The splicing factors 9G8 and SRp20 transactivate splicing through different and specific enhancers

RNA

Volumn 5, Issue 3, 1999, Pages 468-483

  Cavaloc, Yvon ^b   Bourgeois, Cyril F ^c   Kister, Liliane ^c   Stévenin, James ^a  

^a INSTITUT DE GÉNÉTIQUE ET DE BIOLOGIE MOLÉCULAIRE ET CELLULAIRE   (France)

^b Inst de Rech Contre le Cancer IRCC   (France)

^c NONE

Author keywords

9G8; Alternative splicing; RNA protein interactions; Splicing enhancer; SR proteins

Indexed keywords

RNA BINDING PROTEIN;

ALTERNATIVE RNA SPLICING; ARTICLE; BINDING AFFINITY; MOLECULAR RECOGNITION; NONHUMAN; PRIORITY JOURNAL; PROTEIN INTERACTION; RNA ANALYSIS; RNA SEQUENCE; TRANSACTIVATION;

ALTERNATIVE SPLICING; BINDING SITES; CONSENSUS SEQUENCE; HUMANS; MUTATION; NUCLEAR PROTEINS; NUCLEOCYTOPLASMIC TRANSPORT PROTEINS; RECOMBINANT PROTEINS; RIBONUCLEOPROTEINS; RNA PRECURSORS; RNA SPLICING; RNA-BINDING PROTEINS; SEQUENCE ALIGNMENT; TRANS-ACTIVATION (GENETICS); ULTRAVIOLET RAYS;

EID: 0033017499     PISSN: 13558382     EISSN: None     Source Type: Journal    
DOI: 10.1017/S1355838299981967     Document Type: Article

References (75)

