메뉴 건너뛰기




Volumn 368, Issue 4, 2003, Pages 239-246

NHE-1 inhibition: From protection during acute ischaemia/reperfusion to prevention/reversal of myocardial remodelling

Author keywords

Cariporide; Hypertrophy; Ischaemia; Myocardial remodelling; NHE 1; Reperfusion

Indexed keywords

(3 METHYLSULFONYL 4 PIPERIDINOBENZOYL)GUANIDINE METHANESULFONATE; 1 (3,4 DIHYDRO 4 ISOPROPYL 2,2 DIMETHYL 3 OXO 2H 1,4 BENZOXAZINE 6 CARBONYL)GUANIDINE; 5 (N ETHYL N ISOPROPYL)AMILORIDE; ACETYLCHOLINE; ALPHA 1 ADRENERGIC RECEPTOR; AMILORIDE; ANGIOTENSIN; BRADYKININ; CARDIOVASCULAR AGENT; CARIPORIDE; ENDOTHELIN 1; ENIPORIDE; G PROTEIN COUPLED RECEPTOR; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE 1; N AMIDINO 1,4 DIMETHYL 1H INDOLE 2 CARBOXAMIDE; PHOSPHATIDYLINOSITOL 4,5 BISPHOSPHATE; SODIUM PROTON EXCHANGE PROTEIN; SODIUM PROTON EXCHANGE PROTEIN 1; SODIUM PROTON EXCHANGE PROTEIN 1 INHIBITOR; SODIUM PROTON EXCHANGE PROTEIN 2; SODIUM PROTON EXCHANGE PROTEIN 3; SODIUM PROTON EXCHANGE PROTEIN 4; SODIUM PROTON EXCHANGE PROTEIN 5; SODIUM PROTON EXCHANGE PROTEIN 6; SODIUM PROTON EXCHANGE PROTEIN 7; SODIUM PROTON EXCHANGE PROTEIN 8; THROMBIN; UNCLASSIFIED DRUG; UNINDEXED DRUG;

EID: 0242643761     PISSN: 00281298     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00210-003-0808-2     Document Type: Review
Times cited : (36)

References (99)
  • 3
    • 0034919120 scopus 로고    scopus 로고
    • + exchange inhibitors: Potential mechanisms of action
    • + exchange inhibitors: potential mechanisms of action. Basic Res Cardiol 96:306-311
    • (2001) Basic Res Cardiol , vol.96 , pp. 306-311
    • Avkiran, M.1
  • 4
    • 0037028890 scopus 로고    scopus 로고
    • + exchange inhibitors for cardioprotective therapy: Progress, problems and prospects
    • + exchange inhibitors for cardioprotective therapy: progress, problems and prospects. J Am Col Cardiol 39:747-753
    • (2002) J Am Col Cardiol , vol.39 , pp. 747-753
    • Avkiran, M.1    Marber, M.S.2
  • 5
    • 0032767849 scopus 로고    scopus 로고
    • + exchanger activity: Potential pathophysiological significance of endogenous mediators and oxidant stress
    • + exchanger activity: potential pathophysiological significance of endogenous mediators and oxidant stress. J Thromb Thrombolysis 8:25-31
    • (2001) J Thromb Thrombolysis , vol.8 , pp. 25-31
    • Avkiran, M.1    Snabaitis, A.K.2
  • 7
    • 0037426418 scopus 로고    scopus 로고
    • Sodium-hydrogen exchange inhibition during ventricular fibrillation. Beneficial effects on ischemic contracture, action potential duration, reperfusion arrhythmias, myocardial function, and resuscitability
    • Ayoub IM, Kolarova J, Yi Z, Trevedi A, Deshmukh H, Lubell DL, Franz MR, Maldonado FA, Gazmuri RJ (2003) Sodium-hydrogen exchange inhibition during ventricular fibrillation. Beneficial effects on ischemic contracture, action potential duration, reperfusion arrhythmias, myocardial function, and resuscitability. Circulation 107:1804-1809
    • (2003) Circulation , vol.107 , pp. 1804-1809
    • Ayoub, I.M.1    Kolarova, J.2    Yi, Z.3    Trevedi, A.4    Deshmukh, H.5    Lubell, D.L.6    Franz, M.R.7    Maldonado, F.A.8    Gazmuri, R.J.9
  • 10
    • 0024840740 scopus 로고
    • Pharmacological interference with the cardiac renin angiotensin system
    • Becker RHA, Linz W, Schölkens BA (1989) Pharmacological interference with the cardiac renin angiotensin system. J Cardiovasc Pharmacol 14 (suppl. 4):S10-S15
    • (1989) J Cardiovasc Pharmacol , vol.14 , Issue.4 SUPPL.
