Aspergillus SteA (Sterile12-like) is a homeodomain-C2/H2-Zn+2 finger transcription factor required for sexual reproduction

Molecular Microbiology

Volumn 36, Issue 2, 2000, Pages 290-301

  Vallim, Marcelo A ^a   Miller, Karen Y ^a   Miller, Bruce L ^a  

^a UNIVERSITY OF IDAHO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HOMEODOMAIN PROTEIN; ZINC FINGER PROTEIN;

ARTICLE; ASPERGILLUS NIDULANS; CARBOXY TERMINAL SEQUENCE; MORPHOGENESIS; PRIORITY JOURNAL; PROTEIN ANALYSIS; REPRODUCTION; SIGNAL TRANSDUCTION;

AMINO ACID SEQUENCE; ASPERGILLUS NIDULANS; FUNGAL PROTEINS; GENE DELETION; GENE EXPRESSION REGULATION, FUNGAL; HOMEODOMAIN PROTEINS; MOLECULAR SEQUENCE DATA; REPRODUCTION; SACCHAROMYCES CEREVISIAE PROTEINS; SEQUENCE ANALYSIS, DNA; TRANSCRIPTION FACTORS; ZINC FINGERS;

ASPERGILLUS; CANDIDA ALBICANS; CLEISTOTHECIA; EMERICELLA NIDULANS; EUKARYOTA; FILOBASIDIELA; FILOBASIDIELA NEOFORMANS; FUNGI; SACCHAROMYCES CEREVISIAE; SACCHAROMYCETALES;

EID: 0034098572     PISSN: 0950382X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2958.2000.01874.x     Document Type: Article

References (86)

