Transcriptional activation upon pheromone stimulation mediated by a small domain of Saccharomyces cerevisiae Ste12p

Molecular and Cellular Biology

Volumn 17, Issue 11, 1997, Pages 6410-6418

  Pi, Haiwei ^a,b,c   Chien, Cheng Ting ^c   Fields, Stanley ^a,b  

^a STONY BROOK UNIVERSITY   (United States)

^b UNIVERSITY OF WASHINGTON   (United States)

^c INSTITUTE OF MOLECULAR BIOLOGY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

HYBRID PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; MUTANT PROTEIN; PHEROMONE; SERINE; THREONINE; TRANSCRIPTION FACTOR; TYROSINE;

ARTICLE; CELL TYPE; CONTROLLED STUDY; DNA SEQUENCE; ENZYME PHOSPHORYLATION; NONHUMAN; POINT MUTATION; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN INDUCTION; SACCHAROMYCES CEREVISIAE; TRANSCRIPTION REGULATION;

EID: 0030832043     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.17.11.6410     Document Type: Article

References (52)

1. Bardwell, L., J. G. Cook, C. J. Inouye, and J. Thorner. 1994. Signal propagation and regulation in the mating pheromone response pathway of the yeast Saccharomyces cerevisiae. Dev. Biol. 166:363-379.
2. Bartel, P. L., C.-T. Chien, R. Sternglanz, and S. Fields. 1993. Using the two-hybrid system to detect protein-protein interactions, p. 153-179. In D. A. Hartley (ed.), Cellular interactions in development: a practical approach. Oxford University Press, Oxford, United Kingdom.
3. Binetruy, B., T. Smeal, and M. Karin. 1991. Ha-Ras augments c-Jun activity and stimulates phosphorylation of its activation domain. Nature 351:122-127.
4. Cairns, B. R., S. W. Ramer, and R. D. Kornberg. 1992. Order of action of components in the yeast pheromone response pathway revealed with a dominant allele of the STE11 kinase and the multiple phosphorylation of the STE7 kinase. Genes Dev. 6:1305-1318.
5. Chang, F., and I. Herskowitz. 1990. Identification of a gene necessary for cell cycle arrest by a negative growth factor of yeast: FAR1 is an inhibitor of a G1 cyclin. CLN2. Cell 63:999-1011.
6. Chen, Q., and J. B. Konopka. 1996. Regulation of the G-protein-coupled α-factor pheromone receptor by phosphorylation. Mol. Cell. Biol. 16:247-257.
7. Choi, K.-Y., B. Satterberg, D. M. Lyons, and E. A. Elion. 1994. Ste5 tethers multiple protein kinases in the MAP kinase cascade required for mating in S. cerevisiae. Cell 78:499-512.
8. mpk, the meiosis-activated myelin basic protein kinase. J. Biol. Chem. 266:15180-15184.
9. Cole, G. M., and S. I. Reed. 1991. Pheromone-induced phosphorylation of a G protein β subunit in S. cerevisiae is associated with an adaptive response to mating pheromone. Cell 64:703-716.
10. Cook, J. G., L. Bardwell, S. J. Kron, and J. Thorner. 1996. Two novel targets of the MAP kinase Kss1 are negative regulators of invasive growth in the yeast Saccharomyces cerevisiae. Genes Dev. 10:2831-2848.
11. Courchesne, W. E., R. Kunisawa, and J. Thorner. 1989. A putative protein kinase overcomes pheromone-induced arrest of cell cycling in S. cerevisiae. Cell 58:1107-1119.
12. Crosby, J., and S. Fields. Unpublished data.
13. Dolan, J. W., and S. Fields. 1990. Overproduction of the yeast STE12 protein leads to constitutive transcriptional induction. Genes Dev. 4:492-502.
14. Dolan, J. W., C. Kirkman, and S. Fields. 1989. The yeast STE12 protein binds to the DNA sequence mediating pheromone induction. Proc. Natl. Acad. Sci. USA 86:5703-5707.