    • Becker, R.H.A.1    Linz, W.2    Schölkens, B.A.3
  • 14
    • 0036083415 scopus 로고    scopus 로고
    • + exchanger isoform 6 is found in recycling endosomes of cells, not in mitochondria
    • + exchanger isoform 6 is found in recycling endosomes of cells, not in mitochondria. Am J Physiol 282:C1031-C1041
    • (2002) Am J Physiol , vol.282
    • Brett, C.L.1    Wie, Y.2    Donowitz, M.3    Rao, R.4
  • 18
    • 0033452483 scopus 로고    scopus 로고
    • + exchange hyperactivity and myocardial hypertrophy: Are they linked phenomena?
    • + exchange hyperactivity and myocardial hypertrophy: are they linked phenomena? Cardiovasc Res 44:462-467
    • (1999) Cardiovasc Res , vol.44 , pp. 462-467
    • Cingolani, H.E.1
  • 20
    • 0033577956 scopus 로고    scopus 로고
    • Activation of protein kinase cascades in the heart by hypertrophic G protein coupled receptor agonists
    • Clerk A, Sugden PH (1999) Activation of protein kinase cascades in the heart by hypertrophic G protein coupled receptor agonists. Am J Cardiol 83:64H-69H
    • (1999) Am J Cardiol , vol.83
    • Clerk, A.1    Sugden, P.H.2
  • 22
    • 0027524761 scopus 로고
    • + antiporter isoforms using amiloride analogs and a new inhibitor exhibiting anti-ischemic properties
    • + antiporter isoforms using amiloride analogs and a new inhibitor exhibiting anti-ischemic properties. Mol Pharmacol 44:1041-1045
    • (1993) Mol Pharmacol , vol.44 , pp. 1041-1045
    • Counillon, L.1    Scholz, W.2    Lang, H.J.3    Pouysségur, J.4
  • 23
    • 0031908435 scopus 로고    scopus 로고
    • + exchanger mRNA levels in ischemic hearts from diabetic rats
    • + exchanger mRNA levels in ischemic hearts from diabetic rats. Mol Cell Biochem 180:85-93
    • (1998) Mol Cell Biochem , vol.180 , pp. 85-93
    • Dyck, J.R.1    Lopaschuk, G.D.2
  • 24
    • 0028859824 scopus 로고
    • Induction of expression of the sodium-hydrogen exchanger in rat myocardium
    • Dyck JRB, Maddaford T, Pierce GN, Fliegel L (1995) Induction of expression of the sodium-hydrogen exchanger in rat myocardium. Cardiovasc Res 29:203-208
    • (1995) Cardiovasc Res , vol.29 , pp. 203-208
    • Dyck, J.R.B.1    Maddaford, T.2    Pierce, G.N.3    Fliegel, L.4
  • 25
    • 0037134401 scopus 로고    scopus 로고
    • + exchange prevents hypertrophy, fibrosis, and heart failure in β1-adrenergic receptor transgenic mice
    • + exchange prevents hypertrophy, fibrosis, and heart failure in β1-adrenergic receptor transgenic mice. Circ Res 90:814-819
    • (2002) Circ Res , vol.90 , pp. 814-819
    • Engelhardt, S.1    Hein, L.2    Keller, U.3    Klaembt, K.4    Lohse, M.J.5
  • 26
    • 0033586997 scopus 로고    scopus 로고
    • GUARD During Ischemia Against Necrosis (GUARDIAN) trial in acute coronary syndromes
    • Erhardt LR (1999) GUARD During Ischemia Against Necrosis (GUARDIAN) trial in acute coronary syndromes. Am J Cardiol 83:23G-25G
    • (1999) Am J Cardiol , vol.83
    • Erhardt, L.R.1
  • 28
    • 0031281724 scopus 로고    scopus 로고
    • + exchange regulation and the role of the exchanger in hypertension and cardiac function in health and disease
    • + exchange regulation and the role of the exchanger in hypertension and cardiac function in health and disease. Cardiovasc Res 36:138-148
    • (1997) Cardiovasc Res , vol.36 , pp. 138-148
    • Fröhlich, O.1    Karmazyn, M.2
  • 32