1. Arning S, Grüter P, Bilbe G, Krämer A. 1996. Mammalian splicing factor SF1 is encoded by variant cDNAs and binds to RNA. RNA 2:794-810.
2. Beil B, Screaton G, Stamm S. 1997. Molecular cloning of htra2β-1 and htra2β-2, two human homologs of tra-2 generated by alternative splicing. DNA Cell Biol 16:679-690.
3. Berglund JA, Charpentier B, Rosbash M. 1997. A high affinity binding site for the HIV-1 nucleocapsid protein. Nucleic Acids Res 25:1042-1049.
4. Birney E, Kumar S, Krainer AR. 1993. Analysis of the RNA-recognition motif and RS and RGG domains: Conservation in metazoan premRNA splicing factors. Nucleic Acids Res 21:5803-5816.
5. Blencowe BJ, Issner R, Nickerson JA, Sharp PA. 1998. A coactivator of pre-mRNA splicing. Genes & Dev 12:996-1009.
6. Burd CG, Dreyfuss G. 1994a. Conserved structures and diversity of functions of RNA-binding proteins. Science 265:615-621.
7. Burd CG, Dreyfuss G. 1994b. RNA binding specificity oh hnRNP A1: Significance of hnRNP A1 high-affinity binding sites in pre-mRNA splicing. EMBO J 13:1197-1204.
8. Cáceres JF, Krainer AR. 1993. Functional analysis of pre-mRNA splicing factor SF2/ASF structural domains. EMBO J 12:4715-4726.
9. Cavaloc Y, Popielarz M, Fuchs JP, Gattoni R, Stévenin J. 1994. Characterization and cloning of the human splicing factor 9G8. EMBO J 13:2639-2649.
10. Chandler SD, Mayeda A, Yeakley JM, Krainer AR, Fu XD. 1997. RNA splicing specificity determined by the coordinated action of RNA recognition motifs in SR proteins. Proc Natl Acad Sci USA 94:3596-3601.
11. Coulter LR, Landree MA, Cooper TA. 1997. Identification of a new class of exonic splicing enhancers by in vivo selection. Mol Cell Biol 17:2143-2150.
12. Del Gatto F, Breathnach R. 1995. Exon and intron sequences, respectively, repress and activate splicing of a Fibroblast Growth Factor Receptor 2 alternative exon. Mol Cell Biol 15:4825-4834.
13. Dirksen WP, Hampson RK, Sun Q, Rottman FM. 1994. A purine-rich exon sequence enhances alternative splicing of bovine growth hormone pre-mRNA. J Biol Chem 269:6431-6436.
14. Elrick LL, Humphrey MB, Cooper TA, Berget SM. 1998. A short sequence within two purine-rich enhancers determines 5′ splice site specificity. Mol Cell Biol 18:343-352.
15. Franck DN, Guthrie C. 1992. An essential splicing factor SLU7 mediates 3′ splice site choice in yeast. Genes & Dev 6:2112-2124.
16. Fu XD. 1993. Specific commitment of different pre-mRNAs to splicing by single SR proteins. Nature 365:82-85.
17. Fu XD. 1995. The superfamily of arginine/serine-rich splicing factors. RNA 1:663-680.
18. Fu XD, Maniatis T. 1992. Isolation of a complementary DNA that encodes the mammalian splicing factor SC35. Science 256:535-538.
19. Fu XD, Mayeda A, Maniatis T, Krainer AR. 1992. General splicing factors SF2 and SC35 have equivalent activities in vitro, and both affect alternative 5′ and 3′ splice site selection. Proc Natl Acad Sci USA 89:11224-11228.
20. Gallego ME, Gattoni R, Stévenin J, Marie J, Expert-Bezançon A. 1997. The SR splicing factors ASF/SF2 and SC35 have antagonistic effects on intronic enhancer-dependent splicing of the β-tropomyosin alternative exon 6A. EMBO J 16:1772-1784.
21. Ge H, Manley JL. 1990. A protein factor, ASF, controls cell-specific alternative splicing of SV40 early pre-mRNA in vitro. Cell 62:25-34.
22. Ge H, Zuo P, Manley JL. 1991. Primary structure of the human splicing factor ASF reveals similarities with drosophila regulators. Cell 66:373-382.
23. Gontarek RR, Derse D. 1996. Interactions among SR proteins, an exonic splicing enhancer, and a lentivirus Rev protein regulate alternative splicing. Mol Cell Biol 16:2325-2331.
24. Gorelick RJ, Henderson LE, Hanser JP, Rein A. 1988. Point mutants of Moloney murine leukemia virus that fail to package viral RNA: Evidence for specific RNA recognition by a "zinc finger-like" protein sequence. Proc Natl Acad Sci USA 85:8420-8424.
25. Graveley BR, Maniatis T. 1998. Arginine/serine-rich domains of SR proteins can function as activators of pre-mRNA splicing. Mol Cell 1:765-771.
26. Heinrichs V, Baker BS. 1995. The Drosophila SR protein RBP1 contributes to the regulation of doublesex alternative splicing by recognizing RBP1 RNA target sequences. EMBO J 14:3987-4000.
