Identification of a single nucleotide polymorphism showing no insulin-mediated suppression of the promoter activity in the human insulin receptor substrate 2 gene

Diabetologia

Volumn 45, Issue 8, 2002, Pages 1182-1195

  Iwamoto, K ^b   Mori, H ^b   Okazawa, H ^b   Hashiramoto, M ^a   Kasuga, M ^b  

^a KOBE UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b KOBE UNIVERSITY   (Japan)

Author keywords

Fao; Genetics; Insulin; Insulin receptor substrate 2; Insulin responsive element; Luciferase assay; Promoter; Single nucleotide polymorphism; Transcription; Type II diabetes

Indexed keywords

DEOXYRIBONUCLEASE I; HUMAN INSULIN; INSULIN; INSULIN RECEPTOR SUBSTRATE 2; LUCIFERASE; OLIGONUCLEOTIDE; THYMINE;

ADULT; AGED; ARTICLE; ASSAY; CELL LINE; CELL STRAIN HEPG2; CONTROLLED STUDY; DNA FLANKING REGION; ELECTROPHORETIC MOBILITY; FEMALE; GENE ACTIVITY; GENE REPRESSION; GENETIC SCREENING; GENOTYPE; HELA CELL; HORMONAL REGULATION; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; JAPAN; MAJOR CLINICAL STUDY; MALE; MOLECULAR CLONING; MUTATIONAL ANALYSIS; NON INSULIN DEPENDENT DIABETES MELLITUS; NUCLEOTIDE SEQUENCE; PLASMID; PRIORITY JOURNAL; PROMOTER REGION; REPORTER GENE; SEQUENCE ANALYSIS; SINGLE NUCLEOTIDE POLYMORPHISM; TRANSCRIPTION REGULATION; TRANSLATION INITIATION;

5' UNTRANSLATED REGIONS; AGED; BASE SEQUENCE; CELLS, CULTURED; DEOXYRIBONUCLEASE I; DIABETES MELLITUS, TYPE 2; DNA FOOTPRINTING; ELECTROPHORESIS; FEMALE; HUMANS; HYPOGLYCEMIC AGENTS; INSULIN; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; MIDDLE AGED; MOLECULAR SEQUENCE DATA; MUTATION; PHOSPHOPROTEINS; POLYMORPHISM, SINGLE NUCLEOTIDE; PROMOTER REGIONS (GENETICS);

EID: 0036366991     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00125-002-0871-0     Document Type: Article

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