    • 0036215144 scopus 로고    scopus 로고
    • Myocardial protection during ventricular fibrillation by inhibition of the sodium-hydrogen exchanger isoform-1
    • Gazmuri RJ, Ayoub IM, Kolarova JD, Karmazyn M (2002) Myocardial protection during ventricular fibrillation by inhibition of the sodium-hydrogen exchanger isoform-1. Crit Care Med 30:S166-S171
    • (2002) Crit Care Med , vol.30
    • Gazmuri, R.J.1    Ayoub, I.M.2    Kolarova, J.D.3    Karmazyn, M.4
  • 34
    • 0033613553 scopus 로고    scopus 로고
    • + exchanger confers greater cardioprotection against 90 minutes of myocardial ischemia than ischemic preconditioning in dogs
    • + exchanger confers greater cardioprotection against 90 minutes of myocardial ischemia than ischemic preconditioning in dogs. Circulation 100:2519-2526
    • (1999) Circulation , vol.100 , pp. 2519-2526
    • Gumina, R.J.1    Buerger, E.2    Eickmeier, C.3    Moore, J.4    Daemmgen, J.5    Gross, G.J.6
  • 35
    • 0034685967 scopus 로고    scopus 로고
    • + exchanger attenuates phase 1b ischemic arrhythmias and reperfusion-induced ventricular fibrillation
    • + exchanger attenuates phase 1b ischemic arrhythmias and reperfusion-induced ventricular fibrillation. Eur J Pharmacol 396:119-124
    • (2000) Eur J Pharmacol , vol.396 , pp. 119-124
    • Gumina, R.J.1    Daemmgen, J.2    Gross, G.J.3
  • 36
    • 0034925576 scopus 로고    scopus 로고
    • Do NHE inhibition and ischemic preconditioning convey cardioprotection through a common mechanism?
    • Gumina RJ, Terzic A, Gross GJ (2001) Do NHE inhibition and ischemic preconditioning convey cardioprotection through a common mechanism? Basic Res Cardiol 96:318-324
    • (2001) Basic Res Cardiol , vol.96 , pp. 318-324
    • Gumina, R.J.1    Terzic, A.2    Gross, G.J.3
  • 37
    • 0037372388 scopus 로고    scopus 로고
    • Effective protection by NHE1 inhibition in ischemic and reperfused heart under preconditioning blockade
    • Haist JV, Hirst CN, Karmazyn M (2003) Effective protection by NHE1 inhibition in ischemic and reperfused heart under preconditioning blockade. Am J Physiol 284:H798-H803
    • (2003) Am J Physiol , vol.284
    • Haist, J.V.1    Hirst, C.N.2    Karmazyn, M.3
  • 42
    • 0034920855 scopus 로고    scopus 로고
    • Role of sodium-hydrogen exchange in cardiac hypertrophy and heart failure: A novel and promising therapeutic target
    • Karmazyn M (2001) Role of sodium-hydrogen exchange in cardiac hypertrophy and heart failure: a novel and promising therapeutic target. Basic Res Cardiol 96:325-328
    • (2001) Basic Res Cardiol , vol.96 , pp. 325-328
    • Karmazyn, M.1
  • 43
    • 0036221290 scopus 로고    scopus 로고
    • + exchange inhibition
    • + exchange inhibition. Drug Dev Res 55:22-28
    • (2002) Drug Dev Res , vol.55 , pp. 22-28
    • Karmazyn, M.1
  • 46
    • 0034680325 scopus 로고    scopus 로고
    • + exchange inhibitor cariporide attenuates cell injury predominantly during ischemia and not at onset of reperfusion in porcine hearts with low residual flow
    • + exchange inhibitor cariporide attenuates cell injury predominantly during ischemia and not at onset of reperfusion in porcine hearts with low residual flow. Circulation 102:1977-1982
    • (2000) Circulation , vol.102 , pp. 1977-1982
    • Klein, H.H.1    Pich, S.2    Bohle, R.M.3    Lindert-Heimberg, S.4    Nebendahl, K.5
  • 49