27. Heinrichs V, Ryner LC, Baker BS. 1998. Regulation of sex-specific selection of fruitless 5′ splice sites by transformer and transformer-2. Mol Cell Biol 18:450-458
28. Jumaa H, Nielsen PJ. 1997. The splicing factor SRp20 modifies splicing of its own mRNA and ASF/SF2 antagonizes this regulation. EMBO J 16:5077-5085.
29. Kanopka A, Mühlemann O, Akusjärvi G. 1996. SR proteins that are essential for generic pre-mRNA splicing inhibit splicing of a regulated adenovirus pre-mRNA. Nature 381:535-538.
30. Kim YJ, Zuo P, Manley JL, Baker BS. 1992. The Drosophila RNA-binding protein RBP1 is localized to transcriptionally active sites of chromosomes and shows a functional similarity to human splicing factor. Genes & Dev 6:2569-2579.
31. Kohtz JD, Jamison SF, Will CL, Zuo P, Lührmann R, Garcia-Blanco MA, Manley JL. 1994. Protein-protein interactions and 5′ splice site recognition in mammalian RNA precursors. Nature 368:119-124.
32. Krainer AR, Conway GC, Kozak D. 1990. The essential pre-mRNA splicing factor SF2 influences 5′ splice site selection by activating proximal sites. Cell 62:35-42.
33. Krainer AR, Mayeda A, Kozak D, Binns G. 1991. Functional expression of cloned human splicing factor SF2: Homology to RNA binding proteins U1 70K and Drosophila splicing regulators. Cell 66:383-394.
34. Krämer A. 1996. The structure and function of proteins involved in mammalian pre-mRNA splicing. Ann Rev Biochem 65:367-409.
35. Lavigueur A, La Branche H, Kornblihtt AR, Chabot B. 1993. A splicing enhancer in the human fibronectin alternative ED1 exon interacts with SR proteins and stimulates U2 snRNP binding. Genes & Dev 7:2405-2417.
36. Liu HX, Zhang M, Krainer AR. 1998. Identification of functional exonic splicing enhancer motifs recognized by individual SR proteins. Genes & Dev 12:1998-2012.
37. Lou H, Neugebauer KM, Gagel RF, Berget SM. 1998. Regulation of alternative polyadenylation by U1 snRNPs and SRp20. Mol Cell Biol 18:4977-4985.
38. Lynch KW, Maniatis T. 1995. Synergistic interaction between two distinct elements of a regulated splicing enhancer. Genes & Dev 9:284-293.
39. Lynch KW, Maniatis T. 1996 Assembly of specific SR protein complexes on distinct regulatory elements of the Drosophila double-sex splicing enhancer. Genes & Dev 10:2089-2101.
40. Manley JL, Tacke R. 1996. SR proteins and splicing control. Genes & Dev 10:1569-1579.
41. Mazen A, Gradwohl G, De Murcia G. 1988. Zinc-binding proteins detected by protein blotting. Anal Biochem 172:39-42.
42. McNally LM, McNally MT. 1996. SR protein splicing factors interact with the Rous sarcoma virus negative regulator of splicing element. J Virol 70:1163-1172.
43. Moore JM, Query CC, Sharp PA. 1993. Splicing of precursors to messenger RNAs by the spliceosome. In: Gesteland RF, Atkins JF, eds. The RNA world. Cold Spring Harbor, New York: Cold Spring Harbor Laboratory Press. pp 303-358.
44. Ramchatesingh J, Zahler AM, Neugebauer KM, Roth MB, Cooper TA. 1995. A subset of SR proteins activates splicing of the cardiac troponin T alternative exon by directing interactions with an exonic enhancer. Mol Cell Biol 15:4898-4907.
45. Roscigno RF, Garcia-Blanco MA. 1995. SR proteins escort U4/ U6.U5 tri-snRNP to the spliceosome. RNA 1:692-706.
46. Ryan KJ, Cooper TA. 1996. Muscle-specific enhancers regulate inclusion of the cardiac troponin T alternative exon in embryonic skeletal muscle. Mol Cell Biol 16:4014-4023.
47. Samuels ME, Daniel B, Colvin RA, Roscigno RF, Garcia-Blanco MA, Schedl P. 1994. RNA binding by Sxl proteins in vitro and in vivo. Mol Cell Biol 14:4975-4990.
48. Sarkissian M, Winne A, Lafayatis R. 1996. The mammalian homolog of Suppressor-of-white-apricot regulates alternative mRNA splicing of CD45 exon 4 and fibronectin IIICS. J Biol Chem 271:31106-31114.
49. Schmitt P, Gattoni R, Keohavong P, Stévenin J. 1987. Alternative splicing of E1A transcripts of adenovirus requires appropriate ionic conditions. Cell 50:31-39.
50. Screaton GR, Cáceres JF, Mayeda A, Bell MV, Plebanski M, Jackson DG, Bell JI, Krainer AR. 1995. Identification and characterization of three members of the human SR family of pre-mRNA splicing factors. EMBO J 14:4336-4349.
