SR splicing factors serve as adapter proteins for TAP-dependent mRNA export

Molecular Cell

Volumn 11, Issue 3, 2003, Pages 837-843

  Huang, Yingqun ^a   Gattoni, Renata ^b   Stévenin, James ^b   Steitz, Joan A ^a  

^a YALE UNIVERSITY   (United States)

^b INSTITUT DE GÉNÉTIQUE ET DE BIOLOGIE MOLÉCULAIRE ET CELLULAIRE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ADAPTOR PROTEIN; ARGININE; MESSENGER RNA; PROTEIN; PROTEIN 9G8; PROTEIN NXF1; PROTEIN REF; PROTEIN SRP20; PROTEIN TAP; SERINE; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; CELL NUCLEUS; CONTROLLED STUDY; INTRON; NONHUMAN; OOCYTE; PROMOTER REGION; PROTEIN BINDING; PROTEIN INTERACTION; RNA SPLICING; XENOPUS;

ANIMALIA; MAMMALIA;

EID: 0344211508     PISSN: 10972765     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1097-2765(03)00089-3     Document Type: Article

References (46)

1. Bachi A., Braun I.C., Rodrigues J.P., Pante N., Ribbeck K., von Kobbe C., Kutay U., Wilm M., Görlich D., Carmo-Fonseca M., Izaurralde E. The C-terminal domain of TAP interacts with the nuclear pore complex and promotes export of specific CTE-bearing RNA substrates. RNA. 6:2000;136-158.
2. Braun I.C., Herold A., Rode M., Conti E., Izaurralde E. Overexpression of TAP/p15 heterodimers bypasses nuclear retention and stimulates nuclear mRNA export. J. Biol. Chem. 276:2001;20536-20543.
3. Bray M., Prasad S., Dubay J.W., Hunter E., Jeang K.T., Rekosh D., Hammarskjöld M.L. A small element from the Mason-Pfizer monkey virus genome makes human immunodeficiency virus type 1 expression and replication Rev-independent. Proc. Natl. Acad. Sci. USA. 91:1994;1256-1260.
4. Brennan C.M., Gallouzi I.E., Steitz J.A. Protein ligands to HuR modulate its interaction with target mRNAs in vivo. J. Cell Biol. 151:2000;1-14.
5. Cáceres J.F., Krainer A.R. Functional analysis of pre-mRNA splicing factor SF2/ASF structural domains. EMBO J. 12:1993;4715-4726.
6. Cáceres J.F., Screaton G.R., Krainer A.R. A specific subset of SR proteins shuttles continuously between the nucleus and the cytoplasm. Genes Dev. 12:1998;55-66.
7. Cavaloc Y., Popielarz M., Fuchs J.P., Gattoni R., Stévenin J. Characterization and cloning of the human splicing factor 9G8. a novel 35 kDa factor of the serine/arginine protein family EMBO J. 13:1994;2639-2649.
8. Cavaloc Y., Bourgeois C.F., Kister L., Stévenin J. The splicing factors 9G8 and SRp20 transactivate splicing through different and specific enhancers. RNA. 5:1999;468-483.
9. Cazalla D., Zhu J., Manche L., Huber E., Krainer A.R., Cáceres J.F. Nuclear export and retention signals in the RS domain of SR proteins. Mol. Cell. Biol. 22:2002;6871-6882.
10. Cramer P., Caceres J.F., Cazalla D., Kadener S., Muro A.F., Baralle F.E., Kornblihtt A.R. Coupling of transcription with alternative splicing. RNA pol II promoters modulate SF2/ASF and 9G8 effects on an exonic splicing enhancer Mol. Cell. 4:1999;251-258.
11. Dignam J.D., Lebovitz R.M., Roeder R.G. Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei. Nucleic Acids Res. 11:1983;1475-1489.
12. Fan X.C., Steitz J.A. HNS, a nuclear-cytoplasmic shuttling sequence in HuR. Proc. Natl. Acad. Sci. USA. 95:1998;15293-15298.
13. Fleckner J., Zhang M., Valcarcel J., Green M.R. U2AF65 recruits a novel human DEAD box protein required for the U2 snRNP-branchpoint interaction. Genes Dev. 11:1997;1864-1872.
14. Gallouzi I.E., Steitz J.A. Delineation of mRNA export pathways by the use of cell-permeable peptides. Science. 294:2001;1895-1901.
15. Gatfield D., Izaurralde E. REF1/Aly and the additional exon junction complex proteins are dispensible for nuclear mRNA export. J. Cell Biol. 159:2002;579-588.
16. Gatfield D., Le Hir H., Schmitt C., Braun I.C., Kocher T., Wilm M., Izaurralde E. The DExH/D box protein HEL/UAP56 is essential for mRNA nuclear export in Drosophila. Curr. Biol. 11:2001;1716-1721.
17. Graveley S.R. Sorting out the complexity of SR protein functions. RNA. 6:2000;1197-1211.
18. Grüter P., Tabernero C., von Kobbe C., Schmitt C., Saavedra C., Bachi A., Wilm M., Felber B.K., Izaurralde E. TAP, the human homolog of Mex67p, mediates CTE-dependent RNA export from the nucleus. Mol. Cell. 1:1998;649-659.
19. Guzik B.W., Levesque L., Prasad S., Bor Y.C., Black B.E., Paschal B.M., Rekosh D., Hammarskjold M.L. NXT1 (p15) is a crucial cellular cofactor in TAP-dependent export of intron-containing RNA in mammalian cells. Mol. Cell. Biol. 21:2001;2545-2554.