    • 0035136278 scopus 로고    scopus 로고
    • Pharmacokinetic/pharmacodynamic evaluation of the NHE inhibitor eniporide
    • Kovar, A, Peters T, Beier N, Derendorf H (2001) Pharmacokinetic/ pharmacodynamic evaluation of the NHE inhibitor eniporide. J Clin Pharmacol 41:139-148
    • (2001) J Clin Pharmacol , vol.41 , pp. 139-148
    • Kovar, A.1    Peters, T.2    Beier, N.3    Derendorf, H.4
  • 51
    • 0034996073 scopus 로고    scopus 로고
    • + exchange inhibition reduces hypertrophy and heart failure after myocardial infarction in rats
    • + exchange inhibition reduces hypertrophy and heart failure after myocardial infarction in rats. Am J Physiol 280:H738-H745
    • (2001) Am J Physiol , vol.280
    • Kusumoto, K.1    Haist, J.V.2    Karmazyn, M.3
  • 52
    • 0029981094 scopus 로고    scopus 로고
    • A calcineurin homologous protein inhibits GTPase-stimulated Na-H exchange
    • Lin X, Barber DL (1996) A calcineurin homologous protein inhibits GTPase-stimulated Na-H exchange. J Biol Chem 93: 12631-12636
    • (1996) J Biol Chem , vol.93 , pp. 12631-12636
    • Lin, X.1    Barber, D.L.2
  • 54
    • 0031686683 scopus 로고    scopus 로고
    • Dose-dependent reduction of myocardial infarct mass in rabbits by the NHE-1 inhibitor cariporide (HOE 642)
    • Linz W, Albus U, Crause P, Jung W, Weichert A, Schölkens BA, Scholz W (1998) Dose-dependent reduction of myocardial infarct mass in rabbits by the NHE-1 inhibitor cariporide (HOE 642). Clin Exp Hypertens 20:733-749
    • (1998) Clin Exp Hypertens , vol.20 , pp. 733-749
    • Linz, W.1    Albus, U.2    Crause, P.3    Jung, W.4    Weichert, A.5    Schölkens, B.A.6    Scholz, W.7
  • 55
    • 0037133703 scopus 로고    scopus 로고
    • Effects of cariporide and losartan on hypertrophy, calcium transients, contractility, and gene expression in congestive heart failure
    • Loennechen JP, Wisloff U, Falck G, Ellingsen O (2002) Effects of cariporide and losartan on hypertrophy, calcium transients, contractility, and gene expression in congestive heart failure. Circulation 105:1380-1386
    • (2002) Circulation , vol.105 , pp. 1380-1386
    • Loennechen, J.P.1    Wisloff, U.2    Falck, G.3    Ellingsen, O.4
  • 56
    • 0022362862 scopus 로고
    • A simple method for collagen and total protein determination in formalin-fixed paraffin-embedded sections
    • López-de León A, Rojkind M (1985) A simple method for collagen and total protein determination in formalin-fixed paraffin-embedded sections. J Histochem Cytochem 33:737-743
    • (1985) J Histochem Cytochem , vol.33 , pp. 737-743
    • López-de León, A.1    Rojkind, M.2
  • 59
    • 0032736233 scopus 로고    scopus 로고
    • Acute regulation of proximal tubule apical membrane Na/H exchanger NHE-3: Role of phosphorylation, protein trafficking, and regulatory factors
    • Moe OW (1999) Acute regulation of proximal tubule apical membrane Na/H exchanger NHE-3: role of phosphorylation, protein trafficking, and regulatory factors. J Am Soc Nephrol 10:2412-2425
    • (1999) J Am Soc Nephrol , vol.10 , pp. 2412-2425
    • Moe, O.W.1
  • 60
    • 0033551771 scopus 로고    scopus 로고
    • + exchanger in the rat myocardium by MAP-kinase-dependent pathways
    • + exchanger in the rat myocardium by MAP-kinase-dependent pathways. J Biol Chem 274:22985-229992
    • (1999) J Biol Chem , vol.274 , pp. 22985-229992