15. Durfee, T., K. Becherer, P.-L. Chen, S. H. Yeh, Y. Yang, A. E. Kilburn, W.-H. Lee, and S. J. Elledge. 1993. The retinoblastoma protein associates with the protein phosphatase type 1 catalytic subunit. Genes Dev. 7:555-569.
16. Elion, E. A., J. A. Brill, and G. R. Fink. 1991. FUS3 represses CLN1 and CLN2 and in concert with KSS1 promotes signal transduction. Proc. Natl. Acad. Sci. USA 88:9392-9396.
17. Elion, E. A., B. Satterberg, and J. E. Kranz. 1993. FUS3 phosphorylates multiple components of the mating signal transduction cascade: evidence for STE12 and FAR1. Mol. Biol. Cell 4:495-510.
18. Errede, B., and G. Ammerer. 1989. STE12, a protein involved in cell-type-specific transcription and signal transduction in yeast, is part of protein-DNA complexes. Genes Dev. 3:1349-1361.
19. Errede, B., and D. E. Levin. 1993. A conserved kinase cascade for MAP kinase activation in yeast. Curr. Opin. Cell Biol. 5:254-260.
20. Errede, B., A. Gartner, Z. Zhou, K. Nasmyth, and G. Ammerer. 1993. MAP kinase-related FUS3 from S. cerevisiae is activated by STE7 in vitro. Nature 362:261-264.
21. Fields, S., and I. Herskowitz. 1987. Regulation by the yeast mating type locus of STE12, a gene required for cell-type-specific expression. Mol. Cell. Biol. 7:3818-3821.
22. Gietz, R. D., and A. Sugino. 1988. New yeast-Escherichia coli shuttle vectors constructed with in vitro mutagenized yeast genes lacking six-base pair restriction sites. Gene 74:527-534.
23. Hannon, G. J., D. Demetrick, and D. Beach. 1993. Isolation of the Rb-related p130 through its interaction with CDK2 and cyclins. Genes Dev. 7:2378-2391.
24. Herskowitz, I. 1995. MAP kinase pathways in yeast: for mating and more. Cell 80:187-197.
25. Kirkman-Correia, C., I. L. Stroke, and S. Fields. 1993. Functional domains of the yeast STE12 protein, a pheromone-responsive transcriptional activator. Mol. Cell. Biol. 13:3765-3772.
26. Kosako, H., E. Nishida, and Y. Gotoh. 1993. cDNA cloning of MAP kinase kinase reveals kinase cascade pathways in yeasts to vertebrates. EMBO J. 12:787-794.
27. Kurjan, J. 1993. The pheromone response pathway in Saccharomyces cerevisiae. Annu. Rev. Genet. 27:147-179.
28. Lange-Carter, C. A., C. M. Pleiman, A. M. Gardner, K. J. Blumer, and G. L. Johnson. 1993. A divergence in the MAP kinase regulatory network defined by MEK kinase and Raf. Science 260:315-319.
29. Leberer, E., D. Dignard, D. Harcus, D. Y. Thomas, and M. Whiteway. 1992. The protein kinase homologue Ste20p is required to link the pheromone response G-protein βγ subunits to downstream signalling components. EMBO J. 11:4815-4824.
30. Ma, J., and M. Ptashne. 1987. Deletion analysis of GAL4 defines two transcriptional activating segments. Cell 48:847-853.
31. Malathi, K., K. Ganesan, and A. Datta. 1994. Identification of a putative transcription factor in Candida albicans that can complement the mating defect of Saccharomyces cerevisiae ste12 mutants. J. Biol. Chem. 269:22945-22951.
32. Marais, R., J. Wynne, and R. Treisman. 1993. The SRF accessory protein Elk-1 contains a growth factor-regulated transcriptional activation domain. Cell 73:381-393.
33. Marcus, S., A. Polverino, M. Barr, and M. Wigler. 1994. Complexes between STE5 and components of the pheromone-responsive mitogen-activated protein kinase module. Proc. Natl. Acad. Sci. USA 91:7762-7766.
34. McCaffrey, G., F. J. Clay, K. Kelsay, and G. F. Sprague, Jr. 1987. Identification and regulation of a gene required for cell fusion during mating of the yeast Saccharomyces cerevisiae. Mol. Cell. Biol. 7:2680-2690.
