Hynes, M.J., and Andrianopoulos, A. (2001) An STE12 homolog from the asexual, dimorphic fungus Penicillium marneffei complements the defect in sexual development of an Aspergillus nidulans steA mutant. Genetics 157: 1003-1014.
4. Calderone, R.A., and Fonzi, W.A. (2001) Virulence factors of Candida albicans. Trends Microbiol 9: 327-335.
5. Chang, Y.C., Wickes, B.L., Miller, G.F., Penoyer, L.A., and Kwon-Chung, K.J. (2000) Cryptococcus neoformans STE12alpha regulates virulence but is not essential for mating. J Exp Med 191: 871-882.
6. Chang, Y.C., Penoyer, L.A., and Kwon-Chung, K.J. (2001) The second STE12 homologue of Cryptococcus neoformans is MATa-specific and plays an important role in virulence. Proc Natl Acad Sci USA 98: 3258-3263.
7. Cormack, B.P., Ghori, N., and Falkow, S. (1999) An adhesin of the yeast pathogen Candida glabrata mediating adherence to human epithelial cells. Science 285: 578-582.
8. Csank, C., and Haynes, K. (2000) Candida glabrata displays pseudohyphal growth. FEMS Microbiol Lett 189: 115-120.
9. De Bernardis, F., Muhlschlegel, F.A., Cassone, A., and Fonzi, W.A. (1998) The pH of the host niche controls gene expression in and virulence of Candida albicans. Infect Immun 66: 3317-3325.
10. De Las Penas, A., Pan, S., and Cormack, B.P. (2002) A family of cell wall proteins implicated in virulence of the pathogenic yeast Candida glabrata. Tampa, Florida, USA: 6th American Society for Microbiology Conference on Candida and Candidiasis.
11. Gancedo, J.M. (2001) Control of pseudohyphae formation in Saccharomyces cerevisiae. FEMS Microbiol Rev 25:107-123.
12. Gumbo, T., Isada, C.M., Hall, G., Karafa, M.T., and Gordon, S.M. (1999) Candida glabrata fungemia. Clinical features of 139 patients. Medicine (Baltimore) 78: 220-227.
13. Gustin, M.C., Albertyn, J., Alexander, M., and Davenport, K. (1998) MAP kinase pathways in the yeast Saccharomyces cerevisiae. Microbiol Mol Biol Rev 62: 1264-1300.
14. Hanic-Joyce, P.J., and Joyce, P.B. (1998) A high copy number ADE2-bearing plasmid for transformation of Candida glabrata. Gene 211: 395-400.
15. Haynes, K. (2001) Virulence in Candida species. Trends Microbiol 9: 591-596.
16. Hull, C.M., Raisner, R.M., and Johnson, A.D. (2000) Evidence for mating of the 'asexual' yeast Candida albicans in a mammalian host. Science 289: 307-310.
17. Kitada, K., Yamaguchi, E., and Arisawa, M. (1996) Isolation of a Candida glabrata centromere and its use in construction of plasmid vectors. Gene 175: 105-108.
18. Kuo, M.H., Nadeau, E.T., and Grayhack, E.J. (1997) Multiple phosphorylated forms of the Saccharomyces cerevisiae Mcm1 protein include an isoform induced in response to high salt concentrations. Mol Cell Biol 17: 819-832.
19. Liu, H. (2001) Transcriptional control of dimorphism in Candida albicans. Curr Opin Microbiol 4: 728-735.
20. Liu, H., Kohler, J., and Fink, G.R. (1994) Suppression of hyphal formation in Candida albicans by mutation of a STE12 homolog. Science 266: 1723-1726.
21. Lo, H.J., Kohler, J.R., DiDomenico, B., Loebenberg, D., Cacciapuoti, A., and Fink, G.R. (1997) Nonfilamentous C. albicans mutants are avirulent. Cell 90: 939-949.
22. Madhani, H.D., and Fink, G.R. (1997) Combinatorial control required for the specificity of yeast MAPK signaling. Science 275: 1314-1317.
23. Magee, B.B., and Magee, P.T. (2000) Induction of mating in Candida albicans by construction of MTLa and MTLalpha strains. Science 289: 310-313.
24. Miller, M.G., and Johnson, A.D. (2002) White-opaque switching in Candida albicans is controlled by mating-type locus homeodomain proteins and allows efficient mating. Cell 110: 293-302.
25. Mosch, H.U., and Fink, G.R. (1997) Dissection of filamentous growth by transposon mutagenesis in Saccharomyces cerevisiae. Genetics 145: 671-684.
26. Nakayama, H., Izuta, M., Nagahashi, S., Sihta, E.Y., Sato, Y., Yamazaki, T., et al. (1998) A controllable gene-expression system for the pathogenic fungus Candida glabrata. Microbiology 144: 2407-2415.
27. Navarro-Garcia, F., Sanchez, M., Nombela, C., and Pla, J. (2001) Virulence genes in the pathogenic yeast Candida albicans. FEMS Microbiol Rev 25: 245-268.