1. Adams, T.H., Boylan, M.T., and Timberlake, W.E. (1988) brlA is necessary and sufficient to direct conidiophore development in Aspergillus nidulans. Cell 54: 353-362.
2. Adams, T.H., Wieser, J.K., and Yu, J.H. (1998) Asexual sporulation in Aspergillus nidulans. Microbiol Mol Biol Rev 62: 35-54.
3. Aguirre, J. (1993) Spatial and temporal controls of the Aspergillus brlA developmental regulatory gene. Mol Microbiol 8: 211-218.
4. Andres, V., Chiara, M.D., and Mahdavi, V. (1994) A new bipartite DNA-binding domain: cooperative interaction between the cut repeat and homeo domain of the cut homeo proteins. Genes Dev 8: 245-257.
5. Andrianopoulos, A., and Timberlake, W.E. (1991) ATTS, a new and conserved DNA binding domain (letter). Plant Cell 3: 747-748.
6. Andrianopoulos, A., and Timberlake, W.E. (1994) The Aspergillus nidulans abaA gene encodes a transcriptional activator that acts as a genetic switch to control development. Mol Cell Biol 14: 2503-2515.
7. Axelrod, D.E., Gealt, M., and Pastushok, M. (1973) Gene control of developmental competence in Aspergillus nidulans. Dev Biol 34: 9-15.
8. Banuett, F. (1998) Signaling in the yeasts: an informational cascade with links to the filamentous fungi. Microbiol Mol Biol Rev 62: 249-274.
9. Bardwell, L., Cook, J.G., Voora, D., Baggott, D.M., Martinez, A.R., and Thorner, J. (1998) Repression of yeast Ste12 transcription factor by direct binding of unphosphorylated Kss1 MAPK and its regulation by the Ste7 MEK. Genes Dev 12: 2887-2898.
10. Bendall, A.J., Rincon-Limas, D.E., Botas, J., and Abate-Shen, C. (1998) Protein complex formation between Msx1 and Lhx2 homeoproteins is incompatible with DNA binding activity. Differentiation 63: 151-157.
11. Bhoite, L.T., and Stillman, D.J. (1998) Residues in the Swi5 zinc finger protein that mediate cooperative DNA binding with the Pho2 homeodomain protein. Mol Cell Biol 18: 6436-6446.
12. Boylan, M.T., Mirabito, P.M., Willet, C.E., Zimmermann, C.R., and Timberlake, W.E. (1987) Isolation and physical characterization of three essential conidiation genes from Aspergillus nidulans. Mol Cell Biol 7: 3113-3118.
13. Busby, T.M., Miller, K.Y., and Miller, B.L. (1996) Suppression and enhancement of the Aspergillus nidulans medusa mutation by altered dosage of the bristle and stunted genes. Genetics 143: 155-163.
14. Casselton, L.A., and Olesnicky, N.S. (1998) Molecular genetics of mating recognition in basidiomycete fungi. Microbiol Mol Biol Rev 62: 55-70.
15. Champe, S.P., and el-Zayat, A.A. (1989) Isolation of a sexual sporulation hormone from Aspergillus nidulans. J Bacteriol 171: 3982-3988.
16. Champe, S.P., and Simon, L.D. (1992) Cellular differentiation and tissue formation in the fungus Aspergillus nidulans. In Morphogenesis: an Analysis of the Developmental of Biological Form. Rossomando, E.F., and Alexander, S. (ed.). New York: Marcel Dekker, Inc., pp. 63-91.
17. Champe, S.P., Rao, P., and Chang, A. (1987) An endogenous inducer of sexual development in Aspergillus nidulans. J Gen Microbiol 133: 1383-1387.
18. Champe, S.P., Nagle, D.L., and Yager, L.N. (1994) Sexual sporulation. Prog Ind Microbiol 29: 429-454.
19. Clutterbuck, A.J. (1969) A mutational analysis of conidial development in Aspergillus nidulans. Genetics 63: 317-327.
20. Clutterbuck, A.J. (1974) Aspergillus nidulans. In Handbook of Genetics. King, R.C. (ed.). New York: Plenum Press, pp. 447-510.
21. Clutterbuck, A.J. (1977) The genetics of conidiation in Aspergillus nidulans. In Genetics and Physiology of Aspergillus. Smith, J.E., and Pateman, J.A. (eds). London: Academic Press, Inc., pp. 305-317.
22. Coppin, E., Debuchy, R., Arnaise, S., and Picard, M. (1997) Mating types and sexual development in filamentous ascomycetes. Microbiol Mol Biol Rev 61: 411-428.