35. Michaelis, S., and I. Herskowitz. 1988. The α-factor pheromone of Saccharomyces cerevisiae is essential for mating. Mol. Cell. Biol. 7:1309-1318.
36. Neiman, A. M., and I. Herskowitz. 1994. Reconstitution of a yeast protein kinase cascade in vitro: activation of the yeast MEK homologue STE7 by STE11. Proc. Natl. Acad. Sci. USA 91:3398-3402.
37. Printen, J. A., and G. F. Sprague, Jr. 1994. Protein-protein interactions in the yeast pheromone response pathway: Ste5p interacts with all members of the MAP kinase cascade. Genetics 138:609-619.
38. Pulverer, B. J., J. M. Kyriakis, J. Avruch, E. Nikolakaki, and J. R. Woodgett. 1991. Phosphorylation of C-jun mediated by MAP kinases. Nature 353:670-674.
39. Ramer, S. W., and R. W. Davis. 1993. A dominant truncation allele identifies a gene, STE20, that encodes a putative protein kinase necessary for mating in Saccharomyces cerevisiae. Proc. Natl. Acad. Sci. USA 90:452-456.
40. Rebay, I., and G. M. Rubin. 1995. Yan functions as a general inhibitor of differentiation and is negatively regulated by activation of the Ras1/MAPK pathway. Cell 81:857-866.
41. Russell, P. R., and B. D. Hall. 1983. The primary structure of the alcohol dehydrogenase gene from the fission yeast Schizosaccharomyces pombe. J. Biol. Chem. 258:143-149.
42. IIS directing synergistic activation of transcription. Science 270:1783-1788.
43. Seger, R., D. Seger, F. J. Lozeman, N. G. Ahn, L. M. Graves, J. S. Campbell, L. Ericsson, M. Harrylock, A. M. Jensen, and E. G. Krebs. 1992. Human T-cell mitogen-activated protein kinase kinases are related to yeast signal transduction kinases. J. Biol. Chem. 267:25628-25631.
44. Song, O.-K., J. W. Dolan, Y. O. Yuan, and S. Fields. 1991. Pheromone-dependent phosphorylation of the yeast STE12 protein correlates with transcriptional activation. Genes Dev. 5:741-750.
45. Sprague, G. F., Jr., and J. Thorner. 1992. Pheromone response and signal transduction during the mating process of Saccharomyces cerevisiae, p. 657-744. In E. W. Jones, J. R. Pringle, and J. R. Broach (ed.), The molecular and cellular biology of the yeast Saccharomyces, vol. 2. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N. Y.
46. Tedford, K., S. Kim, D. Sa, K. Stevens, and M. Tyers. 1997. Regulation of the mating pheromone and invasive growth responses in yeast by two MAP kinase substrates. Curr. Biol. 7:228-238.
47. Trueheart, J., J. D. Boeke, and G. R. Fink. 1987. Two genes required for cell fusion during yeast conjugation: evidence for a pheromone-induced surface protein. Mol. Cell. Biol. 7:2316-2328.
48. Tyers, M., G. Tokiwa, R. Nash, and B. Futcher. 1992. The Cln3-Cdc28 kinase complex of S. cerevisiae is regulated by proteolysis and phosphorylation. EMBO J. 11:1773-1784.
49. Vojtek, A. B., S. M. Hollenberg, and J. A. Cooper. 1993. Mammalian Ras interacts directly with the serine/threonine kinase Raf. Cell 74:205-214.
50. Yuan, Y. O., and S. Fields. 1991. Properties of the DNA-binding domain of the Saccharomyces cerevisiae STE12 protein. Mol. Cell. Biol. 11:5910-5918.
51. Yuan, Y. O., I. Stroke, and S. Fields. 1993. Coupling of cell identity to signal response in yeast: interaction between the α1 and STE12 proteins. Genes Dev. 7:1584-1597.
52. Zhou, Z., A. Gartner, R. Cade, G. Ammerer, and B. Errede. 1993. Pheromone-induced signal transduction in Saccharomyces cerevisiae requires the sequential function of three protein kinases. Mol. Cell. Biol. 13:2069-2080.