28. Olson, K.A., Nelson, C., Tai, G., Hung, W., Yong, C., Astell, C., and Sadowski, I. (2000) Two regulators of Ste12p inhibit pheromone-responsive transcription by separate mechanisms. Mol Cell Biol 20: 4199-4209.
29. Park, G., Xue, C., Zheng, L., Lam, S., and Xu, J.R. (2002) MST12 regulates infectious growth but not appressorium formation in the rice blast fungus Magnaporthe grisea. Mol Plant Microbe Interact 15: 183-192.
30. Pfaller, M.A., Diekema, D.J., Jones, R.N., Sader, H.S., Fluit, A.C., Hollis, R.J., and Messer, S.A. (2001) International surveillance of bloodstream infections due to Candida species: frequency of occurrence and in vitro susceptibilities to fluconazole, ravuconazole, and voriconazole of isolates collected from 1997 through 1999 in the SENTRY Antimicrobial Surveillance Program. J Clin Microbiol 39: 3254-3259.
31. Pfaller, M.A., Jones, R.N., Doern, G.V., Sader, M.S., Messer, S.A., Houston, A., et al. (2000) Bloodstream infections due to Candida species: SENTRY antimicrobial surveillance program in North America and Latin America, 1997-98. Antimicrob Agents Chemother 44: 747-751.
32. Pi, H., Chien, C.T., and Fields, S. (1997) Transcriptional activation upon pheromone stimulation mediated by a small domain of Saccharomyces cerevisiae Ste12p. Mol Cell Biol 17: 6410-6418.
33. Quandt, K., Frech, K., Karas, H., Wingender, E., and Werner, T. (1995) MatInd and MatInspector: new fast and versatile tools for detection of consensus matches in nucleotide sequence data. Nucleic Acids Res 23: 4878-4884.
34. Ren, B., Robert, F., Wyrick, J.J., Aparicio, O., Jennings, E.G., Simon, I., et al. (2000) Genome-wide location and function of DNA binding proteins. Science 290: 2306-2309.
35. Riggle, P.J., Andrutis, K.A., Chen, X., Tzipori, S.R., and Kumamoto, C.A. (1999) Invasive lesions containing filamentous forms produced by a Candida albicans mutant that is defective in filamentous growth in culture. Infect Immun 67: 3649-3652.
36. Roberts, C.J., Nelson, B., Marton, M.J., Stoughton, R., Meyer, M.R., Bennett, H.A., et al. (2000) Signaling and circuitry of multiple MAPK pathways revealed by a matrix of global gene expression profiles. Science 287: 873-880.
37. Singh, P., Ganesan, K., Malathi, K., Ghosh, D., and Datta, A. (1994) ACPR, a STE12 homologue from Candida albicans, is a strong inducer of pseudohyphae in Saccharomyces cerevisiae haploids and diploids. Biochem Biophys Res Commun 205: 1079-1085.
38. Srikantha, T., Lachke, S.A., and Soll, D.R. (2003) Three mating type-like loci in Candida glabrata. Euk Cell 2: 328-340.
39. Tsuji, G., Fujii, S., Tsuge, S., Shiraishi, T., and Kubo, Y. (2003) The Colletotrichum lagenariu Ste12-like gene CST1 is essential for appressorium penetration. Mol Plant Microbe Interact 16: 315-325.
40. Vallim, M.A., Miller, K.Y., and Miller, B.L. (2000) Aspergillus SteA (sterile12-like) is a homeodomain-C2/H2-Zn+2 finger transcription factor required for sexual reproduction. Mol Microbiol 36: 290-301.
41. Weig, M., Haynes, K., Rogers, T.R., Kurzai, O., Frosch, M., and Mühlschlegel, F.A. (2001) A GAS-like gene family in the pathogenic fungus Candida glabrata. Microbiology 147: 2007-2019.
42. Wickes, B.L., Edman, U., and Edman, J.C. (1997) The Cryptococcus neoformans STE12alpha gene: a putative Saccharomyces cerevisiae STE12 homologue that is mating type specific. Mol Microbiol 26: 951-960.
43. Wong, S., Fares, M.A., Zimmerman, W., Butler, G., and Wolfe, K.H. (2003) Evidence from comparative genomics for a complete sexual cycle in the 'asexual' pathogenic yeast Candida glabrata. Genome Biol 4: R10.
44. Young, L.Y., Lorenz, M.C., and Heitman, J. (2000) A STE12 homolog is required for mating but dispensable for filamentation in Candida lusitaniae. Genetics 155: 17-29.
45. Yuan, Y.L., and Fields, S. (1991) Properties of the DNA-binding domain of the Saccharomyces cerevisiae STE12 protein. Mol Cell Biol 11: 5910-5918.
46. Yue, C., Cavallo, L.M., Alspaugh, J.A., Wang, P., Cox, G.M., Perfect, J.R., and Heitman, J. (1999) The STE12alpha homolog is required for haploid filamentation but largely dispensable for mating and virulence in Cryptococcus neoformans. Genetics 153: 1601-1615.