23. Darling, D.S., Gaur, N.K., and Zhu, B. (1998) A zinc finger homeodomain transcription factor binds specific thyroid hormone response elements. Mol Cell Endocrinol 139: 25-35.
24. Dolan, J.W., and Fields, S. (1990) Overproduction of the yeast STE12 protein leads to constitutive transcriptional induction. Genes Dev 4: 492-502.
25. Dolan, J.W., Kirkman, C., and Fields, S. (1989) The yeast STE12 protein binds to the DNA sequence mediating pheromone induction. Proc Natl Acad Sci USA 86: 5703-5707.
26. Dowzer, C.E., and Kelly, J.M. (1991) Analysis of the creA gene, a regulator of carbon catabolite repression in Aspergillus nidulans. Mol Cell Biol 11: 5701-5709.
27. Dutton, J.R., Johns, S., and Miller, B.L. (1997) StuAp is a sequence-specific transcription factor that regulates developmental complexity in Aspergillus nidulans. EMBO J 16: 5710-5721.
28. Errede, B., and Ammerer, G. (1989) STE12, a protein involved in cell-type-specitic transcription and signal transduction in yeast, is part of protein-DNA complexes. Genes Dev 3: 1349-1361.
29. Gavrias, V., Andrianopoulos, A., Gimeno, C.J., and Timberlake, W.E. (1996) Saccharomyces cerevisiae TEC1 is required for pseudohyphal growth. Mol Microbiol 19: 1255-1263.
30. Geiser, D.M., Timberlake, W.E., and Arnold, M.L. (1996) Loss of meiosis in Aspergillus. Mol Biol Evol 13: 809-817.
31. Gimeno, C.J., and Fink, G.R. (1994) Induction of pseudohyphal growth by overexpression of PHD1, a Saccharomyces cerevisiae gene related to transcriptional regulators of fungal development. Mol Cell Biol 14: 2100-2112.
32. Grueneberg, D.A., Natesan, S., Alexandre, C., and Gilman, M.Z. (1992) Human and Drosophila homeodomain proteins that enhance the DNA-binding activity of serum response factor. Science 257: 1089-1095.
33. Gustin, M.C., Albertyn, J., Alexander, M., and Davenport, K. (1998) MAP kinase pathways in the yeast Saccharomyces cerevisiae. Microbiol Mol Biol Rev 62: 1264-1300.
34. Han, S., Navarro, J., Greve, R.A., and Adams, T.H. (1993) Translational repression of brlA expression prevents premature development in Aspergillus. EMBO J 12: 2449-2457.
35. Hartmann, H.A., Kahmann, R., and Bolker, M. (1996) The pheromone response factor coordinates filamentous growth and pathogenicity in Ustilago maydis. EMBO J 15: 1632-1641.
36. Hermann, T.E., Kurtz, M.B., and Champe, S.P. (1983) Laccase localized in Hülle cells and cleistothecial primordia of Aspergillus nidulans. J Bacteriol 154: 955-964.
37. Ikeda, K., and Kawakami, K. (1995) DNA binding through distinct domains of zinc-finger-homeodomain protein AREB6 has different effects on gene transcription. Eur J Biochem 233: 73-82.
38. Johnson, A.D. (1995) Molecular mechanisms of cell-type determination in budding yeast. Curr Opin Genet Dev 5: 552-558.
39. Käfer, E. (1977) Meiotic and mitotic recombination in Aspergillus and its chromosomal aberrations. Adv Genetics 19: 33-131.
40. Kirk, K.E., and Morris, R.N. (1991) The tubB α-tubulin gene is essential for sexual development in Aspergillus nidulans. Genes Dev 5: 2014-2023.
41. Kirkman-Correia, C., Stroke, I.L., and Fields, S. (1993) Functional domains of the yeast STE12 protein, a pheromone-responsive transcriptional activator. Mol Cell Biol 13: 3765-3772.
42. Kron, S.J. (1997) Filamentous growth in budding yeast. Trends Microbiol 5: 450-454.
43. Kron, S.J., and Gow, N.A. (1995) Budding yeast morphogenesis: signaling, cytoskeleton and cell cycle. Curr Opin Cell Biol 7: 845-855.
44. Kronstad, J.W., and Staben, C. (1997) Mating type in filamentous fungi. Annu Rev Genet 31: 245-276.
45. Kurihara, L.J., Stewart, B.G., Gammie, A.E., and Rose, M.D. (1996) Kar4p, a karyogamy-specific component of the yeast pheromone response pathway. Mol Cell Biol 16: 3990-4002.
