The camptothecin-resistant topoisomerase I mutant F361S is cross- resistant to antitumor rebeccamycin derivatives. A model for topoisomerase I inhibition by indolocarbazoles

Biochemistry

Volumn 38, Issue 27, 1999, Pages 8605-8611

  Bailly, Christian ^b   Carrasco, Carolina ^a,b   Hamy, François ^c   Vezin, Hervé ^d   Prudhomme, Michelle ^e   Saleem, Ahamed ^f   Rubin, Eric ^f  

^a UNIVERSITY OF ALCALÁ   (Spain)

^b INSERM   (France)

^c NOVARTIS PHARMA AG   (Switzerland)

^d CNRS   (France)

^e UNIVERSITÉ CLERMONT AUVERGNE   (France)

^f RUTGERS CANCER INSTITUTE OF NEW JERSEY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

6 FORMYLAMINO 12,13 DIHYDRO 1,11 DIHYDROXY 5H INDOLO[2,3 A][PYRROLO[3,4 C]CARBAZOLE 5,7(6H) DIONE 13 GLUCOSIDE; CAMPTOTHECIN; CARBAZOLE DERIVATIVE; DNA TOPOISOMERASE; DNA TOPOISOMERASE INHIBITOR; HOE 33342; IRINOTECAN; LURTOTECAN; MUTANT PROTEIN; REBECCAMYCIN; TOPOTECAN; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; COLORECTAL CANCER; CROSS RESISTANCE; DNA CLEAVAGE; DRUG STRUCTURE; ENZYME ACTIVITY; ENZYME INHIBITION; MOLECULAR MODEL; OVARY CANCER; PHARMACOPHORE; PRIORITY JOURNAL;

AMINO ACID SUBSTITUTION; AMINOGLYCOSIDES; ANTI-BACTERIAL AGENTS; ANTIBIOTICS, ANTINEOPLASTIC; BASE SEQUENCE; BINDING SITES; CAMPTOTHECIN; CARBAZOLES; DNA DAMAGE; DNA TOPOISOMERASES, TYPE I; DRUG RESISTANCE, NEOPLASM; ENZYME INHIBITORS; GLUCOSIDES; HUMANS; INDOLES; INTERCALATING AGENTS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PHENYLALANINE; RECOMBINANT PROTEINS; SERINE;

EID: 0033529311     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi983052y     Document Type: Article

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