    • Moor, A.N.1    Fliegel, L.2
  • 62
    • 0035844256 scopus 로고    scopus 로고
    • + exchanger-directed protein kinases in the ischemic and ischemic-reperfused rat myocardium
    • + exchanger-directed protein kinases in the ischemic and ischemic-reperfused rat myocardium. J Biol Chem 276:16113-16122
    • (2001) J Biol Chem , vol.276 , pp. 16113-16122
    • Moor, A.N.1    Gan, X.T.2    Karmazyn, M.3    Fliegel, L.4
  • 63
    • 0035907355 scopus 로고    scopus 로고
    • + exchanger localized to the trans-Golgi network
    • + exchanger localized to the trans-Golgi network. J Biol Chem 276:17387-17394
    • (2001) J Biol Chem , vol.276 , pp. 17387-17394
    • Numata, M.1    Orlowski, J.2
  • 67
    • 0021949370 scopus 로고
    • High-performance liquid chromatographic analysis of free hydroxyproline and proline in blood plasma and of free and peptide-bound hydroxyproline in urine
    • Palmerini CA, Fini C, Floridi A, Morelli H, Vedovelli A (1985) High-performance liquid chromatographic analysis of free hydroxyproline and proline in blood plasma and of free and peptide-bound hydroxyproline in urine. J Chromatogr 339:285-292
    • (1985) J Chromatogr , vol.339 , pp. 285-292
    • Palmerini, C.A.1    Fini, C.2    Floridi, A.3    Morelli, H.4    Vedovelli, A.5
  • 73
    • 0036623825 scopus 로고    scopus 로고
    • Hypertrophic responsiveness of cardiomyocytes to α- or β-adrenoceptor stimulation requires sodium-proton-exchanger-1 (NHE-1) activation but not cellular alkalization
    • Schäfer M, Schäfer C, Piper H, Schlüter K-D (2002) Hypertrophic responsiveness of cardiomyocytes to α-or β-adrenoceptor stimulation requires sodium-proton-exchanger-1 (NHE-1) activation but not cellular alkalization. Eur J Heart Fail 4:249-254
    • (2002) Eur J Heart Fail , vol.4 , pp. 249-254
    • Schäfer, M.1    Schäfer, C.2    Piper, H.3    Schlüter, K.-D.4
  • 75
  • 76
    • 0032790859 scopus 로고    scopus 로고
    • + exchange inhibitor cariporide as a cardioprotective drug: From the laboratory to the GUARDIAN trial
    • + exchange inhibitor cariporide as a cardioprotective drug: from the laboratory to the GUARDIAN trial. J Thromb Thrombolysis 8:61-70
    • (1999) J Thromb Thrombolysis , vol.8 , pp. 61-70
    • Scholz, W.1    Jessel, A.2    Albus, U.3
  • 83
    • 0034687597 scopus 로고    scopus 로고
    • Inhibition of the sodium-hydrogen exchanger with cariporide to prevent myocardial infarction in high-risk ischemic situations. Main results of the GUARDIAN trial
    • Guard during ischemia against necrosis (GUARDIAN) Investigators
    • Theroux P, Chaitman BR, Danchin N, Erhardt L, Meinertz T, Schroeder JS, Tognoni G, White HD, Willerson J-T, Jessel A (2000) Inhibition of the sodium-hydrogen exchanger with cariporide to prevent myocardial infarction in high-risk ischemic situations. Main results of the GUARDIAN trial. Guard during ischemia against necrosis (GUARDIAN) Investigators. Circulation 102:3032-3038
    • (2000) Circulation , vol.102 , pp. 3032-3038
    • Theroux, P.1    Chaitman, B.R.2    Danchin, N.3    Erhardt, L.4    Meinertz, T.5    Schroeder, J.S.6    Tognoni, G.7    White, H.D.8    Willerson, J.-T.9    Jessel, A.10
  • 84
    • 0037219497 scopus 로고    scopus 로고
    • MRI/MRS evaluation of cariporide in a canine long-term model of reperfused ischemic insults