46. Leberer, E., Harcus, D., Broadbent, I.D., Clark, K.L., Dignard, D., Ziegelbauer, K., et al. (1996) Signal transduction through homologs of the Ste20p and Ste7p protein kinases can trigger hyphal formation in the pathogenic fungus Candida albicans. Proc Natl Acad Sci USA 93: 13217-13222.
47. Lee, B.N., and Adams, T.H. (1994) The Aspergillus nidulans fluG gene is required for production of an extracellular developmental signal and is related to prokaryotic glutamine synthetase.1. Genes Dev 8: 641-651.
48. Lee, Y., Shioi, T., Kasahara, H., Jobe, S.M., Wiese, R.J., Markham, B.E., et al. (1998) The cardiac tissue-restricted homeobox protein Csx/Nkx2.5 physically associates with the zinc finger protein GATA4 and cooperatively activates atrial natriuretic factor gene expression. Mol Cell Biol 18: 3120-3129.
49. Lints, R., Davis, M.A., and Hynes, M.J. (1995) The positively acting amdA gene of Aspergillus nidulans encodes a protein with two C2H2 zinc-finger motifs. Mol Micro 15: 965-975.
50. Liu, H., Kohler, J., and Fink, G.R. (1994) Suppression of hyphal formation in Candida albicans by mutation of a STE12 homolog. Science 266: 1723-1726.
51. Liu, H., Styles, C.A., and Fink, G.R. (1993) Elements of the yeast pheromone response pathway required for filamentous growth of diploids. Science 262: 1741-1744.
52. Lo, H.J., Kohler, J.R., DiDomenico, B., Loebenberg, D., Cacciapuoti, A., and Fink, G.R. (1997) Nonfilamentous C. albicans mutants are avirulent. Cell 90: 939-949.
53. Madhani, H.D., and Fink, G.R. (1997) Combinatorial control required for the specificity of yeast MAPK signaling. Science 275: 1314-1317.
54. Madhani, H.D., and Fink, G.R. (1998) The riddle of MAP kinase signaling specificity. Trends Genet 14: 151-155.
55. Madhani, H.D., Styles, C.A., and Fink, G.R. (1997) MAP kinases with distinct inhibitory functions impart signaling specificity during yeast differentiation. Cell 91: 673-684.
56. Malathi, K., Ganesan, K., and Datta, A. (1994) Identification of a putative transcription factor in Candida albicans that can complement the mating defect of Saccharomyces cerevisiae ste12 mutants. J Biol Chem 269: 22945-22951.
57. Miller, B.L. (1990) The developmental genetics of asexual reproduction in Aspergillus nidulans. Semin Dev Biol 1: 207-219.
58. Miller, B.L., Miller, K.Y., and Timberlake, W.E. (1985) Direct and indirect gene replacements in Aspergillus nidulans. Mol Cell Biol 5: 1714-1721.
59. Miller, K.Y., Toennis, T.M., Adams, T.H., and Miller, B.L. (1991) Isolation and transcriptional characterization of a morphological modifier: the Aspergillus nidulans stunted (stuA) gene. Mol Gen Genet 227: 285-292.
60. Miller, K.Y., Wu, J., and Miller, B.L. (1992) StuA is required for cell pattern formation in Aspergillus. Genes Dev 6: 1770-1782.
61. Mirabito, P.M., Adams, T.H., and Timberlake, W.E. (1989) Interactions of three sequentially expressed genes control temporal and spatial specificity in Aspergillus development. Cell 57: 859-868.
62. Mooney, J.L., and Yager, L.N. (1990) Light is required for conidiation in Aspergillus nidulans. Genes Dev 4: 1473-1482.
63. Mooney, J.L., Hassett, D.E., and Yager, L.N. (1990) Genetic analysis of suppressors of the veA1 mutation in Aspergillus nidulans. Genetics 126: 869-874.
64. Nehlin, J.O., and Ronne, H. (1990) Yeast MIG1 repressor is related to the mammalian early growth response and Wilms' tumour finger proteins. EMBO J 9: 2891-2898.
65. Pan, X., and Heitman, J. (1999) Cyclic AMP-dependent protein kinase regulates pseudohyphal differentiation in Saccharomyces cerevisiae. Mol Cell Biol 19: 4874-4887.