51. Shi H, Hoffman BE, Lis JT. 1997. A specific RNA hairpin loop structure binds the RNA recognition motifs of the Drosophila SR proteins B52. Mol Cell Biol 17:2649-2657.
52. Soret J, Gattoni R, Guyon C, Sureau A, Popielarz M, Dumon S, Le Rouzic E, Apiou F, Dutrillaux B, Voss H, Ansorge W, Stévenin J, Perbal B. 1998. Characterization of SRp46, a novel human SR splicing factor encoded by a PR264/SC35 retropseudogene. Mol Cell Biol 18:4924-4934.
53. Staknis D, Reed R. 1994. SR proteins promote the first specific recognition of pre-mRNA and are present together with the U1 small nuclear ribonucleoprotein particle in a general splicing enhancer complex. Mol Cell Biol 14:7670-7682.
54. Sun Q, Mayeda A, Hampson RK, Krainer AR, Rottman FM. 1993. General splicing factor ASF/SF2 promotes alternative splicing by binding to an exonic splicing enhancer. Genes & Dev 7:2598-2608.
55. Tacke R, Chen Y, Manley JL. 1997. Sequence-specific RNA binding by an SR protein requires RS domain phosphorylation: Creation of an SRp40-specific splicing enhancer. Proc Natl Acad Sci USA 94:1148-1153.
56. Tacke R, Manley JL. 1995. The human splicing factors ASF/SF2 and SC35 possess different, functionally significant, RNA binding specificities. EMBO J 14:3540-3551.
57. Tacke R, Tohyama M, Ogawa S, Manley JL 1998. Human Tra2 proteins are sequence-specific activators of pre-mRNA splicing. Cell 93:139-148.
58. Tronchère H, Wang J, Fu XD. 1997. A protein related to splicing factor U2AF35 that interacts with U2AF65 and SR proteins in splicing of pre-mRNA. Nature 388:397-400.
59. Tuerk C, Gold L. 1990. Systematic evolution of ligands by exponential enrichment: RNA ligands to bacteriophage T4 DNA polymerase. Science 249:505-510.
60. Valcárcel J, Singh R, Zamore PD, Green MR. 1993. The protein Sex-lethal antagonizes the splicing factor U2AF to regulate alternative splicing of the transformer pre-mRNA. Nature 362:171-175.
61. Vellard M, Sureau A, Soret J, Martinerie C, Perbal B. 1992. A potential splicing factor is encoded by the opposite strand of the trans-spliced c-myb exon. Proc Natl Acad Sci USA 89:2511-2515.
62. Wang J, Manley JL 1995. Overexpression of the SR proteins ASF/ SF2 and SC35 influences alternative splicing in vivo in diverse ways. RNA 1:335-346.
63. Wang J, Takagaki Y, Manley JL. 1996. Targeted disruption of an essential vertebrate gene: ASF/SF2 is required for cell viability. Genes & Dev 10:2588-2599.
64. Wang J, Xiao SH, Manley JL 1998. Genetic analysis of the SR protein ASF/SF2: Interchangeability of RS domains and negative control of splicing. Genes & Dev 12:2222-2233.
65. Wu JY, Maniatis T. 1993. Specific interactions between proteins implicated in splice site selection and regulated alternative splicing. Cell 75:1061-1070.
66. Xiao SH, Manley JL. 1997. Phosphorylation of the ASF/SF2 RS domain affects both protein-protein and protein-RNA interactions and is necessary for splicing. Genes & Dev 11:334-344.
67. Xu R, Teng J, Cooper TA. 1993. The cardiac troponin T alternative exon contains a novel purine-rich positive splicing element. Mol Cell Biol 13:3660-3674.
68. Zahler AM, Lane WS, Stolk JA, Roth MB. 1992. SR proteins: A conserved family of pre-mRNA splicing factors. Genes & Dev 6:837-847.
69. Zahler AM, Neugebauer KM, Lane WS, Roth MB. 1993a. Distinct functions of SR proteins in alternative pre-mRNA splicing. Science 260:219-222.
70. Zahler AM, Neugebauer KM, Stolk JA, Roth MB. 1993b. Human SR proteins and isolation of a cDNA encoding SRp75. Mol Cell Biol 13:4023-4028.
71. Zahler AM, Roth MB. 1995. Distinct functions of SR proteins in recruitment of U1 small nuclear ribonucleoprotein to alternative 5′ splice sites. Proc Natl Acad Sci USA 92:2642-2646.
72. Zhang WJ, Wu JY. 1996. Functional properties of p54, a novel SR protein active in constitutive and alternative splicing. Mol Cell Biol 16:5400-5408.
73. Zhang WJ, Wu JY. 1998. Sip1, a novel RS domain-containing protein essential for pre-mRNA splicing. Mol Cell Biol 18:676-684.
74. Zuo P, Manley JL. 1993. Functional domains of the human splicing factor ASF/SF2. EMBO J 12:4727-4737.
75. Zuo P, Manley JL 1994. The human splicing ASF/SF2 can specifically recognize pre-mRNA 5′ splice sites. Proc Natl Acad Sci USA 91:3363-3367.