    • Thompson K, Wisenberg G, Sykes RVT, Thompson RT (2003) MRI/MRS evaluation of cariporide in a canine long-term model of reperfused ischemic insults. J. Magn Reson Imaging. 17: 136-141
    • (2003) J Magn Reson Imaging , vol.17 , pp. 136-141
    • Thompson, K.1    Wisenberg, G.2    Sykes, R.V.T.3    Thompson, R.T.4
  • 85
    • 0037449475 scopus 로고    scopus 로고
    • Characterization of sabiporide, a new specific NHE-1 inhibitor exhibiting slow dissociation kinetics and cardioprotective effects
    • Touret N, Tanneur V, Godart H, Seidler R, Taki N, Bürger E, Dämmgen J, Counillon L (2003) Characterization of sabiporide, a new specific NHE-1 inhibitor exhibiting slow dissociation kinetics and cardioprotective effects. Eur J Pharmacol. 459:151-158
    • (2003) Eur J Pharmacol , vol.459 , pp. 151-158
    • Touret, N.1    Tanneur, V.2    Godart, H.3    Seidler, R.4    Taki, N.5    Bürger, E.6    Dämmgen, J.7    Counillon, L.8
  • 92
    • 0035075571 scopus 로고    scopus 로고
    • NHE-1 inhibitor cariporide prevents the transient reperfusion-induced shortening of the monophasic action potential after coronary ischemia in pigs
    • Wirth KJ, Maier T, Busch AE (2001) NHE-1 inhibitor cariporide prevents the transient reperfusion-induced shortening of the monophasic action potential after coronary ischemia in pigs. Basic Res Cardiol 96:192-197
    • (2001) Basic Res Cardiol , vol.96 , pp. 192-197
    • Wirth, K.J.1    Maier, T.2    Busch, A.E.3
  • 93
    • 0035010664 scopus 로고    scopus 로고
    • + exchange inhibitor, SM-20550, on ischemia/reperfusion-induced endothelial dysfunction in isolated perfused rat hearts
    • + exchange inhibitor, SM-20550, on ischemia/ reperfusion-induced endothelial dysfunction in isolated perfused rat hearts. Int J Tissue React 23:1-7
    • (2001) Int J Tissue React , vol.23 , pp. 1-7
    • Yamamoto, S.1    Matsui, K.2    Itoh, N.3    Ohashi, N.4
  • 94
    • 0032498850 scopus 로고    scopus 로고
    • Role of ion channels and exchangers in mechanical stretch-induced cardiomyocyte hypertrophy
    • Yamazaki T, Komuro I, Kudoh S, et al. (1998) Role of ion channels and exchangers in mechanical stretch-induced cardiomyocyte hypertrophy. Circ Res 82:430-437
    • (1998) Circ Res , vol.82 , pp. 430-437
    • Yamazaki, T.1    Komuro, I.2    Kudoh, S.3
  • 97
    • 0033982650 scopus 로고    scopus 로고
    • + exchange inhibition attenuates hypertrophy and heart failure in 1-wk postinfarction rat myocardium
    • + exchange inhibition attenuates hypertrophy and heart failure in 1-wk postinfarction rat myocardium. Am J Physiol 278:H300-H304
    • (2000) Am J Physiol , vol.278
    • Yoshida, H.1    Karmazyn, M.2
  • 98
    • 0035890319 scopus 로고    scopus 로고
    • + exchange inhibitor eniporide as an adjunct to early reperfusion therapy for acute myocardial infarction: Results of the Evaluation of the Safety and Cardioprotective Effects of Eniporide in Acute Myocardial Infarction (ESCAMI) trial
    • + exchange inhibitor eniporide as an adjunct to early reperfusion therapy for acute myocardial infarction: results of the Evaluation of the Safety and Cardioprotective Effects of Eniporide in Acute Myocardial Infarction (ESCAMI) trial. J Am Coll Cardiol 38:1644-1650
    • (2001) J Am Coll Cardiol , vol.38 , pp. 1644-1650
    • Zeymer, U.1    Suryapranata, H.2    Monassier, J.P.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.