66. Pi, H., Chien, C.T., and Fields, S. (1997) Transcriptional activation upon pheromone stimulation mediated by a small domain of Saccharomyces cerevisiae Ste12p. Mol Cell Biol 17: 6410-6418.
67. Pontecorvo, G., Roper, J.A., Hemmons, L.M., MacDonald, K.D., and Button, A.W.J. (1953) The genetics of Aspergillus nidulans. Adv Genetics 5: 141-238.
68. Rosen, S., Yu, J.H., and Adams, T.H. (1999) The Aspergillus nidulans sfaD gene encodes a G protein beta subunit that is required for normal growth and repression of sporulation. EMBO J 18: 5592-5600.
69. Rosenfeld, R., and Margalit, H. (1993) Zinc fingers: conserved properties that can distinguish between spurious and actual DNA-binding motifs. J Biomol Struct Dyn 11: 557-570.
70. Rupp, S., Summers, E., Lo, H.-J., Madhani, H., and Fink, G. (1999) MAP kinase and cAMP filamentation signaling pathways converge on the unusually large promoter of the yeast FLO11 gene. Embo J 18: 1257-1269.
71. Scott, M.P., Tamkun, J.W., and Hartzell, G.W.D. (1989) The structure and function of the homeodomain. Biochim Biophys Acta 989: 25-48.
72. Singh, P., Ghosh, S., and Datta, A. (1997) A novel MAP-kinase kinase from Candida albicans. Gene 190: 99-104.
73. Skromne, I., Sanchez, O., and Aguirre, J. (1995) Starvation stress modulates the expression of the Aspergillus nidulans brlA regulatory gene. Microbiology 141: 21-28.
74. Som, T., and Kolaparthi, V.S. (1994) Developmental decisions in Aspergillus nidulans are modulated by Ras activity. Mol Cell Biol 14: 5333-5348.
75. Sprague, Jr, G.F. (1998) Control of MAP kinase signaling specificity or how not to go HOG wild. Genes Dev 12:2817-2820.
76. Stoldt, V.R., Sonneborn, A., Leuker, C.E., and Ernst, J.F. (1997) Efg1p, an essential regulator of morphogenesis of the human pathogen Candida albicans, is a member of a conserved class of bHLH proteins regulating morphogenetic processes in fungi. EMBO J 16: 1982-1991.
77. Treisman, J., Harris, E., and Desplan, C. (1991) The paired box encodes a second DNA-binding domain in the paired homeo domain protein. Genes Dev 5: 594-604.
78. Tsai, R.Y.L., and Reed, R.R. (1998) Identification of DNA recognition sequences and protein interaction domains of the multiple-Zn-finger protein roaz. Mol Cell Biol 18: 6447-6456.
79. Verrijzer, C.P., Alkema, M.J., van Weperen, W.W., Van Leeuwen, H.C., Strating, M.J., and van der Vliet, P.C. (1992) The DNA binding specificity of the bipartite POU domain and its subdomains. EMBO J 11: 4993-5003.
80. Wickes, B.L., Edman, U., and Edman, J.C. (1997) The Cryptococcus neoformans STE12alpha gene: a putative Saccharomyces cerevisiae STE12 homologue that is mating type specific. Mol Microbiol 26: 951-960.
81. Wu, J., and Miller, B.L. (1997) Aspergillus asexual reproduction and sexual reproduction are differentially affected by transcriptional and translational mechanisms regulating stunted gene expression. Mol Cell Biol 17: 6191-6201.
82. Yager, L.N., Kurtz, M.B., and Champe, S.P. (1982) Temperature-shift analysis of conidial development in Aspergillus nidulans. Dev Biol 93: 92-103.
83. Yelton, M.M., Hamer, J.E., and Timberlake, W.E. (1984) Transformation of Aspergillus nidulans by using a trpC plasmid. Proc Natl Acad Sci USA 81: 1470-1474.
84. Yuan, Y.L., and Fields, S. (1991) Properties of the DNA-binding domain of the Saccharomyces cerevisiae STE12 protein. Mol Cell Biol 11: 5910-5918.
85. Yuan, Y.O., Stroke, I.L., and Fields, S. (1993) Coupling of cell identity to signal response in yeast: interaction between the alpha1 and STE12 proteins. Genes Dev 7: 1584-1597.
86. Yue, C., Cavallo, L.M., Alspaugh, J.A., Wang, P., Cox, G.A., Perfect, J.R., et al. (1999) The STE12α Homolog is required for haploid filamentation but largely dispensable for mating and virulence in Cryptococcus neoformans. Genetics 153: 1601-1615.