20. Huang Y., Steitz J.A. Splicing factors SRp20 and 9G8 promote the nucleocytoplasmic export of mRNA. Mol. Cell. 7:2001;899-905.
21. Huang Y., Wimler K.M., Carmichael G.G. Intronless mRNA transport elements may affect multiple steps of pre-mRNA processing. EMBO J. 18:1999;1642-1652.
22. Izaurralde E. Nuclear export of messenger RNA. Results Probl. Cell Differ. 35:2002;133-150.
23. Jarmolowski A., Boelens W.C., Izaurralde E., Mattaj I.W. Nuclear export of different classes of RNA is mediated by specific factors. J. Cell Biol. 124:1994;627-635.
24. Jensen T.H., Boulay J., Rosbash M., Libri D. The DECD box putative ATPase Sub2p is an early mRNA export factor. Curr. Biol. 11:2001;1711-1715.
25. Kang Y., Cullen B.R. The human Tap protein is a nuclear mRNA export factor that contains novel RNA-binding and nucleocytoplasmic transport sequences. Genes Dev. 13:1999;1126-1139.
26. Katahira J., Strasser K., Podtelejnikov A., Mann M., Jung J.U., Hurt E. The Mex67p-mediated nuclear mRNA export pathway is conserved from yeast to human. EMBO J. 18:1999;2593-2609.
27. Kim V.N., Kataoka N., Dreyfuss G. Role of the nonsense-mediated decay factor hUpf3 in the splicing-dependent exon-exon junction complex. Science. 293:2001;1832-1836. a.
28. Kim V.N., Yong J., Kataoka N., Abel L., Diem M.D., Dreyfuss G. The Y14 protein communicates to the cytoplasm the position of exon-exon junctions. EMBO J. 20:2001;2062-2068. b.
29. Kistler A.L., Guthrie C. Deletion of MUD2, the yeast homolog of U2AF65, can bypass the requirement of Sub2, an essential spliceosomal ATPase. Genes Dev. 15:2001;42-49.
30. Koizumi J., Okamoto Y., Onogi H., Mayeda A., Krainer A.R., Hagiwara M. The subcellular localization of SF2/ASF is regulated by direct interaction with SR protein kinases (SRPKs). J. Biol. Chem. 274:1999;11125-11131.
31. Le Hir H., Izaurralde E., Maquat L.E., Moore M.J. The spliceosome deposits multiple proteins 20-24 nucleotides upstream of mRNA exon-exon junctions. EMBO J. 19:2000;6860-6869.
32. Le Hir H., Gatfield D., Izaurralde E., Moore M.J. The exon-exon junction complex provides a binding platform for factors involved in mRNA export and nonsense-mediated mRNA decay. EMBO J. 20:2001;4987-4997.
33. Lei E.P., Silver P.A. Protein and RNA export from the nucleus. Dev. Cell. 2:2002;261-272.
34. Luo M.L., Zhou Z., Magni K., Christoforides C., Rappsilber J., Mann M., Reed R. Pre-mRNA splicing and mRNA export linked by direct interactions between UAP56 and Aly. Nature (Lond.). 413:2001;644-647.
35. Lykke-Andersen J., Shu M.D., Steitz J.A. Communication of the position of exon-exon junctions to the mRNA surveillance machinery by the protein RNPS1. Science. 293:2001;1836-1839.
36. Ohno M., Segref A., Kuersten S., Mattaj I.W. Identity elements used in export of mRNAs. Mol. Cell. 9:2002;659-671.
37. Piñol-Roma S., Dreyfuss G. Shuttling of pre-mRNA binding proteins between nucleus and cytoplasm. Nature. 355:1992;730-732.
38. Pollard V.W., Michael W.M., Nakielny S., Siomi M.C., Wang F., Dreyfuss G. A novel receptor-mediated nuclear protein import pathway. Cell. 86:1996;985-994.
39. Reed R., Hurt E. A conserved mRNA export machinery coupled to pre-mRNA splicing. Cell. 108:2002;523-531.
40. Reichert V.L., Le Hir H., Jurica M.S., Moore M.J. 5′ exon interactions within the human spliceosome establish a framework for exon junction complex structure and assembly. Genes Dev. 16:2002;2778-2791.
41. Rodrigues J.P., Rode M., Gatfield D., Blencowe B.J., Carmo-Fonseca M., Izaurralde E. REF proteins mediate the export of spliced and unspliced mRNAs from the nucleus. Proc. Natl. Acad. Sci. USA. 98:2001;1030-1035.
42. Sanford J.R., Bruzik J.P. Regulation of SR protein localization during development. Proc. Natl. Acad. Sci. USA. 98:2001;10184-10189.
43. Straesser K., Hurt E. Yrap1, a conserved nuclear RNA-binding protein, interacts directly with Mex67p and is required for mRNA export. EMBO J. 19:2000;410-420.
44. Straesser K., Hurt E. Splicing factor Sub2p is required for nuclear mRNA export through its interaction with Yra1p. Nature (Lond.). 413:2001;648-652.
45. Stutz F., Bachi A., Doerks T., Braun I.C., Seraphin B., Wilm M., Bork P., Izaurralde E. REF, an evolutionary conserved family of hnRNP-like proteins, interacts with TAP/Mex67p and participates in mRNA nuclear export. RNA. 6:2000;638-650.
46. Zhou Z., Luo M., Straesser K., Katahira J., Hurt E., Reed R. The protein Aly links pre-messenger-RNA splicing to nuclear export in metazoans. Nature. 407:2000;401-405.